Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:7331369 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2022-08-23 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3148828 |
Pattern: |
Regionally restricted |
Stage: |
TS28 |
Assay Id: |
MGI:7331370 |
Age: |
postnatal |
Image: |
3A/B |
Note: |
Expression is restricted to the tail. |
Specimen Label: |
3A/B |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7331369 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2022-08-23 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3148828 |
Pattern: |
Regionally restricted |
Stage: |
TS28 |
Assay Id: |
MGI:7331370 |
Age: |
postnatal |
Image: |
3C/D |
Note: |
Expression is restricted to the tail. |
Specimen Label: |
3C/D |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7331369 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2022-08-23 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3148828 |
Pattern: |
Regionally restricted |
Stage: |
TS28 |
Assay Id: |
MGI:7331370 |
Age: |
postnatal |
Image: |
3E/F |
Note: |
Expression is restricted to the tail. |
Specimen Label: |
3E/F |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7331369 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2022-08-23 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3148828 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:7331370 |
Age: |
postnatal |
|
|
Specimen Label: |
not shown: male +/- |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4423639 |
Assay Type: |
RNA in situ |
Annotation Date: |
2019-12-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3806722 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:6381399 |
Age: |
embryonic day 14.5 |
Image: |
1C60 |
|
Specimen Label: |
1C60 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
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Year: |
1999 |
Journal: |
Mol Cell Biol |
Title: |
The JIP group of mitogen-activated protein kinase scaffold proteins. |
Volume: |
19 |
Issue: |
10 |
Pages: |
7245-54 |
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•
•
•
•
•
|
Publication |
First Author: |
Kennedy NJ |
Year: |
2007 |
Journal: |
Genes Dev |
Title: |
Requirement of JIP scaffold proteins for NMDA-mediated signal transduction. |
Volume: |
21 |
Issue: |
18 |
Pages: |
2336-46 |
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•
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•
•
•
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Publication |
First Author: |
Standen CL |
Year: |
2009 |
Journal: |
Mol Cell Biol |
Title: |
Signal transduction cross talk mediated by Jun N-terminal kinase-interacting protein and insulin receptor substrate scaffold protein complexes. |
Volume: |
29 |
Issue: |
17 |
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Publication |
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Taru H |
Year: |
2002 |
Journal: |
J Biol Chem |
Title: |
Differential roles of JIP scaffold proteins in the modulation of amyloid precursor protein metabolism. |
Volume: |
277 |
Issue: |
30 |
Pages: |
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•
•
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Publication |
First Author: |
Fu MM |
Year: |
2013 |
Journal: |
J Cell Biol |
Title: |
JIP1 regulates the directionality of APP axonal transport by coordinating kinesin and dynein motors. |
Volume: |
202 |
Issue: |
3 |
Pages: |
495-508 |
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Publication |
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Year: |
2010 |
Journal: |
Mol Cell Biol |
Title: |
Requirement of JIP1-mediated c-Jun N-terminal kinase activation for obesity-induced insulin resistance. |
Volume: |
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Issue: |
19 |
Pages: |
4616-25 |
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Publication |
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Year: |
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Journal: |
Genes Dev |
Title: |
An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue. |
Volume: |
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•
•
•
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Publication |
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2005 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Notch interferes with the scaffold function of JNK-interacting protein 1 to inhibit the JNK signaling pathway. |
Volume: |
102 |
Issue: |
40 |
Pages: |
14308-13 |
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•
•
•
•
•
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Publication |
First Author: |
Scheinfeld MH |
Year: |
2002 |
Journal: |
J Biol Chem |
Title: |
Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP). |
Volume: |
277 |
Issue: |
5 |
Pages: |
3767-75 |
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•
•
•
•
•
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Publication |
First Author: |
Cunningham CA |
Year: |
2013 |
Journal: |
Eur J Immunol |
Title: |
The POSH/JIP-1 scaffold network regulates TCR-mediated JNK1 signals and effector function in CD8(+) T cells. |
Volume: |
43 |
Issue: |
12 |
Pages: |
3361-71 |
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•
•
•
•
•
|
Publication |
First Author: |
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Year: |
2010 |
Journal: |
Neurodegener Dis |
Title: |
LRRK2 and the stress response: interaction with MKKs and JNK-interacting proteins. |
Volume: |
7 |
Issue: |
1-3 |
Pages: |
68-75 |
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•
•
•
•
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Publication |
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2011 |
Journal: |
J Cell Sci |
Title: |
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Volume: |
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Issue: |
Pt 7 |
Pages: |
1032-42 |
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•
•
•
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Publication |
First Author: |
Verhey KJ |
Year: |
2001 |
Journal: |
J Cell Biol |
Title: |
Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules. |
Volume: |
152 |
Issue: |
5 |
Pages: |
959-70 |
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•
•
•
•
•
|
Publication |
First Author: |
Stockinger W |
Year: |
2000 |
Journal: |
J Biol Chem |
Title: |
The reelin receptor ApoER2 recruits JNK-interacting proteins-1 and -2. |
Volume: |
275 |
Issue: |
33 |
Pages: |
25625-32 |
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•
•
•
•
•
|
Publication |
First Author: |
Whitmarsh AJ |
Year: |
2001 |
Journal: |
Genes Dev |
Title: |
Requirement of the JIP1 scaffold protein for stress-induced JNK activation. |
Volume: |
15 |
Issue: |
18 |
Pages: |
2421-32 |
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•
•
•
•
•
|
Publication |
First Author: |
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Year: |
2007 |
Journal: |
Mol Cell Biol |
Title: |
Vaccinia-related kinase 2 modulates the stress response to hypoxia mediated by TAK1. |
Volume: |
27 |
Issue: |
20 |
Pages: |
7273-83 |
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•
•
•
•
|
Publication |
First Author: |
Taru H |
Year: |
2002 |
Journal: |
J Biol Chem |
Title: |
Interaction of Alzheimer's beta -amyloid precursor family proteins with scaffold proteins of the JNK signaling cascade. |
Volume: |
277 |
Issue: |
22 |
Pages: |
20070-8 |
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•
•
•
•
•
|
Publication |
First Author: |
Shiroshima T |
Year: |
2009 |
Journal: |
FEBS Lett |
Title: |
Identification of LRP1B-interacting proteins and inhibition of protein kinase Calpha-phosphorylation of LRP1B by association with PICK1. |
Volume: |
583 |
Issue: |
1 |
Pages: |
43-8 |
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•
•
•
•
|
Publication |
First Author: |
Matsuda S |
Year: |
2001 |
Journal: |
J Neurosci |
Title: |
c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK. |
Volume: |
21 |
Issue: |
17 |
Pages: |
6597-607 |
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•
•
•
•
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Publication |
First Author: |
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Year: |
2010 |
Journal: |
J Neurosci |
Title: |
Distinct roles of c-Jun N-terminal kinase isoforms in neurite initiation and elongation during axonal regeneration. |
Volume: |
30 |
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23 |
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7804-16 |
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Publication |
First Author: |
Ehringer MA |
Year: |
2002 |
Journal: |
Alcohol Clin Exp Res |
Title: |
Fine mapping of polymorphic alcohol-related quantitative trait loci candidate genes using interval-specific congenic recombinant mice. |
Volume: |
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Issue: |
11 |
Pages: |
1603-8 |
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Publication |
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Year: |
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Journal: |
EMBO J |
Title: |
DCX, a new mediator of the JNK pathway. |
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4 |
Pages: |
823-32 |
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Publication |
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Year: |
2010 |
Journal: |
Sci Signal |
Title: |
Apolipoprotein E controls ATP-binding cassette transporters in the ischemic brain. |
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142 |
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Publication |
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Eur J Neurosci |
Title: |
Spatial, temporal and subcellular localization of islet-brain 1 (IB1), a homologue of JIP-1, in mouse brain. |
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2 |
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621-32 |
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Publication |
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J Biol Chem |
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Publication |
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A Protein Scaffold Coordinates SRC-Mediated JNK Activation in Response to Metabolic Stress. |
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Sci Rep |
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Age-dependent motor dysfunction due to neuron-specific disruption of stress-activated protein kinase MKK7. |
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MGI Direct Data Submission |
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Protein Ontology Association Load. |
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Allele |
Name: |
mitogen-activated protein kinase 8 interacting protein 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
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Publication |
First Author: |
Beeler N |
Year: |
2009 |
Journal: |
Brain Res Bull |
Title: |
Role of the JNK-interacting protein 1/islet brain 1 in cell degeneration in Alzheimer disease and diabetes. |
Volume: |
80 |
Issue: |
4-5 |
Pages: |
274-81 |
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Publication |
First Author: |
Koushika SP |
Year: |
2008 |
Journal: |
Bioessays |
Title: |
"JIP"ing along the axon: the complex roles of JIPs in axonal transport. |
Volume: |
30 |
Issue: |
1 |
Pages: |
10-4 |
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Protein Domain |
Type: |
Domain |
Description: |
JNK-interacting protein 1 (JIP1, also known as IB1, MAPK8IP1 or C-Jun-amino-terminal kinase-interacting protein 1) is highly expressed in neurons where it functions as an adaptor linking motor to cargo during axonal transport []. It also affects microtubule dynamics in neurons. JIP1 is also found in pancreatic beta-cells where it is involved in regulating insulin secretion []. In addition to a JNK binding domain, JIP1 also contains SH3 and Phosphotyrosine-binding (PTB) domains. Its SH3 domain homodimerizes at the interface usually involved in proline-rich ligand recognition, despite the lack of this motif in the domain itself []. |
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Publication |
First Author: |
Kristensen O |
Year: |
2006 |
Journal: |
EMBO J |
Title: |
A unique set of SH3-SH3 interactions controls IB1 homodimerization. |
Volume: |
25 |
Issue: |
4 |
Pages: |
785-97 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
707
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Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
673
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Fragment?: |
false |
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Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
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