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Search results 1 to 39 out of 39 for Ddx58

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Categories

Hits by Pathway

Hits by Category

Type Details Score
Protein
Q05CC6
Organism: Mus musculus/domesticus
Length: 763  
Fragment?: true
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Protein
Q3KQQ7
Organism: Mus musculus/domesticus
Length: 763  
Fragment?: true
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Publication
26525917 | J:346362
First Author: MacNair L
Year: 2016
Journal: Brain
Title: MTHFSD and DDX58 are novel RNA-binding proteins abnormally regulated in amyotrophic lateral sclerosis.
Volume: 139
Issue: Pt 1
Pages: 86-100
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GO Term
GO:0039552 | RIG-I binding
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Protein Coding Gene
MGI:2442858 | Rigi
Type: protein_coding_gene
Organism: mouse, laboratory
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GO Term
GO:0039535 | regulation of RIG-I signaling pathway
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GO Term
GO:0039536 | negative regulation of RIG-I signaling pathway
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Protein
Q6Q899
Organism: Mus musculus/domesticus
Length: 926  
Fragment?: false
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Protein
Q6Q899-4
Organism: Mus musculus/domesticus
Length: 227  
Fragment?: false
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Protein
Q6Q899-2
Organism: Mus musculus/domesticus
Length: 472  
Fragment?: false
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Protein
Q6Q899-3
Organism: Mus musculus/domesticus
Length: 410  
Fragment?: false
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GO Term
GO:0039529 | RIG-I signaling pathway
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GO Term
GO:0039540 | symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of RIG-I activity
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Publication
23063562 | -
First Author: Ferrage F
Year: 2012
Journal: Structure
Title: Structure and dynamics of the second CARD of human RIG-I provide mechanistic insights into regulation of RIG-I activation.
Volume: 20
Issue: 12
Pages: 2048-61
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Protein Domain
IPR031964 | CARD_dom
Type: Domain
Description: This entry represents the CARD domain found in the DDX58 protein (also known as RIG1), which is a key protein in the cellular chordates' sentinel system to detect viral infection. This domain is near the N terminus of RIG1 and interacts with its C-terminal domain [].
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GO Term
GO:1900246 | positive regulation of RIG-I signaling pathway
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Protein
F7B5Z3
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: true
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Publication
27312109 | -
First Author: Wang S
Year: 2016
Journal: EMBO Rep
Title: RNF123 has an E3 ligase-independent function in RIG-I-like receptor-mediated antiviral signaling.
Volume: 17
Issue: 8
Pages: 1155-68
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Protein Domain
IPR045129 | RNF123/RSPRY1-like
Type: Family
Description: This entry represents a group of RING finger-containing proteins, including RNF123/RSPRY1 from humans and RKP from Arabidopsis.RNF123 is the catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. It also functions as an inhibitor of innate antiviral signalling mediated by DDX58 and IFIH1 independently of its E3 ligase activity []. The role of RSPRY1 (RING finger and SPRY domain-containing protein 1) is not known, but it may have a role in bone development. Mutations in RSPRY1 cause skeletal dysplasia [].RKP is an E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of KRP1 and KRP2 [, ].
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Publication
25024400 | J:220134
First Author: Sheikh F
Year: 2014
Journal: J Leukoc Biol
Title: An essential role for IFN-β in the induction of IFN-stimulated gene expression by LPS in macrophages.
Volume: 96
Issue: 4
Pages: 591-600
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Publication
38331257 | J:345928
 
First Author: Li ZA
Year: 2024
Journal: Virus Res
Title: Systems genetics of influenza A virus-infected mice identifies TRIM21 as a critical regulator of pulmonary innate immune response.
Volume: 342
Pages: 199335
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Publication
26365341 | J:230757
First Author: Faden M
Year: 2015
Journal: Am J Hum Genet
Title: Identification of a Recognizable Progressive Skeletal Dysplasia Caused by RSPRY1 Mutations.
Volume: 97
Issue: 4
Pages: 608-15
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Publication
19000158 | -
First Author: Lai J
Year: 2009
Journal: Plant J
Title: RKP, a RING finger E3 ligase induced by BSCTV C4 protein, affects geminivirus infection by regulation of the plant cell cycle.
Volume: 57
Issue: 5
Pages: 905-17
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Publication
18005227 | -
First Author: Ren H
Year: 2008
Journal: Plant J
Title: Degradation of the cyclin-dependent kinase inhibitor KRP1 is regulated by two different ubiquitin E3 ligases.
Volume: 53
Issue: 5
Pages: 705-16
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Protein
Q3UE16
Organism: Mus musculus/domesticus
Length: 267  
Fragment?: false
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Protein
Q3U0Y5
Organism: Mus musculus/domesticus
Length: 267  
Fragment?: false
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Protein
Q8VCF0
Organism: Mus musculus/domesticus
Length: 503  
Fragment?: false
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Protein
Q05CH9
Organism: Mus musculus/domesticus
Length: 1239  
Fragment?: true
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Protein
Q3TGP5
Organism: Mus musculus/domesticus
Length: 549  
Fragment?: false
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Protein
Q8R5F7
Organism: Mus musculus/domesticus
Length: 1025  
Fragment?: false
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Protein
Q5XPI3
Organism: Mus musculus/domesticus
Length: 1314  
Fragment?: false
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Protein
Q8BVR6
Organism: Mus musculus/domesticus
Length: 576  
Fragment?: false
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Protein
Q3U1I9
Organism: Mus musculus/domesticus
Length: 733  
Fragment?: false
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Protein
D2CGM4
Organism: Mus musculus/domesticus
Length: 1025  
Fragment?: false
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Protein
A2AP29
Organism: Mus musculus/domesticus
Length: 707  
Fragment?: true
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Protein
D2CGM5
Organism: Mus musculus/domesticus
Length: 1025  
Fragment?: false
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Protein
A1L0V6
Organism: Mus musculus/domesticus
Length: 924  
Fragment?: true
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Protein
A7YY79
Organism: Mus musculus/domesticus
Length: 925  
Fragment?: true
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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