Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
hamster, Chinese |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
The Origin Recognition Complex (ORC) is a six-subunit ATP-dependent DNA-binding complex encoded in yeast by ORC1-6 []. ORC is a central component for eukaryotic DNA replication, and binds chromatin at replication origins throughout the cell cycle []. ORC directs DNA replication throughout the genome and is required for its initiation [, , ]. ORC bound at replication origins serves as the foundation for assembly of the pre-replicative complex (pre-RC), which includes Cdc6, Tah11 (aka Cdt1), and the Mcm2-7 complex [, , ]. Pre-RC assembly during G1 is required for replication licensing of chromosomes prior to DNA synthesis during S phase [, , ]. Cell cycle-regulated phosphorylation of ORC2, ORC6, Cdc6, and MCM by the cyclin-dependent protein kinase Cdc28 regulates initiation of DNA replication, including blocking reinitiation in G2/M phase [, , , ]. In yeast, ORC also plays a role in the establishment of silencing at the mating-type loci Hidden MAT Left (HML) and Hidden MAT Right (HMR) [, , ]. ORC participates in the assembly of transcriptionally silent chromatin at HML and HMR by recruiting the Sir1 silencing protein to the HML and HMR silencers [, , ]. Both ORC1 and ORC5 bind ATP, although only ORC1 has ATPase activity []. The binding of ATP by ORC1 is required for ORC binding to DNA and is essential for cell viability []. The ATPase activity of ORC1 is involved in formation of the pre-RC [, , ]. ATP binding by ORC5 is crucial for the stability of ORC as a whole. Only the ORC1-5 subunits are required for origin binding; ORC6 is essential for maintenance of pre-RCs once formed []. Interactions within ORC suggest that ORC2-3-6 may form a core complex []. ORC homologues have been found in various eukaryotes, including fission yeast, insects, amphibians, and humans []. This entry represents subunit 2, which binds the origin of replication. It plays a role in chromosome replication and mating type transcriptional silencing. |
|
•
•
•
•
•
|
Publication |
First Author: |
Ortega MA |
Year: |
2012 |
Journal: |
Biol Reprod |
Title: |
Unique pattern of ORC2 and MCM7 localization during DNA replication licensing in the mouse zygote. |
Volume: |
87 |
Issue: |
3 |
Pages: |
62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Takahara K |
Year: |
1996 |
Journal: |
Genomics |
Title: |
Mouse and human homologues of the yeast origin of replication recognition complex subunit ORC2 and chromosomal localization of the cognate human gene ORC2L. |
Volume: |
31 |
Issue: |
1 |
Pages: |
119-22 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
576
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
576
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
528
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Chesnokov IN |
Year: |
2007 |
Journal: |
Int Rev Cytol |
Title: |
Multiple functions of the origin recognition complex. |
Volume: |
256 |
|
Pages: |
69-109 |
|
•
•
•
•
•
|
Publication |
First Author: |
Matsuda K |
Year: |
2007 |
Journal: |
FEMS Yeast Res |
Title: |
Yeast two-hybrid analysis of the origin recognition complex of Saccharomyces cerevisiae: interaction between subunits and identification of binding proteins. |
Volume: |
7 |
Issue: |
8 |
Pages: |
1263-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bell SP |
Year: |
1992 |
Journal: |
Nature |
Title: |
ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex. |
Volume: |
357 |
Issue: |
6374 |
Pages: |
128-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bell SP |
Year: |
1995 |
Journal: |
Cell |
Title: |
The multidomain structure of Orc1p reveals similarity to regulators of DNA replication and transcriptional silencing. |
Volume: |
83 |
Issue: |
4 |
Pages: |
563-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gibson DG |
Year: |
2006 |
Journal: |
Genes Cells |
Title: |
Cell cycle execution point analysis of ORC function and characterization of the checkpoint response to ORC inactivation in Saccharomyces cerevisiae. |
Volume: |
11 |
Issue: |
6 |
Pages: |
557-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rao H |
Year: |
1995 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
The origin recognition complex interacts with a bipartite DNA binding site within yeast replicators. |
Volume: |
92 |
Issue: |
6 |
Pages: |
2224-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rowley A |
Year: |
1995 |
Journal: |
EMBO J |
Title: |
Initiation complex assembly at budding yeast replication origins begins with the recognition of a bipartite sequence by limiting amounts of the initiator, ORC. |
Volume: |
14 |
Issue: |
11 |
Pages: |
2631-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Speck C |
Year: |
2005 |
Journal: |
Nat Struct Mol Biol |
Title: |
ATPase-dependent cooperative binding of ORC and Cdc6 to origin DNA. |
Volume: |
12 |
Issue: |
11 |
Pages: |
965-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kelly TJ |
Year: |
2000 |
Journal: |
Annu Rev Biochem |
Title: |
Regulation of chromosome replication. |
Volume: |
69 |
|
Pages: |
829-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bell SP |
Year: |
2002 |
Journal: |
Annu Rev Biochem |
Title: |
DNA replication in eukaryotic cells. |
Volume: |
71 |
|
Pages: |
333-74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stillman B |
Year: |
2005 |
Journal: |
FEBS Lett |
Title: |
Origin recognition and the chromosome cycle. |
Volume: |
579 |
Issue: |
4 |
Pages: |
877-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
Weinreich M |
Year: |
2001 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Binding of cyclin-dependent kinases to ORC and Cdc6p regulates the chromosome replication cycle. |
Volume: |
98 |
Issue: |
20 |
Pages: |
11211-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nguyen VQ |
Year: |
2001 |
Journal: |
Nature |
Title: |
Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms. |
Volume: |
411 |
Issue: |
6841 |
Pages: |
1068-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Archambault V |
Year: |
2005 |
Journal: |
Mol Cell Biol |
Title: |
Disruption of mechanisms that prevent rereplication triggers a DNA damage response. |
Volume: |
25 |
Issue: |
15 |
Pages: |
6707-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Triolo T |
Year: |
1996 |
Journal: |
Nature |
Title: |
Role of interactions between the origin recognition complex and SIR1 in transcriptional silencing. |
Volume: |
381 |
Issue: |
6579 |
Pages: |
251-3 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fox CA |
Year: |
1997 |
Journal: |
Science |
Title: |
The origin recognition complex, SIR1, and the S phase requirement for silencing. |
Volume: |
276 |
Issue: |
5318 |
Pages: |
1547-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Klemm RD |
Year: |
1997 |
Journal: |
Cell |
Title: |
Coordinate binding of ATP and origin DNA regulates the ATPase activity of the origin recognition complex. |
Volume: |
88 |
Issue: |
4 |
Pages: |
493-502 |
|
•
•
•
•
•
|
Publication |
First Author: |
Klemm RD |
Year: |
2001 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
ATP bound to the origin recognition complex is important for preRC formation. |
Volume: |
98 |
Issue: |
15 |
Pages: |
8361-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bowers JL |
Year: |
2004 |
Journal: |
Mol Cell |
Title: |
ATP hydrolysis by ORC catalyzes reiterative Mcm2-7 assembly at a defined origin of replication. |
Volume: |
16 |
Issue: |
6 |
Pages: |
967-78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Randell JC |
Year: |
2006 |
Journal: |
Mol Cell |
Title: |
Sequential ATP hydrolysis by Cdc6 and ORC directs loading of the Mcm2-7 helicase. |
Volume: |
21 |
Issue: |
1 |
Pages: |
29-39 |
|
•
•
•
•
•
|
Publication |
First Author: |
Semple JW |
Year: |
2006 |
Journal: |
EMBO J |
Title: |
An essential role for Orc6 in DNA replication through maintenance of pre-replicative complexes. |
Volume: |
25 |
Issue: |
21 |
Pages: |
5150-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dutta A |
Year: |
1997 |
Journal: |
Annu Rev Cell Dev Biol |
Title: |
Initiation of DNA replication in eukaryotic cells. |
Volume: |
13 |
|
Pages: |
293-332 |
|
•
•
•
•
•
|
Publication |
First Author: |
Natale DA |
Year: |
2000 |
Journal: |
EMBO J |
Title: |
Selective instability of Orc1 protein accounts for the absence of functional origin recognition complexes during the M-G(1) transition in mammals. |
Volume: |
19 |
Issue: |
11 |
Pages: |
2728-38 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chan KM |
Year: |
2011 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Diverse factors are involved in maintaining X chromosome inactivation. |
Volume: |
108 |
Issue: |
40 |
Pages: |
16699-704 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jaremko MJ |
Year: |
2020 |
Journal: |
Elife |
Title: |
The dynamic nature of the human origin recognition complex revealed through five cryoEM structures. |
Volume: |
9 |
|
|
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:28158 |
Assay Type: |
Northern blot |
Annotation Date: |
2003-03-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1876728 |
|
Stage: |
TS28 |
Assay Id: |
MGI:2652185 |
Age: |
postnatal adult |
|
|
Specimen Label: |
3 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:28158 |
Assay Type: |
Northern blot |
Annotation Date: |
2003-03-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1737328 |
|
Stage: |
TS28 |
Assay Id: |
MGI:2652185 |
Age: |
postnatal adult |
|
|
Specimen Label: |
7 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:28158 |
Assay Type: |
Northern blot |
Annotation Date: |
2003-03-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1672828 |
|
Stage: |
TS28 |
Assay Id: |
MGI:2652185 |
Age: |
postnatal adult |
|
|
Specimen Label: |
4 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:28158 |
Assay Type: |
Northern blot |
Annotation Date: |
2003-03-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3598828 |
|
Stage: |
TS28 |
Assay Id: |
MGI:2652185 |
Age: |
postnatal adult |
|
|
Specimen Label: |
6 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:28158 |
Assay Type: |
Northern blot |
Annotation Date: |
2003-03-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1610528 |
|
Stage: |
TS28 |
Assay Id: |
MGI:2652185 |
Age: |
postnatal adult |
|
|
Specimen Label: |
1 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:28158 |
Assay Type: |
Northern blot |
Annotation Date: |
2003-03-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603910 |
|
Stage: |
TS10 |
Assay Id: |
MGI:2652188 |
Age: |
embryonic day 7.0 |
|
|
Specimen Label: |
7 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:28158 |
Assay Type: |
Northern blot |
Annotation Date: |
2003-03-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603918 |
|
Stage: |
TS18 |
Assay Id: |
MGI:2652188 |
Age: |
embryonic day 11.0 |
|
|
Specimen Label: |
11 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:28158 |
Assay Type: |
Northern blot |
Annotation Date: |
2003-03-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603923 |
|
Stage: |
TS23 |
Assay Id: |
MGI:2652188 |
Age: |
embryonic day 15.0 |
|
|
Specimen Label: |
15 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:28158 |
Assay Type: |
Northern blot |
Annotation Date: |
2003-03-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603925 |
|
Stage: |
TS25 |
Assay Id: |
MGI:2652188 |
Age: |
embryonic day 17.0 |
|
|
Specimen Label: |
17 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:28158 |
Assay Type: |
Northern blot |
Annotation Date: |
2003-03-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1684628 |
|
Stage: |
TS28 |
Assay Id: |
MGI:2652185 |
Age: |
postnatal adult |
|
|
Specimen Label: |
5 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6388636 |
Assay Type: |
RT-PCR |
Annotation Date: |
2020-02-05 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1684625 |
|
Stage: |
TS25 |
Assay Id: |
MGI:6388688 |
Age: |
embryonic day 17.5 |
Image: |
6 |
|
Specimen Label: |
E17.5 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6388636 |
Assay Type: |
RT-PCR |
Annotation Date: |
2020-02-05 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1684628 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6388688 |
Age: |
postnatal week 1 |
Image: |
6 |
|
Specimen Label: |
1wk |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6388636 |
Assay Type: |
RT-PCR |
Annotation Date: |
2020-02-05 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1684628 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6388688 |
Age: |
postnatal week 2 |
Image: |
6 |
|
Specimen Label: |
2wk |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6388636 |
Assay Type: |
RT-PCR |
Annotation Date: |
2020-02-05 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1684628 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6388688 |
Age: |
postnatal week 3 |
Image: |
6 |
|
Specimen Label: |
3wk |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6388636 |
Assay Type: |
RT-PCR |
Annotation Date: |
2020-02-05 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1684628 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6388688 |
Age: |
postnatal week 6 |
Image: |
6 |
|
Specimen Label: |
6wk |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6388636 |
Assay Type: |
RT-PCR |
Annotation Date: |
2020-02-05 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1684628 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6388688 |
Age: |
postnatal week 9 |
Image: |
6 |
|
Specimen Label: |
9wk |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:28158 |
Assay Type: |
Northern blot |
Annotation Date: |
2003-03-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1797228 |
|
Stage: |
TS28 |
Assay Id: |
MGI:2652185 |
Age: |
postnatal adult |
|
|
Specimen Label: |
8 |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:28158 |
Assay Type: |
Northern blot |
Annotation Date: |
2003-03-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:2652185 |
Age: |
postnatal adult |
|
|
Specimen Label: |
2 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4844660 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-12-22 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1619819 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:4848545 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Table S4 - E11.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4844660 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-12-22 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1680017 |
Pattern: |
Not Specified |
Stage: |
TS17 |
Assay Id: |
MGI:4848545 |
Age: |
embryonic day 10.5 |
|
Note: |
Staining is present in the olfactory placode. |
Specimen Label: |
Table S4 - E10.5 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4844660 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-12-22 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:3270519 |
Pattern: |
Regionally restricted |
Stage: |
TS19 |
Assay Id: |
MGI:4848545 |
Age: |
embryonic day 11.5 |
|
Note: |
Staining is present in the progress zone. |
Specimen Label: |
Table S4 - E11.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4844660 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-12-22 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1666917 |
Pattern: |
Not Specified |
Stage: |
TS17 |
Assay Id: |
MGI:4848545 |
Age: |
embryonic day 10.5 |
|
Note: |
Staining is present in the otic pit. |
Specimen Label: |
Table S4 - E10.5 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4844660 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-12-22 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1638817 |
Pattern: |
Not Specified |
Stage: |
TS17 |
Assay Id: |
MGI:4848545 |
Age: |
embryonic day 10.5 |
|
Note: |
Staining is present in the maxillary process. |
Specimen Label: |
Table S4 - E10.5 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Craig JM |
Year: |
2003 |
Journal: |
Hum Mol Genet |
Title: |
Analysis of mammalian proteins involved in chromatin modification reveals new metaphase centromeric proteins and distinct chromosomal distribution patterns. |
Volume: |
12 |
Issue: |
23 |
Pages: |
3109-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dannenberg JH |
Year: |
2005 |
Journal: |
Genes Dev |
Title: |
mSin3A corepressor regulates diverse transcriptional networks governing normal and neoplastic growth and survival. |
Volume: |
19 |
Issue: |
13 |
Pages: |
1581-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kneissl M |
Year: |
2003 |
Journal: |
J Mol Biol |
Title: |
Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells. |
Volume: |
327 |
Issue: |
1 |
Pages: |
111-28 |
|
•
•
•
•
•
|
Publication |
First Author: |
Geng Y |
Year: |
2003 |
Journal: |
Cell |
Title: |
Cyclin E ablation in the mouse. |
Volume: |
114 |
Issue: |
4 |
Pages: |
431-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Okano-Uchida T |
Year: |
2018 |
Journal: |
Genes Dev |
Title: |
Endoreduplication of the mouse genome in the absence of ORC1. |
Volume: |
32 |
Issue: |
13-14 |
Pages: |
978-990 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ishii H |
Year: |
2005 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis. |
Volume: |
102 |
Issue: |
27 |
Pages: |
9655-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Campbell GR |
Year: |
2011 |
Journal: |
Mol Cell Neurosci |
Title: |
Transcription factors expressed in olfactory bulb local progenitor cells revealed by genome-wide transcriptome profiling. |
Volume: |
46 |
Issue: |
2 |
Pages: |
548-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom |
Year: |
2023 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Ko MS |
Year: |
2000 |
Journal: |
Development |
Title: |
Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. |
Volume: |
127 |
Issue: |
8 |
Pages: |
1737-49 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yokoyama S |
Year: |
2009 |
Journal: |
Dev Cell |
Title: |
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. |
Volume: |
17 |
Issue: |
6 |
Pages: |
836-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory |
Year: |
2012 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by The Jackson Laboratory |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen J |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. |
Volume: |
100 |
Issue: |
17 |
Pages: |
9918-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Friedel RH |
Year: |
2007 |
Journal: |
Brief Funct Genomic Proteomic |
Title: |
EUCOMM--the European conditional mouse mutagenesis program. |
Volume: |
6 |
Issue: |
3 |
Pages: |
180-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stryke D |
Year: |
2003 |
Journal: |
Nucleic Acids Res |
Title: |
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
Volume: |
31 |
Issue: |
1 |
Pages: |
278-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Helmholtz Zentrum Muenchen GmbH |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|