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Search results 101 to 200 out of 205 for Ecel1

0.038s
Type Details Score
GXD Expression  
Probe: MGI:4882673
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3266028
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945902
Age: postnatal day 7
Image: g01941 P7
Specimen Label: g01941 P7
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4882673
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3266028
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945902
Age: postnatal day 42
Image: g01941 Adult
Specimen Label: g01941 Adult
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4882673
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754028
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945902
Age: postnatal day 7
Image: g01941 P7
Specimen Label: g01941 P7
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4882673
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754028
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945902
Age: postnatal day 42
Image: g01941 Adult
Specimen Label: g01941 Adult
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4882673
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280923
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945902
Age: embryonic day 15.5
Image: g01941 E15.5
Specimen Label: g01941 E15.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4882673
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280928
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945902
Age: postnatal day 7
Image: g01941 P7
Specimen Label: g01941 P7
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4882673
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280928
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945902
Age: postnatal day 42
Image: g01941 Adult
Specimen Label: g01941 Adult
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4882673
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3266523
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945902
Age: embryonic day 15.5
Image: g01941 E15.5
Specimen Label: g01941 E15.5
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:4882673
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4945902
Age: embryonic day 15.5
Image: g01941 E15.5
Note: Expression was region specific and scattered.
Specimen Label: g01941 E15.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4882673
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945902
Age: postnatal day 7
Image: g01941 P7
Specimen Label: g01941 P7
Detected: true
Specimen Num: 3
GXD Expression
Probe: MGI:4882673
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945902
Age: postnatal day 42
Image: g01941 Adult
Note: Expression was region specific and scattered.
Specimen Label: g01941 Adult
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:2465478
Assay Type: RNA in situ
Annotation Date: 2020-08-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3747122
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:6451798
Age: embryonic day 14.5
Image: S7B/C
Specimen Label: S7B/C
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:2465478
Assay Type: RNA in situ
Annotation Date: 2020-08-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3746922
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:6451798
Age: embryonic day 14.5
Image: S7D
Specimen Label: S7D
Detected: true
Specimen Num: 3
Publication
First Author: Nagata K
Year: 2010
Journal: J Neurosci
Title: Damage-induced neuronal endopeptidase is critical for presynaptic formation of neuromuscular junctions.
Volume: 30
Issue: 20
Pages: 6954-62
Publication
First Author: Kiryu-Seo S
Year: 2008
Journal: J Biol Chem
Title: Neuronal injury-inducible gene is synergistically regulated by ATF3, c-Jun, and STAT3 through the interaction with Sp1 in damaged neurons.
Volume: 283
Issue: 11
Pages: 6988-96
Publication
First Author: Kiral FR
Year: 2023
Journal: Cell Stem Cell
Title: Generation of ventralized human thalamic organoids with thalamic reticular nucleus.
Volume: 30
Issue: 5
Pages: 677-688.e5
Publication
First Author: Yao SQ
Year: 2023
Journal: PLoS One
Title: Retinal transcriptome of neonatal mice after optic nerve injury.
Volume: 18
Issue: 5
Pages: e0286344
Publication
First Author: Lindström NO
Year: 2018
Journal: J Am Soc Nephrol
Title: Conserved and Divergent Features of Mesenchymal Progenitor Cell Types within the Cortical Nephrogenic Niche of the Human and Mouse Kidney.
Volume: 29
Issue: 3
Pages: 806-824
Publication
First Author: Vendrell V
Year: 2015
Journal: Development
Title: Otx2 is a target of N-myc and acts as a suppressor of sensory development in the mammalian cochlea.
Volume: 142
Issue: 16
Pages: 2792-800
Publication
First Author: Puelles L
Year: 2021
Journal: J Comp Neurol
Title: LacZ-reporter mapping of Dlx5/6 expression and genoarchitectural analysis of the postnatal mouse prethalamus.
Volume: 529
Issue: 2
Pages: 367-420
Publication
First Author: Matsumoto S
Year: 2016
Journal: J Neurosci
Title: Motor Nerve Arborization Requires Proteolytic Domain of Damage-Induced Neuronal Endopeptidase (DINE) during Development.
Volume: 36
Issue: 17
Pages: 4744-57
Publication
First Author: Zhang Q
Year: 2018
Journal: Cell Death Dis
Title: Temporal requirements for ISL1 in sympathetic neuron proliferation, differentiation, and diversification.
Volume: 9
Issue: 2
Pages: 247
Publication
First Author: Loo L
Year: 2019
Journal: Nat Commun
Title: Single-cell transcriptomic analysis of mouse neocortical development.
Volume: 10
Issue: 1
Pages: 134
Publication      
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
Publication
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication
First Author: Sato K
Year: 2018
Journal: Invest Ophthalmol Vis Sci
Title: Ecel1 Knockdown With an AAV2-Mediated CRISPR/Cas9 System Promotes Optic Nerve Damage-Induced RGC Death in the Mouse Retina.
Volume: 59
Issue: 10
Pages: 3943-3951
Publication  
First Author: Valdenaire O
Year: 2000
Journal: Biochem J
Title: Organization and chromosomal localization of the human ECEL1 (XCE) gene encoding a zinc metallopeptidase involved in the nervous control of respiration.
Volume: 346 Pt 3
Pages: 611-6
Allele
Name: endothelin converting enzyme-like 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
DO Term
Allele
Name: transgene insertion JT37, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
Allele
Name: transgene insertion NU146, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
Strain
Attribute String: mutant stock, transgenic
Strain
Attribute String: transgenic, mutant stock
Publication
First Author: Oefner C
Year: 2004
Journal: Acta Crystallogr D Biol Crystallogr
Title: Structural analysis of neprilysin with various specific and potent inhibitors.
Volume: 60
Issue: Pt 2
Pages: 392-6
Publication
First Author: Kiryu-Seo S
Year: 2004
Journal: Protein Pept Lett
Title: DINE (damage induced neuronal endopeptidase).
Volume: 11
Issue: 5
Pages: 451-60
Publication
First Author: Schulz H
Year: 2009
Journal: J Mol Biol
Title: Structure of human endothelin-converting enzyme I complexed with phosphoramidon.
Volume: 385
Issue: 1
Pages: 178-87
Publication
First Author: Kiryu-Seo S
Year: 2006
Journal: Anat Sci Int
Title: Identification and functional analysis of damage-induced neuronal endopeptidase (DINE), a nerve injury associated molecule.
Volume: 81
Issue: 1
Pages: 1-6
Publication
First Author: Sha Q
Year: 2006
Journal: J Biol Chem
Title: Endothelin-3-converting enzyme activity of the KEL1 and KEL6 phenotypes of the Kell blood group system.
Volume: 281
Issue: 11
Pages: 7180-2
Publication
First Author: Lee S
Year: 2000
Journal: Semin Hematol
Title: The Kell blood group system: Kell and XK membrane proteins.
Volume: 37
Issue: 2
Pages: 113-21
Publication
First Author: Turner AJ
Year: 1997
Journal: FASEB J
Title: Mammalian membrane metallopeptidases: NEP, ECE, KELL, and PEX.
Volume: 11
Issue: 5
Pages: 355-64
Protein Domain
Type: Family
Description: This group of metallopeptidases belong to the MEROPS peptidase family M13 (neprilysin family, clan MA(E)). The M13 family includes neprilysin (neutral endopeptidase, NEP, enkephalinase, CD10, CALLA, ), endothelin-converting enzyme I (ECE-1, ), erythrocyte surface antigen KELL (ECE-3), phosphate-regulating gene on the X chromosome (PHEX), soluble secreted endopeptidase (SEP), and damage-induced neuronal endopeptidase (DINE)/X-converting enzyme (XCE). These proteins consist of a short N-terminal cytoplasmic domain, a single transmembrane helix, and a larger C-terminal extracellular domain containing the active site. The cytoplasmic domain contains a conformationally-restrained octapeptide, which is thought to act as a stop transfer sequence that prevents proteolysis and secretion [, ]. Proteins in this family fulfill a broad range of physiological roles due to the greater variation in the S2' subsite allowing substrate specificity [, ]. The protein fold of the peptidase domain for members of this family resembles that of thermolysin, the type example for clan MA and the predicted active site residues for members of this family and thermolysin occur in the motif HEXXH [].M13 peptidases are well-studied proteases found in a wide range of organisms including mammals and bacteria. In mammals they participate in processes such as cardiovascular development, blood-pressure regulation, nervous control of respiration, and regulation of the function of neuropeptides in the central nervous system. In bacteria they may be used for digestion of milk [, ]. The family includes eukaryotic and prokaryotic oligopeptidases, as well as some of the proteins responsible for the molecular basis of the blood group antigens e.g. Kell []. Neprilysin (NEP), is expressed in a variety of tissues including kidney and brain, and is involved in many physiological and pathological processes, including blood pressure and inflammatory response. It is a plasma membrane-bound mammalian enzyme that is able to digest biologically-active peptides, including enkephalins [], substance P, cholecystokinin, neurotensin and somatostatin. It is an important enzyme in the regulation of amyloid-beta (Abeta) protein that forms amyloid plaques that are associated with Alzeimers disease (AD). The zinc ligands of neprilysin are known and are analogous to those in thermolysin, a related peptidase [, ]. Neprilysins, like thermolysin, are inhibited by phosphoramidon, which appears to selectively inhibit this family in mammals. The enzymes are all oligopeptidases, digesting oligo- and polypeptides, but not proteins [].ECE-1 catalyzes the final rate-limiting step in the biosynthesis of endothelins via post-translational conversion of the biologically inactive big endothelins. Like NEP, it also hydrolyses bradykinin, substance P, neurotensin and Abeta. Endothelin-1 overproduction has been implicated in various diseases, including stroke, asthma, hypertension, and cardiac and renal failure. Kell is a homologue of NEP and constitutes a major antigen on human erythrocytes; it preferentially cleaves big endothelin-3 to produce bioactive endothelin-3, but is also known to cleave substance P and neurokinin A. PHEX forms a complex interaction with fibroblast growth factor 23 (FGF23) and matrix extracellular phosphoglycoprotein, causing bone mineralization. A loss-of-function mutation in PHEX disrupts this interaction leading to hypophosphatemic rickets; X-linked hypophosphatemic (XLH) rickets is the most common form of metabolic rickets. ECEL1 is a brain metalloprotease involved in the critical role in the nervous regulation of the respiratory system, while DINE (damage induced neuronal endopeptidase) is abundantly expressed in the hypothalamus and its expression responds to nerve injury as well. Thus, majority of these M13 proteases are prime therapeutic targets for selective inhibition [, , , , , , , , , , , ].
Protein
Organism: Mus musculus/domesticus
Length: 69  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 34  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 548  
Fragment?: true
Publication
First Author: Kyrieleis OJ
Year: 2005
Journal: J Mol Biol
Title: Crystal structures of the tricorn interacting factor F3 from Thermoplasma acidophilum, a zinc aminopeptidase in three different conformations.
Volume: 349
Issue: 4
Pages: 787-800
Protein
Organism: Mus musculus/domesticus
Length: 187  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 130  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 178  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 279  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 252  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 205  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 150  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 133  
Fragment?: true
Publication
First Author: Le Moual H
Year: 1993
Journal: FEBS Lett
Title: Substitution of potential metal-coordinating amino acid residues in the zinc-binding site of endopeptidase-24.11.
Volume: 324
Issue: 2
Pages: 196-200
Publication  
First Author: Turner AJ
Year: 2000
Journal: Adv Exp Med Biol
Title: The neprilysin family in health and disease.
Volume: 477
Pages: 229-40
Protein
Organism: Mus musculus/domesticus
Length: 881  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 765  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 763  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 749  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 713  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 769  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 750  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 709  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 527  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 526  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 782  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 780  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 763  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 709  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 286  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 749  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 766  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 734  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 749  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 763  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 768  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 753  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 745  
Fragment?: false