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Search results 101 to 197 out of 197 for Crb3

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Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:4886204
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3266028
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945475
Age: postnatal day 42
Image: g00997 Adult
Specimen Label: g00997 Adult
Detected: true
Specimen Num: 4
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•
GXD Expression
GXD Expression
 
Probe: MGI:4886204
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754028
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945475
Age: postnatal day 7
Image: g00997 P7
Specimen Label: g00997 P7
Detected: true
Specimen Num: 3
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•
GXD Expression
GXD Expression
 
Probe: MGI:4886204
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754028
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945475
Age: postnatal day 42
Image: g00997 Adult
Specimen Label: g00997 Adult
Detected: true
Specimen Num: 4
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•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4886204
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280923
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945475
Age: embryonic day 15.5
Image: g00997 E15.5
Specimen Label: g00997 E15.5
Detected: true
Specimen Num: 2
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•
GXD Expression
GXD Expression
 
Probe: MGI:4886204
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280928
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945475
Age: postnatal day 7
Image: g00997 P7
Specimen Label: g00997 P7
Detected: true
Specimen Num: 3
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•
GXD Expression
GXD Expression
 
Probe: MGI:4886204
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280928
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945475
Age: postnatal day 42
Image: g00997 Adult
Specimen Label: g00997 Adult
Detected: true
Specimen Num: 4
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•
GXD Expression
GXD Expression
Probe: MGI:7434426
Assay Type: Immunohistochemistry
Annotation Date: 2023-02-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1779024
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:7435351
Age: embryonic day 16.5
Image: 8G
Note: Expressed in the apical junctional complex of neuroepithelium at the ventricular surface continuously.
Specimen Label: 8G
Detected: true
Specimen Num: 1
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•
GXD Expression
GXD Expression
   
Probe: MGI:7434426
Assay Type: Immunohistochemistry
Annotation Date: 2023-02-17
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1779024
Stage: TS24
Assay Id: MGI:7435351
Age: embryonic day 16.5
Image: 8H
Specimen Label: 8H
Detected: false
Specimen Num: 2
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•
GXD Expression
GXD Expression
Probe: MGI:7434426
Assay Type: Immunohistochemistry
Annotation Date: 2023-02-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1779022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:7435351
Age: embryonic day 14.5
Image: 8K
Note: Expressed in the apical junctional complex of neuroepithelium at the ventricular surface continuously.
Specimen Label: 8K
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:7434426
Assay Type: Immunohistochemistry
Annotation Date: 2023-02-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1779022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:7435351
Age: embryonic day 14.5
Image: 8L
Note: Loss of apical localization of Crbs correlated with the Yap1-reduced area.
Specimen Label: 8L
Detected: true
Specimen Num: 4
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•
GXD Expression
GXD Expression
Probe: MGI:7434426
Assay Type: Immunohistochemistry
Annotation Date: 2023-02-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1779024
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:7435353
Age: embryonic day 16.5
Image: S7C/C'
Note: Expressed in the apical junctional complex of neuroepithelium at the ventricular surface continuously.
Specimen Label: S7C/C'
Detected: true
Specimen Num: 1
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•
GXD Expression
GXD Expression
Probe: MGI:7434426
Assay Type: Immunohistochemistry
Annotation Date: 2023-02-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1779024
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:7435353
Age: embryonic day 16.5
Image: S7D/D'
Note: Not expressed at the ventricular surface in some areas.
Specimen Label: S7D/D'
Detected: true
Specimen Num: 2
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•
GXD Expression
GXD Expression
 
Probe: MGI:4886204
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3266523
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945475
Age: embryonic day 15.5
Image: g00997 E15.5
Specimen Label: g00997 E15.5
Detected: true
Specimen Num: 2
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•
GXD Expression
GXD Expression
Probe: MGI:4886204
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4945475
Age: embryonic day 15.5
Image: g00997 E15.5
Note: Expression was region specific and scattered.
Specimen Label: g00997 E15.5
Detected: true
Specimen Num: 2
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•
GXD Expression
GXD Expression
 
Probe: MGI:4886204
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945475
Age: postnatal day 7
Image: g00997 P7
Specimen Label: g00997 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4886204
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945475
Age: postnatal day 42
Image: g00997 Adult
Specimen Label: g00997 Adult
Detected: true
Specimen Num: 4
•
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•
GXD Expression
GXD Expression
Probe: MGI:6192126
Assay Type: Immunohistochemistry
Annotation Date: 2018-07-31
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:160362
Pattern: Uniform
Stage: TS02
Assay Id: MGI:6192260
Age: embryonic day 1.0
Image: S2 2c
Note: Expression is in the cytoplasm.
Specimen Label: S2 2c
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
Probe: MGI:3721110
Assay Type: Immunohistochemistry
Annotation Date: 2019-03-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1657719
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:6283607
Age: embryonic day 11.5
Image: 6I
Note: Expression localized to all sub-apical tight junctions.
Specimen Label: 6I
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:3721110
Assay Type: Immunohistochemistry
Annotation Date: 2019-03-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1657719
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:6283607
Age: embryonic day 11.5
Image: 6M
Note: Authors report expression is dicontinuous within abnormal epithelium of the mutant nephric duct.
Specimen Label: 6M
Detected: true
Specimen Num: 2
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Publication
12697824 | J:83166
First Author: Rubio-Aliaga I
Year: 2003
Journal: Mol Cell Biol
Title: Targeted disruption of the peptide transporter Pept2 gene in mice defines its physiological role in the kidney.
Volume: 23
Issue: 9
Pages: 3247-52
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Publication
27435623 | J:241172
 
First Author: Fernando RN
Year: 2016
Journal: Nat Commun
Title: Optimal myelin elongation relies on YAP activation by axonal growth and inhibition by Crb3/Hippo pathway.
Volume: 7
Pages: 12186
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Publication
15177033 | J:92210
First Author: Saotome I
Year: 2004
Journal: Dev Cell
Title: Ezrin is essential for epithelial organization and villus morphogenesis in the developing intestine.
Volume: 6
Issue: 6
Pages: 855-64
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Publication
16885194 | J:114927
First Author: van Rossum AG
Year: 2006
Journal: Hum Mol Genet
Title: Pals1/Mpp5 is required for correct localization of Crb1 at the subapical region in polarized Muller glia cells.
Volume: 15
Issue: 18
Pages: 2659-72
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Publication
16399075 | J:105283
First Author: Davis MA
Year: 2006
Journal: Dev Cell
Title: Blocked acinar development, E-cadherin reduction, and intraepithelial neoplasia upon ablation of p120-catenin in the mouse salivary gland.
Volume: 10
Issue: 1
Pages: 21-31
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Publication
31391582 | J:283645
First Author: Peng G
Year: 2019
Journal: Nature
Title: Molecular architecture of lineage allocation and tissue organization in early mouse embryo.
Volume: 572
Issue: 7770
Pages: 528-532
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Publication
22410172 | J:184878
First Author: Soofi A
Year: 2012
Journal: Dev Biol
Title: Two novel EGFP insertion alleles reveal unique aspects of Pax2 function in embryonic and adult kidneys.
Volume: 365
Issue: 1
Pages: 241-50
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Publication
28536193 | J:242275
First Author: Schell C
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: The FERM protein EPB41L5 regulates actomyosin contractility and focal adhesion formation to maintain the kidney filtration barrier.
Volume: 114
Issue: 23
Pages: E4621-E4630
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Publication
32673396 | J:313432
 
First Author: Qi Y
Year: 2020
Journal: J Cell Biol
Title: PTEN dephosphorylates Abi1 to promote epithelial morphogenesis.
Volume: 219
Issue: 9
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Publication
21145499 | J:169049
First Author: Varelas X
Year: 2010
Journal: Dev Cell
Title: The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway.
Volume: 19
Issue: 6
Pages: 831-44
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Publication
27647853 | J:307229
First Author: McNeill H
Year: 2017
Journal: J Am Soc Nephrol
Title: Lats1/2 Regulate Yap/Taz to Control Nephron Progenitor Epithelialization and Inhibit Myofibroblast Formation.
Volume: 28
Issue: 3
Pages: 852-861
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Publication
25371366 | J:316286
First Author: Francou A
Year: 2014
Journal: Development
Title: TBX1 regulates epithelial polarity and dynamic basal filopodia in the second heart field.
Volume: 141
Issue: 22
Pages: 4320-31
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Publication
18403412 | J:134686
First Author: Srinivasan K
Year: 2008
Journal: Development
Title: MALS-3 regulates polarity and early neurogenesis in the developing cerebral cortex.
Volume: 135
Issue: 10
Pages: 1781-90
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Publication
28552558 | J:241995
First Author: Jossin Y
Year: 2017
Journal: Dev Cell
Title: Llgl1 Connects Cell Polarity with Cell-Cell Adhesion in Embryonic Neural Stem Cells.
Volume: 41
Issue: 5
Pages: 481-495.e5
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Publication
21880782 | J:178336
First Author: Grosse AS
Year: 2011
Journal: Development
Title: Cell dynamics in fetal intestinal epithelium: implications for intestinal growth and morphogenesis.
Volume: 138
Issue: 20
Pages: 4423-32
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Publication
21606200 | J:174237
First Author: Sripathy S
Year: 2011
Journal: Mol Cell Biol
Title: Mammalian Llgl2 is necessary for proper branching morphogenesis during placental development.
Volume: 31
Issue: 14
Pages: 2920-33
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Publication
17507402 | J:122548
First Author: Lee JD
Year: 2007
Journal: Development
Title: The FERM protein Epb4.1l5 is required for organization of the neural plate and for the epithelial-mesenchymal transition at the primitive streak of the mouse embryo.
Volume: 134
Issue: 11
Pages: 2007-16
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Publication
37172642 | J:336187
 
First Author: Barlow HR
Year: 2023
Journal: Dev Biol
Title: Rab11 is essential to pancreas morphogenesis, lumen formation and endocrine mass.
Volume: 499
Pages: 59-74
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Publication
22398208 | J:184469
First Author: Cho SH
Year: 2012
Journal: Hum Mol Genet
Title: Genetic ablation of Pals1 in retinal progenitor cells models the retinal pathology of Leber congenital amaurosis.
Volume: 21
Issue: 12
Pages: 2663-76
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Publication
27870829 | J:238551
First Author: Ramkumar N
Year: 2016
Journal: Nat Cell Biol
Title: Crumbs2 promotes cell ingression during the epithelial-to-mesenchymal transition at gastrulation.
Volume: 18
Issue: 12
Pages: 1281-1291
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Publication
25742799 | J:220469
First Author: Grego-Bessa J
Year: 2015
Journal: Development
Title: Morphogenesis of the mouse neural plate depends on distinct roles of cofilin 1 in apical and basal epithelial domains.
Volume: 142
Issue: 7
Pages: 1305-14
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Publication
33332551 | J:306851
 
First Author: Kunii M
Year: 2021
Journal: J Cell Biol
Title: SNAP23 deficiency causes severe brain dysplasia through the loss of radial glial cell polarity.
Volume: 220
Issue: 1
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Publication
31586559 | J:283394
First Author: Hughes LJ
Year: 2020
Journal: Dev Biol
Title: Yap/Taz are required for establishing the cerebellar radial glia scaffold and proper foliation.
Volume: 457
Issue: 1
Pages: 150-162
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Publication
27616714 | J:237224
First Author: Kim JY
Year: 2016
Journal: Dev Biol
Title: Yap is essential for retinal progenitor cell cycle progression and RPE cell fate acquisition in the developing mouse eye.
Volume: 419
Issue: 2
Pages: 336-347
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Publication
19914171 | J:157396
First Author: Kesavan G
Year: 2009
Journal: Cell
Title: Cdc42-mediated tubulogenesis controls cell specification.
Volume: 139
Issue: 4
Pages: 791-801
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Publication
29058721 | J:246200
First Author: Löf-Öhlin ZM
Year: 2017
Journal: Nat Cell Biol
Title: EGFR signalling controls cellular fate and pancreatic organogenesis by regulating apicobasal polarity.
Volume: 19
Issue: 11
Pages: 1313-1325
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Publication
26243870 | J:224142
First Author: Reginensi A
Year: 2015
Journal: Development
Title: Yap and Taz are required for Ret-dependent urinary tract morphogenesis.
Volume: 142
Issue: 15
Pages: 2696-703
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Publication
33526661 | J:302296
 
First Author: Vong KI
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: SOX9-COL9A3-dependent regulation of choroid plexus epithelial polarity governs blood-cerebrospinal fluid barrier integrity.
Volume: 118
Issue: 6
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Publication
24191021 | J:202984
First Author: Rockich BE
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Sox9 plays multiple roles in the lung epithelium during branching morphogenesis.
Volume: 110
Issue: 47
Pages: E4456-64
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Publication
27480037 | J:241275
 
First Author: Reginensi A
Year: 2016
Journal: Nat Commun
Title: A critical role for NF2 and the Hippo pathway in branching morphogenesis.
Volume: 7
Pages: 12309
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Publication
33737325 | J:306107
 
First Author: Niborski LL
Year: 2021
Journal: Dis Model Mech
Title: Hnf1b haploinsufficiency differentially affects developmental target genes in a new renal cysts and diabetes mouse model.
Volume: 14
Issue: 5
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Publication
30718289 | J:272613
 
First Author: Koutelou E
Year: 2019
Journal: Development
Title: USP22 controls multiple signaling pathways that are essential for vasculature formation in the mouse placenta.
Volume: 146
Issue: 4
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Publication
21947380 | J:181586
First Author: Hald J
Year: 2012
Journal: Diabetologia
Title: Pancreatic islet and progenitor cell surface markers with cell sorting potential.
Volume: 55
Issue: 1
Pages: 154-65
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Publication
20562862 | J:161922
First Author: Tang T
Year: 2010
Journal: Nat Biotechnol
Title: A mouse knockout library for secreted and transmembrane proteins.
Volume: 28
Issue: 7
Pages: 749-55
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Publication
- | J:171883
     
First Author: Lexicon Genetics, Inc
Year: 2011
Journal: Database Download
Title: MGI download of Lexicon knockout data
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Publication
10725249 | J:60984
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:155856
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
25080976 | J:225211
 
First Author: Mojallal M
Year: 2014
Journal: Nat Commun
Title: AmotL2 disrupts apical-basal cell polarity and promotes tumour invasion.
Volume: 5
Pages: 4557
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Publication
20362667 | -
First Author: Yamaguchi M
Year: 2010
Journal: Mech Dev
Title: Mutations in N-cadherin and a Stardust homolog, Nagie oko, affect cell-cycle exit in zebrafish retina.
Volume: 127
Issue: 5-6
Pages: 247-64
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Publication
20861315 | -
First Author: Bulgakova NA
Year: 2010
Journal: Mol Biol Cell
Title: Antagonistic functions of two stardust isoforms in Drosophila photoreceptor cells.
Volume: 21
Issue: 22
Pages: 3915-25
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Publication
22114289 | J:178056
First Author: Park B
Year: 2011
Journal: J Neurosci
Title: PALS1 is essential for retinal pigment epithelium structure and neural retina stratification.
Volume: 31
Issue: 47
Pages: 17230-41
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Publication
28416478 | -
First Author: Das S
Year: 2017
Journal: J Cell Biol
Title: Stardust, the Janus-faced partner of Crumbs.
Volume: 216
Issue: 5
Pages: 1219-1221
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Publication
21479189 | -
First Author: Carvalho G
Year: 2011
Journal: PLoS One
Title: Participation of the cell polarity protein PALS1 to T-cell receptor-mediated NF-κB activation.
Volume: 6
Issue: 3
Pages: e18159
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Protein Domain
IPR035601 | MPP5_SH3
Type: Domain
Description: MPP5, also called PALS1 (protein associated with Lin7) or Nagie oko protein in zebrafish []or Stardust in Drosophila [], is a scaffolding protein which associates with Crumbs homologue 1 (CRB1), CRB2, or CRB3 through its PDZ domain and with PALS1-associated tight junction protein (PATJ) or multi-PDZ domain protein 1 (MUPP1) through its L27 domain []. The resulting tri-protein complexes are core proteins of the Crumb complex, which localizes at tight junctions or subapical regions, and is involved in the maintenance of apical-basal polarity in epithelial cells and the morphogenesis and function of photoreceptor cells []. MPP5 is critical for the proper stratification of the retina and is also expressed in T lymphocytes where it is important for TCR-mediated activation of NFkB []. Drosophila Stardust exists in several isoforms, some of which show opposing functions in photoreceptor cells, which suggests that the relative ratio of different Crumbs complexes regulates photoreceptor homeostasis []. MPP5 belongs to the membrane-associated guanylate kinase (MAGUK) p55 subfamily.The membrane-associated guanylate kinase (MAGUK) p55 subfamily (also known as MPP subfamily) members include the Drosophila Stardust protein and its vertebrate homologues, MPP1-7. They contain the core of three domains characteristic of MAGUK (membrane-associated guanylate kinase) proteins: PDZ, SH3, and guanylate kinase (GuK). In addition, they also contain the Hook (Protein 4.1 Binding) motif in between the SH3 and GuK domains []. MPP2-7 have two additional L27 domains at their N terminus. The GuK domain in MAGUK proteins is enzymatically inactive; instead, the domain mediates protein-protein interactions and associates intramolecularly with the SH3 domain [].
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Publication
15316081 | J:92068
First Author: van de Pavert SA
Year: 2004
Journal: J Cell Sci
Title: Crumbs homologue 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposure.
Volume: 117
Issue: Pt 18
Pages: 4169-77
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Publication
26404741 | J:298908
 
First Author: Paniagua AE
Year: 2015
Journal: Sci Rep
Title: CRB2 completes a fully expressed Crumbs complex in the Retinal Pigment Epithelium.
Volume: 5
Pages: 14504
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Publication
25809849 | J:225273
First Author: Pan X
Year: 2015
Journal: Genesis
Title: A Cre-inducible fluorescent reporter for observing apical membrane dynamics.
Volume: 53
Issue: 3-4
Pages: 285-93
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Publication
28154200 | J:289471
First Author: Weide T
Year: 2017
Journal: J Am Soc Nephrol
Title: Pals1 Haploinsufficiency Results in Proteinuria and Cyst Formation.
Volume: 28
Issue: 7
Pages: 2093-2107
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Publication
16098509 | J:102605
First Author: Satohisa S
Year: 2005
Journal: Exp Cell Res
Title: Behavior of tight-junction, adherens-junction and cell polarity proteins during HNF-4alpha-induced epithelial polarization.
Volume: 310
Issue: 1
Pages: 66-78
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Publication
26279473 | J:227728
First Author: Zhai Y
Year: 2016
Journal: J Pathol
Title: Arid1a inactivation in an Apc- and Pten-defective mouse ovarian cancer model enhances epithelial differentiation and prolongs survival.
Volume: 238
Issue: 1
Pages: 21-30
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Publication
11414766 | -
First Author: Stöhr H
Year: 2001
Journal: Genomics
Title: Cloning and characterization of the human retina-specific gene MPP4, a novel member of the p55 subfamily of MAGUK proteins.
Volume: 74
Issue: 3
Pages: 377-84
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Publication
17678554 | -
 
First Author: te Velthuis AJ
Year: 2007
Journal: BMC Evol Biol
Title: Molecular evolution of the MAGUK family in metazoan genomes.
Volume: 7
Pages: 129
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Protein
Q9JLB2
Organism: Mus musculus/domesticus
Length: 675  
Fragment?: false
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Protein
B2RRY4
Organism: Mus musculus/domesticus
Length: 675  
Fragment?: false
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