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Search results 101 to 150 out of 150 for Mkks

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Type Details Score
Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
20173330 | J:196352
First Author: Hsu CH
Year: 2010
Journal: Neurodegener Dis
Title: LRRK2 and the stress response: interaction with MKKs and JNK-interacting proteins.
Volume: 7
Issue: 1-3
Pages: 68-75
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Gene
108716568 | mkks.L
Type: gene
Organism: frog, African clawed
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DO Term
DOID:0111255 | McKusick-Kaufman syndrome
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Allele
Mkks<em1Smoc> | MGI:7291099
Name: McKusick-Kaufman syndrome; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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DO Term
DOID:0110128 | Bardet-Biedl syndrome 6
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Allele
Mkks<tm1Vcs> | MGI:3526444
Name: McKusick-Kaufman syndrome; targeted mutation 1, Val C Sheffield
Allele Type: Targeted
Attribute String: Null/knockout
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Genotype
Genotype
Symbol: Mkks/Mkks
Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
Zygosity: hm
Has Mutant Allele: true
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Publication
27783952 | J:240903
First Author: May-Simera HL
Year: 2016
Journal: Cell Rep
Title: Loss of MACF1 Abolishes Ciliogenesis and Disrupts Apicobasal Polarity Establishment in the Retina.
Volume: 17
Issue: 5
Pages: 1399-1413
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Publication
25859007 | J:222403
First Author: Rachel RA
Year: 2015
Journal: Hum Mol Genet
Title: CEP290 alleles in mice disrupt tissue-specific cilia biogenesis and recapitulate features of syndromic ciliopathies.
Volume: 24
Issue: 13
Pages: 3775-91
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Publication
8621675 | J:36237
First Author: Han J
Year: 1996
Journal: J Biol Chem
Title: Characterization of the structure and function of a novel MAP kinase kinase (MKK6).
Volume: 271
Issue: 6
Pages: 2886-91
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Publication
9841871 | J:51869
 
First Author: Chan-Hui PY
Year: 1998
Journal: Biochem J
Title: Human mitogen-activated protein kinase kinase kinase mediates the stress-induced activation of mitogen-activated protein kinase cascades.
Volume: 336 ( Pt 3)
Pages: 599-609
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Publication
11416147 | -
First Author: Xu Z
Year: 2001
Journal: Mol Cell Biol
Title: The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis.
Volume: 21
Issue: 14
Pages: 4713-24
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Publication
20067472 | -
First Author: Ola A
Year: 2010
Journal: Br J Pharmacol
Title: The mixed-lineage kinase 1-3 signalling pathway regulates stress response in cardiac myocytes via GATA-4 and AP-1 transcription factors.
Volume: 159
Issue: 3
Pages: 717-25
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Publication
27259981 | -
First Author: Craige SM
Year: 2016
Journal: Biochim Biophys Acta
Title: Mixed - Lineage Protein kinases (MLKs) in inflammation, metabolism, and other disease states.
Volume: 1862
Issue: 9
Pages: 1581-6
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Publication
17408454 | -
First Author: Handley ME
Year: 2007
Journal: Int J Exp Pathol
Title: Mixed lineage kinases (MLKs): a role in dendritic cells, inflammation and immunity?
Volume: 88
Issue: 2
Pages: 111-26
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Publication
15610029 | -
First Author: Durkin JT
Year: 2004
Journal: Biochemistry
Title: Phosphoregulation of mixed-lineage kinase 1 activity by multiple phosphorylation in the activation loop.
Volume: 43
Issue: 51
Pages: 16348-55
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Publication
18414056 | J:137358
First Author: Bisson N
Year: 2008
Journal: Cell Cycle
Title: Mice lacking both mixed-lineage kinase genes Mlk1 and Mlk2 retain a wild type phenotype.
Volume: 7
Issue: 7
Pages: 909-16
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Publication
19332348 | -
First Author: Nagao M
Year: 2009
Journal: J Neurol Sci
Title: Mixed lineage kinase 2 and hippocalcin are localized in Lewy bodies of Parkinson's disease.
Volume: 281
Issue: 1-2
Pages: 51-4
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Publication
20514022 | -
First Author: Chen J
Year: 2010
Journal: Oncogene
Title: MLK3 is critical for breast cancer cell migration and promotes a malignant phenotype in mammary epithelial cells.
Volume: 29
Issue: 31
Pages: 4399-411
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Publication
19782705 | J:164833
First Author: Cole ET
Year: 2009
Journal: Biochim Biophys Acta
Title: Mixed lineage kinase 3 negatively regulates IKK activity and enhances etoposide-induced cell death.
Volume: 1793
Issue: 12
Pages: 1811-8
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Protein Domain
IPR035779 | MLK1-3_SH3
Type: Domain
Description: MLKs 1, 2, and 3 are Serine/Threonine Kinases (STKs), catalyzing the transfer of the gamma-phosphoryl group from ATP to S/T residues on protein substrates. MLKs act as mitogen-activated protein kinase kinase kinases (MAP3Ks, MKKKs, MAPKKKs), which phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals [, ]. MLKs play roles in immunity and inflammation, as well as in cell death, proliferation, and cell cycle regulation [, ]. Little is known about the specific function of MLK1, also called MAP3K9. It is capable of activating the c-Jun N-terminal kinase pathway []. Mice lacking both MLK1 and MLK2 are viable, fertile, and have normal life spans []. MLK2, also called MAP3K10, is abundant in brain, skeletal muscle, and testis. It functions upstream of the MAPK, c-Jun N-terminal kinase. It binds hippocalcin, a calcium-sensor protein that protects neurons against calcium-induced cell death. Both MLK2 and hippocalcin may be associated with the pathogenesis of Parkinson's disease []. MLK3, also called MAP3K11, is highly expressed in breast cancer cells and its signaling through c-Jun N-terminal kinase has been implicated in the migration, invasion, and malignancy of cancer cells []. It also functions as a negative regulator of Inhibitor of Nuclear Factor-KappaB Kinase (IKK) and thus impacts inflammation and immunity []. MLKs contain an SH3 domain, a catalytic kinase domain, a leucine zipper, a proline-rich region, and a CRIB domain that mediates binding to GTP-bound Cdc42 and Rac.This entry represents the SH3 domains of MLKs.
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Protein
Q66L42
Organism: Mus musculus/domesticus
Length: 940  
Fragment?: false
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Protein
Q3U1V8
Organism: Mus musculus/domesticus
Length: 1077  
Fragment?: false
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Protein
Q80XI6
Organism: Mus musculus/domesticus
Length: 850  
Fragment?: false
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Protein
A0A0U1RQ74
Organism: Mus musculus/domesticus
Length: 289  
Fragment?: false
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Protein
D3YXM8
Organism: Mus musculus/domesticus
Length: 942  
Fragment?: false
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Protein
A0A1Y7VKX4
Organism: Mus musculus/domesticus
Length: 1100  
Fragment?: false
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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