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Search results 301 to 372 out of 372 for Rcc1

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Hits by Pathway

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Hits by Category

Type Details Score
Protein
A2CER2
Organism: Mus musculus/domesticus
Length: 116  
Fragment?: true
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Protein
Q9D3M1
Organism: Mus musculus/domesticus
Length: 168  
Fragment?: false
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Protein
Q3U6D2
Organism: Mus musculus/domesticus
Length: 421  
Fragment?: false
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Protein
Q8CDM3
Organism: Mus musculus/domesticus
Length: 972  
Fragment?: false
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Protein
Q9D417
Organism: Mus musculus/domesticus
Length: 589  
Fragment?: false
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Protein
F2Z461
Organism: Mus musculus/domesticus
Length: 1003  
Fragment?: false
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Protein
Q6PAV2
Organism: Mus musculus/domesticus
Length: 1057  
Fragment?: false
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Protein
Q9CYM1
Organism: Mus musculus/domesticus
Length: 913  
Fragment?: false
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Protein
Q80U90
Organism: Mus musculus/domesticus
Length: 938  
Fragment?: true
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Protein
Q8BTL0
Organism: Mus musculus/domesticus
Length: 391  
Fragment?: false
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Protein
Q8CFQ0
Organism: Mus musculus/domesticus
Length: 1050  
Fragment?: false
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Protein
G5E876
Organism: Mus musculus/domesticus
Length: 913  
Fragment?: false
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Protein
A6H6S0
Organism: Mus musculus/domesticus
Length: 1050  
Fragment?: false
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Strain
MGI:6261217 | C57BL/6N-Rccd1<tm1.1(KOMP)Wtsi>/Bay
Attribute String: coisogenic, targeted mutation
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Genotype
Genotype
Symbol: Rccd1/Rccd1
Background: C57BL/6N-Rccd1/Bay
Zygosity: hm
Has Mutant Allele: true
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Publication
12919680 | -
First Author: Mollinari C
Year: 2003
Journal: Dev Cell
Title: The mammalian passenger protein TD-60 is an RCC1 family member with an essential role in prometaphase to metaphase progression.
Volume: 5
Issue: 2
Pages: 295-307
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Protein
A0A087WNN3
Organism: Mus musculus/domesticus
Length: 495  
Fragment?: false
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Strain
MGI:6344842 | C57BL/6N-A<tm1Brd> Rccd1<tm1(KOMP)Wtsi>/BayMmucd
Attribute String: mutant strain, coisogenic, targeted mutation
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Genotype
Genotype
Symbol: Rccd1/Rccd1<+>
Background: C57BL/6N-Rccd1/Bay
Zygosity: ht
Has Mutant Allele: true
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Protein
Q6ZPR6
Organism: Mus musculus/domesticus
Length: 1352  
Fragment?: false
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Protein
Q8K1R7
Organism: Mus musculus/domesticus
Length: 984  
Fragment?: false
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Protein
Q69Z43
Organism: Mus musculus/domesticus
Length: 1005  
Fragment?: true
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Allele
Mycbp2<m274-4Tpo> | MGI:3849603
 
Name: MYC binding protein 2, E3 ubiquitin protein ligase; mutation 274-4, Timothy P O'Brien
Allele Type: Chemically induced (ENU)
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Protein
Q91ZR4
Organism: Mus musculus/domesticus
Length: 698  
Fragment?: false
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Protein
Q920R0
Organism: Mus musculus/domesticus
Length: 1651  
Fragment?: false
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Protein
Q7TPH6
Organism: Mus musculus/domesticus
Length: 4749  
Fragment?: false
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Protein
F6SMY7
Organism: Mus musculus/domesticus
Length: 4636  
Fragment?: true
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Genotype
Genotype
Symbol: Ednrb/Ednrb<+> Mycbp2/Mycbp2<+>
Background: involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mycbp2/Mycbp2
Background: involves: C57BL/6J * SSL/LeJ
Zygosity: hm
Has Mutant Allele: true
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Protein
E9PZP8
Organism: Mus musculus/domesticus
Length: 4859  
Fragment?: false
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Protein
Q4U2R1
Organism: Mus musculus/domesticus
Length: 4836  
Fragment?: false
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Protein
C6EQH2
Organism: Mus musculus/domesticus
Length: 4746  
Fragment?: false
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Publication
19391113 | J:149893
First Author: Hagarman JA
Year: 2009
Journal: Genesis
Title: An essential gene mutagenesis screen across the highly conserved piebald deletion region of mouse chromosome 14.
Volume: 47
Issue: 6
Pages: 392-403
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Protein Domain
IPR006762 | Gtr1_RagA
Type: Family
Description: GTR1 was first identified in Saccharomyces cerevisiae (Baker's yeast) as a suppressor of a mutation in RCC1. RCC1 catalyzes guanine nucleotide exchange on Ran, a well characterised nuclear Ras-like small G protein that plays an essential role in the import and export of proteins and RNAs across the nuclear membrane through the nuclear pore complex. RCC1 is located inside the nucleus, bound to chromatin. The concentration of GTP within the cell is ~30 times higher than the concentration of GDP, thus resulting in the preferential production of the GTP form of Ran by RCC1 within the nucleus.Gtr1p is located within both the cytoplasm and the nucleus and has been reported to play a role in cell growth. Biochemical analysis revealed that Gtr1 is in fact a G protein of the Ras family. The RagA/B proteins are the human homologues of Gtr1 and Rag A and Gtr1p belong to the sixth subfamily of the Ras-like small GTPase superfamily [].
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Publication
26967905 | J:232407
First Author: Grampa V
Year: 2016
Journal: PLoS Genet
Title: Novel NEK8 Mutations Cause Severe Syndromic Renal Cystic Dysplasia through YAP Dysregulation.
Volume: 12
Issue: 3
Pages: e1005894
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Protein Domain
IPR044120 | STKc_Nek8
Type: Domain
Description: Nek8 contains an N-terminal kinase catalytic domain and a C-terminal RCC1 (regulator of chromosome condensation) domain. Nek8 human mutations have been shown to cause major organ developmental defects due to altered ciliogenesis and cell differentiation/proliferation through deregulation of the Hippo pathway []. Nek8 is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control [].This entry represents the catalytic domain of Nek8.
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Protein
Q3TSI5
Organism: Mus musculus/domesticus
Length: 727  
Fragment?: true
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Protein Domain
IPR009091 | RCC1/BLIP-II
Type: Homologous_superfamily
Description: The beta-lactamase-inhibitor protein II (BLIP-II) is a secreted protein produced by the soil bacteria Streptomyces exfoliates SMF19. BLIP-II acts as a potent inhibitor of beta-lactamases such as TEM-1, which is the most widespread resistance enzyme to penicillin antibiotics. BLIP-II binds competitively to TEM-1, but no direct contacts are made with TEM-1 active site residues. BLIP-II shows no sequence similarity with BLIP, even though both bind to and inhibit TEM-1. However, BLIP-II does share significant sequence identity with the regulator of chromosome condensation (RCC1) family of proteins. These two families are clearly related, both having a seven-bladed β-propeller structure, although they differ in the number of strands per blade, BLIP-II having three antiparallel β-strands per blade, while RCC1 has four-stranded blades []. RCC1 is a eukaryotic nuclear protein that acts as a guanine nucleotide exchange factor for Ran, a member of the Ras GTPase family. RCC1 mediates a Ran-GTP gradient necessary for the regulation of spindle formation and nuclear assembly during mitosis, as well as for the transport of macromolecules across the nuclear membrane during interphase.
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Publication
8255297 | J:19326
First Author: Coutavas E
Year: 1993
Journal: Nature
Title: Characterization of proteins that interact with the cell-cycle regulatory protein Ran/TC4.
Volume: 366
Issue: 6455
Pages: 585-7
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Publication
10471364 | J:57496
First Author: Nishimoto T
Year: 1999
Journal: Biochem Biophys Res Commun
Title: A new role of ran GTPase.
Volume: 262
Issue: 3
Pages: 571-4
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Publication
11073942 | -
First Author: Sekiguchi T
Year: 2001
Journal: J Biol Chem
Title: Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B.
Volume: 276
Issue: 10
Pages: 7246-57
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Protein
B1AWT4
Organism: Mus musculus/domesticus
Length: 279  
Fragment?: false
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Protein
G3UYP1
Organism: Mus musculus/domesticus
Length: 116  
Fragment?: true
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Publication
11573088 | -
First Author: Lim D
Year: 2001
Journal: Nat Struct Biol
Title: Crystal structure and kinetic analysis of beta-lactamase inhibitor protein-II in complex with TEM-1 beta-lactamase.
Volume: 8
Issue: 10
Pages: 848-52
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Publication
9689098 | J:49046
First Author: Lehman AL
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: A very large protein with diverse functional motifs is deficient in rjs (runty, jerky, sterile) mice.
Volume: 95
Issue: 16
Pages: 9436-41
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Publication
9677393 | J:48951
First Author: Yan D
Year: 1998
Journal: J Biol Chem
Title: Biochemical characterization and subcellular localization of the mouse retinitis pigmentosa GTPase regulator (mRpgr).
Volume: 273
Issue: 31
Pages: 19656-63
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Publication
12840069 | J:85064
First Author: Di Fiore B
Year: 2003
Journal: J Cell Sci
Title: Mammalian RanBP1 regulates centrosome cohesion during mitosis.
Volume: 116
Issue: Pt 16
Pages: 3399-411
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Publication
7882974 | J:23614
First Author: Bischoff FR
Year: 1995
Journal: EMBO J
Title: Co-activation of RanGTPase and inhibition of GTP dissociation by Ran-GTP binding protein RanBP1.
Volume: 14
Issue: 4
Pages: 705-15
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Publication
9365272 | J:45030
 
First Author: Nicolás FJ
Year: 1997
Journal: J Cell Sci
Title: Xenopus Ran-binding protein 1: molecular interactions and effects on nuclear assembly in Xenopus egg extracts.
Volume: 110 ( Pt 24)
Pages: 3019-30
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Publication
18199800 | J:150174
First Author: Otto EA
Year: 2008
Journal: J Am Soc Nephrol
Title: NEK8 mutations affect ciliary and centrosomal localization and may cause nephronophthisis.
Volume: 19
Issue: 3
Pages: 587-92
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Publication
9671460 | J:48643
First Author: Pelczar P
Year: 1998
Journal: Mol Cell Biol
Title: The host gene for intronic U17 small nucleolar RNAs in mammals has no protein-coding potential and is a member of the 5'-terminal oligopyrimidine gene family.
Volume: 18
Issue: 8
Pages: 4509-18
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Protein
Q80X95
Organism: Mus musculus/domesticus
Length: 313  
Fragment?: false
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Protein
Q99K70
Organism: Mus musculus/domesticus
Length: 398  
Fragment?: false
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Protein
Q7TT45
Organism: Mus musculus/domesticus
Length: 449  
Fragment?: false
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Protein
Q6NTA4
Organism: Mus musculus/domesticus
Length: 374  
Fragment?: false
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Protein
B1AWT2
Organism: Mus musculus/domesticus
Length: 399  
Fragment?: false
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Protein
B1AWT3
Organism: Mus musculus/domesticus
Length: 454  
Fragment?: false
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Publication
16280549 | -
First Author: Quarmby LM
Year: 2005
Journal: J Cell Sci
Title: Caught Nek-ing: cilia and centrioles.
Volume: 118
Issue: Pt 22
Pages: 5161-9
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Protein
Q80TP3
Organism: Mus musculus/domesticus
Length: 2792  
Fragment?: false
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Protein
E9Q2H1
Organism: Mus musculus/domesticus
Length: 2792  
Fragment?: false
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Protein
A0A2I3BQS6
Organism: Mus musculus/domesticus
Length: 2798  
Fragment?: false
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Publication
27480124 | J:237787
First Author: Liu X
Year: 2016
Journal: BMC Immunol
Title: Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA.
Volume: 17
Issue: 1
Pages: 25
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:73796
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Function or Process or Component Unknown following Literature Review
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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