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Search results 201 to 257 out of 257 for Get3

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Type Details Score
Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
22684149 | -
First Author: Kubota K
Year: 2012
Journal: J Mol Biol
Title: Get1 stabilizes an open dimer conformation of get3 ATPase by binding two distinct interfaces.
Volume: 422
Issue: 3
Pages: 366-75
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Publication
24727835 | -
First Author: Gristick HB
Year: 2014
Journal: Nat Struct Mol Biol
Title: Crystal structure of ATP-bound Get3-Get4-Get5 complex reveals regulation of Get3 by Get4.
Volume: 21
Issue: 5
Pages: 437-42
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GO Term
GO:0072380 | TRC complex
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GO Term
GO:0071818 | BAT3 complex
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Publication
21444755 | -
First Author: Vilardi F
Year: 2011
Journal: J Cell Sci
Title: WRB is the receptor for TRC40/Asna1-mediated insertion of tail-anchored proteins into the ER membrane.
Volume: 124
Issue: Pt 8
Pages: 1301-7
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Protein Domain
IPR028945 | Get1
Type: Family
Description: In budding yeasts, Golgi to ER traffic protein 1 (Get1) is a component of the Golgi to ER traffic (GET) complex, which is composed of Get1, Get2 and Get3. The GET complex mediates posttranslational insertion of newly synthesised tail-anchored (TA) proteins to the endoplasmic reticulum (ER) membrane.The GET complex is composed of the homodimeric Get3 ATPase and its heterooligomeric receptor, Get1/2. Get1 stabilises an open dimer conformation of Get3 [].In metazoa, the homologue to Get1 is known as tail-anchored protein insertion receptor WRB, which is a receptor for ASNA1/TRC40 (Get3 in yeast) [].
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Protein
Q8K0D7
Organism: Mus musculus/domesticus
Length: 174  
Fragment?: false
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Protein
A0A3B2W7E0
Organism: Mus musculus/domesticus
Length: 139  
Fragment?: false
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Protein
A0A3B2WCW9
Organism: Mus musculus/domesticus
Length: 113  
Fragment?: false
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Protein Coding Gene
MGI:1914854 | Get4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2444615 | Sgtb
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
10970874 | -
First Author: Zhou T
Year: 2000
Journal: EMBO J
Title: Structure of the ArsA ATPase: the catalytic subunit of a heavy metal resistance pump.
Volume: 19
Issue: 17
Pages: 4838-45
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Publication
17419726 | -
First Author: Tseng YY
Year: 2007
Journal: FEBS J
Title: Caenorhabditis elegans expresses a functional ArsA.
Volume: 274
Issue: 10
Pages: 2566-72
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Publication
12680698 | -
First Author: Shen J
Year: 2003
Journal: Biometals
Title: The Saccharomyces cerevisiae Arr4p is involved in metal and heat tolerance.
Volume: 16
Issue: 3
Pages: 369-78
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Publication
17289575 | -
First Author: Kao G
Year: 2007
Journal: Cell
Title: ASNA-1 positively regulates insulin secretion in C. elegans and mammalian cells.
Volume: 128
Issue: 3
Pages: 577-87
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Publication
18724936 | -
First Author: Schuldiner M
Year: 2008
Journal: Cell
Title: The GET complex mediates insertion of tail-anchored proteins into the ER membrane.
Volume: 134
Issue: 4
Pages: 634-45
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Publication
20981284 | -
 
First Author: Castillo R
Year: 2010
Journal: Int J Microbiol
Title: Functional Promiscuity of Homologues of the Bacterial ArsA ATPases.
Volume: 2010
Pages: 187373
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Publication
21658170 | -
First Author: Sherrill J
Year: 2011
Journal: Traffic
Title: A conserved archaeal pathway for tail-anchored membrane protein insertion.
Volume: 12
Issue: 9
Pages: 1119-23
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Publication
20406421 | -
First Author: Borgese N
Year: 2010
Journal: Traffic
Title: Remote origins of tail-anchored proteins.
Volume: 11
Issue: 7
Pages: 877-85
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Protein Domain
IPR016300 | ATPase_ArsA/GET3
Type: Family
Description: Active extrusion is a common mechanism for the detoxification of heavy metals, drugs and antibiotics in bacteria, protozoa and mammals. This is particularly important for arsenic extrusion because of its prevalence in the environment and its potential to cause health and environmental problems. In prokaryotes, arsenic detoxification is accomplished by chromosomal and plasmid-borne operon-encoded efflux systems. ArsA from Escherichia coli is the catalytic subunit of the ArsAB extrusion pump, providing resistance to arsenite and antimonite. This pump consists of a soluble ATPase (ArsA) and a membrane channel (ArsB). Maintenance of a low intracellular concentration of oxidation produces resistance to the toxic agents. A third protein, ArsC, expands the substrate specificity to allow for arsenate resistance. ArsC reduces arsenate to arsenite, which is subsequently pumped out of the cell []. ArsA contains two nucleotide-binding sites (NBSs) and a binding site for arsenic or antimony. Binding of metalloids to the pump stimulates the ATPase activity [].Homologues of the bacterial ArsA ATPase are found in eukaryotes, where theyhave several recognised functions unrelated to arsenic resistance []. Caenorhabditis elegans homologue Asna-1 is required for defence against arsenite and antimonite toxicity [], and may be also involved in insulin signaling []. The homologue in yeast, GET3/Arr4, is part of the GET complex and not only is involved in stress tolerance to metals and heat [], but also specifically recognises transmenbrane domains of tail-anchored (TA) proteins destined for the secretory pathway []. Archaeal GET3 homologues have also been discovered, suggesting that that archaea may possess a TA protein targeting pathway similar to that in eukaryotes [, ].
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Protein Domain
IPR027542 | ATPase_ArsA/GET3_euk
Type: Family
Description: Active extrusion is a common mechanism for the detoxification of heavy metals, drugs and antibiotics in bacteria, protozoa and mammals. This is particularly important for arsenic extrusion because of its prevalence in the environment and its potential to cause health and environmental problems. In prokaryotes, arsenic detoxification is accomplished by chromosomal and plasmid-borne operon-encoded efflux systems. ArsA from Escherichia coli is the catalytic subunit of the ArsAB extrusion pump, providing resistance to arsenite and antimonite. This pump consists of a soluble ATPase (ArsA) and a membrane channel (ArsB). Maintenance of a low intracellular concentration of oxidation produces resistance to the toxic agents. A third protein, ArsC, expands the substrate specificity to allow for arsenate resistance. ArsC reduces arsenate to arsenite, which is subsequently pumped out of the cell []. ArsA contains two nucleotide-binding sites (NBSs) and a binding site for arsenic or antimony. Binding of metalloids to the pump stimulates the ATPase activity [].Homologues of the bacterial ArsA ATPase are found in eukaryotes, where theyhave several recognised functions unrelated to arsenic resistance []. Caenorhabditis elegans homologue Asna-1 is required for defence against arsenite and antimonite toxicity [], and may be also involved in insulin signaling []. The homologue in yeast, GET3/Arr4, is part of the GET complex and not only is involved in stress tolerance to metals and heat [], but also specifically recognises transmenbrane domains of tail-anchored (TA) proteins destined for the secretory pathway []. Archaeal GET3 homologues have also been discovered, suggesting that that archaea may possess a TA protein targeting pathway similar to that in eukaryotes [, ].This entry represents the eukaryotic branch of the ArsA/GET3 family.
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Protein Coding Gene
MGI:95049 | Ubl4a
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:95048 | Slc10a3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:5621304 | Gm44504
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
1704144 | -
First Author: Rosen BP
Year: 1990
Journal: Res Microbiol
Title: The plasmid-encoded arsenical resistance pump: an anion-translocating ATPase.
Volume: 141
Issue: 3
Pages: 336-41
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Protein Coding Gene
MGI:1098703 | Sgta
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q8VEI6
Organism: Mus musculus/domesticus
Length: 218  
Fragment?: false
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Protein
Q8C1Q1
Organism: Mus musculus/domesticus
Length: 246  
Fragment?: false
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Protein Coding Gene
MGI:1919439 | Bag6
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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