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Search results 401 to 500 out of 911 for Traf6

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Type Details Score
Publication
19091594 | -
First Author: Funakoshi-Tago M
Year: 2009
Journal: Cytokine
Title: TRAF6 negatively regulates TNFalpha-induced NF-kappaB activation.
Volume: 45
Issue: 2
Pages: 72-9
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Publication
16023795 | -
 
First Author: Inoue J
Year: 2005
Journal: Gene
Title: Identification and characterization of Xenopus laevis homologs of mammalian TRAF6 and its binding protein TIFA.
Volume: 358
Pages: 53-9
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Publication
25861989 | -
First Author: Wang W
Year: 2015
Journal: J Biol Chem
Title: TRAF Family Member-associated NF-κB Activator (TANK) Inhibits Genotoxic Nuclear Factor κB Activation by Facilitating Deubiquitinase USP10-dependent Deubiquitination of TRAF6 Ligase.
Volume: 290
Issue: 21
Pages: 13372-85
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Publication
16052631 | -
First Author: Takeshita F
Year: 2005
Journal: Eur J Immunol
Title: TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF.
Volume: 35
Issue: 8
Pages: 2477-85
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Publication
25134449 | -
First Author: Hadweh P
Year: 2014
Journal: Cell Signal
Title: The PP4R1 subunit of protein phosphatase PP4 targets TRAF2 and TRAF6 to mediate inhibition of NF-κB activation.
Volume: 26
Issue: 12
Pages: 2730-7
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Interaction Experiment
Ryu J (2005)
Description: Proteomic identification of the TRAF6 regulation of vacuolar ATPase for osteoclast function.
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Interaction Experiment
Xia X (2011)
Description: NLRX1 negatively regulates TLR-induced NF-B signaling by targeting TRAF6 and IKK.
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Interaction Experiment
Wang Y (2006)
Description: Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling.
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Interaction Experiment
Chiou WF (2014)
Description: (+)-Vitisin A Inhibits Osteoclast Differentiation by Preventing TRAF6 Ubiquitination and TRAF6-TAK1 Formation to Suppress NFATc1 Activation.
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Interaction Experiment
Chen H (2006)
Description: Hsp70 inhibits lipopolysaccharide-induced NF-kappaB activation by interacting with TRAF6 and inhibiting its ubiquitination.
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Interaction Experiment
Feng Y (2007)
Description: The LIM protein, Limd1, regulates AP-1 activation through an interaction with Traf6 to influence osteoclast development.
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Interaction Experiment
Panda S (2015)
Description: Deubiquitinase MYSM1 Regulates Innate Immunity through Inactivation of TRAF3 and TRAF6 Complexes.
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Interaction Experiment
Ko R (2015)
Description: Glycogen synthase kinase 3 ubiquitination by TRAF6 regulates TLR3-mediated pro-inflammatory cytokine production.
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Interaction Experiment
Zhu Z (2016)
Description: Cutting Edge: A Cullin-5-TRAF6 Interaction Promotes TRAF6 Polyubiquitination and Lipopolysaccharide Signaling.
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Interaction Experiment
Li T (2017)
Description: The Ubiquitin E3 Ligase TRAF6 Exacerbates Ischemic Stroke by Ubiquitinating and Activating Rac1.
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Interaction Experiment
Hu L (2017)
Description: Oligomerization-primed coiled-coil domain interaction with Ubc13 confers processivity to TRAF6 ubiquitin ligase activity.
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Interaction Experiment
Lei H (2022)
Description: Ubiquitin-specific protease 47 regulates intestinal inflammation through deubiquitination of TRAF6 in epithelial cells.
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Interaction Experiment
Liu X (2008)
Description: Herpesvirus tegument protein activates NF-kappaB signaling through the TRAF6 adaptor protein.
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Publication
15147900 | -
First Author: Wooff J
Year: 2004
Journal: FEBS Lett
Title: The TRAF6 RING finger domain mediates physical interaction with Ubc13.
Volume: 566
Issue: 1-3
Pages: 229-33
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Publication
10882101 | -
First Author: Takaesu G
Year: 2000
Journal: Mol Cell
Title: TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway.
Volume: 5
Issue: 4
Pages: 649-58
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Pathway
R-MMU-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
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Interaction Experiment
Lin YC (2013)
Description: The Tyrosine Kinase Syk Differentially Regulates Toll-like Receptor Signaling Downstream of the Adaptor Molecules TRAF6 and TRAF3.
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Allele
Traf6<em1Smoc> | MGI:7292947
Name: TNF receptor-associated factor 6; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Publication
14960584 | -
First Author: Gentry JJ
Year: 2004
Journal: J Biol Chem
Title: A functional interaction between the p75 neurotrophin receptor interacting factors, TRAF6 and NRIF.
Volume: 279
Issue: 16
Pages: 16646-56
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Publication
16079148 | -
First Author: Wooten MW
Year: 2005
Journal: J Biol Chem
Title: The p62 scaffold regulates nerve growth factor-induced NF-kappaB activation by influencing TRAF6 polyubiquitination.
Volume: 280
Issue: 42
Pages: 35625-9
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Publication
18682563 | -
First Author: Liu X
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Herpesvirus tegument protein activates NF-kappaB signaling through the TRAF6 adaptor protein.
Volume: 105
Issue: 32
Pages: 11335-9
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Publication
16196101 | -
First Author: Ryu J
Year: 2005
Journal: Proteomics
Title: Proteomic identification of the TRAF6 regulation of vacuolar ATPase for osteoclast function.
Volume: 5
Issue: 16
Pages: 4152-60
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Publication
24558484 | -
First Author: Chiou WF
Year: 2014
Journal: PLoS One
Title: (+)-Vitisin A inhibits osteoclast differentiation by preventing TRAF6 ubiquitination and TRAF6-TAK1 formation to suppress NFATc1 activation.
Volume: 9
Issue: 2
Pages: e89159
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Publication
28993672 | -
First Author: Hu L
Year: 2017
Journal: Nat Commun
Title: Oligomerization-primed coiled-coil domain interaction with Ubc13 confers processivity to TRAF6 ubiquitin ligase activity.
Volume: 8
Issue: 1
Pages: 814
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Publication
35235149 | -
First Author: Lei H
Year: 2022
Journal: Sci China Life Sci
Title: Ubiquitin-specific protease 47 regulates intestinal inflammation through deubiquitination of TRAF6 in epithelial cells.
Volume: 65
Issue: 8
Pages: 1624-1635
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Interaction Experiment
Takaesu G (2000)
Description: TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway.
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Interaction Experiment
Rim HK (2012)
Description: Nodakenin suppresses lipopolysaccharide-induced inflammatory responses in macrophage cells by inhibiting TRAF6 and NF-B pathways and protects mice from lethal endotoxin shock.
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Interaction Experiment
Masperone L (2022)
Description: The E3 Ubiquitin Ligase TRAF6 Interacts with the Cellular Prion Protein and Modulates Its Solubility and Recruitment to Cytoplasmic p62/SQSTM1-Positive Aggresome-Like Structures.
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Pathway
R-MMU-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
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GO Term
GO:0097076 | transforming growth factor beta activated kinase 1 complex
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Publication
10346818 | -
First Author: Baud V
Year: 1999
Journal: Genes Dev
Title: Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain.
Volume: 13
Issue: 10
Pages: 1297-308
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Publication
35000151 | -
First Author: Masperone L
Year: 2022
Journal: Mol Neurobiol
Title: The E3 Ubiquitin Ligase TRAF6 Interacts with the Cellular Prion Protein and Modulates Its Solubility and Recruitment to Cytoplasmic p62/SQSTM1-Positive Aggresome-Like Structures.
Volume: 59
Issue: 3
Pages: 1577-1588
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Strain
MGI:6476529 | C57BL/6-Traf6<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Traf6<tm2Ywc> | MGI:3773273
Name: TNF receptor-associated factor 6; targeted mutation 2, Yongwon Choi
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Publication
22773835 | J:190237
First Author: Maruyama K
Year: 2012
Journal: J Biol Chem
Title: TRAF family member-associated NF-κB activator (TANK) is a negative regulator of osteoclastogenesis and bone formation.
Volume: 287
Issue: 34
Pages: 29114-24
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Publication
12133833 | -
First Author: Chariot A
Year: 2002
Journal: J Biol Chem
Title: Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases.
Volume: 277
Issue: 40
Pages: 37029-36
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Protein
Q05BS9
Organism: Mus musculus/domesticus
Length: 167  
Fragment?: true
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Publication
19465916 | -
First Author: Yin Q
Year: 2009
Journal: Nat Struct Mol Biol
Title: E2 interaction and dimerization in the crystal structure of TRAF6.
Volume: 16
Issue: 6
Pages: 658-66
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Protein Domain
IPR041310 | TRAF6_Z2
Type: Domain
Description: This domain is the second of three zinc fingers of Homo sapiens TNF receptor associated factor 6 (TRAF6). TRAF6 mediates Lys63 (K63)-linked polyubiquitination for Necrosis Factor-kappaB activation. The first three residues and the last Cys of finger 1 form a classical type I β-turn [].
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Protein Domain
IPR039669 | TANK
Type: Family
Description: TANK-binding kinase 1 (TBK1) and inducible IkappaB-kinase (IKK) are central regulators of type-I interferon induction. TANK (TRAF family member-associated NF-kappa-B activator) is aadaptor protein that connects IKK complexes with IKK epsilon and TBK1 kinases [, ]. It negatively regulates NF-kappaB activation by DNA damage via inhibiting ubiquitination of TRAF6 []. It is also a negative regulator of osteoclastogenesis and bone formation [].
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Allele
Malt1<em1Krad> | MGI:7571552
Name: MALT1 paracaspase; endonuclease-mediated mutation 1, Daniel Krappmann
Allele Type: Endonuclease-mediated
Attribute String: Constitutively active
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Genotype
Genotype
Symbol: Traf6/Traf6 Tg(Cd4-cre)1Cwi/?
Background: involves: C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Protein
Q793I8
Organism: Mus musculus/domesticus
Length: 184  
Fragment?: false
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Publication
19935683 | -
First Author: Kulathu Y
Year: 2009
Journal: Nat Struct Mol Biol
Title: Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain.
Volume: 16
Issue: 12
Pages: 1328-30
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Publication
17449468 | -
First Author: Tian Y
Year: 2007
Journal: J Biol Chem
Title: RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation.
Volume: 282
Issue: 23
Pages: 16776-82
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Publication
14633987 | -
First Author: Ishitani T
Year: 2003
Journal: EMBO J
Title: Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling.
Volume: 22
Issue: 23
Pages: 6277-88
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Protein Domain
IPR037309 | TRAF6_MATH
Type: Domain
Description: TNF receptor-associated factor 6 (TRAF6) regulates a diverse array of processes, including adaptive immunity, innate immunity, bone metabolism and tissue development. It is a unique member of the TRAF family of adaptor proteins in that it is involved in both the TNF receptor superfamily and the interleukin-1 receptor (IL-1R)/Toll-like receptor (TLR) superfamily signal transduction pathways [, , , ]. TRAF6 possesses ubiquitin ligase activity that controls the activation of IKK and NF-kappaB [, ]. TRAF6 contains a RING finger domain, five zinc finger domains, and a TRAF domain.The TRAF domain can be divided into a more divergent N-terminal alpha helical region (TRAF-N), and a highly conserved C-terminal MATH subdomain (TRAF-C) with an eight-stranded β-sandwich structure. TRAF-N mediates trimerization while TRAF-C interacts with receptors [, ].
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Protein Domain
IPR041911 | TAB2/3_CUE
Type: Domain
Description: TAB2 (TGF-beta-activated kinase 1 and MAP3K7-binding protein 2) is an adaptor protein that regulates activation of TAK1, a MAP kinase kinase kinase (MAPKKK), through linking TAK1 to TRAF6 in the Interleukin-1 (IL-1) induced NF-kappaB activation pathway []. TAB3 is a TAB2-like TAK1-binding protein that activates NF-kappaB similar to TAB2 []. It activates TAK1 and regulates its association with TRAF2 and TRAF6. Moreover, TAB3 interacts with TRAF6 and TRAF2 in an IL-1- and a TNF-dependent manner, respectively. TAB2 and TAB3 function redundantly as mediators of TAK1 activation in IL-1 and TNF signal transduction []. Both of them contain an N-terminal CUE domain, a coiled-coil (CC) region, a TAK1-binding domain and a C-terminal Npl4 zinc finger (NZF) ubiquitin-binding domain (UBD) [].This entry represents the CUE domain found in TAB2 and TAB3.
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Protein
E0CX37
Organism: Mus musculus/domesticus
Length: 37  
Fragment?: true
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Publication
18845156 | -
First Author: Kalverda AP
Year: 2009
Journal: J Mol Biol
Title: Poxvirus K7 protein adopts a Bcl-2 fold: biochemical mapping of its interactions with human DEAD box RNA helicase DDX3.
Volume: 385
Issue: 3
Pages: 843-53
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Publication
18636090 | -
First Author: Schröder M
Year: 2008
Journal: EMBO J
Title: Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKepsilon-mediated IRF activation.
Volume: 27
Issue: 15
Pages: 2147-57
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Publication
28257484 | -
First Author: Teferi WM
Year: 2017
Journal: PLoS One
Title: The vaccinia virus K7 protein promotes histone methylation associated with heterochromatin formation.
Volume: 12
Issue: 3
Pages: e0173056
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Publication
23580427 | -
First Author: Benfield CTO
Year: 2013
Journal: J Gen Virol
Title: Vaccinia virus protein K7 is a virulence factor that alters the acute immune response to infection.
Volume: 94
Issue: Pt 7
Pages: 1647-1657
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Publication
9325055 | -
First Author: Huang X
Year: 1997
Journal: Genomics
Title: Genomic organization of the human PP4 gene encoding a serine/threonine protein phosphatase (PP4) suggests a common ancestry with PP2A.
Volume: 44
Issue: 3
Pages: 336-43
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Publication
10769191 | -
 
First Author: Hastie CJ
Year: 2000
Journal: Biochem J
Title: A novel 50 kDa protein forms complexes with protein phosphatase 4 and is located at centrosomal microtubule organizing centres.
Volume: 347 Pt 3
Pages: 845-55
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Publication
10026142 | -
First Author: Kloeker S
Year: 1999
Journal: J Biol Chem
Title: Purification and identification of a novel subunit of protein serine/threonine phosphatase 4.
Volume: 274
Issue: 9
Pages: 5339-47
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Publication
11069759 | -
 
First Author: Li J
Year: 2000
Journal: J Cell Sci
Title: The FHA domain mediates phosphoprotein interactions.
Volume: 113 Pt 23
Pages: 4143-9
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Publication
15492226 | -
First Author: Ea CK
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: TIFA activates IkappaB kinase (IKK) by promoting oligomerization and ubiquitination of TRAF6.
Volume: 101
Issue: 43
Pages: 15318-23
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Publication
22158899 | -
First Author: Yu JW
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Crystal structure of the mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) paracaspase region.
Volume: 108
Issue: 52
Pages: 21004-9
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Publication
22366302 | J:197705
First Author: Wiesmann C
Year: 2012
Journal: J Mol Biol
Title: Structural determinants of MALT1 protease activity.
Volume: 419
Issue: 1-2
Pages: 4-21
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Publication
23946259 | -
First Author: Schlauderer F
Year: 2013
Journal: Angew Chem Int Ed Engl
Title: Structural analysis of phenothiazine derivatives as allosteric inhibitors of the MALT1 paracaspase.
Volume: 52
Issue: 39
Pages: 10384-7
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Protein Domain
IPR041077 | MALT1_Ig
Type: Domain
Description: This is an immunoglobulin-like domain which can be found in the mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) paracaspase. Malt1 is a key component of the Carma1/Bcl10/MALT1 signalosome and is critical for NF-kB signaling in multiple contexts. The MALT1 C-terminal Ig domain is suggested to recruit key factors to promote NF-kB activation. It is also proposed to undergo Lys63-linked ubiquitylation via TRAF6 in potentially nine different lysines to recruit the IKK complex [, , ].
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Protein Domain
IPR009174 | Orthopox_K7
Type: Family
Description: This family represents Protein K7 from Orthopoxvirus. K7 is Bcl-2-like protein which, through its interaction with the DEAD box RNA helicase DDX3X/DDX3, prevents TBK1/IKKepsilon-mediated IRF3 activation []. It contributes to virulence by binding to the host TRAF6 and IRAK2 and preventing host NF-kappa-B activation and affects the acute immune response to infection [, , ]. In vaccinia virus, this protein has been related to the increase in cellular histone methylation during infection [].
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Protein Domain
IPR033621 | TIFA
Type: Family
Description: TRAF-interacting protein with a forkhead-associated domain (TIFA), also called T2BP, is an adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the downstream activation of NF-kappa-B and c-Jun amino-terminal kinase (JNK) []. TIFA has been shown to induce the oligomerization and polyubiquitination of TRAF6, which in turn activates transforming growth factor-activated kinase (TAK1) and IkappaB kinase (IKK) []. TIFA contains a phosphothreonine and phosphoserine-binding FHA domain []and a consensus TRAF6-binding motif [].
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Protein Domain
IPR031087 | PP4R1
Type: Family
Description: PP4R1 is a regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). The catalytic subunit of PP4 (PP4C) belongs to the PP2A family of serine/threonine protein phosphatases []. Although 65% identical to the catalytic subunit of PP2AC, PP4C does not associate with the regulatory subunit of PP2A. Instead, PP4C associates with two other regulatory subunits, PP4R1 []and PP4R2 [].PP4R1 targets TRAF2 and TRAF6 to mediate inhibition of NF-kB activation [].
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Protein
Q571K4
Organism: Mus musculus/domesticus
Length: 716  
Fragment?: false
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Protein
Q99K90
Organism: Mus musculus/domesticus
Length: 693  
Fragment?: false
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Protein
P39429
Organism: Mus musculus/domesticus
Length: 501  
Fragment?: false
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Strain
MGI:7571553 | (C57BL/6N x 129-Malt1<em1Krad>)F1
Attribute String: F1 hybrid, mutant stock, endonuclease-mediated mutation
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Genotype
Genotype
Symbol: Cd28/Cd28 Tg(Cd4-cre)1Cwi/? Traf6/Traf6
Background: involves: 129S2/SvPas * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Publication
14764729 | J:88064
First Author: Zhou H
Year: 2004
Journal: J Immunol
Title: Microtubule-associated serine/threonine kinase-205 kDa and Fc gamma receptor control IL-12 p40 synthesis and NF-kappa B activation.
Volume: 172
Issue: 4
Pages: 2559-68
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Protein
B1AST6
Organism: Mus musculus/domesticus
Length: 144  
Fragment?: true
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Protein
B1AST5
Organism: Mus musculus/domesticus
Length: 203  
Fragment?: true
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Publication
890221 | -
First Author: Aylwin S
Year: 1977
Journal: Br J Psychol
Title: The structure of visual and kinaesthetic imagery: a free association study.
Volume: 68
Issue: 3
Pages: 353-60
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Protein Domain
IPR028779 | MAST2
Type: Family
Description: Microtubule-associated serine/threonine-protein kinase 2 (MAST2, also known as MAST205) belongs to the MAST family, which is characterised by containing a serine/threonine kinase domain and a PDZ (postsynaptic density protein-95/discs large/zona occludens-1) domain []. MAST2 regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation [, ]. It localises in the DAPC/UAPC, which is found within the postsynaptic region of the neuromuscular junction (NMJ) and central synapses []. It also functions in spermatid maturation in mammals [].
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Protein Domain
IPR027138 | TRAF4
Type: Family
Description: TNF receptor-associated factor 4 (TRAF4) is an adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. TRAF4 plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. It regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. TRAF4 modulates TRAF6 functions [, , , , , ]. In mouse, it has been shown to be required for normal skeleton development, and for normal development of the respiratory tract []. TRAF4 contains a RING finger domain, seven zinc finger domains, and a TRAF domain.
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Protein Coding Gene
MGI:1346872 | Map3k1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1891445 | Peli2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1924963 | Peli3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1859212 | Irf7
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1349469 | Ecsit
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q9QZH6
Organism: Mus musculus/domesticus
Length: 435  
Fragment?: false
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Protein
P70434
Organism: Mus musculus/domesticus
Length: 457  
Fragment?: false
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Protein
P53349
Organism: Mus musculus/domesticus
Length: 1493  
Fragment?: false
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Protein
Q8BXR6
Organism: Mus musculus/domesticus
Length: 445  
Fragment?: false
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Protein
Q8BST6
Organism: Mus musculus/domesticus
Length: 419  
Fragment?: false
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Publication
10934170 | J:74252
First Author: Shiels H
Year: 2000
Journal: Am J Pathol
Title: TRAF4 deficiency leads to tracheal malformation with resulting alterations in air flow to the lungs.
Volume: 157
Issue: 2
Pages: 679-88
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Protein
F7AT87
Organism: Mus musculus/domesticus
Length: 108  
Fragment?: true
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Protein
D3Z216
Organism: Mus musculus/domesticus
Length: 553  
Fragment?: true
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Publication
12023963 | -
First Author: Xu YC
Year: 2002
Journal: J Biol Chem
Title: Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase.
Volume: 277
Issue: 31
Pages: 28051-7
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Publication
12801526 | -
First Author: Fleckenstein DS
Year: 2003
Journal: Leuk Res
Title: Tumor necrosis factor receptor-associated factor (TRAF) 4 is a new binding partner for the p70S6 serine/threonine kinase.
Volume: 27
Issue: 8
Pages: 687-94
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Publication
18953416 | -
First Author: Kédinger V
Year: 2008
Journal: PLoS One
Title: Tumor necrosis factor receptor-associated factor 4 is a dynamic tight junction-related shuttle protein involved in epithelium homeostasis.
Volume: 3
Issue: 10
Pages: e3518
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Publication
19937093 | -
First Author: Li S
Year: 2010
Journal: Mol Cell Biochem
Title: Ubiquitin ligase Smurf1 targets TRAF family proteins for ubiquitination and degradation.
Volume: 338
Issue: 1-2
Pages: 11-7
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Publication
9734363 | J:341420
First Author: Medzhitov R
Year: 1998
Journal: Mol Cell
Title: MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways.
Volume: 2
Issue: 2
Pages: 253-8
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Genotype
Genotype
Symbol: Tg(Cd4-cre)1Cwi/? Tg(TcraTcrb)425Cbn/? Traf6/Traf6
Background: involves: C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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