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Search results 901 to 1000 out of 1066 for Apob

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Type Details Score
Publication  
First Author: Wen D
Year: 2023
Journal: Front Cardiovasc Med
Title: Mechanical injury accentuates lipid deposition in ApoE(-/-) mice and advance aortic valve stenosis: A novel modified aortic valve stenosis model.
Volume: 10
Pages: 1119746
Protein
Organism: Mus musculus/domesticus
Length: 229  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 229  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 229  
Fragment?: false
Publication
First Author: Blanc V
Year: 2001
Journal: J Biol Chem
Title: Identification of GRY-RBP as an apolipoprotein B RNA-binding protein that interacts with both apobec-1 and apobec-1 complementation factor to modulate C to U editing.
Volume: 276
Issue: 13
Pages: 10272-83
Publication
First Author: Blanc V
Year: 2019
Journal: RNA
Title: Apobec1 complementation factor (A1CF) and RBM47 interact in tissue-specific regulation of C to U RNA editing in mouse intestine and liver.
Volume: 25
Issue: 1
Pages: 70-81
Publication
First Author: Wilson PG
Year: 2018
Journal: Arterioscler Thromb Vasc Biol
Title: Serum Amyloid A Is an Exchangeable Apolipoprotein.
Volume: 38
Issue: 8
Pages: 1890-1900
Publication
First Author: VerHague MA
Year: 2013
Journal: Arterioscler Thromb Vasc Biol
Title: Apolipoprotein A-IV expression in mouse liver enhances triglyceride secretion and reduces hepatic lipid content by promoting very low density lipoprotein particle expansion.
Volume: 33
Issue: 11
Pages: 2501-8
Publication
First Author: Bi X
Year: 2013
Journal: Arterioscler Thromb Vasc Biol
Title: Liver ABCA1 deletion in LDLrKO mice does not impair macrophage reverse cholesterol transport or exacerbate atherogenesis.
Volume: 33
Issue: 10
Pages: 2288-96
Publication
First Author: Tavori H
Year: 2016
Journal: Cardiovasc Res
Title: Human PCSK9 promotes hepatic lipogenesis and atherosclerosis development via apoE- and LDLR-mediated mechanisms.
Volume: 110
Issue: 2
Pages: 268-78
Publication
First Author: Joyce CW
Year: 2006
Journal: J Biol Chem
Title: ABCA1 overexpression in the liver of LDLr-KO mice leads to accumulation of pro-atherogenic lipoproteins and enhanced atherosclerosis.
Volume: 281
Issue: 44
Pages: 33053-65
Publication
First Author: Vishnyakova TG
Year: 2020
Journal: PLoS One
Title: SR-BI mediates neutral lipid sorting from LDL to lipid droplets and facilitates their formation.
Volume: 15
Issue: 10
Pages: e0240659
Publication
First Author: Mensenkamp AR
Year: 1999
Journal: J Biol Chem
Title: Apolipoprotein E participates in the regulation of very low density lipoprotein-triglyceride secretion by the liver.
Volume: 274
Issue: 50
Pages: 35711-8
Publication
First Author: González-Navarro H
Year: 2004
Journal: J Biol Chem
Title: The ligand-binding function of hepatic lipase modulates the development of atherosclerosis in transgenic mice.
Volume: 279
Issue: 44
Pages: 45312-21
Publication
First Author: Dichek HL
Year: 1998
Journal: J Biol Chem
Title: Overexpression of hepatic lipase in transgenic mice decreases apolipoprotein B-containing and high density lipoproteins. Evidence that hepatic lipase acts as a ligand for lipoprotein uptake.
Volume: 273
Issue: 4
Pages: 1896-903
Publication
First Author: Kanuri G
Year: 2011
Journal: Lab Invest
Title: Fructose-induced steatosis in mice: role of plasminogen activator inhibitor-1, microsomal triglyceride transfer protein and NKT cells.
Volume: 91
Issue: 6
Pages: 885-95
Publication
First Author: Khatun I
Year: 2012
Journal: Hepatology
Title: Phospholipid transfer activity of microsomal triglyceride transfer protein produces apolipoprotein B and reduces hepatosteatosis while maintaining low plasma lipids in mice.
Volume: 55
Issue: 5
Pages: 1356-68
Publication  
First Author: Behlen JC
Year: 2022
Journal: Antioxidants (Basel)
Title: NRF2-Dependent Placental Effects Vary by Sex and Dose following Gestational Exposure to Ultrafine Particles.
Volume: 11
Issue: 2
Publication
First Author: Laatsch A
Year: 2012
Journal: PLoS One
Title: Low density lipoprotein receptor-related protein 1 dependent endosomal trapping and recycling of apolipoprotein E.
Volume: 7
Issue: 1
Pages: e29385
Publication
First Author: Kendrick JS
Year: 2001
Journal: Biochem J
Title: Superior role of apolipoprotein B48 over apolipoprotein B100 in chylomicron assembly and fat absorption: an investigation of apobec-1 knock-out and wild-type mice.
Volume: 356
Issue: Pt 3
Pages: 821-7
Publication
First Author: Escolà-Gil JC
Year: 2000
Journal: J Lipid Res
Title: Expression of human apolipoprotein A-II in apolipoprotein E-deficient mice induces features of familial combined hyperlipidemia.
Volume: 41
Issue: 8
Pages: 1328-38
Publication
First Author: Kitagawa K
Year: 1994
Journal: Lab Invest
Title: Age-associated decreases in the messenger ribonucleic acid level and the rate of synthesis of apolipoprotein A-II in murine senile amyloidosis.
Volume: 70
Issue: 4
Pages: 565-71
Publication
First Author: Srivastava RA
Year: 1995
Journal: Biochem Biophys Res Commun
Title: Increased apoB100 mRNA in inbred strains of mice by estrogen is caused by decreased RNA editing protein mRNA.
Volume: 212
Issue: 2
Pages: 381-7
Publication
First Author: Huang Y
Year: 1996
Journal: J Biol Chem
Title: Hypolipidemic and hyperlipidemic phenotypes in transgenic mice expressing human apolipoprotein E2.
Volume: 271
Issue: 46
Pages: 29146-51
Publication
First Author: Grunwald KA
Year: 1999
Journal: J Lipid Res
Title: Identification of a novel Arg-->Cys mutation in the LDL receptor that contributes to spontaneous hypercholesterolemia in pigs.
Volume: 40
Issue: 3
Pages: 475-85
Publication
First Author: Fujino T
Year: 1999
Journal: Nucleic Acids Res
Title: C-->U editing of apolipoprotein B mRNA in marsupials: identification and characterisation of APOBEC-1 from the American opossum Monodelphus domestica.
Volume: 27
Issue: 13
Pages: 2662-71
Publication
First Author: Lau PP
Year: 2003
Journal: J Biol Chem
Title: Involvement of a chaperone regulator, Bcl2-associated athanogene-4, in apolipoprotein B mRNA editing.
Volume: 278
Issue: 52
Pages: 52988-96
Publication
First Author: Ribas V
Year: 2004
Journal: Circ Res
Title: Human apolipoprotein A-II enrichment displaces paraoxonase from HDL and impairs its antioxidant properties: a new mechanism linking HDL protein composition and antiatherogenic potential.
Volume: 95
Issue: 8
Pages: 789-97
Publication
First Author: Noordmans GA
Year: 2014
Journal: PLoS One
Title: Genetic analysis of intracapillary glomerular lipoprotein deposits in aging mice.
Volume: 9
Issue: 10
Pages: e111308
Publication
First Author: Ali K
Year: 2014
Journal: PLoS One
Title: A Western-fed diet increases plasma HDL and LDL-cholesterol levels in apoD-/- mice.
Volume: 9
Issue: 12
Pages: e115744
Publication
First Author: Uemura Y
Year: 2017
Journal: PLoS One
Title: The intratracheal administration of locked nucleic acid containing antisense oligonucleotides induced gene silencing and an immune-stimulatory effect in the murine lung.
Volume: 12
Issue: 11
Pages: e0187286
Publication  
First Author: Gaglione R
Year: 2017
Journal: Biochem Pharmacol
Title: Novel human bioactive peptides identified in Apolipoprotein B: Evaluation of their therapeutic potential.
Volume: 130
Pages: 34-50
Publication  
First Author: Nettersheim FS
Year: 2021
Journal: Front Cardiovasc Med
Title: Autoimmune Regulator (AIRE) Deficiency Does Not Affect Atherosclerosis and CD4 T Cell Immune Tolerance to Apolipoprotein B.
Volume: 8
Pages: 812769
Publication
First Author: Moraes KC
Year: 2006
Journal: RNA
Title: CUG-BP binds to RNA substrates and recruits PARN deadenylase.
Volume: 12
Issue: 6
Pages: 1084-91
Publication
First Author: Timchenko LT
Year: 1996
Journal: Nucleic Acids Res
Title: Identification of a (CUG)n triplet repeat RNA-binding protein and its expression in myotonic dystrophy.
Volume: 24
Issue: 22
Pages: 4407-14
Publication
First Author: Leroy O
Year: 2006
Journal: J Neurosci Res
Title: ETR-3 represses Tau exons 2/3 inclusion, a splicing event abnormally enhanced in myotonic dystrophy type I.
Volume: 84
Issue: 4
Pages: 852-9
Publication
First Author: Timchenko NA
Year: 2001
Journal: J Biol Chem
Title: RNA CUG repeats sequester CUGBP1 and alter protein levels and activity of CUGBP1.
Volume: 276
Issue: 11
Pages: 7820-6
Publication
First Author: Graindorge A
Year: 2008
Journal: Nucleic Acids Res
Title: Identification of CUG-BP1/EDEN-BP target mRNAs in Xenopus tropicalis.
Volume: 36
Issue: 6
Pages: 1861-70
Publication
First Author: Cosson B
Year: 2006
Journal: Biol Cell
Title: Oligomerization of EDEN-BP is required for specific mRNA deadenylation and binding.
Volume: 98
Issue: 11
Pages: 653-65
Publication
First Author: Anant S
Year: 2001
Journal: J Biol Chem
Title: Novel role for RNA-binding protein CUGBP2 in mammalian RNA editing. CUGBP2 modulates C to U editing of apolipoprotein B mRNA by interacting with apobec-1 and ACF, the apobec-1 complementation factor.
Volume: 276
Issue: 50
Pages: 47338-51
Publication
First Author: Ladd AN
Year: 2004
Journal: J Cell Sci
Title: Multiple domains control the subcellular localization and activity of ETR-3, a regulator of nuclear and cytoplasmic RNA processing events.
Volume: 117
Issue: Pt 16
Pages: 3519-29
Protein
Organism: Mus musculus/domesticus
Length: 191  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 198  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 440  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 180  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 180  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 396  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 198  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 396  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 180  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 198  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 198  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 373  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 396  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 198  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 392  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 198  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 180  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 198  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 198  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 180  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 97  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 198  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 113  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 191  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 421  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 373  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 198  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 198  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 429  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 429  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 121  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 372  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 180  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 198  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 429  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 297  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 180  
Fragment?: true
Publication
First Author: Yang C
Year: 1992
Journal: Biochemistry
Title: Cloning and nucleotide sequence of the Escherichia coli cytidine deaminase (ccd) gene.
Volume: 31
Issue: 17
Pages: 4168-74
Protein Domain
Type: Domain
Description: The human CELF family has six members, which can be divided into two subfamilies based on their phylogeny: CELF1-2 and CELF3-6. This entry represents the RNA recognition motif 2 (RRM2) of CELF-1 and CELF-2 protein. CELF-1 and CELF-2 belong to the CELF (CUGBP and ETR-3 Like Factor)/Bruno-like protein family, whose members play important roles in the regulation of alternative splicing and translation. CELF-1 and CELF-2 share sequence similarity to the Drosophila Bruno protein and binds to the Bruno response elements (cis-acting sequences in the 3'-untranslated region (UTR) ofoskar mRNA) [].The human CELF-1 (also known as CUG-BP or BRUNOL-2) binds to RNA substrates and recruits PARN deadenylase []. It preferentially targets UGU-rich mRNA elements []. CELF-1 has been implicated in onset of type 1 myotonic dystrophy (DM1), a neuromuscular disease associated with an unstable CUG triplet expansion in the 3'-UTR (3'-untranslated region) of the DMPK (myotonic dystrophy protein kinase) gene [, ]. CELF-1 contain three highly conserved RNA recognition motifs (RRMs): two consecutive RRMs (RRM1 and RRM2) situated in the N-terminal region followed by a linker region and the third RRM (RRM3) close to the C terminus of the protein. The Xenopus homologue of CELF-1 is EDEN-BP (embryo deadenylation element-binding protein), which mediates sequence-specific deadenylation of Eg5 mRNA. It binds specifically to the EDEN motif in the 3'-untranslated regions of maternal mRNAs and targets these mRNAs for deadenylation and translational repression []. The two N-terminal RRMs of EDEN-BP are necessary for the interaction with EDEN as well as a part of the linker region (between RRM2 and RRM3). Oligomerization of EDEN-BP is required for specific mRNA deadenylation and binding []. CELF-2 (also known as CUGBP2 or ETR-3) shares high sequence identity with CELF-1, but shows different binding specificity; it binds preferentially to sequences with UG repeats and UGUU motifs. It also binds to the 3'-UTR of cyclooxygenase-2 messages, affecting both translation and mRNA stability, and binds to apoB mRNA, regulating its C to U editing []. CELF-2 also contains three highly conserved RRMs. It binds to RNA via the first two RRMs, which are also important for localization in the cytoplasm. The splicing activation or repression activity of CELF-2 on some specific substrates is mediated by RRM1/RRM2. Both, RRM1 and RRM2 of CELF-2, can activate cardiac troponin T (cTNT) exon 5 inclusion. In addition, CELF-2 possesses a typical arginine and lysine-rich nuclear localization signal (NLS) in the C terminus, within RRM3 [].
Protein Domain
Type: Domain
Description: The human CELF family has six members, which can be divided into two subfamilies based on their phylogeny: CELF1-2 and CELF3-6. This entry represents the RNA recognition motif 3 (RRM3) of CELF-1 andCELF-2 protein. CELF-1 and CELF-2 belong to the CELF (CUGBP and ETR-3 Like Factor)/Bruno-like protein family, whose members play important roles in the regulation of alternative splicing and translation. CELF-1 and CELF-2 share sequence similarity to the Drosophila Bruno protein and binds to the Bruno response elements (cis-acting sequences in the 3'-untranslated region (UTR) ofoskar mRNA) [].The human CELF-1 (also known as CUG-BP or BRUNOL-2) binds to RNA substrates and recruits PARN deadenylase []. It preferentially targets UGU-rich mRNA elements []. CELF-1 has been implicated in onset of type 1 myotonic dystrophy (DM1), a neuromuscular disease associated with an unstable CUG triplet expansion in the 3'-UTR (3'-untranslated region) of the DMPK (myotonic dystrophy protein kinase) gene [, ]. CELF-1 contain three highly conserved RNA recognition motifs (RRMs): two consecutive RRMs (RRM1 and RRM2) situated in the N-terminal region followed by a linker region and the third RRM (RRM3) close to the C terminus of the protein. The Xenopus homologue of CELF-1 is EDEN-BP (embryo deadenylation element-binding protein), which mediates sequence-specific deadenylation of Eg5 mRNA. It binds specifically to the EDEN motif in the 3'-untranslated regions of maternal mRNAs and targets these mRNAs for deadenylation and translational repression []. The two N-terminal RRMs of EDEN-BP are necessary for the interaction with EDEN as well as a part of the linker region (between RRM2 and RRM3). Oligomerization of EDEN-BP is required for specific mRNA deadenylation and binding []. CELF-2 (also known as CUGBP2 or ETR-3) shares high sequenceidentity with CELF-1, but shows different binding specificity; it binds preferentially to sequences with UG repeats and UGUU motifs. It also binds to the 3'-UTR of cyclooxygenase-2 messages, affecting both translation and mRNA stability, and binds to apoB mRNA, regulating its C to U editing []. CELF-2 also contains three highly conserved RRMs. It binds to RNA via the first two RRMs, which are also important for localization in the cytoplasm. The splicing activation or repression activity of CELF-2 on some specific substrates is mediated by RRM1/RRM2. Both, RRM1 and RRM2 of CELF-2, can activate cardiac troponin T (cTNT) exon 5 inclusion. In addition, CELF-2 possesses a typical arginine and lysine-rich nuclear localization signal (NLS) in the C terminus, within RRM3 [].
Publication
First Author: Rosenblat M
Year: 2010
Journal: Atherosclerosis
Title: Increased macrophage cholesterol biosynthesis and decreased cellular paraoxonase 2 (PON2) expression in Delta6-desaturase knockout (6-DS KO) mice: beneficial effects of arachidonic acid.
Volume: 210
Issue: 2
Pages: 414-21
Publication
First Author: Olzmann JA
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Spatial regulation of UBXD8 and p97/VCP controls ATGL-mediated lipid droplet turnover.
Volume: 110
Issue: 4
Pages: 1345-50
Publication
First Author: Nakamuta M
Year: 1995
Journal: J Biol Chem
Title: Alternative mRNA splicing and differential promoter utilization determine tissue-specific expression of the apolipoprotein B mRNA-editing protein (Apobec1) gene in mice. Structure and evolution of Apobec1 and related nucleoside/nucleotide deaminases.
Volume: 270
Issue: 22
Pages: 13042-56
Publication  
First Author: Spencer B
Year: 2019
Journal: Neurobiol Dis
Title: Systemic peptide mediated delivery of an siRNA targeting α-syn in the CNS ameliorates the neurodegenerative process in a transgenic model of Lewy body disease.
Volume: 127
Pages: 163-177
Publication
First Author: Smallwood TL
Year: 2014
Journal: G3 (Bethesda)
Title: High-resolution genetic mapping in the diversity outbred mouse population identifies Apobec1 as a candidate gene for atherosclerosis.
Volume: 4
Issue: 12
Pages: 2353-63
Publication
First Author: Hersberger M
Year: 1999
Journal: J Biol Chem
Title: Phylogenetic analysis of the apolipoprotein B mRNA-editing region. Evidence for a secondary structure between the mooring sequence and the 3' efficiency element.
Volume: 274
Issue: 49
Pages: 34590-7
Publication
First Author: Srivastava RA
Year: 1991
Journal: Biochim Biophys Acta
Title: In vivo regulation of low-density lipoprotein receptor and apolipoprotein B gene expressions by dietary fat and cholesterol in inbred strains of mice.
Volume: 1086
Issue: 1
Pages: 29-43
Publication
First Author: Oka K
Year: 1997
Journal: J Biol Chem
Title: Tissue-specific inhibition of apolipoprotein B mRNA editing in the liver by adenovirus-mediated transfer of a dominant negative mutant APOBEC-1 leads to increased low density lipoprotein in mice.
Volume: 272
Issue: 3
Pages: 1456-60
Publication
First Author: Srivastava RA
Year: 1997
Journal: Mol Cell Biochem
Title: Regulation of lipoprotein metabolism by estrogen in inbred strains of mice occurs primarily by posttranscriptional mechanisms.
Volume: 173
Issue: 1-2
Pages: 161-8
Publication
First Author: Srivastava RA
Year: 1997
Journal: J Biol Chem
Title: Estrogen up-regulates apolipoprotein E (ApoE) gene expression by increasing ApoE mRNA in the translating pool via the estrogen receptor alpha-mediated pathway.
Volume: 272
Issue: 52
Pages: 33360-6
Publication
First Author: Good PJ
Year: 2000
Journal: J Biol Chem
Title: A family of human RNA-binding proteins related to the Drosophila Bruno translational regulator.
Volume: 275
Issue: 37
Pages: 28583-92
Protein
Organism: Mus musculus/domesticus
Length: 486  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 487  
Fragment?: false
Publication  
First Author: Hagmann H
Year: 2023
Journal: Cells
Title: Capsazepine (CPZ) Inhibits TRPC6 Conductance and Is Protective in Adriamycin-Induced Nephropathy and Diabetic Glomerulopathy.
Volume: 12
Issue: 2
Publication
First Author: Yang L
Year: 2018
Journal: Nat Commun
Title: UBXN3B positively regulates STING-mediated antiviral immune responses.
Volume: 9
Issue: 1
Pages: 2329
Protein
Organism: Mus musculus/domesticus
Length: 146  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 523  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 407  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 363  
Fragment?: false