Type |
Details |
Score |
Publication |
First Author: |
Tsuji S |
Year: |
2005 |
Journal: |
Dev Genes Evol |
Title: |
Choice of either beta-catenin or Groucho/TLE as a co-factor for Xtcf-3 determines dorsal-ventral cell fate of diencephalon during Xenopus development. |
Volume: |
215 |
Issue: |
6 |
Pages: |
275-84 |
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•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Transcription factor 7-like 1 (Tcf7L1 or Tcf3) participates in the Wnt signalling pathway []. Tcf3 mediates beta-catenin-induced axis formation [, , , ]. |
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•
•
•
•
•
|
Allele |
Name: |
CBFA2/RUNX1 translocation partner 3; endonuclease-mediated mutation 1, Christopher S Williams |
Allele Type: |
Endonuclease-mediated |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Morgner J |
Year: |
2015 |
Journal: |
Nat Commun |
Title: |
Integrin-linked kinase regulates the niche of quiescent epidermal stem cells. |
Volume: |
6 |
|
Pages: |
8198 |
|
•
•
•
•
•
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Allele |
Name: |
transgene insertion 1, Michael L Cleary |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
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•
•
•
•
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Allele |
Name: |
transgene insertion HK84, GENSAT Project at Rockefeller University |
Allele Type: |
Transgenic |
Attribute String: |
Reporter |
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•
•
•
•
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Allele |
Name: |
transgene insertion 1, Elaine Fuchs |
Allele Type: |
Transgenic |
Attribute String: |
Epitope tag, Inducible, Inserted expressed sequence |
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•
•
•
•
•
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Strain |
Attribute String: |
mutant stock, transgenic |
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•
•
•
•
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Allele |
Name: |
transcription factor 3; targeted mutation 1, Hiroaki Honda |
Allele Type: |
Targeted |
|
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•
•
•
•
•
|
Allele |
Name: |
transgene insertion 23, Guy Sauvageau |
Allele Type: |
Transgenic |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
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•
•
•
•
•
|
Allele |
Name: |
transgene insertion 19, Guy Sauvageau |
Allele Type: |
Transgenic |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
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•
•
•
•
•
|
Genotype |
Symbol: |
Tg(TCF3/HLF)1Mlc/? |
Background: |
involves: FVB/N |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tcf3/Tcf3<+> |
Background: |
involves: 129P2/OlaHsd * C57BL/6 |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Min JN |
Year: |
2013 |
Journal: |
Cell Res |
Title: |
The mINO80 chromatin remodeling complex is required for efficient telomere replication and maintenance of genome stability. |
Volume: |
23 |
Issue: |
12 |
Pages: |
1396-413 |
|
•
•
•
•
•
|
Allele |
Name: |
transcription factor 3; targeted mutation 5, Yuan Zhuang |
Allele Type: |
Targeted |
Attribute String: |
No functional change, Reporter |
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•
•
•
•
•
|
Publication |
First Author: |
Brown RE |
Year: |
2022 |
Journal: |
JCI Insight |
Title: |
MTG16 regulates colonic epithelial differentiation, colitis, and tumorigenesis by repressing E protein transcription factors. |
Volume: |
7 |
Issue: |
10 |
|
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, targeted mutation |
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•
•
•
•
|
Genotype |
Symbol: |
Tg(KRT14-rtTA)F42Efu/? Tg(tetO-Tcf3)1Efu/? |
Background: |
involves: FVB |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tcf3/Tcf3 |
Background: |
involves: 129S4/SvJae * C57BL/6 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tcf3/Tcf3<+> Tg(Mx1-cre)1Cgn/? |
Background: |
involves: 129P2/OlaHsd * C57BL/6 * CBA |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(Tcrb-TCF3/PBX1)23Gusa/? |
Background: |
involves: C3H * C57BL/6 * C57BL/6J |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(Tcrb-TCF3/PBX1)19Gusa/? |
Background: |
involves: C3H * C57BL/6 * C57BL/6J |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tcf3/Tcf3<+> Tg(Emu-Zfp521)1Homy/? Tg(Mx1-cre)1Cgn/? |
Background: |
involves: 129P2/OlaHsd * C57BL/6 * CBA |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Martello G |
Year: |
2012 |
Journal: |
Cell Stem Cell |
Title: |
Esrrb is a pivotal target of the Gsk3/Tcf3 axis regulating embryonic stem cell self-renewal. |
Volume: |
11 |
Issue: |
4 |
Pages: |
491-504 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ho R |
Year: |
2013 |
Journal: |
Cell Rep |
Title: |
Stage-specific regulation of reprogramming to induced pluripotent stem cells by Wnt signaling and T cell factor proteins. |
Volume: |
3 |
Issue: |
6 |
Pages: |
2113-26 |
|
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•
•
•
•
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Publication |
First Author: |
Cao Y |
Year: |
2007 |
Journal: |
EMBO J |
Title: |
POU-V factors antagonize maternal VegT activity and beta-Catenin signaling in Xenopus embryos. |
Volume: |
26 |
Issue: |
12 |
Pages: |
2942-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Guo G |
Year: |
2011 |
Journal: |
PLoS One |
Title: |
A PiggyBac-based recessive screening method to identify pluripotency regulators. |
Volume: |
6 |
Issue: |
4 |
Pages: |
e18189 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fischer U |
Year: |
2015 |
Journal: |
Nat Genet |
Title: |
Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options. |
Volume: |
47 |
Issue: |
9 |
Pages: |
1020-1029 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
154
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Fournier M |
Year: |
2014 |
Journal: |
Exp Hematol |
Title: |
Inability of HOXB4 to enhance self-renewal of malignant B cells: favorable profile for the expansion of autologous hematopoietic stem cells. |
Volume: |
42 |
Issue: |
7 |
Pages: |
526-35.e4 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Cd3e/Cd3e Tg(Tcrb-TCF3/PBX1)23Gusa/? |
Background: |
involves: C3H * C57BL/6 * C57BL/6J |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim BM |
Year: |
2007 |
Journal: |
Gastroenterology |
Title: |
Phases of canonical Wnt signaling during the development of mouse intestinal epithelium. |
Volume: |
133 |
Issue: |
2 |
Pages: |
529-38 |
|
•
•
•
•
•
|
Publication |
First Author: |
Andoniadou CL |
Year: |
2011 |
Journal: |
Development |
Title: |
HESX1- and TCF3-mediated repression of Wnt/β-catenin targets is required for normal development of the anterior forebrain. |
Volume: |
138 |
Issue: |
22 |
Pages: |
4931-42 |
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•
•
•
•
•
|
Publication |
First Author: |
Wang H |
Year: |
2011 |
Journal: |
Development |
Title: |
Tcf/Lef repressors differentially regulate Shh-Gli target gene activation thresholds to generate progenitor patterning in the developing CNS. |
Volume: |
138 |
Issue: |
17 |
Pages: |
3711-21 |
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•
•
•
•
•
|
Publication |
First Author: |
Yin M |
Year: |
2019 |
Journal: |
JCI Insight |
Title: |
A unique mutator phenotype reveals complementary oncogenic lesions leading to acute leukemia. |
Volume: |
4 |
Issue: |
23 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Merrill BJ |
Year: |
2004 |
Journal: |
Development |
Title: |
Tcf3: a transcriptional regulator of axis induction in the early embryo. |
Volume: |
131 |
Issue: |
2 |
Pages: |
263-74 |
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•
•
•
•
•
|
Publication |
First Author: |
da Silva-Diz V |
Year: |
2013 |
Journal: |
Oncogene |
Title: |
Progeny of Lgr5-expressing hair follicle stem cell contributes to papillomavirus-induced tumor development in epidermis. |
Volume: |
32 |
Issue: |
32 |
Pages: |
3732-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tam WL |
Year: |
2008 |
Journal: |
Stem Cells |
Title: |
T-cell factor 3 regulates embryonic stem cell pluripotency and self-renewal by the transcriptional control of multiple lineage pathways. |
Volume: |
26 |
Issue: |
8 |
Pages: |
2019-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vendrell V |
Year: |
2009 |
Journal: |
Gene Expr Patterns |
Title: |
Gene expression analysis of canonical Wnt pathway transcriptional regulators during early morphogenesis of the facial region in the mouse embryo. |
Volume: |
9 |
Issue: |
5 |
Pages: |
296-305 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ohtsuka T |
Year: |
2011 |
Journal: |
Stem Cells |
Title: |
Gene expression profiling of neural stem cells and identification of regulators of neural differentiation during cortical development. |
Volume: |
29 |
Issue: |
11 |
Pages: |
1817-28 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yu S |
Year: |
2016 |
Journal: |
J Biol Chem |
Title: |
Hematopoietic and Leukemic Stem Cells Have Distinct Dependence on Tcf1 and Lef1 Transcription Factors. |
Volume: |
291 |
Issue: |
21 |
Pages: |
11148-60 |
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•
•
•
•
•
|
Publication |
First Author: |
Tamashiro DA |
Year: |
2012 |
Journal: |
Differentiation |
Title: |
Nkx1-2 is a transcriptional repressor and is essential for the activation of Brachyury in P19 mouse embryonal carcinoma cell. |
Volume: |
83 |
Issue: |
5 |
Pages: |
282-92 |
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•
•
•
•
•
|
Publication |
First Author: |
Bijl J |
Year: |
2005 |
Journal: |
Genes Dev |
Title: |
High incidence of proviral integrations in the Hoxa locus in a new model of E2a-PBX1-induced B-cell leukemia. |
Volume: |
19 |
Issue: |
2 |
Pages: |
224-33 |
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•
•
•
•
•
|
Publication |
First Author: |
Jacoby E |
Year: |
2016 |
Journal: |
Nat Commun |
Title: |
CD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity. |
Volume: |
7 |
|
Pages: |
12320 |
|
•
•
•
•
•
|
Publication |
First Author: |
DasGupta R |
Year: |
1999 |
Journal: |
Development |
Title: |
Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation. |
Volume: |
126 |
Issue: |
20 |
Pages: |
4557-68 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kamiya N |
Year: |
2016 |
Journal: |
Bone |
Title: |
Targeted disruption of BMP signaling through type IA receptor (BMPR1A) in osteocyte suppresses SOST and RANKL, leading to dramatic increase in bone mass, bone mineral density and mechanical strength. |
Volume: |
91 |
|
Pages: |
53-63 |
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•
•
•
•
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Publication |
First Author: |
Lo YH |
Year: |
2017 |
Journal: |
Gastroenterology |
Title: |
SPDEF Induces Quiescence of Colorectal Cancer Cells by Changing the Transcriptional Targets of β-catenin. |
Volume: |
153 |
Issue: |
1 |
Pages: |
205-218.e8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom |
Year: |
2023 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2001 |
|
Title: |
RIKEN Data Curation in Mouse Genome Informatics |
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•
•
•
•
•
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Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute |
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•
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•
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Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
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•
•
•
•
•
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Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
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|
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
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•
•
•
•
•
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Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
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•
•
•
•
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Publication |
First Author: |
The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY) |
Year: |
2005 |
Journal: |
Database Download |
Title: |
MGI download of GENSAT transgene data |
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Publication |
First Author: |
Huttlin EL |
Year: |
2010 |
Journal: |
Cell |
Title: |
A tissue-specific atlas of mouse protein phosphorylation and expression. |
Volume: |
143 |
Issue: |
7 |
Pages: |
1174-89 |
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•
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Publication |
First Author: |
Church DM |
Year: |
2009 |
Journal: |
PLoS Biol |
Title: |
Lineage-specific biology revealed by a finished genome assembly of the mouse. |
Volume: |
7 |
Issue: |
5 |
Pages: |
e1000112 |
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