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Search results 1 to 100 out of 4310 for Apc

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Type Details Score
Gene
324 | APC
Type: gene
Organism: human
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Gene
533233 | APC
Type: gene
Organism: cattle
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Gene
386762 | apc
Type: gene
Organism: zebrafish
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Gene
461999 | APC
Type: gene
Organism: chimpanzee
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Gene
693443 | APC
Type: gene
Organism: macaque, rhesus
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Gene
415607 | APC
Type: gene
Organism: chicken
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Gene
779466 | apc
Type: gene
Organism: frog, western clawed
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Gene
24205 | Apc
Type: gene
Organism: rat
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Gene
479139 | APC
Type: gene
Organism: dog, domestic
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Protein Domain
IPR026836 | APC
Type: Family
Description: Adenomatous polyposis coli (APC) is a tumor suppressor protein that induces thedegradation of oncogenic beta-catenin and negatively regulates Wnt signalling []. It has roles in regulating cell migration, DNA replication/repair, mitosis and apoptosis [, ]. APC regulates cell-cell adhesion and cell migration through activating the APC-stimulated guanine nucleotide-exchange factor (GEF; Asef) [, ]. It acts as a mediator of ERBB2-dependent stabilisation of microtubules at the cell cortex []. It is required for the localisation of MACF1/ACF7 to the cell membrane and this localisation of MACF1/ACF7 is critical for its function in microtubule stabilisation []. APC mutations are particularly prevalent in colorectal cancer [].
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Protein Coding Gene
MGI:88039 | Apc
Type: protein_coding_gene
Organism: mouse, laboratory
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GXD Expression
GXD Expression
Probe: MGI:6502587
Assay Type: RNA in situ
Annotation Date: 2021-01-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1859021
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:6502635
Age: embryonic day 13.5
Image: 4A Apc Vax2-/-
Note: Expression lost specifically in the ventral retina.
Specimen Label: 4A Apc Vax2-/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:6502587
Assay Type: RNA in situ
Annotation Date: 2021-01-28
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1859021
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:6502635
Age: embryonic day 13.5
Image: 4A Apc WT
Note: Strongest expression in retinal ganglion cell layer.
Specimen Label: 4A Apc WT
Detected: true
Specimen Num: 1
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Protein
Q61315
Organism: Mus musculus/domesticus
Length: 2845  
Fragment?: false
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Publication
1528264 | -
First Author: Powell SM
Year: 1992
Journal: Nature
Title: APC mutations occur early during colorectal tumorigenesis.
Volume: 359
Issue: 6392
Pages: 235-7
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Gene
147495 | APCDD1
Type: gene
Organism: human
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Publication
10947987 | -
First Author: Kawasaki Y
Year: 2000
Journal: Science
Title: Asef, a link between the tumor suppressor APC and G-protein signaling.
Volume: 289
Issue: 5482
Pages: 1194-7
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Publication
22162224 | -
First Author: Lui C
Year: 2012
Journal: IUBMB Life
Title: APC as a mobile scaffold: regulation and function at the nucleus, centrosomes, and mitochondria.
Volume: 64
Issue: 3
Pages: 209-14
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Gene
164284 | APCDD1L
Type: gene
Organism: human
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Publication
17881494 | J:128366
First Author: Aoki K
Year: 2007
Journal: J Cell Sci
Title: Adenomatous polyposis coli (APC): a multi-functional tumor suppressor gene.
Volume: 120
Issue: Pt 19
Pages: 3327-35
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Publication
19619488 | J:151984
First Author: MacDonald BT
Year: 2009
Journal: Dev Cell
Title: Wnt/beta-catenin signaling: components, mechanisms, and diseases.
Volume: 17
Issue: 1
Pages: 9-26
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Publication
21788986 | -
First Author: Zhang Z
Year: 2012
Journal: Cell Res
Title: Structural basis for the recognition of Asef by adenomatous polyposis coli.
Volume: 22
Issue: 2
Pages: 372-86
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Publication
20937854 | -
First Author: Zaoui K
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells.
Volume: 107
Issue: 43
Pages: 18517-22
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Publication
27694902 | J:241092
First Author: Daly CS
Year: 2017
Journal: Oncogene
Title: Functional redundancy between Apc and Apc2 regulates tissue homeostasis and prevents tumorigenesis in murine mammary epithelium.
Volume: 36
Issue: 13
Pages: 1793-1803
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Protein
Q3UQT2
Organism: Mus musculus/domesticus
Length: 344  
Fragment?: true
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Protein
Q8C9I9
Organism: Mus musculus/domesticus
Length: 146  
Fragment?: true
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Protein
Q8C493
Organism: Mus musculus/domesticus
Length: 324  
Fragment?: false
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Protein
F6Q4R2
Organism: Mus musculus/domesticus
Length: 51  
Fragment?: true
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Protein
B2RUG9
Organism: Mus musculus/domesticus
Length: 2842  
Fragment?: false
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Protein
E9QLQ9
Organism: Mus musculus/domesticus
Length: 2808  
Fragment?: false
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Protein
Q8BNP7
Organism: Mus musculus/domesticus
Length: 1056  
Fragment?: true
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Protein
E9Q4H1
Organism: Mus musculus/domesticus
Length: 1133  
Fragment?: true
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Protein
Q8BRD8
Organism: Mus musculus/domesticus
Length: 489  
Fragment?: false
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CL Term
CL:0000145 | professional antigen presenting cell
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Protein
Q6NS69
Organism: Mus musculus/domesticus
Length: 780  
Fragment?: false
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Protein
Q7TS75
Organism: Mus musculus/domesticus
Length: 1132  
Fragment?: false
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Protein
Q8CCJ4
Organism: Mus musculus/domesticus
Length: 672  
Fragment?: false
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Protein
A0A0R4J030
Organism: Mus musculus/domesticus
Length: 635  
Fragment?: false
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Protein
A0A286YCG0
Organism: Mus musculus/domesticus
Length: 254  
Fragment?: true
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Protein
Q9CY86
Organism: Mus musculus/domesticus
Length: 146  
Fragment?: false
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Protein
G3UXZ3
Organism: Mus musculus/domesticus
Length: 96  
Fragment?: false
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Protein
Q9D818
Organism: Mus musculus/domesticus
Length: 391  
Fragment?: false
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Gene
139285 | AMER1
Type: gene
Organism: human
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Gene
401251 | SAPCD1
Type: gene
Organism: human
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Gene
205147 | AMER3
Type: gene
Organism: human
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Gene
219287 | AMER2
Type: gene
Organism: human
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Gene
89958 | SAPCD2
Type: gene
Organism: human
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Protein
P70382
Organism: Mus musculus/domesticus
Length: 25  
Fragment?: true
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Publication
18538487 | J:139896
First Author: McCart AE
Year: 2008
Journal: Pathol Res Pract
Title: Apc mice: models, modifiers and mutants.
Volume: 204
Issue: 7
Pages: 479-90
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Publication
23580574 | J:197040
First Author: Zeineldin M
Year: 2013
Journal: Cancer Res
Title: Understanding phenotypic variation in rodent models with germline Apc mutations.
Volume: 73
Issue: 8
Pages: 2389-99
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Publication
32380568 | J:292554
     
First Author: Jung YS
Year: 2020
Journal: Hepatology
Title: TMEM9-v-ATPase Activates Wnt/β-Catenin Signaling via APC Lysosomal Degradation for Liver Regeneration and Tumorigenesis.
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Publication
- | J:159014
     
First Author: Jacks T
Year: 2010
Journal: MGI Direct Data Submission
Title: Generation of a conditional Apc allele
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Publication
16116480 | J:104413
First Author: Sansom OJ
Year: 2005
Journal: Oncogene
Title: Apc deficiency predisposes to renal carcinoma in the mouse.
Volume: 24
Issue: 55
Pages: 8205-10
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Publication
9771477 | J:110641
First Author: Wasan HS
Year: 1998
Journal: J Pathol
Title: APC in the regulation of intestinal crypt fission.
Volume: 185
Issue: 3
Pages: 246-55
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GXD Expression
GXD Expression
   
Probe: MGI:6167542
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6189790
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Apc
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6167542
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6189790
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Apc
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6167542
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6189790
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Apc
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6167542
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6189790
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Apc
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6167542
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189790
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Apc
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6167542
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189790
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Apc
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6167542
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189790
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Apc
Detected: true
Specimen Num: 7
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Publication
21892206 | J:186141
First Author: Fischer JM
Year: 2012
Journal: Oncogene
Title: Different phenotypic consequences of simultaneous versus stepwise Apc loss.
Volume: 31
Issue: 16
Pages: 2028-38
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Publication
17377531 | J:121434
First Author: Sansom OJ
Year: 2007
Journal: Nature
Title: Myc deletion rescues Apc deficiency in the small intestine.
Volume: 446
Issue: 7136
Pages: 676-9
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Publication
10489374 | J:57721
First Author: Roose J
Year: 1999
Journal: Science
Title: Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1.
Volume: 285
Issue: 5435
Pages: 1923-6
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Publication
7954428 | J:21856
First Author: Levy DB
Year: 1994
Journal: Cancer Res
Title: Inactivation of both APC alleles in human and mouse tumors.
Volume: 54
Issue: 22
Pages: 5953-8
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Publication
16740478 | J:109544
First Author: Benhamouche S
Year: 2006
Journal: Dev Cell
Title: Apc tumor suppressor gene is the "zonation-keeper" of mouse liver.
Volume: 10
Issue: 6
Pages: 759-70
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Publication
17363566 | J:120308
First Author: Bruxvoort KJ
Year: 2007
Journal: Cancer Res
Title: Inactivation of Apc in the mouse prostate causes prostate carcinoma.
Volume: 67
Issue: 6
Pages: 2490-6
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Publication
15695381 | J:96023
First Author: Méniel V
Year: 2005
Journal: Cancer Res
Title: Mutations in Apc and p53 synergize to promote mammary neoplasia.
Volume: 65
Issue: 2
Pages: 410-6
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Publication
31337618 | J:279990
First Author: Schatoff EM
Year: 2019
Journal: Cancer Discov
Title: Distinct Colorectal Cancer-Associated APC Mutations Dictate Response to Tankyrase Inhibition.
Volume: 9
Issue: 10
Pages: 1358-1371
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Publication
20010873 | J:160399
First Author: Cheung AF
Year: 2010
Journal: Oncogene
Title: Complete deletion of Apc results in severe polyposis in mice.
Volume: 29
Issue: 12
Pages: 1857-64
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Publication
20886217 | J:202877
First Author: Crist RC
Year: 2010
Journal: Mamm Genome
Title: The armadillo repeat domain of Apc suppresses intestinal tumorigenesis.
Volume: 21
Issue: 9-10
Pages: 450-7
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Gene
10297 | APC2
Type: gene
Organism: human
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Gene
442317 | SAPCD2P2
Type: gene
Organism: human
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Gene
442318 | SAPCD2P4
Type: gene
Organism: human
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Gene
442320 | SAPCD2P1
Type: gene
Organism: human
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Gene
643353 | SAPCD2P3
Type: gene
Organism: human
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Publication
27617574 | J:236456
First Author: Liu S
Year: 2017
Journal: Oncogene
Title: Disruption of the RP-MDM2-p53 pathway accelerates APC loss-induced colorectal tumorigenesis.
Volume: 36
Issue: 10
Pages: 1374-1383
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Publication
28710436 | J:252923
First Author: He Z
Year: 2017
Journal: Sci Rep
Title: Epithelial-derived IL-33 promotes intestinal tumorigenesis in Apc Min/+ mice.
Volume: 7
Issue: 1
Pages: 5520
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Publication
24667635 | J:211324
First Author: Lapierre M
Year: 2014
Journal: J Clin Invest
Title: RIP140 increases APC expression and controls intestinal homeostasis and tumorigenesis.
Volume: 124
Issue: 5
Pages: 1899-913
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Publication
27852007 | J:259632
 
First Author: Pirone A
Year: 2017
Journal: Neurobiol Dis
Title: APC conditional knock-out mouse is a model of infantile spasms with elevated neuronal β-catenin levels, neonatal spasms, and chronic seizures.
Volume: 98
Pages: 149-157
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Publication
8945503 | J:36817
First Author: Prescott SM
Year: 1996
Journal: Cell
Title: Self-promotion? Intimate connections between APC and prostaglandin H synthase-2.
Volume: 87
Issue: 5
Pages: 783-6
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Publication
9601641 | J:319997
First Author: Hart MJ
Year: 1998
Journal: Curr Biol
Title: Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta.
Volume: 8
Issue: 10
Pages: 573-81
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Publication
25535916 | J:311814
First Author: Eom TY
Year: 2014
Journal: Dev Cell
Title: Differential regulation of microtubule severing by APC underlies distinct patterns of projection neuron and interneuron migration.
Volume: 31
Issue: 6
Pages: 677-89
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Publication
19578404 | J:151494
First Author: Gaspar C
Year: 2009
Journal: PLoS Genet
Title: A targeted constitutive mutation in the APC tumor suppressor gene underlies mammary but not intestinal tumorigenesis.
Volume: 5
Issue: 7
Pages: e1000547
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Publication
15198980 | J:90759
First Author: Sansom OJ
Year: 2004
Journal: Genes Dev
Title: Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration.
Volume: 18
Issue: 12
Pages: 1385-90
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Publication
9311916 | J:43301
First Author: Shibata H
Year: 1997
Journal: Science
Title: Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene.
Volume: 278
Issue: 5335
Pages: 120-3
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Publication
34385594 | J:312450
First Author: Cen B
Year: 2021
Journal: Oncogene
Title: Mutant APC promotes tumor immune evasion via PD-L1 in colorectal cancer.
Volume: 40
Issue: 41
Pages: 5984-5992
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Publication
24685131 | J:211824
First Author: Song JH
Year: 2014
Journal: Cell Rep
Title: The APC network regulates the removal of mutated cells from colonic crypts.
Volume: 7
Issue: 1
Pages: 94-103
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Publication
23547052 | J:198202
First Author: Li W
Year: 2013
Journal: Blood
Title: Apc regulates the function of hematopoietic stem cells largely through β-catenin-dependent mechanisms.
Volume: 121
Issue: 20
Pages: 4063-72
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Publication
20140021 | J:168177
First Author: Athineos D
Year: 2010
Journal: Oncogene
Title: Myc heterozygosity attenuates the phenotypes of APC deficiency in the small intestine.
Volume: 29
Issue: 17
Pages: 2585-90
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Publication
17570218 | J:125809
First Author: Abal M
Year: 2007
Journal: Gastroenterology
Title: APC inactivation associates with abnormal mitosis completion and concomitant BUB1B/MAD2L1 up-regulation.
Volume: 132
Issue: 7
Pages: 2448-58
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Publication
27207671 | J:232780
First Author: Tao Y
Year: 2016
Journal: Carcinogenesis
Title: Hsp70 exerts oncogenic activity in the Apc mutant Min mouse model.
Volume: 37
Issue: 7
Pages: 731-739
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Publication
9060821 | J:38930
First Author: Bjerknes M
Year: 1997
Journal: Am J Pathol
Title: APC mutation and the crypt cycle in murine and human intestine.
Volume: 150
Issue: 3
Pages: 833-9
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Publication
19248780 | J:180275
First Author: Pollard P
Year: 2009
Journal: Gastroenterology
Title: The Apc 1322T mouse develops severe polyposis associated with submaximal nuclear beta-catenin expression.
Volume: 136
Issue: 7
Pages: 2204-2213.e1-13
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Publication
22009253 | J:180057
First Author: Lewis A
Year: 2012
Journal: J Pathol
Title: The C-terminus of Apc does not influence intestinal adenoma development or progression.
Volume: 226
Issue: 1
Pages: 73-83
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Publication
22884366 | J:196014
First Author: Radulescu S
Year: 2012
Journal: Cell Rep
Title: Luminal iron levels govern intestinal tumorigenesis after Apc loss in vivo.
Volume: 2
Issue: 2
Pages: 270-82
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Publication
17942902 | J:126018
First Author: Hinoi T
Year: 2007
Journal: Cancer Res
Title: Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivation.
Volume: 67
Issue: 20
Pages: 9721-30
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Publication
7496034 | J:27993
First Author: Moser AR
Year: 1995
Journal: Dev Dyn
Title: Homozygosity for the Min allele of Apc results in disruption of mouse development prior to gastrulation.
Volume: 203
Issue: 4
Pages: 422-33
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Publication
26193883 | J:226066
First Author: Cai J
Year: 2015
Journal: Genes Dev
Title: β-Catenin destruction complex-independent regulation of Hippo-YAP signaling by APC in intestinal tumorigenesis.
Volume: 29
Issue: 14
Pages: 1493-506
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Publication
26091037 | J:223512
First Author: Dow LE
Year: 2015
Journal: Cell
Title: Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer.
Volume: 161
Issue: 7
Pages: 1539-1552
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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