Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
TNF receptor-associated factor 6 (TRAF6) regulates a diverse array of processes, including adaptive immunity, innate immunity, bone metabolism and tissue development. It is a unique member of the TRAF family of adaptor proteins in that it is involved in both the TNF receptor superfamily and the interleukin-1 receptor (IL-1R)/Toll-like receptor (TLR) superfamily signal transduction pathways [, , , ]. TRAF6 possesses ubiquitin ligase activity that controls the activation of IKK and NF-kappaB [, ]. TRAF6 contains a RING finger domain, five zinc finger domains, and a TRAF domain. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Kobayashi T |
Year: |
2003 |
Journal: |
Immunity |
Title: |
TRAF6 is a critical factor for dendritic cell maturation and development. |
Volume: |
19 |
Issue: |
3 |
Pages: |
353-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lomaga MA |
Year: |
1999 |
Journal: |
Genes Dev |
Title: |
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. |
Volume: |
13 |
Issue: |
8 |
Pages: |
1015-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sun L |
Year: |
2004 |
Journal: |
Mol Cell |
Title: |
The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes. |
Volume: |
14 |
Issue: |
3 |
Pages: |
289-301 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
530
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Matsumoto R |
Year: |
2018 |
Journal: |
JCI Insight |
Title: |
Epithelial TRAF6 drives IL-17-mediated psoriatic inflammation. |
Volume: |
3 |
Issue: |
15 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Cejas PJ |
Year: |
2010 |
Journal: |
Blood |
Title: |
TRAF6 inhibits Th17 differentiation and TGF-beta-mediated suppression of IL-2. |
Volume: |
115 |
Issue: |
23 |
Pages: |
4750-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Paul PK |
Year: |
2010 |
Journal: |
J Cell Biol |
Title: |
Targeted ablation of TRAF6 inhibits skeletal muscle wasting in mice. |
Volume: |
191 |
Issue: |
7 |
Pages: |
1395-411 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fang J |
Year: |
2017 |
Journal: |
Nat Immunol |
Title: |
Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia. |
Volume: |
18 |
Issue: |
2 |
Pages: |
236-245 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu H |
Year: |
2003 |
Journal: |
Bioessays |
Title: |
TRAF6, a molecular bridge spanning adaptive immunity, innate immunity and osteoimmunology. |
Volume: |
25 |
Issue: |
11 |
Pages: |
1096-105 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chung JY |
Year: |
2007 |
Journal: |
Adv Exp Med Biol |
Title: |
Molecular basis for the unique specificity of TRAF6. |
Volume: |
597 |
|
Pages: |
122-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lamothe B |
Year: |
2007 |
Journal: |
J Biol Chem |
Title: |
Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation. |
Volume: |
282 |
Issue: |
6 |
Pages: |
4102-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Arcipowski KM |
Year: |
2014 |
Journal: |
Int Immunol |
Title: |
TRAF6 is a critical regulator of LMP1 functions in vivo. |
Volume: |
26 |
Issue: |
3 |
Pages: |
149-58 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hindi SM |
Year: |
2012 |
Journal: |
Mol Cell Biol |
Title: |
Reciprocal interaction between TRAF6 and notch signaling regulates adult myofiber regeneration upon injury. |
Volume: |
32 |
Issue: |
23 |
Pages: |
4833-45 |
|
•
•
•
•
•
|
Publication |
First Author: |
O'Neill TJ |
Year: |
2021 |
Journal: |
Sci Immunol |
Title: |
TRAF6 prevents fatal inflammation by homeostatic suppression of MALT1 protease. |
Volume: |
6 |
Issue: |
65 |
Pages: |
eabh2095 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yang WL |
Year: |
2009 |
Journal: |
Science |
Title: |
The E3 ligase TRAF6 regulates Akt ubiquitination and activation. |
Volume: |
325 |
Issue: |
5944 |
Pages: |
1134-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mueck T |
Year: |
2011 |
Journal: |
Differentiation |
Title: |
TRAF6 regulates proliferation and differentiation of skeletal myoblasts. |
Volume: |
81 |
Issue: |
2 |
Pages: |
99-106 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yao K |
Year: |
2018 |
Journal: |
Oncogene |
Title: |
RSK2 is required for TRAF6 phosphorylation-mediated colon inflammation. |
Volume: |
37 |
Issue: |
26 |
Pages: |
3501-3513 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xiong H |
Year: |
2004 |
Journal: |
J Biol Chem |
Title: |
Interaction of TRAF6 with MAST205 regulates NF-kappaB activation and MAST205 stability. |
Volume: |
279 |
Issue: |
42 |
Pages: |
43675-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
King CG |
Year: |
2008 |
Journal: |
J Immunol |
Title: |
Cutting edge: requirement for TRAF6 in the induction of T cell anergy. |
Volume: |
180 |
Issue: |
1 |
Pages: |
34-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim H |
Year: |
2018 |
Journal: |
Mol Cells |
Title: |
TRAF6 Distinctly Regulates Hematopoietic Stem and Progenitors at Different Periods of Development in Mice. |
Volume: |
41 |
Issue: |
8 |
Pages: |
753-761 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fang J |
Year: |
2018 |
Journal: |
Cell Rep |
Title: |
TRAF6 Mediates Basal Activation of NF-κB Necessary for Hematopoietic Stem Cell Homeostasis. |
Volume: |
22 |
Issue: |
5 |
Pages: |
1250-1262 |
|
•
•
•
•
•
|
Publication |
First Author: |
Han D |
Year: |
2017 |
Journal: |
Int Immunol |
Title: |
Dendritic cell expression of the signaling molecule TRAF6 is required for immune tolerance in the lung. |
Volume: |
29 |
Issue: |
2 |
Pages: |
71-78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yamashita M |
Year: |
2008 |
Journal: |
Mol Cell |
Title: |
TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-beta. |
Volume: |
31 |
Issue: |
6 |
Pages: |
918-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ohazama A |
Year: |
2004 |
Journal: |
Dev Dyn |
Title: |
Traf6 is essential for murine tooth cusp morphogenesis. |
Volume: |
229 |
Issue: |
1 |
Pages: |
131-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang X |
Year: |
2016 |
Journal: |
Mol Cell |
Title: |
TRAF6 Restricts p53 Mitochondrial Translocation, Apoptosis, and Tumor Suppression. |
Volume: |
64 |
Issue: |
4 |
Pages: |
803-814 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhou C |
Year: |
2020 |
Journal: |
Mol Immunol |
Title: |
TRAF6 promotes IL-4-induced M2 macrophage activation by stabilizing STAT6. |
Volume: |
127 |
|
Pages: |
223-229 |
|
•
•
•
•
•
|
Publication |
First Author: |
King CG |
Year: |
2006 |
Journal: |
Nat Med |
Title: |
TRAF6 is a T cell-intrinsic negative regulator required for the maintenance of immune homeostasis. |
Volume: |
12 |
Issue: |
9 |
Pages: |
1088-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Paul PK |
Year: |
2012 |
Journal: |
Mol Cell Biol |
Title: |
The E3 ubiquitin ligase TRAF6 intercedes in starvation-induced skeletal muscle atrophy through multiple mechanisms. |
Volume: |
32 |
Issue: |
7 |
Pages: |
1248-59 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yoon K |
Year: |
2008 |
Journal: |
Cell Death Differ |
Title: |
TRAF6 deficiency promotes TNF-induced cell death through inactivation of GSK3beta. |
Volume: |
15 |
Issue: |
4 |
Pages: |
730-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Motegi H |
Year: |
2011 |
Journal: |
Genes Cells |
Title: |
TRAF6 negatively regulates the Jak1-Erk pathway in interleukin-2 signaling. |
Volume: |
16 |
Issue: |
2 |
Pages: |
179-89 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shimo Y |
Year: |
2011 |
Journal: |
Genes Cells |
Title: |
TRAF6 directs commitment to regulatory T cells in thymocytes. |
Volume: |
16 |
Issue: |
4 |
Pages: |
437-47 |
|
•
•
•
•
•
|
Publication |
First Author: |
Muto T |
Year: |
2022 |
Journal: |
Cell Stem Cell |
Title: |
TRAF6 functions as a tumor suppressor in myeloid malignancies by directly targeting MYC oncogenic activity. |
Volume: |
29 |
Issue: |
2 |
Pages: |
298-314.e9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Muto G |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
TRAF6 is essential for maintenance of regulatory T cells that suppress Th2 type autoimmunity. |
Volume: |
8 |
Issue: |
9 |
Pages: |
e74639 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yamamoto M |
Year: |
2019 |
Journal: |
Commun Biol |
Title: |
TRAF6 maintains mammary stem cells and promotes pregnancy-induced mammary epithelial cell expansion. |
Volume: |
2 |
|
Pages: |
292 |
|
•
•
•
•
•
|
Publication |
First Author: |
Han D |
Year: |
2013 |
Journal: |
Immunity |
Title: |
Dendritic cell expression of the signaling molecule TRAF6 is critical for gut microbiota-dependent immune tolerance. |
Volume: |
38 |
Issue: |
6 |
Pages: |
1211-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhu Z |
Year: |
2016 |
Journal: |
J Immunol |
Title: |
Cutting Edge: A Cullin-5-TRAF6 Interaction Promotes TRAF6 Polyubiquitination and Lipopolysaccharide Signaling. |
Volume: |
197 |
Issue: |
1 |
Pages: |
21-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang Y |
Year: |
2006 |
Journal: |
Nat Immunol |
Title: |
Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling. |
Volume: |
7 |
Issue: |
2 |
Pages: |
139-47 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang Y |
Year: |
2015 |
Journal: |
Mol Immunol |
Title: |
TRAF6 is required for the GM-CSF-induced JNK, p38 and Akt activation. |
Volume: |
65 |
Issue: |
2 |
Pages: |
224-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jiang G |
Year: |
2020 |
Journal: |
J Immunol |
Title: |
Tob2 Inhibits TLR-Induced Inflammatory Responses by Association with TRAF6 and MyD88. |
Volume: |
205 |
Issue: |
4 |
Pages: |
981-986 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ko R |
Year: |
2015 |
Journal: |
Nat Commun |
Title: |
Glycogen synthase kinase 3β ubiquitination by TRAF6 regulates TLR3-mediated pro-inflammatory cytokine production. |
Volume: |
6 |
|
Pages: |
6765 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xing Y |
Year: |
2017 |
Journal: |
J Immunol |
Title: |
Cutting Edge: TRAF6 Mediates TLR/IL-1R Signaling-Induced Nontranscriptional Priming of the NLRP3 Inflammasome. |
Volume: |
199 |
Issue: |
5 |
Pages: |
1561-1566 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xia X |
Year: |
2011 |
Journal: |
Immunity |
Title: |
NLRX1 negatively regulates TLR-induced NF-κB signaling by targeting TRAF6 and IKK. |
Volume: |
34 |
Issue: |
6 |
Pages: |
843-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vlantis K |
Year: |
2016 |
Journal: |
Gut |
Title: |
TLR-independent anti-inflammatory function of intestinal epithelial TRAF6 signalling prevents DSS-induced colitis in mice. |
Volume: |
65 |
Issue: |
6 |
Pages: |
935-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ni X |
Year: |
2019 |
Journal: |
EMBO J |
Title: |
TRAF6 directs FOXP3 localization and facilitates regulatory T-cell function through K63-linked ubiquitination. |
Volume: |
38 |
Issue: |
9 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hindi SM |
Year: |
2014 |
Journal: |
Hum Mol Genet |
Title: |
Distinct roles of TRAF6 at early and late stages of muscle pathology in the mdx model of Duchenne muscular dystrophy. |
Volume: |
23 |
Issue: |
6 |
Pages: |
1492-505 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu DJ |
Year: |
2016 |
Journal: |
J Autoimmun |
Title: |
Autophagy-linked FYVE containing protein WDFY3 interacts with TRAF6 and modulates RANKL-induced osteoclastogenesis. |
Volume: |
73 |
|
Pages: |
73-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hindi SM |
Year: |
2016 |
Journal: |
J Clin Invest |
Title: |
TRAF6 regulates satellite stem cell self-renewal and function during regenerative myogenesis. |
Volume: |
126 |
Issue: |
1 |
Pages: |
151-68 |
|
•
•
•
•
•
|
Publication |
First Author: |
Panda S |
Year: |
2015 |
Journal: |
Immunity |
Title: |
Deubiquitinase MYSM1 Regulates Innate Immunity through Inactivation of TRAF3 and TRAF6 Complexes. |
Volume: |
43 |
Issue: |
4 |
Pages: |
647-59 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ji YX |
Year: |
2016 |
Journal: |
Nat Commun |
Title: |
The ubiquitin E3 ligase TRAF6 exacerbates pathological cardiac hypertrophy via TAK1-dependent signalling. |
Volume: |
7 |
|
Pages: |
11267 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang P |
Year: |
2005 |
Journal: |
EMBO Rep |
Title: |
Activation of IKK by thymosin alpha1 requires the TRAF6 signalling pathway. |
Volume: |
6 |
Issue: |
6 |
Pages: |
531-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Strickson S |
Year: |
2017 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Roles of the TRAF6 and Pellino E3 ligases in MyD88 and RANKL signaling. |
Volume: |
114 |
Issue: |
17 |
Pages: |
E3481-E3489 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yang YJ |
Year: |
2008 |
Journal: |
J Biol Chem |
Title: |
TRAF6 specifically contributes to FcepsilonRI-mediated cytokine production but not mast cell degranulation. |
Volume: |
283 |
Issue: |
46 |
Pages: |
32110-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dewayani A |
Year: |
2022 |
Journal: |
Biochem Biophys Res Commun |
Title: |
TRAF6 signaling pathway in T cells regulates anti-tumor immunity through the activation of tumor specific Th9 cells and CTLs. |
Volume: |
613 |
|
Pages: |
26-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu J |
Year: |
2022 |
Journal: |
Autophagy |
Title: |
Increased alveolar epithelial TRAF6 via autophagy-dependent TRIM37 degradation mediates particulate matter-induced lung metastasis. |
Volume: |
18 |
Issue: |
5 |
Pages: |
971-989 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kisiswa L |
Year: |
2018 |
Journal: |
Cell Rep |
Title: |
RIP2 Gates TRAF6 Interaction with Death Receptor p75NTR to Regulate Cerebellar Granule Neuron Survival. |
Volume: |
24 |
Issue: |
4 |
Pages: |
1013-1024 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lamothe B |
Year: |
2007 |
Journal: |
Biochem Biophys Res Commun |
Title: |
TRAF6 ubiquitin ligase is essential for RANKL signaling and osteoclast differentiation. |
Volume: |
359 |
Issue: |
4 |
Pages: |
1044-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Deepak V |
Year: |
2022 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
IFT80 negatively regulates osteoclast differentiation via association with Cbl-b to disrupt TRAF6 stabilization and activation. |
Volume: |
119 |
Issue: |
26 |
Pages: |
e2201490119 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shi CS |
Year: |
2010 |
Journal: |
Sci Signal |
Title: |
TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy. |
Volume: |
3 |
Issue: |
123 |
Pages: |
ra42 |
|
•
•
•
•
•
|
Publication |
First Author: |
O'Neill TJ |
Year: |
2023 |
Journal: |
Front Immunol |
Title: |
TRAF6 controls T cell homeostasis by maintaining the equilibrium of MALT1 scaffolding and protease functions. |
Volume: |
14 |
|
Pages: |
1111398 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yan H |
Year: |
2020 |
Journal: |
J Immunol |
Title: |
B Cell Endosomal RAB7 Promotes TRAF6 K63 Polyubiquitination and NF-κB Activation for Antibody Class-Switching. |
Volume: |
204 |
Issue: |
5 |
Pages: |
1146-1157 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen H |
Year: |
2006 |
Journal: |
FEBS Lett |
Title: |
Hsp70 inhibits lipopolysaccharide-induced NF-kappaB activation by interacting with TRAF6 and inhibiting its ubiquitination. |
Volume: |
580 |
Issue: |
13 |
Pages: |
3145-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li T |
Year: |
2017 |
Journal: |
J Neurosci |
Title: |
The Ubiquitin E3 Ligase TRAF6 Exacerbates Ischemic Stroke by Ubiquitinating and Activating Rac1. |
Volume: |
37 |
Issue: |
50 |
Pages: |
12123-12140 |
|
•
•
•
•
•
|
Publication |
First Author: |
He L |
Year: |
2006 |
Journal: |
J Biol Chem |
Title: |
TRAF6 regulates cell fate decisions by inducing caspase 8-dependent apoptosis and the activation of NF-kappaB. |
Volume: |
281 |
Issue: |
16 |
Pages: |
11235-49 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lamothe B |
Year: |
2008 |
Journal: |
J Biol Chem |
Title: |
The RING domain and first zinc finger of TRAF6 coordinate signaling by interleukin-1, lipopolysaccharide, and RANKL. |
Volume: |
283 |
Issue: |
36 |
Pages: |
24871-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yoshida R |
Year: |
2008 |
Journal: |
J Biol Chem |
Title: |
TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway. |
Volume: |
283 |
Issue: |
52 |
Pages: |
36211-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Feng Y |
Year: |
2007 |
Journal: |
J Biol Chem |
Title: |
The LIM protein, Limd1, regulates AP-1 activation through an interaction with Traf6 to influence osteoclast development. |
Volume: |
282 |
Issue: |
1 |
Pages: |
39-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
Swarnkar G |
Year: |
2017 |
Journal: |
Sci Rep |
Title: |
NUMBL Interacts with TAK1, TRAF6 and NEMO to Negatively Regulate NF-κB Signaling During Osteoclastogenesis. |
Volume: |
7 |
Issue: |
1 |
Pages: |
12600 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schneider M |
Year: |
2012 |
Journal: |
Nat Immunol |
Title: |
The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB. |
Volume: |
13 |
Issue: |
9 |
Pages: |
823-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jabara H |
Year: |
2002 |
Journal: |
Immunity |
Title: |
The binding site for TRAF2 and TRAF3 but not for TRAF6 is essential for CD40-mediated immunoglobulin class switching. |
Volume: |
17 |
Issue: |
3 |
Pages: |
265-76 |
|
•
•
•
•
•
|
Publication |
First Author: |
He H |
Year: |
2021 |
Journal: |
J Immunol |
Title: |
Helicobacter pylori CagA Interacts with SHP-1 to Suppress the Immune Response by Targeting TRAF6 for K63-Linked Ubiquitination. |
Volume: |
206 |
Issue: |
6 |
Pages: |
1161-1170 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kobayashi T |
Year: |
2009 |
Journal: |
PLoS One |
Title: |
TRAF6 is required for generation of the B-1a B cell compartment as well as T cell-dependent and -independent humoral immune responses. |
Volume: |
4 |
Issue: |
3 |
Pages: |
e4736 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee CS |
Year: |
2023 |
Journal: |
Cell Death Differ |
Title: |
IKK-mediated TRAF6 and RIPK1 interaction stifles cell death complex assembly leading to the suppression of TNF-α-induced cell death. |
Volume: |
30 |
Issue: |
6 |
Pages: |
1575-1584 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lin YC |
Year: |
2013 |
Journal: |
Sci Signal |
Title: |
The tyrosine kinase Syk differentially regulates Toll-like receptor signaling downstream of the adaptor molecules TRAF6 and TRAF3. |
Volume: |
6 |
Issue: |
289 |
Pages: |
ra71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ning S |
Year: |
2008 |
Journal: |
Mol Cell Biol |
Title: |
TRAF6 and the three C-terminal lysine sites on IRF7 are required for its ubiquitination-mediated activation by the tumor necrosis factor receptor family member latent membrane protein 1. |
Volume: |
28 |
Issue: |
20 |
Pages: |
6536-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jiang Y |
Year: |
2023 |
Journal: |
J Biol Chem |
Title: |
c-Src regulates δ-secretase activation and truncated Tau production by phosphorylating the E3 ligase Traf6. |
Volume: |
299 |
Issue: |
12 |
Pages: |
105462 |
|
•
•
•
•
•
|
Publication |
First Author: |
Noguchi K |
Year: |
2018 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Autoimmune sialadenitis is associated with the upregulation of chemokine/chemokine receptor pairs in T cell-specific TRAF6-deficient mice. |
Volume: |
504 |
Issue: |
1 |
Pages: |
245-250 |
|
•
•
•
•
•
|
Publication |
First Author: |
Han D |
Year: |
2015 |
Journal: |
PLoS One |
Title: |
Microbiota-Independent Ameliorative Effects of Antibiotics on Spontaneous Th2-Associated Pathology of the Small Intestine. |
Volume: |
10 |
Issue: |
2 |
Pages: |
e0118795 |
|
•
•
•
•
•
|
Publication |
First Author: |
Takatsuna H |
Year: |
2003 |
Journal: |
J Biol Chem |
Title: |
Identification of TIFA as an adapter protein that links tumor necrosis factor receptor-associated factor 6 (TRAF6) to interleukin-1 (IL-1) receptor-associated kinase-1 (IRAK-1) in IL-1 receptor signaling. |
Volume: |
278 |
Issue: |
14 |
Pages: |
12144-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bonito AJ |
Year: |
2013 |
Journal: |
J Clin Invest |
Title: |
Medullary thymic epithelial cell depletion leads to autoimmune hepatitis. |
Volume: |
123 |
Issue: |
8 |
Pages: |
3510-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yao Z |
Year: |
2017 |
Journal: |
J Biol Chem |
Title: |
RANKL cytokine enhances TNF-induced osteoclastogenesis independently of TNF receptor associated factor (TRAF) 6 by degrading TRAF3 in osteoclast precursors. |
Volume: |
292 |
Issue: |
24 |
Pages: |
10169-10179 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kanaya T |
Year: |
2018 |
Journal: |
J Exp Med |
Title: |
Development of intestinal M cells and follicle-associated epithelium is regulated by TRAF6-mediated NF-κB signaling. |
Volume: |
215 |
Issue: |
2 |
Pages: |
501-519 |
|
•
•
•
•
•
|
Publication |
First Author: |
Inoue J |
Year: |
2007 |
Journal: |
Adv Exp Med Biol |
Title: |
Characteristics and biological functions of TRAF6. |
Volume: |
597 |
|
Pages: |
72-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Serrano-Lopez J |
Year: |
2021 |
Journal: |
Elife |
Title: |
Inflammation rapidly recruits mammalian GMP and MDP from bone marrow into regional lymphatics. |
Volume: |
10 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Pearce EL |
Year: |
2009 |
Journal: |
Nature |
Title: |
Enhancing CD8 T-cell memory by modulating fatty acid metabolism. |
Volume: |
460 |
Issue: |
7251 |
Pages: |
103-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kaji K |
Year: |
2001 |
Journal: |
J Bone Miner Res |
Title: |
Tumor necrosis factor alpha-induced osteoclastogenesis requires tumor necrosis factor receptor-associated factor 6. |
Volume: |
16 |
Issue: |
9 |
Pages: |
1593-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen L |
Year: |
2008 |
Journal: |
FEBS Lett |
Title: |
Protein phosphatase 4 negatively regulates LPS cascade by inhibiting ubiquitination of TRAF6. |
Volume: |
582 |
Issue: |
19 |
Pages: |
2843-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gohda J |
Year: |
2004 |
Journal: |
J Immunol |
Title: |
Cutting edge: TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not toll/IL-1 receptor domain-containing adaptor-inducing IFN-beta (TRIF)-dependent pathway in TLR signaling. |
Volume: |
173 |
Issue: |
5 |
Pages: |
2913-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dickson KM |
Year: |
2004 |
Journal: |
Dev Dyn |
Title: |
TRAF6-dependent NF-kB transcriptional activity during mouse development. |
Volume: |
231 |
Issue: |
1 |
Pages: |
122-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Snelling T |
Year: |
2022 |
Journal: |
Biochem J |
Title: |
Co-ordinated control of the ADP-heptose/ALPK1 signalling network by the E3 ligases TRAF6, TRAF2/c-IAP1 and LUBAC. |
Volume: |
479 |
Issue: |
20 |
Pages: |
2195-2216 |
|
•
•
•
•
•
|