BTBD9 contains BTB/POZ, BACK, and two Coagulation factor 5/8 C-terminal (FA58C) domains. Single-nucleotide polymorphisms in the BTBD9 gene have been associated with a higher risk of Restless Legs Syndrome (RLS), a sensory-motor neurological disorder with a circadian component []. BTBD9 may be involved in regulating synaptic plasticity and memory []. Some BACK-like domain containing proteins function as adaptor proteins that play a role in ubiquitination of various substrates. In these proteins, the BACK domain is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization [].
