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Search results 1 to 100 out of 105 for Rab3gap1

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Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
22930 | RAB3GAP1
Type: gene
Organism: human
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Gene
304759 | Rab3gap1
Type: gene
Organism: rat
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Gene
470548 | RAB3GAP1
Type: gene
Organism: chimpanzee
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Gene
535393 | RAB3GAP1
Type: gene
Organism: cattle
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Gene
424290 | RAB3GAP1
Type: gene
Organism: chicken
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Gene
777744 | rab3gap1
Type: gene
Organism: zebrafish
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Gene
708191 | RAB3GAP1
Type: gene
Organism: macaque, rhesus
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Gene
100488581 | rab3gap1
Type: gene
Organism: frog, western clawed
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Gene
476127 | RAB3GAP1
Type: gene
Organism: dog, domestic
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Protein Domain
IPR045700 | Rab3GAP1
Type: Family
Description: Small G proteins of the Rab family are regulators of intracellular vesicle traffic. Their rate of GTP hydrolysis is enhanced by specific GTPase-activating proteins (GAPs) that switch G proteins to their inactive form []. Rab3GAP1 (catalytic subunit) has been shown to form a heterodimeric complex with Rab3GAP2 (the regulatory subunit), and this complex acts as a guanosine nucleotide exchange factor for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3GAP complex may participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters [, ]. It also activates Rab18 and promotes autolysosome maturation through the Vps34 Complex I [].Mutations in the Rab3GAP1/2 gene cause Warburg micro syndrome (WMS), a hereditary autosomal neuromuscular disorder [].
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Protein Coding Gene
MGI:2445001 | Rab3gap1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q80UJ7
Organism: Mus musculus/domesticus
Length: 981  
Fragment?: false
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Protein
A0A1D5RLG3
Organism: Mus musculus/domesticus
Length: 988  
Fragment?: false
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Protein
Q3UYK8
Organism: Mus musculus/domesticus
Length: 982  
Fragment?: false
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Publication
15696165 | -
First Author: Aligianis IA
Year: 2005
Journal: Nat Genet
Title: Mutations of the catalytic subunit of RAB3GAP cause Warburg Micro syndrome.
Volume: 37
Issue: 3
Pages: 221-3
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Publication
9030515 | -
First Author: Fukui K
Year: 1997
Journal: J Biol Chem
Title: Isolation and characterization of a GTPase activating protein specific for the Rab3 subfamily of small G proteins.
Volume: 272
Issue: 8
Pages: 4655-8
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Publication
9852129 | -
First Author: Oishi H
Year: 1998
Journal: J Biol Chem
Title: Localization of the Rab3 small G protein regulators in nerve terminals and their involvement in Ca2+-dependent exocytosis.
Volume: 273
Issue: 51
Pages: 34580-5
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Publication
10859313 | -
First Author: Clabecq A
Year: 2000
Journal: J Biol Chem
Title: Biochemical characterization of Rab3-GTPase-activating protein reveals a mechanism similar to that of Ras-GAP.
Volume: 275
Issue: 41
Pages: 31786-91
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Publication
32248620 | -
First Author: Takáts S
Year: 2021
Journal: FEBS J
Title: The Warburg Micro Syndrome-associated Rab3GAP-Rab18 module promotes autolysosome maturation through the Vps34 Complex I.
Volume: 288
Issue: 1
Pages: 190-211
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Publication
24239381 | J:206668
First Author: Liegel RP
Year: 2013
Journal: Am J Hum Genet
Title: Loss-of-function mutations in TBC1D20 cause cataracts and male infertility in blind sterile mice and Warburg micro syndrome in humans.
Volume: 93
Issue: 6
Pages: 1001-14
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Protein Coding Gene
MGP_CAROLIEiJ_G0014541 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0016424 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0016407 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0016372 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0016367 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0016193 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2445001 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0016828 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0015774 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0016166 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0016272 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0016271 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0016343 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0016296 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0016864 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0015560 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0015836 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0027777 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0015348 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
Probe: MGI:3584591
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915526
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:3585812
Age: embryonic day 18.0
Image: E18
Note: Expression was detected in the inner neuroblastic layer.
Specimen Label: E18
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:3584591
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915527
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:3585812
Age: postnatal day 0-1
Image: P0/1
Note: Expression was detected in the scleral inner neuroblastic layer.
Specimen Label: P0/1
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
Probe: MGI:3584591
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915527
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:3585812
Age: postnatal day 2-3
Image: P2/3
Note: Expression was detected in the scleral inner neuroblastic layer.
Specimen Label: P2/3
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:3584591
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585812
Age: postnatal day 6-7
Specimen Label: P6/7
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
   
Probe: MGI:3584591
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585812
Age: postnatal day 8-10
Specimen Label: P8/10
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
 
Probe: MGI:3584591
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Male
Emaps: EMAPS:1915528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585812
Age: postnatal adult
Image: Adult
Specimen Label: Adult
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
   
Probe: MGI:3584591
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585812
Age: postnatal day 6
Specimen Label: CNS
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
   
Probe: MGI:3584591
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585812
Age: postnatal day 6
Specimen Label: CNS
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
 
Probe: MGI:3584591
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603924
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:3585812
Age: embryonic day 16.0
Note: Expression was widespread.
Specimen Label: Embryo
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
Probe: MGI:3584591
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915726
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:3585812
Age: embryonic day 18.0
Image: E18
Note: Expression was detected in the outer neuroblastic layer.
Specimen Label: E18
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:3584591
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915727
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3585812
Age: postnatal day 0-1
Image: P0/1
Note: Expression was detected in the outer neuroblastic layer.
Specimen Label: P0/1
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
Probe: MGI:3584591
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915727
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3585812
Age: postnatal day 2-3
Image: P2/3
Note: Expression was detected in the outer neuroblastic layer.
Specimen Label: P2/3
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:3584591
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585812
Age: postnatal day 6-7
Specimen Label: P6/7
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:3584591
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:3585812
Age: postnatal day 8-10
Note: Expression was detected in the inner segment.
Specimen Label: P8/10
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
Probe: MGI:3584591
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Male
Emaps: EMAPS:1915728
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:3585812
Age: postnatal adult
Image: Adult
Note: Expression was detected in the inner segment.
Specimen Label: Adult
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
 
Probe: MGI:3584591
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1859224
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:3585812
Age: embryonic day 16.0
Note: Expression was detected in the inner neuroblastic layer.
Specimen Label: E16
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:3584591
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1717120
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:3585812
Age: embryonic day 12.0
Note: Expression was detected in the inner neuroblastic layer.
Specimen Label: E12
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:3584591
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1717122
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:3585812
Age: embryonic day 14.0
Note: Expression was detected in the inner neuroblastic layer and in a subset of cells in the outer neuroblastic layer. The expression level was higher in the inner neuroblastic layer.
Specimen Label: E14
Detected: true
Specimen Num: 2
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Publication
19923287 | J:155752
First Author: Szodorai A
Year: 2009
Journal: J Neurosci
Title: APP anterograde transport requires Rab3A GTPase activity for assembly of the transport vesicle.
Volume: 29
Issue: 46
Pages: 14534-44
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Publication
21677172 | J:173537
First Author: Rocha-Sanchez SM
Year: 2011
Journal: J Neurosci
Title: Mature mice lacking Rbl2/p130 gene have supernumerary inner ear hair cells and supporting cells.
Volume: 31
Issue: 24
Pages: 8883-93
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Publication
18559336 | J:140259
First Author: Figueiredo AC
Year: 2008
Journal: J Biol Chem
Title: Rab3GEP is the non-redundant guanine nucleotide exchange factor for Rab27a in melanocytes.
Volume: 283
Issue: 34
Pages: 23209-16
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Publication
21825075 | J:176968
First Author: Sdek P
Year: 2011
Journal: J Cell Biol
Title: Rb and p130 control cell cycle gene silencing to maintain the postmitotic phenotype in cardiac myocytes.
Volume: 194
Issue: 3
Pages: 407-23
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Publication
16782817 | J:111069
First Author: Sakane A
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Rab3 GTPase-activating protein regulates synaptic transmission and plasticity through the inactivation of Rab3.
Volume: 103
Issue: 26
Pages: 10029-34
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Publication
16923123 | J:123368
First Author: Itoh T
Year: 2006
Journal: Genes Cells
Title: Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity.
Volume: 11
Issue: 9
Pages: 1023-37
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Publication
18329113 | J:136723
First Author: Vaillend C
Year: 2008
Journal: Behav Brain Res
Title: Genes, plasticity and mental retardation.
Volume: 192
Issue: 1
Pages: 88-105
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Publication
15226823 | J:93300
First Author: Blackshaw S
Year: 2004
Journal: PLoS Biol
Title: Genomic analysis of mouse retinal development.
Volume: 2
Issue: 9
Pages: E247
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Publication
- | J:188991
     
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
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Publication
- | J:346132
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:155856
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
23685254 | J:199582
First Author: Youssef G
Year: 2013
Journal: Dev Biol
Title: Rab3Gap1 mediates exocytosis of Claudin-1 and tight junction formation during epidermal barrier acquisition.
Volume: 380
Issue: 2
Pages: 274-85
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DO Term
DOID:0110716 | Warburg micro syndrome 1
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Protein
Q8BMG7
Organism: Mus musculus/domesticus
Length: 1366  
Fragment?: false
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Protein
E9QKE4
Organism: Mus musculus/domesticus
Length: 1387  
Fragment?: false
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Protein
A0A0A6YWM5
Organism: Mus musculus/domesticus
Length: 1367  
Fragment?: false
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Protein Domain
IPR026147 | Rab3GAP1_conserved
Type: Domain
Description: This entry represents a conserved domain found in the Rab3 GTPase-activating protein catalytic subunit (Rab3GAP1).Small G proteins of the Rab family are regulators of intracellular vesicle traffic. Their rate of GTP hydrolysis is enhanced by specific GTPase-activating proteins (GAPs) that switch G proteins to their inactive form []. Rab3GAP1 (catalytic subunit) has been shown to form a heterodimeric complex with Rab3GAP2 (the regulatory subunit), and this complex acts as a guanosine nucleotide exchange factor for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3GAP complex may participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters [, ]. It also activates Rab18 and promotes autolysosome maturation through the Vps34 Complex I [].Mutations in the Rab3GAP1/2 gene cause Warburg micro syndrome (WMS), a hereditary autosomal neuromuscular disorder [].
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Protein Domain
IPR026059 | Rab3GAP2
Type: Family
Description: This family represents the regulatory subunit of the Rab3GAP complex, also known as Rab3GAP2. Small G proteins of the Rab family are regulators of intracellular vesicle traffic. Their rate of GTP hydrolysis is enhanced by specific GTPase-activating proteins (GAPs) that switch G proteins to their inactive form []. Rab3GAP1 (catalytic subunit) has been shown to form a heterodimeric complex with Rab3GAP2 (the regulatory subunit), and this complex acts as a guanosine nucleotide exchange factor for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3GAP complex may participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters [, ]. It also activates Rab18 and promotes autolysosome maturation through the Vps34 Complex I [].Mutations in the Rab3GAP1/2 gene cause Warburg micro syndrome (WMS), a hereditary autosomal neuromuscular disorder [].
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Protein Domain
IPR032839 | RAB3GAP_N
Type: Domain
Description: This family includes the N terminus of the Rab3 GTPase-activating protein (GAP) non-catalytic subunit.Small G proteins of the Rab family are regulators of intracellular vesicle traffic. Their rate of GTP hydrolysis is enhanced by specific GTPase-activating proteins (GAPs) that switch G proteins to their inactive form []. Rab3GAP1 (catalytic subunit) has been shown to form a heterodimeric complex with Rab3GAP2 (the regulatory subunit), and this complex acts as a guanosine nucleotide exchange factor for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3GAP complex may participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters [, ]. It also activates Rab18 and promotes autolysosome maturation through the Vps34 Complex I [].Mutations in the Rab3GAP1/2 gene cause Warburg micro syndrome (WMS), a hereditary autosomal neuromuscular disorder [].
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Protein Domain
IPR029257 | RAB3GAP2_C
Type: Domain
Description: This entry represents the C terminus of the Rab3 GTPase-activating protein non-catalytic subunit.Small G proteins of the Rab family are regulators of intracellular vesicle traffic. Their rate of GTP hydrolysis is enhanced by specific GTPase-activating proteins (GAPs) that switch G proteins to their inactive form []. Rab3GAP1 (catalytic subunit) has been shown to form a heterodimeric complex with Rab3GAP2 (the regulatory subunit), and this complex acts as a guanosine nucleotide exchange factor for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3GAP complex may participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters [, ]. It also activates Rab18 and promotes autolysosome maturation through the Vps34 Complex I [].Mutations in the Rab3GAP1/2 gene cause Warburg micro syndrome (WMS), a hereditary autosomal neuromuscular disorder [].
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