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Search results 101 to 200 out of 218 for Mcm4

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Type Details Score
Publication
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
Publication  
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
Publication
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
Publication      
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
Publication      
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
UniProt Feature
Begin: 2
Description: DNA replication licensing factor MCM4
Type: chain
End: 862
Protein
Organism: Mus musculus/domesticus
Length: 220  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 86  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 677  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
DO Term
Publication
First Author: Hendrickson M
Year: 1996
Journal: Proc Natl Acad Sci U S A
Title: Phosphorylation of MCM4 by cdc2 protein kinase inhibits the activity of the minichromosome maintenance complex.
Volume: 93
Issue: 22
Pages: 12223-8
Publication
First Author: Eisenhardt N
Year: 2015
Journal: Nat Struct Mol Biol
Title: A new vertebrate SUMO enzyme family reveals insights into SUMO-chain assembly.
Volume: 22
Issue: 12
Pages: 959-67
Allele
Name: minichromosome maintenance complex component 4; gene trap RRE056, BayGenomics
Allele Type: Gene trapped
Attribute String: Null/knockout, Reporter
HT Experiment
Series Id: GSE40527
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
Genotype
Symbol: Mcm4/Mcm4<+>
Background: involves: 129P2/OlaHsd
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Mcm4/Mcm4
Background: involves: 129P2/OlaHsd
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Mcm4/Mcm4<+>
Background: involves: 129P2/OlaHsd * C3HeB/FeJ
Zygosity: ht
Has Mutant Allele: true
Strain
Attribute String: chemically induced mutation, congenic, gene trap, mutant strain
Genotype
Symbol: Mcm4/Mcm4
Background: B6.Cg-Mcm4 Mcm4
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Mcm4/Mcm4
Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Mcm2/Mcm2<+> Mcm4/Mcm4<+>
Background: involves: 129P2/OlaHsd * C3HeB/FeJ
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Mcm3/Mcm3<+> Mcm4/Mcm4<+>
Background: involves: 129P2/OlaHsd * C3HeB/FeJ
Zygosity: cx
Has Mutant Allele: true
Protein Domain
Type: Family
Description: The MCM2-7 complex consists of six closely related proteins that are highly conserved throughout the eukaryotic kingdom. In eukaryotes, Mcm4 is a component of the MCM2-7 complex (MCM complex), which consists of six sequence-related AAA + type ATPases/helicases that form a hetero-hexameric ring []. MCM2-7 complex is part of the pre-replication complex (pre-RC). In G1 phase, inactive MCM2-7 complex is loaded onto origins of DNA replication [, , ]. During G1-S phase, MCM2-7 complex is activated to unwind the double stranded DNA and plays an important role in DNA replication forks elongation [].The components of the MCM2-7 complex are: .DNA replication licensing factor MCM2, DNA replication licensing factor MCM3, DNA replication licensing factor MCM4, DNA replication licensing factor MCM5, DNA replication licensing factor MCM6, DNA replication licensing factor MCM7, Mcm4 is thought to play a pivotal role in ensuring DNA replication occursonly once per cell cycle. Phosphorylation of Mcm4 dramatically reduces itsaffinity for chromatin - it has been proposed that this cell cycle-dependentphosphorylation is the mechanism that inactivates the MCM complex from lateS phase through mitosis, thus preventing illegitimate DNA replication during that period of the cell cycle [].
Genotype
Symbol: Mcm3/Mcm3<+> Mcm4/Mcm4
Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Mcm2/Mcm2<+> Mcm3/Mcm3<+> Mcm4/Mcm4<+>
Background: involves: 129P2/OlaHsd * C3HeB/FeJ
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Mcm2/Mcm2<+> Mcm4/Mcm4<+> Mcm6/Mcm6<+>
Background: involves: 129P2/OlaHsd * C3HeB/FeJ
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Mcm3/Mcm3<+> Mcm4/Mcm4<+> Mcm6/Mcm6<+>
Background: involves: 129P2/OlaHsd * C3HeB/FeJ
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Mcm2/Mcm2<+> Mcm3/Mcm3<+> Mcm4/Mcm4<+> Mcm6/Mcm6<+>
Background: involves: 129P2/OlaHsd * C3HeB/FeJ
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Mcm2/Mcm2<+> Mcm3/Mcm3<+> Mcm4/Mcm4<+> Mcm6/Mcm6<+> Mcm7/Mcm7<+>
Background: involves: 129P2/OlaHsd * C3HeB/FeJ
Zygosity: cx
Has Mutant Allele: true
Protein
Organism: Mus musculus/domesticus
Length: 165  
Fragment?: false
Publication  
First Author: Terrell AM
Year: 2015
Journal: Exp Eye Res
Title: Molecular characterization of mouse lens epithelial cell lines and their suitability to study RNA granules and cataract associated genes.
Volume: 131
Pages: 42-55
Publication
First Author: Ishimi Y
Year: 1997
Journal: J Biol Chem
Title: A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex.
Volume: 272
Issue: 39
Pages: 24508-13
Publication
First Author: Adachi Y
Year: 1997
Journal: Genes Cells
Title: A globular complex formation by Nda1 and the other five members of the MCM protein family in fission yeast.
Volume: 2
Issue: 7
Pages: 467-79
Publication
First Author: Sherman DA
Year: 1998
Journal: Mol Biol Cell
Title: Multiple domains of fission yeast Cdc19p (MCM2) are required for its association with the core MCM complex.
Volume: 9
Issue: 7
Pages: 1833-45
Publication
First Author: Pasion SG
Year: 1999
Journal: Mol Biol Cell
Title: Nuclear localization of Schizosaccharomyces pombe Mcm2/Cdc19p requires MCM complex assembly.
Volume: 10
Issue: 12
Pages: 4043-57
Protein
Organism: Mus musculus/domesticus
Length: 358  
Fragment?: false
Publication
First Author: Forsburg SL
Year: 1997
Journal: Genetics
Title: Mutational analysis of Cdc19p, a Schizosaccharomyces pombe MCM protein.
Volume: 147
Issue: 3
Pages: 1025-41
Protein Domain
Type: Conserved_site
Description: MCM proteins are DNA-dependent ATPases required for the initiation ofeukaryotic DNA replication [, , ]. In eukaryotes there is a family of six proteins, MCM2 to MCM7. They were first identified in yeast where most of them have adirect role in the initiation of chromosomal DNA replication by interacting directly with autonomously replicating sequences (ARS). They were thus called minichromosome maintenance proteins, MCM proteins [].This family is also present in the archebacteria in 1 to 4 copies. Methanocaldococcus jannaschii (Methanococcus jannaschii) has four members, MJ0363, MJ0961, MJ1489 and MJECL13.The "MCM motif"contains Walker-A and Walker-B type nucleotide binding motifs. The diagnostic sequence defining the MCMs is IDEFDKM. Only Mcm2 (aka Cdc19 or Nda1) has been subjected to mutational analysis in this region, and most mutations abolish its activity []. The presence of a putative ATP-binding domain implies that these proteins may be involved in an ATP-consuming step in the initiation of DNA replication in eukaryotes.The MCM proteins bind together in a large complex [].Within this complex, individual subunits associate with different affinities, and there is a tightly associated core of Mcm4 (Cdc21), Mcm6 (Mis5) and Mcm7 []. This core complex in human MCMs has been associated with helicase activity in vitro[], leading to the suggestion that the MCM proteins are the eukaryotic replicative helicase.Schizosaccharomyces pombe (Fission yeast) MCMs, like those in metazoans, are found in the nucleus throughout the cell cycle. This is in contrast to the Saccharomyces cerevisiae (Baker's yeast) in which MCM proteins move in and out of the nucleus during each cell cycle. The assembly of the MCM complex in S. pombe is required for MCM localisation, ensuring that only intact MCM complexes remain in the nucleus [].The signature pattern used in this entry represents a perfectly conserved region that is a special version of the B motif found in ATP-binding proteins.
Protein Domain
Type: Family
Description: MCM proteins are DNA-dependent ATPases required for the initiation of eukaryotic DNA replication [, , ]. In eukaryotes there is a family of eight proteins, MCM2 to MCM9. They were first identified in yeast where most of them have adirect role in the initiation of chromosomal DNA replication by interacting directly with autonomously replicating sequences (ARS). They were thus called minichromosome maintenance proteins, MCM proteins []. These proteins are evolutionarily related and belong to the AAA+ superfamily. They contain the Mcm family domain, which includes motifs that are required for ATP hydrolysis (such as the Walker A and B, and R-finger motifs). Mcm2-7 forms a hexameric complex []in which individual subunits associate with different affinities, and there is a tightly associated core of Mcm4 (Cdc21), Mcm6 (Mis5) and Mcm7 []. Mcm2-7 complex is the replicative helicase involved in replication initiation and elongation [], whereas Mcm8 and Mcm9 from and separate one, conserved among many eukaryotes except yeast and C. elegans. Mcm8/9 complex play a role during replication elongation or recombination, being involved in the repair of double-stranded DNA breaks and DNA interstrand cross-links by homologous recombination. Drosophila is the only organism that has MCM8 without MCM9, involved in meiotic recombination [, ].This family is also present in the archebacteria in 1 to 4 copies. Methanocaldococcus jannaschii (Methanococcus jannaschii) has four members, MJ0363, MJ0961, MJ1489 and MJECL13.Schizosaccharomyces pombe (Fission yeast) MCMs, like those in metazoans, are found in the nucleus throughout the cell cycle. This is in contrast to the Saccharomyces cerevisiae (Baker's yeast) in which MCM proteins move in and out of the nucleus during each cell cycle. The assembly of the MCM complex in S. pombe is required for MCM localisation, ensuring that only intact MCM complexes remain in the nucleus [].
Publication
First Author: Remus D
Year: 2009
Journal: Cell
Title: Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing.
Volume: 139
Issue: 4
Pages: 719-30
Publication
First Author: Evrin C
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication.
Volume: 106
Issue: 48
Pages: 20240-5
Publication
First Author: Symeonidou IE
Year: 2012
Journal: FEBS Lett
Title: Control over DNA replication in time and space.
Volume: 586
Issue: 18
Pages: 2803-12
Publication  
First Author: Singleton MR
Year: 2007
Journal: Annu Rev Biochem
Title: Structure and mechanism of helicases and nucleic acid translocases.
Volume: 76
Pages: 23-50
Protein
Organism: Mus musculus/domesticus
Length: 681  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 604  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 692  
Fragment?: false
Publication
First Author: Nishimura K
Year: 2012
Journal: Mol Cell
Title: Mcm8 and Mcm9 form a complex that functions in homologous recombination repair induced by DNA interstrand crosslinks.
Volume: 47
Issue: 4
Pages: 511-22
Publication  
First Author: Griffin WC
Year: 2019
Journal: DNA Repair (Amst)
Title: The MCM8/9 complex: A recent recruit to the roster of helicases involved in genome maintenance.
Volume: 76
Pages: 1-10
Protein
Organism: Mus musculus/domesticus
Length: 393  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 489  
Fragment?: true
Publication
First Author: Coxon A
Year: 1992
Journal: Nucleic Acids Res
Title: Fission yeast cdc21+ belongs to a family of proteins involved in an early step of chromosome replication.
Volume: 20
Issue: 21
Pages: 5571-7
Publication
First Author: Koonin EV
Year: 1993
Journal: Nucleic Acids Res
Title: A common set of conserved motifs in a vast variety of putative nucleic acid-dependent ATPases including MCM proteins involved in the initiation of eukaryotic DNA replication.
Volume: 21
Issue: 11
Pages: 2541-7
Publication
First Author: Hu B
Year: 1993
Journal: Nucleic Acids Res
Title: The P1 family: a new class of nuclear mammalian proteins related to the yeast Mcm replication proteins.
Volume: 21
Issue: 23
Pages: 5289-93
Publication
First Author: Tye BK
Year: 1994
Journal: Trends Cell Biol
Title: The MCM2-3-5 proteins: are they replication licensing factors?
Volume: 4
Issue: 5
Pages: 160-6
Protein
Organism: Mus musculus/domesticus
Length: 821  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 719  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 904  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 734  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 812  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 821  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 719  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 720  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 913  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 904  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 821  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 734  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 812  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 812  
Fragment?: false