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Search results 401 to 500 out of 575 for Pdk1

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Type Details Score
Publication
21034549 | J:168636
First Author: Di RM
Year: 2010
Journal: Chin Med J (Engl)
Title: PDK1 plays a critical role in regulating cardiac function in mice and human.
Volume: 123
Issue: 17
Pages: 2358-63
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Publication
26809587 | J:230653
 
First Author: Grego-Bessa J
Year: 2016
Journal: Elife
Title: The tumor suppressor PTEN and the PDK1 kinase regulate formation of the columnar neural epithelium.
Volume: 5
Pages: e12034
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Publication
26099023 | J:226194
First Author: Yu M
Year: 2015
Journal: J Invest Dermatol
Title: Conditional PDK1 Ablation Promotes Epidermal and T-Cell-Mediated Dysfunctions Leading to Inflammatory Skin Disease.
Volume: 135
Issue: 11
Pages: 2688-2696
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Publication
22544756 | J:192998
First Author: Seong HA
Year: 2012
Journal: J Biol Chem
Title: PDK1 protein phosphorylation at Thr354 by murine protein serine-threonine kinase 38 contributes to negative regulation of PDK1 protein activity.
Volume: 287
Issue: 25
Pages: 20811-22
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Publication
33595435 | J:301717
   
First Author: Sun Z
Year: 2021
Journal: Elife
Title: The kinase PDK1 is critical for promoting T follicular helper cell differentiation.
Volume: 10
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Publication
32487697 | J:291516
First Author: Liu R
Year: 2020
Journal: J Neurosci
Title: PDK1 Regulates the Maintenance of Cell Body and the Development of Dendrites of Purkinje Cells by pS6 and PKCγ.
Volume: 40
Issue: 29
Pages: 5531-5548
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Publication
33568757 | J:305717
First Author: Kuramoto N
Year: 2021
Journal: Sci Rep
Title: Role of PDK1 in skeletal muscle hypertrophy induced by mechanical load.
Volume: 11
Issue: 1
Pages: 3447
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Publication
23131847 | J:259483
First Author: Kikani CK
Year: 2012
Journal: Sci Signal
Title: Proliferative and antiapoptotic signaling stimulated by nuclear-localized PDK1 results in oncogenesis.
Volume: 5
Issue: 249
Pages: ra80
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Publication
27184845 | J:269851
First Author: Dainichi T
Year: 2016
Journal: Cell Rep
Title: PDK1 Is a Regulator of Epidermal Differentiation that Activates and Organizes Asymmetric Cell Division.
Volume: 15
Issue: 8
Pages: 1615-23
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Publication
23955714 | J:202038
First Author: Pietri M
Year: 2013
Journal: Nat Med
Title: PDK1 decreases TACE-mediated α-secretase activity and promotes disease progression in prion and Alzheimer's diseases.
Volume: 19
Issue: 9
Pages: 1124-31
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Publication
19423553 | J:150212
First Author: Reddy P
Year: 2009
Journal: Hum Mol Genet
Title: PDK1 signaling in oocytes controls reproductive aging and lifespan by manipulating the survival of primordial follicles.
Volume: 18
Issue: 15
Pages: 2813-24
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Publication
20051528 | J:162895
First Author: Sanchez Canedo C
Year: 2010
Journal: Am J Physiol Endocrinol Metab
Title: Activation of the cardiac mTOR/p70(S6K) pathway by leucine requires PDK1 and correlates with PRAS40 phosphorylation.
Volume: 298
Issue: 4
Pages: E761-9
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Publication
24037523 | J:214355
First Author: Scortegagna M
Year: 2014
Journal: Oncogene
Title: Genetic inactivation or pharmacological inhibition of Pdk1 delays development and inhibits metastasis of Braf(V600E)::Pten(-/-) melanoma.
Volume: 33
Issue: 34
Pages: 4330-9
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Publication
15116068 | J:90081
First Author: McManus EJ
Year: 2004
Journal: EMBO J
Title: The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation.
Volume: 23
Issue: 10
Pages: 2071-82
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Publication
23275438 | J:315254
First Author: Zurashvili T
Year: 2013
Journal: Mol Cell Biol
Title: Interaction of PDK1 with phosphoinositides is essential for neuronal differentiation but dispensable for neuronal survival.
Volume: 33
Issue: 5
Pages: 1027-40
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Publication
12912918 | J:85056
First Author: Collins BJ
Year: 2003
Journal: EMBO J
Title: In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation.
Volume: 22
Issue: 16
Pages: 4202-11
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Publication
18430722 | J:138078
First Author: Nakamura K
Year: 2008
Journal: J Biol Chem
Title: PDK1 regulates cell proliferation and cell cycle progression through control of cyclin D1 and p27Kip1 expression.
Volume: 283
Issue: 25
Pages: 17702-11
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Publication
23030823 | J:190940
First Author: Najafov A
Year: 2012
Journal: Biochem J
Title: Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5)P3-dependent mechanisms leading to resistance to PDK1 inhibitors.
Volume: 448
Issue: 2
Pages: 285-95
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Publication
12711546 | J:83323
First Author: Kohn M
Year: 2003
Journal: Gene Expr Patterns
Title: Expression pattern of the Rsk2, Rsk4 and Pdk1 genes during murine embryogenesis.
Volume: 3
Issue: 2
Pages: 173-7
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Publication
19920149 | J:159953
First Author: Seong HA
Year: 2010
Journal: J Biol Chem
Title: Reciprocal negative regulation of PDK1 and ASK1 signaling by direct interaction and phosphorylation.
Volume: 285
Issue: 4
Pages: 2397-414
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Publication
25712345 | J:220158
First Author: Scortegagna M
Year: 2015
Journal: Cancer Res
Title: PDK1 and SGK3 Contribute to the Growth of BRAF-Mutant Melanomas and Are Potential Therapeutic Targets.
Volume: 75
Issue: 7
Pages: 1399-412
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Publication
31504280 | J:306386
First Author: Han X
Year: 2020
Journal: Cereb Cortex
Title: PDK1 Regulates Transition Period of Apical Progenitors to Basal Progenitors by Controlling Asymmetric Cell Division.
Volume: 30
Issue: 1
Pages: 406-420
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Publication
23183047 | J:194209
First Author: Finlay DK
Year: 2012
Journal: J Exp Med
Title: PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells.
Volume: 209
Issue: 13
Pages: 2441-53
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Publication
16219676 | J:102388
First Author: Collins BJ
Year: 2005
Journal: J Cell Sci
Title: In vivo role of the phosphate groove of PDK1 defined by knockin mutation.
Volume: 118
Issue: Pt 21
Pages: 5023-34
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Publication
18396135 | J:134336
First Author: Belgardt BF
Year: 2008
Journal: Cell Metab
Title: PDK1 deficiency in POMC-expressing cells reveals FOXO1-dependent and -independent pathways in control of energy homeostasis and stress response.
Volume: 7
Issue: 4
Pages: 291-301
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Publication
19122654 | J:144512
First Author: Park SG
Year: 2009
Journal: Nat Immunol
Title: The kinase PDK1 integrates T cell antigen receptor and CD28 coreceptor signaling to induce NF-kappaB and activate T cells.
Volume: 10
Issue: 2
Pages: 158-66
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Publication
10074427 | -
First Author: Casamayor A
Year: 1999
Journal: Curr Biol
Title: Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast.
Volume: 9
Issue: 4
Pages: 186-97
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Publication
29358916 | J:310530
 
First Author: Yang S
Year: 2017
Journal: Front Aging Neurosci
Title: Reducing the Levels of Akt Activation by PDK1 Knock-in Mutation Protects Neuronal Cultures against Synthetic Amyloid-Beta Peptides.
Volume: 9
Pages: 435
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Publication
19047061 | J:146938
First Author: Wang C
Year: 2009
Journal: J Biol Chem
Title: Protein kinase C theta (PKCtheta)-dependent phosphorylation of PDK1 at Ser504 and Ser532 contributes to palmitate-induced insulin resistance.
Volume: 284
Issue: 4
Pages: 2038-44
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Publication
22133875 | J:184575
First Author: Shim JH
Year: 2012
Journal: J Clin Invest
Title: Administration of BMP2/7 in utero partially reverses Rubinstein-Taybi syndrome-like skeletal defects induced by Pdk1 or Cbp mutations in mice.
Volume: 122
Issue: 1
Pages: 91-106
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Publication
31894307 | J:324075
First Author: Gao J
Year: 2020
Journal: Int J Mol Med
Title: Deficiency of Pdk1 contributes to primordial follicle activation via the upregulation of YAP expression and the pro‑inflammatory response.
Volume: 45
Issue: 2
Pages: 647-657
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Publication
26876212 | J:230809
First Author: Du L
Year: 2016
Journal: Oncogene
Title: Overexpression of PIK3CA in murine head and neck epithelium drives tumor invasion and metastasis through PDK1 and enhanced TGFβ signaling.
Volume: 35
Issue: 35
Pages: 4641-52
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Protein Coding Gene
MGI:1338068 | Pdpk1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
32457586 | J:288698
 
First Author: Giménez-Llort L
Year: 2020
Journal: Front Behav Neurosci
Title: The Impact of the PI3K/Akt Signaling Pathway in Anxiety and Working Memory in Young and Middle-Aged PDK1 K465E Knock-In Mice.
Volume: 14
Pages: 61
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Publication
15457207 | -
First Author: Komander D
Year: 2004
Journal: EMBO J
Title: Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates.
Volume: 23
Issue: 20
Pages: 3918-28
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Allele
Pdk1<em1Smoc> | MGI:7291591
Name: pyruvate dehydrogenase kinase, isoenzyme 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Publication
28473254 | J:261093
 
First Author: Gagliardi PA
Year: 2018
Journal: Semin Cancer Biol
Title: PDK1: At the crossroad of cancer signaling pathways.
Volume: 48
Pages: 27-35
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Publication
18616680 | -
First Author: Kurata A
Year: 2008
Journal: Cancer Sci
Title: TUSC4/NPRL2, a novel PDK1-interacting protein, inhibits PDK1 tyrosine phosphorylation and its downstream signaling.
Volume: 99
Issue: 9
Pages: 1827-34
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Strain
MGI:6429341 | C57BL/6J-Pdk1<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Publication
19716369 | J:153076
First Author: Zhang Y
Year: 2009
Journal: FEBS Lett
Title: Epinephrine-induced hyperpolarization of pancreatic islet cells is sensitive to PI3K-PDK1 signaling.
Volume: 583
Issue: 18
Pages: 3101-6
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Publication
21775285 | -
First Author: Sundaresan NR
Year: 2011
Journal: Sci Signal
Title: The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy.
Volume: 4
Issue: 182
Pages: ra46
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Publication
9748166 | -
First Author: Le Good JA
Year: 1998
Journal: Science
Title: Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1.
Volume: 281
Issue: 5385
Pages: 2042-5
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Publication
14625898 | -
First Author: Gräub R
Year: 2003
Journal: J Basic Microbiol
Title: Ksg1, a homologue of the phosphoinositide-dependent protein kinase 1, controls cell wall integrity in Schizosaccharomyces pombe.
Volume: 43
Issue: 6
Pages: 473-82
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Publication
15857958 | -
First Author: Bimbó A
Year: 2005
Journal: Mol Biol Cell
Title: Roles of Pdk1p, a fission yeast protein related to phosphoinositide-dependent protein kinase, in the regulation of mitosis and cytokinesis.
Volume: 16
Issue: 7
Pages: 3162-75
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Publication
9094314 | -
First Author: Alessi DR
Year: 1997
Journal: Curr Biol
Title: Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha.
Volume: 7
Issue: 4
Pages: 261-9
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Publication
9895304 | -
 
First Author: Currie RA
Year: 1999
Journal: Biochem J
Title: Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1.
Volume: 337 ( Pt 3)
Pages: 575-83
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Publication
28287465 | -
 
First Author: Di Blasio L
Year: 2017
Journal: Cancers (Basel)
Title: Serine/Threonine Kinase 3-Phosphoinositide-Dependent Protein Kinase-1 (PDK1) as a Key Regulator of Cell Migration and Cancer Dissemination.
Volume: 9
Issue: 3
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Publication
10191262 | -
 
First Author: Kobayashi T
Year: 1999
Journal: Biochem J
Title: Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2.
Volume: 339 ( Pt 2)
Pages: 319-28
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Publication
16314505 | J:103767
First Author: Fiory F
Year: 2005
Journal: Mol Cell Biol
Title: Tyrosine phosphorylation of phosphoinositide-dependent kinase 1 by the insulin receptor is necessary for insulin metabolic signaling.
Volume: 25
Issue: 24
Pages: 10803-14
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Protein Domain
IPR039046 | PDPK1
Type: Family
Description: This family includes 3-phosphoinositide-dependent protein kinase 1 (PDK1 or PDPK1) and related kinases from yeast: Pkh1 and Pkh2 from S. cerevisiae, which function similarly to PDK1 [], and Ksg1 []and Ppk21 from S. pombe [].PDK1 is the kinase responsible for the phosphorylation of PKB/Akt on the activation loop, at threonine 308, which is essential for Akt activation [, ]. Beyond Akt, PDK1 is responsible for the phosphorylation of many other AGC kinases including serum/glucocorticoid regulated kinase (SGK) []and the members of protein kinase C (PKC) family []. PDK1 is implicated in signaling pathways frequently altered in cancer, such as PI3K/Akt, Ras/MAPK and Myc []. It is a key regulator of cell migration and tumor invasion []. PDK1 binds to the insulin receptor, followed by tyrosine phosphorylation of PDK1 by the insulin receptor, which is necessary for insulin metabolic signaling []. Deficiency of PDK1 in liver results in glucose intolerance [].
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Publication
17077284 | J:117110
First Author: Budas GR
Year: 2006
Journal: FASEB J
Title: 3'Phosphoinositide-dependent kinase-1 is essential for ischemic preconditioning of the myocardium.
Volume: 20
Issue: 14
Pages: 2556-8
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Allele
Pdpk1<tm1Mlw> | MGI:2677460
Name: 3-phosphoinositide dependent protein kinase 1; targeted mutation 1, Margaret A Lawlor
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Pdpk1<tm1.1Mlw> | MGI:2677461
Name: 3-phosphoinositide dependent protein kinase 1; targeted mutation 1.1, Margaret A Lawlor
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Publication
17991746 | J:130347
First Author: Zaru R
Year: 2008
Journal: J Biol Chem
Title: 3-phosphoinositide-dependent kinase 1 deficiency perturbs Toll-like receptor signaling events and actin cytoskeleton dynamics in dendritic cells.
Volume: 283
Issue: 2
Pages: 929-39
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Publication
16563390 | J:107639
First Author: Kelly AP
Year: 2006
Journal: FEBS Lett
Title: Phosphoinositide-dependent kinase l (PDK1) haplo-insufficiency inhibits production of alpha/beta (alpha/beta) but not gamma delta (gamma/delta) T lymphocytes.
Volume: 580
Issue: 8
Pages: 2135-40
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Publication
17599070 | J:123268
First Author: Kelly AP
Year: 2007
Journal: EMBO J
Title: Notch-induced T cell development requires phosphoinositide-dependent kinase 1.
Volume: 26
Issue: 14
Pages: 3441-50
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Publication
15077109 | J:89811
First Author: Hinton HJ
Year: 2004
Journal: Nat Immunol
Title: The serine kinase phosphoinositide-dependent kinase 1 (PDK1) regulates T cell development.
Volume: 5
Issue: 5
Pages: 539-45
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Publication
19549840 | J:151894
First Author: Oishi K
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Selective induction of neocortical GABAergic neurons by the PDK1-Akt pathway through activation of Mash1.
Volume: 106
Issue: 31
Pages: 13064-9
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Publication
16741145 | J:141516
First Author: Artunc F
Year: 2006
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Impaired intestinal and renal glucose transport in PDK-1 hypomorphic mice.
Volume: 291
Issue: 5
Pages: R1533-8
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Publication
12855688 | J:85804
First Author: Sakaue H
Year: 2003
Journal: J Biol Chem
Title: Requirement for 3-phosphoinositide-kependent dinase-1 (PDK-1) in insulin-induced glucose uptake in immortalized brown adipocytes.
Volume: 278
Issue: 40
Pages: 38870-4
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Genotype
Genotype
Symbol: Pdpk1/Pdpk1
Background: involves: BALB/c
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pdpk1/Pdpk1
Background: involves: BALB/c
Zygosity: hm
Has Mutant Allele: true
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Publication
16887794 | J:117278
First Author: Bayascas JR
Year: 2006
Journal: J Biol Chem
Title: Evaluation of approaches to generation of tissue-specific knock-in mice.
Volume: 281
Issue: 39
Pages: 28772-81
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Publication
20687898 | J:166171
First Author: Mouton V
Year: 2010
Journal: Biochem J
Title: Heart 6-phosphofructo-2-kinase activation by insulin requires PKB (protein kinase B), but not SGK3 (serum- and glucocorticoid-induced protein kinase 3).
Volume: 431
Issue: 2
Pages: 267-75
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Publication
24662050 | J:215360
First Author: Zhao X
Year: 2014
Journal: Mol Cell Biol
Title: Phosphoinositide-dependent kinase 1 and mTORC2 synergistically maintain postnatal heart growth and heart function in mice.
Volume: 34
Issue: 11
Pages: 1966-75
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Publication
20944007 | J:165626
First Author: Finlay DK
Year: 2010
Journal: J Immunol
Title: Temporal differences in the dependency on phosphoinositide-dependent kinase 1 distinguish the development of invariant Valpha14 NKT cells and conventional T cells.
Volume: 185
Issue: 10
Pages: 5973-82
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Publication
19808258 | J:154070
First Author: Finlay DK
Year: 2009
Journal: J Exp Med
Title: Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes.
Volume: 206
Issue: 11
Pages: 2441-54
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Publication
30951706 | J:276572
First Author: Jin H
Year: 2019
Journal: Dev Biol
Title: Differential contribution of the two waves of cardiac progenitors and their derivatives to aorta and pulmonary artery.
Volume: 450
Issue: 2
Pages: 82-89
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Publication
27170189 | J:233892
First Author: Itoh Y
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: PDK1-Akt pathway regulates radial neuronal migration and microtubules in the developing mouse neocortex.
Volume: 113
Issue: 21
Pages: E2955-64
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Publication
15003271 | -
First Author: Biondi RM
Year: 2004
Journal: Trends Biochem Sci
Title: Phosphoinositide-dependent protein kinase 1, a sensor of protein conformation.
Volume: 29
Issue: 3
Pages: 136-42
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Publication
10698680 | -
 
First Author: Vanhaesebroeck B
Year: 2000
Journal: Biochem J
Title: The PI3K-PDK1 connection: more than just a road to PKB.
Volume: 346 Pt 3
Pages: 561-76
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Publication
11897568 | -
 
First Author: Storz P
Year: 2002
Journal: Front Biosci
Title: 3'-phosphoinositide-dependent kinase-1 (PDK-1) in PI 3-kinase signaling.
Volume: 7
Pages: d886-902
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Protein Domain
IPR033931 | PDK1-typ_PH
Type: Domain
Description: This entry represents the pleckstrin homology (PH) domain from 3-phosphoinositide-dependent protein kinase 1 (PDK1) type proteins.PDK1 plays an important role in insulin and growth factor signalling cascades. It phosphorylates and activates many AGC (cAMP-dependent, cGMP-dependent, protein kinase C (PKC)) family of protein kinases members, including protein kinase B (PKB, also known as Akt), p70 ribosomal S6-kinase (S6K), serum and glucocorticoid responsive kinase (SGK), p90 ribosomal S6 kinase (RSK), and PKC []. PDK1 contains an N-terminal serine/threonine kinase domain followed by a PH domain. Following binding of the PH domain to PtdIns(3,4,5)P3 and PtdIns(3,4)P2, PDK1 activates these enzymes by phosphorylating a Ser/Thr residue in their activation loop. [, , , ].Pleckstrin homology (PH) domains are small modular domains that occur in a large variety of signalling proteins, where they serve as simple targeting domains that bind lipids [, , ].
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Publication
20584979 | J:163291
First Author: Chaurasia B
Year: 2010
Journal: Mol Cell Biol
Title: Phosphoinositide-dependent kinase 1 provides negative feedback inhibition to Toll-like receptor-mediated NF-kappaB activation in macrophages.
Volume: 30
Issue: 17
Pages: 4354-66
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Publication
26476238 | J:251507
First Author: Noh J
Year: 2015
Journal: J Mol Cell Cardiol
Title: Phosphoinositide dependent protein kinase 1 is required for exercise-induced cardiac hypertrophy but not the associated mitochondrial adaptations.
Volume: 89
Issue: Pt B
Pages: 297-305
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Genotype
Genotype
Symbol: Pdpk1/Pdpk1
Background: involves: BALB/c
Zygosity: ht
Has Mutant Allele: true
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Publication
15961082 | J:99781
First Author: Mora A
Year: 2005
Journal: FEBS Lett
Title: Role of the PDK1-PKB-GSK3 pathway in regulating glycogen synthase and glucose uptake in the heart.
Volume: 579
Issue: 17
Pages: 3632-8
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Publication
10021376 | J:52843
First Author: Belham C
Year: 1999
Journal: Curr Biol
Title: Intracellular signalling: PDK1--a kinase at the hub of things.
Volume: 9
Issue: 3
Pages: R93-6
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Publication
23979601 | J:205424
First Author: McGuire VA
Year: 2013
Journal: Mol Cell Biol
Title: Cross talk between the Akt and p38α pathways in macrophages downstream of Toll-like receptor signaling.
Volume: 33
Issue: 21
Pages: 4152-65
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Genotype
Genotype
Symbol: Pdpk1/Pdpk1 Tg(Ckmm-cre)5Khn/?
Background: involves: BALB/c
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pdpk1/Pdpk1 Tg(Cd4-cre)1Cwi/?
Background: involves: C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Pdpk1/Pdpk1 Ptf1a/Ptf1a<+>
Background: involves: 129S6/SvEvTac
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Kras/Kras<+> Pdpk1/Pdpk1 Tg(Cela1-cre/ERT)1Dam/?
Background: involves: 129S4/SvJae
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Kras/Kras<+> Pdpk1/Pdpk1 Ptf1a/Ptf1a<+>
Background: involves: 129S4/SvJae
Zygosity: cn
Has Mutant Allele: true
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Publication
12694559 | -
First Author: Lemmon MA
Year: 2003
Journal: Traffic
Title: Phosphoinositide recognition domains.
Volume: 4
Issue: 4
Pages: 201-13
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Publication
19605683 | J:150710
First Author: Chalhoub N
Year: 2009
Journal: Genes Dev
Title: Cell type specificity of PI3K signaling in Pdk1- and Pten-deficient brains.
Volume: 23
Issue: 14
Pages: 1619-24
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Publication
22147265 | J:195605
First Author: Sperow M
Year: 2012
Journal: J Physiol
Title: Phosphatase and tensin homologue (PTEN) regulates synaptic plasticity independently of its effect on neuronal morphology and migration.
Volume: 590
Issue: 4
Pages: 777-92
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Publication
26401001 | J:269887
First Author: Zaru R
Year: 2015
Journal: J Immunol
Title: The PDK1-Rsk Signaling Pathway Controls Langerhans Cell Proliferation and Patterning.
Volume: 195
Issue: 9
Pages: 4264-72
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Genotype
Genotype
Symbol: Pdpk1/Pdpk1 Tg(Cd4-cre)1Cwi/?
Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Kras/Kras<+> Pdpk1/Pdpk1 Ptf1a/Ptf1a<+>
Background: involves: 129S4/SvJae * 129S6/SvEvTac
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pdpk1/Pdpk1 Tnfrsf4/Tnfrsf4<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Protein
F2Z400
Organism: Mus musculus/domesticus
Length: 457  
Fragment?: false
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Protein
Q3UEW8
Organism: Mus musculus/domesticus
Length: 434  
Fragment?: true
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Protein
Q3UHZ0
Organism: Mus musculus/domesticus
Length: 559  
Fragment?: false
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Protein
Q8K3L3
Organism: Mus musculus/domesticus
Length: 532  
Fragment?: false
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Protein
Q3UGN6
Organism: Mus musculus/domesticus
Length: 559  
Fragment?: false
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Protein
F2Z3X6
Organism: Mus musculus/domesticus
Length: 532  
Fragment?: false
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Protein
Q810Z4
Organism: Mus musculus/domesticus
Length: 551  
Fragment?: true
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Protein
Q3TRL2
Organism: Mus musculus/domesticus
Length: 522  
Fragment?: false
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Publication
21059917 | J:166594
First Author: Liu J
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Three-amino-acid-loop-extension homeodomain factor Meis3 regulates cell survival via PDK1.
Volume: 107
Issue: 47
Pages: 20494-9
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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