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Search results 201 to 263 out of 263 for Pcdh18

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0.028s
Type Details Score
Publication
First Author: Telo' P
Year: 1998
Journal: J Biol Chem
Title: Identification of a novel cadherin (vascular endothelial cadherin-2) located at intercellular junctions in endothelial cells.
Volume: 273
Issue: 28
Pages: 17565-72
Publication
First Author: Rampon C
Year: 2008
Journal: Physiol Genomics
Title: Protocadherin 12 deficiency alters morphogenesis and transcriptional profile of the placenta.
Volume: 34
Issue: 2
Pages: 193-204
Publication
First Author: Philibert C
Year: 2012
Journal: Pathol Biol (Paris)
Title: Protocadherin-12 deficiency leads to modifications in the structure and function of arteries in mice.
Volume: 60
Issue: 1
Pages: 34-40
Protein
Organism: Mus musculus/domesticus
Length: 121  
Fragment?: false
Publication
First Author: Hulpiau P
Year: 2009
Journal: Int J Biochem Cell Biol
Title: Molecular evolution of the cadherin superfamily.
Volume: 41
Issue: 2
Pages: 349-69
Publication
First Author: Makarenkova H
Year: 2005
Journal: Biochim Biophys Acta
Title: Alternatively spliced variants of protocadherin 8 exhibit distinct patterns of expression during mouse development.
Volume: 1681
Issue: 2-3
Pages: 150-6
Publication
First Author: Redies C
Year: 2005
Journal: Cell Mol Life Sci
Title: delta-Protocadherins: unique structures and functions.
Volume: 62
Issue: 23
Pages: 2840-52
Publication
First Author: Zhang D
Year: 2012
Journal: Oncol Rep
Title: Frequent silencing of protocadherin 8 by promoter methylation, a candidate tumor suppressor for human gastric cancer.
Volume: 28
Issue: 5
Pages: 1785-91
Publication
First Author: Yu JS
Year: 2008
Journal: Oncogene
Title: PCDH8, the human homolog of PAPC, is a candidate tumor suppressor of breast cancer.
Volume: 27
Issue: 34
Pages: 4657-65
Publication
First Author: Jao TM
Year: 2014
Journal: Int J Cancer
Title: Protocadherin 10 suppresses tumorigenesis and metastasis in colorectal cancer and its genetic loss predicts adverse prognosis.
Volume: 135
Issue: 11
Pages: 2593-603
Publication
First Author: Li Z
Year: 2014
Journal: Mol Med Rep
Title: Nuclear factor-κB is involved in the protocadherin-10-mediated pro-apoptotic effect in multiple myeloma.
Volume: 10
Issue: 2
Pages: 832-8
Publication
First Author: Bouillot S
Year: 2011
Journal: J Biol Chem
Title: Protocadherin-12 cleavage is a regulated process mediated by ADAM10 protein: evidence of shedding up-regulation in pre-eclampsia.
Volume: 286
Issue: 17
Pages: 15195-204
Protein Domain
Type: Family
Description: Protocadherin-12 (Pcdh12), also known as vascular cadherin-2 or VE-cadherin-2, is located at the intercellular junctions of endothelial cells, where it promotes homotypic cellular adhesion []. It is required for placental development [, ]and its deficiency leads to modifications in the structure and function of arteries in adult mice [].The cadherin family consists of a large group of cell adhesion proteins. It can be classified into three subfamilies: classical cadherins, desmosomal cadherins and protocadherins (PCDHs). Based on the genomic structure, the PCDH family can be divided into two groups, clustered PCDHs and non-clustered PCDHs. Non-clustered PCDHs can be further classified into three subgroups: delta1 (PCDH1, PCDH7, PCDH9, PCDH11 and PCDH20), delta2 (PCDH8, PCDH10, PCDH12, PCDH17, PCDH18 and PCDH19) and epsilon (PCDH15, PCDH16, PCDH21 and MUCDHL). Non-clustered PCDHs are expressed predominantly in the nervous system and have spatiotemporally diverse expression patterns [].
Protein Domain
Type: Family
Description: Protocadherin-10 (Pcdh10) belongs to the delta-2 subfamily of nonclustered protocadherins []. Pcdh10 is a pivotal tumour suppressor in colorectal cancer []and induces myeloma cell apoptosis, probably by inhibiting the NF-kappaB pathway [].The cadherin family consists of a large group of cell adhesion proteins. It can be classified into three subfamilies: classical cadherins, desmosomal cadherins and protocadherins (PCDHs). Based on the genomic structure, the PCDH family can be divided into two groups, clustered PCDHs and non-clustered PCDHs. Non-clustered PCDHs can be further classified into three subgroups: delta1 (PCDH1, PCDH7, PCDH9, PCDH11 and PCDH20), delta2 (PCDH8, PCDH10, PCDH12, PCDH17, PCDH18 and PCDH19) and epsilon (PCDH15, PCDH16, PCDH21 and MUCDHL). Non-clustered PCDHs are expressed predominantly in the nervous system and have spatiotemporally diverse expression patterns [].
Protein Domain
Type: Family
Description: Protocadherin-8 (Pcdh8) belongs to the delta-2 subfamily of nonclustered protocadherins [, ]. It is involved in development [, ]and can act as a tumour suppressor [, ].The cadherin family consists of a large group of cell adhesion proteins. It can be classified into three subfamilies: classical cadherins, desmosomal cadherins and protocadherins (PCDHs). Based on the genomic structure, the PCDH family can be divided into two groups, clustered PCDHs and non-clustered PCDHs. Non-clustered PCDHs can be further classified into three subgroups: delta1 (PCDH1, PCDH7, PCDH9, PCDH11 and PCDH20), delta2 (PCDH8, PCDH10, PCDH12, PCDH17, PCDH18 and PCDH19) and epsilon (PCDH15, PCDH16, PCDH21 and MUCDHL). Non-clustered PCDHs are expressed predominantly in the nervous system and have spatiotemporally diverse expression patterns [].
Publication
First Author: Haywood-Watson RJ 2nd
Year: 2006
Journal: Invest Ophthalmol Vis Sci
Title: Ames Waltzer deaf mice have reduced electroretinogram amplitudes and complex alternative splicing of Pcdh15 transcripts.
Volume: 47
Issue: 7
Pages: 3074-84
Publication
First Author: Maeda R
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Tip-link protein protocadherin 15 interacts with transmembrane channel-like proteins TMC1 and TMC2.
Volume: 111
Issue: 35
Pages: 12907-12
Protein
Organism: Mus musculus/domesticus
Length: 121  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 283  
Fragment?: true
Publication
First Author: Hayashi S
Year: 2014
Journal: Dev Cell
Title: Protocadherin-17 mediates collective axon extension by recruiting actin regulator complexes to interaxonal contacts.
Volume: 30
Issue: 6
Pages: 673-87
Publication
First Author: Chen Y
Year: 2013
Journal: Dev Neurobiol
Title: Protocadherin-17 function in Zebrafish retinal development.
Volume: 73
Issue: 4
Pages: 259-73
Publication
First Author: Hu X
Year: 2013
Journal: J Pathol
Title: Protocadherin 17 acts as a tumour suppressor inducing tumour cell apoptosis and autophagy, and is frequently methylated in gastric and colorectal cancers.
Volume: 229
Issue: 1
Pages: 62-73
Publication
First Author: Haruki S
Year: 2010
Journal: Carcinogenesis
Title: Frequent silencing of protocadherin 17, a candidate tumour suppressor for esophageal squamous cell carcinoma.
Volume: 31
Issue: 6
Pages: 1027-36
Publication
First Author: Liu Q
Year: 2009
Journal: Gene Expr Patterns
Title: Expression of protocadherin-9 and protocadherin-17 in the nervous system of the embryonic zebrafish.
Volume: 9
Issue: 7
Pages: 490-6
Publication
First Author: Krishna-K
Year: 2009
Journal: J Cereb Blood Flow Metab
Title: Expression of cadherin superfamily genes in brain vascular development.
Volume: 29
Issue: 2
Pages: 224-9
Publication
First Author: Hoshina N
Year: 2013
Journal: Neuron
Title: Protocadherin 17 regulates presynaptic assembly in topographic corticobasal Ganglia circuits.
Volume: 78
Issue: 5
Pages: 839-54
Publication
First Author: Liu Q
Year: 2015
Journal: J Comp Neurol
Title: Differential expression of protocadherin-19, protocadherin-17, and cadherin-6 in adult zebrafish brain.
Volume: 523
Issue: 9
Pages: 1419-42
Publication
First Author: Depienne C
Year: 2012
Journal: Hum Mutat
Title: PCDH19-related infantile epileptic encephalopathy: an unusual X-linked inheritance disorder.
Volume: 33
Issue: 4
Pages: 627-34
Publication
First Author: Camacho A
Year: 2012
Journal: Epilepsy Behav
Title: Cognitive and behavioral profile in females with epilepsy with PDCH19 mutation: two novel mutations and review of the literature.
Volume: 24
Issue: 1
Pages: 134-7
Publication
First Author: Duszyc K
Year: 2015
Journal: J Appl Genet
Title: Epilepsy and mental retardation restricted to females: X-linked epileptic infantile encephalopathy of unusual inheritance.
Volume: 56
Issue: 1
Pages: 49-56
Publication
First Author: Pepermans E
Year: 2014
Journal: EMBO Mol Med
Title: The CD2 isoform of protocadherin-15 is an essential component of the tip-link complex in mature auditory hair cells.
Volume: 6
Issue: 7
Pages: 984-92
Publication
First Author: Zheng QY
Year: 2005
Journal: Hum Mol Genet
Title: Digenic inheritance of deafness caused by mutations in genes encoding cadherin 23 and protocadherin 15 in mice and humans.
Volume: 14
Issue: 1
Pages: 103-11
Publication
First Author: Washington JL 3rd
Year: 2005
Journal: Hear Res
Title: Characterization of a new allele of Ames waltzer generated by ENU mutagenesis.
Volume: 202
Issue: 1-2
Pages: 161-9
Protein Domain
Type: Family
Description: Protocadherin-15 (Pcdh15) belongs to the epsilon subfamily of nonclustered protocadherins. It is a component of the tip-links, the extracellular filaments that connect the tips of stereocilia and gate hair cell mechano-electrical transduction channels in the inner ear []. Pcdh15 interacts with transmembrane channel-like proteins TMC1 and TMC2, which have been implicated in mechanotransduction in mammalian hair cells []. Mutations in genes coding for Pcdh15 cause deafness in both mice and humans [, ]. Pcdh15 plays an important role in hair-bundle morphogenesis [].The cadherin family consists of a large group of cell adhesion proteins. It can be classified into three subfamilies: classical cadherins, desmosomal cadherins and protocadherins (PCDHs). Based on the genomic structure, the PCDH family can be divided into two groups, clustered PCDHs and non-clustered PCDHs. Non-clustered PCDHs can be further classified into three subgroups: delta1 (PCDH1, PCDH7, PCDH9, PCDH11 and PCDH20), delta2 (PCDH8, PCDH10, PCDH12, PCDH17, PCDH18 and PCDH19) and epsilon (PCDH15, PCDH16, PCDH21 and MUCDHL). Non-clustered PCDHs are expressed predominantly in the nervous system and have spatiotemporally diverse expression patterns [].
Protein Domain
Type: Family
Description: Protocadherin-19 (Pcdh19) belongs to the delta-2 subfamily of nonclustered protocadherins. The non-clustered PCDHs appear to have homophilic/heterophilc cell-cell adhesion properties [], and the delta-2 subfamily (comprising protocadherin-8, -10, -17, -18, and -19) is widely expressed in the nervous system [, ]. Pcdh19 is highly expressed during brain development, and could play significant roles in neuronal migration or establishment of synaptic connections. Pcdh19 mutations cause an unusual X-linked inheritance disorder resulting in epilepsy and mental retardation [, , ].The cadherin family consists of a large group of cell adhesion proteins. It can be classified into three subfamilies: classical cadherins, desmosomal cadherins and protocadherins (PCDHs). Based on the genomic structure, the PCDH family can be divided into two groups, clustered PCDHs and non-clustered PCDHs. Non-clustered PCDHs can be further classified into three subgroups: delta1 (PCDH1, PCDH7, PCDH9, PCDH11 and PCDH20), delta2 (PCDH8, PCDH10, PCDH12, PCDH17, PCDH18 and PCDH19) and epsilon (PCDH15, PCDH16, PCDH21 and MUCDHL). Non-clustered PCDHs are expressed predominantly in the nervous system and have spatiotemporally diverse expression patterns [].
Protein Domain
Type: Family
Description: Protocadherin-17 (Pcdh17) belongs to the delta-2 subfamily of nonclustered protocadherins. The non-clustered PCDHs appear to have homophilic/heterophilc cell-cell adhesion properties [], and the delta-2 subfamily (comprising protocadherin-8, -10, -17, -18, and -19) is widely expressed in the nervous system [, ]. Pcdh17 mediates collective axon extension in amygdala neurons [], regulates presynaptic assembly in corticobasal ganglia circuits [], and is involved in brain vascular development []. In addition, it has been shown to have a role in the formation of the zebrafish retina []and to act as a tumour suppressor [, ].The cadherin family consists of a large group of cell adhesion proteins. It can be classified into three subfamilies: classical cadherins, desmosomal cadherins and protocadherins (PCDHs). Based on the genomic structure, the PCDH family can be divided into two groups, clustered PCDHs and non-clustered PCDHs. Non-clustered PCDHs can be further classified into three subgroups: delta1 (PCDH1, PCDH7, PCDH9, PCDH11 and PCDH20), delta2 (PCDH8, PCDH10, PCDH12, PCDH17, PCDH18 and PCDH19) and epsilon (PCDH15, PCDH16, PCDH21 and MUCDHL). Non-clustered PCDHs are expressed predominantly in the nervous system and have spatiotemporally diverse expression patterns [].
Protein
Organism: Mus musculus/domesticus
Length: 455  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 1134  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 917  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 440  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 1943  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1783  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 683  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 1865  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1333  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 992  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1714  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 641  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 1675  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1180  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1145  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1070  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1157  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1057  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1047  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 896  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1157  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1098  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 755  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 1097  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 998  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 896  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1040  
Fragment?: false