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Search results 3601 to 3700 out of 4209 for C3

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Type Details Score
Publication
12456587 | J:80832
First Author: Bagavant H
Year: 2002
Journal: Int Immunol
Title: Differential effect of neonatal thymectomy on systemic and organ-specific autoimmune disease.
Volume: 14
Issue: 12
Pages: 1397-406
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Publication
12925675 | J:85057
First Author: Rossbacher J
Year: 2003
Journal: J Exp Med
Title: The B cell receptor itself can activate complement to provide the complement receptor 1/2 ligand required to enhance B cell immune responses in vivo.
Volume: 198
Issue: 4
Pages: 591-602
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Publication
14681219 | J:89016
First Author: Weernink PA
Year: 2004
Journal: J Biol Chem
Title: Activation of type I phosphatidylinositol 4-phosphate 5-kinase isoforms by the Rho GTPases, RhoA, Rac1, and Cdc42.
Volume: 279
Issue: 9
Pages: 7840-9
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Publication
10644975 | J:94545
First Author: Cleverley SC
Year: 2000
Journal: Oncogene
Title: Loss of Rho function in the thymus is accompanied by the development of thymic lymphoma.
Volume: 19
Issue: 1
Pages: 13-20
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Publication
15923637 | J:99173
First Author: Marler KJ
Year: 2005
Journal: Mol Cell Biol
Title: Outgrowth of neurites from NIE-115 neuroblastoma cells is prevented on repulsive substrates through the action of PAK.
Volume: 25
Issue: 12
Pages: 5226-41
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Publication
15845872 | J:101245
First Author: He H
Year: 2005
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Glycine-extended gastrin stimulates cell proliferation and migration through a Rho- and ROCK-dependent pathway, not a Rac/Cdc42-dependent pathway.
Volume: 289
Issue: 3
Pages: G478-88
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Publication
16638805 | J:108925
First Author: Tomas A
Year: 2006
Journal: J Cell Sci
Title: Regulation of pancreatic beta-cell insulin secretion by actin cytoskeleton remodelling: role of gelsolin and cooperation with the MAPK signalling pathway.
Volume: 119
Issue: Pt 10
Pages: 2156-67
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Publication
16705022 | J:109420
First Author: de Buhr MF
Year: 2006
Journal: Physiol Genomics
Title: Cd14, Gbp1, and Pla2g2a: three major candidate genes for experimental IBD identified by combining QTL and microarray analyses.
Volume: 25
Issue: 3
Pages: 426-34
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Publication
12730217 | J:120700
First Author: Chellaiah MA
Year: 2003
Journal: J Biol Chem
Title: Rho-dependent Rho kinase activation increases CD44 surface expression and bone resorption in osteoclasts.
Volume: 278
Issue: 31
Pages: 29086-97
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Publication
1336441 | J:4297
First Author: Nakamura T
Year: 1992
Journal: Clin Sci (Lond)
Title: Glucocorticoid ameliorates altered gene expression of extracellular matrix components in kidneys of New Zealand black/white F1 mice.
Volume: 83
Issue: 6
Pages: 701-9
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Publication
16751412 | J:132351
First Author: Harokopakis E
Year: 2006
Journal: J Immunol
Title: TLR2 transmodulates monocyte adhesion and transmigration via Rac1- and PI3K-mediated inside-out signaling in response to Porphyromonas gingivalis fimbriae.
Volume: 176
Issue: 12
Pages: 7645-56
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Publication
18515569 | J:141802
First Author: Inomata Y
Year: 2008
Journal: Invest Ophthalmol Vis Sci
Title: Suppression of choroidal neovascularization by thioredoxin-1 via interaction with complement factor H.
Volume: 49
Issue: 11
Pages: 5118-25
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Publication
17715065 | J:145244
First Author: Arumugam TV
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Intravenous immunoglobulin (IVIG) protects the brain against experimental stroke by preventing complement-mediated neuronal cell death.
Volume: 104
Issue: 35
Pages: 14104-9
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Publication
19286565 | J:147055
First Author: Babbin BA
Year: 2009
Journal: Am J Pathol
Title: The bacterial virulence factor lymphostatin compromises intestinal epithelial barrier function by modulating rho GTPases.
Volume: 174
Issue: 4
Pages: 1347-57
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Publication
17548650 | J:148576
First Author: McPhillips K
Year: 2007
Journal: J Immunol
Title: TNF-alpha inhibits macrophage clearance of apoptotic cells via cytosolic phospholipase A2 and oxidant-dependent mechanisms.
Volume: 178
Issue: 12
Pages: 8117-26
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Publication
19106222 | J:151813
First Author: Hammar E
Year: 2009
Journal: Endocrinology
Title: Role of the Rho-ROCK (Rho-associated kinase) signaling pathway in the regulation of pancreatic beta-cell function.
Volume: 150
Issue: 5
Pages: 2072-9
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Publication
19864026 | J:155346
First Author: Gancz D
Year: 2009
Journal: Mol Immunol
Title: Involvement of the c-jun N-terminal kinases JNK1 and JNK2 in complement-mediated cell death.
Volume: 47
Issue: 2-3
Pages: 310-7
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Publication
19853600 | J:156837
First Author: Vallon M
Year: 2010
Journal: Exp Cell Res
Title: Tumor endothelial marker 5 expression in endothelial cells during capillary morphogenesis is induced by the small GTPase Rac and mediates contact inhibition of cell proliferation.
Volume: 316
Issue: 3
Pages: 412-21
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Publication
20233577 | J:159229
First Author: Ando S
Year: 2010
Journal: Biochem Biophys Res Commun
Title: FTY720 exerts a survival advantage through the prevention of end-stage glomerular inflammation in lupus-prone BXSB mice.
Volume: 394
Issue: 3
Pages: 804-10
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Publication
20977478 | J:167363
First Author: Maekawa M
Year: 2010
Journal: J Neurochem
Title: Analysis of strain-dependent prepulse inhibition points to a role for Shmt1 (SHMT1) in mice and in schizophrenia.
Volume: 115
Issue: 6
Pages: 1374-85
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Publication
20974943 | J:167377
First Author: Wu X
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Properdin homeostasis requires turnover of the alternative complement pathway.
Volume: 107
Issue: 45
Pages: 19444-8
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Publication
31515267 | J:283066
First Author: Civciristov S
Year: 2019
Journal: J Biol Chem
Title: Ligand-dependent spatiotemporal signaling profiles of the μ-opioid receptor are controlled by distinct protein-interaction networks.
Volume: 294
Issue: 44
Pages: 16198-16213
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Publication
21447825 | J:173260
First Author: Ståhl AL
Year: 2011
Journal: Blood
Title: Complement activation on platelet-leukocyte complexes and microparticles in enterohemorrhagic Escherichia coli-induced hemolytic uremic syndrome.
Volume: 117
Issue: 20
Pages: 5503-13
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Publication
22000720 | J:177500
First Author: Sekine H
Year: 2011
Journal: Mol Immunol
Title: The dual role of complement in the progression of renal disease in NZB/W F(1) mice and alternative pathway inhibition.
Volume: 49
Issue: 1-2
Pages: 317-23
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Publication
22038518 | J:181667
First Author: Osanai T
Year: 2012
Journal: Diabetologia
Title: Coupling factor 6-induced activation of ecto-F1F(o) complex induces insulin resistance, mild glucose intolerance and elevated blood pressure in mice.
Volume: 55
Issue: 2
Pages: 520-9
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Publication
22442351 | J:186733
First Author: Elvington M
Year: 2012
Journal: Blood
Title: A targeted complement-dependent strategy to improve the outcome of mAb therapy, and characterization in a murine model of metastatic cancer.
Volume: 119
Issue: 25
Pages: 6043-51
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Publication
22689817 | J:186993
First Author: Harris JV
Year: 2012
Journal: Infect Immun
Title: Sequential Plasmodium chabaudi and Plasmodium berghei infections provide a novel model of severe malarial anemia.
Volume: 80
Issue: 9
Pages: 2997-3007
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Publication
24019458 | J:201149
First Author: Lee E
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Inhibition of androgen receptor and β-catenin activity in prostate cancer.
Volume: 110
Issue: 39
Pages: 15710-5
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Publication
27297552 | J:236803
First Author: Wang Y
Year: 2016
Journal: Cancer Discov
Title: Autocrine Complement Inhibits IL10-Dependent T-cell-Mediated Antitumor Immunity to Promote Tumor Progression.
Volume: 6
Issue: 9
Pages: 1022-35
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Publication
28222172 | J:245704
First Author: Wang F
Year: 2017
Journal: PLoS One
Title: RhoA promotes epidermal stem cell proliferation via PKN1-cyclin D1 signaling.
Volume: 12
Issue: 2
Pages: e0172613
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Publication
28839129 | J:253476
First Author: Lohman RJ
Year: 2017
Journal: Nat Commun
Title: Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a.
Volume: 8
Issue: 1
Pages: 351
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Publication
29158418 | J:253407
First Author: Huang W
Year: 2018
Journal: J Immunol
Title: A Novel Pkhd1 Mutation Interacts with the Nonobese Diabetic Genetic Background To Cause Autoimmune Cholangitis.
Volume: 200
Issue: 1
Pages: 147-162
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Publication
26393521 | J:255027
First Author: Huang L
Year: 2015
Journal: PLoS One
Title: Severe Nephrotoxic Nephritis following Conditional and Kidney-Specific Knockdown of Stanniocalcin-1.
Volume: 10
Issue: 9
Pages: e0138440
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Publication
29579399 | J:280643
First Author: Wang L
Year: 2018
Journal: FASEB J
Title: GSK3-activated STAT5 regulates expression of SFRPs to modulate adipogenesis.
Volume: 32
Issue: 9
Pages: 4714-4726
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Publication
31518371 | J:279443
First Author: Lee J
Year: 2019
Journal: PLoS One
Title: Irisin promotes C2C12 myoblast proliferation via ERK-dependent CCL7 upregulation.
Volume: 14
Issue: 9
Pages: e0222559
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Publication
16302095 | J:281134
First Author: Kurihara RS
Year: 2005
Journal: Braz J Med Biol Res
Title: Genetic potential for an acute inflammatory response in IgA glomerulonephritis in mice.
Volume: 38
Issue: 12
Pages: 1807-15
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Publication
32238460 | J:288494
First Author: Skopelja-Gardner S
Year: 2020
Journal: J Immunol
Title: Complement Deficiencies Result in Surrogate Pathways of Complement Activation in Novel Polygenic Lupus-like Models of Kidney Injury.
Volume: 204
Issue: 10
Pages: 2627-2640
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Publication
31200339 | J:289263
 
First Author: Li Y
Year: 2019
Journal: Int Immunopharmacol
Title: Interleukin-25 is upregulated in patients with systemic lupus erythematosus and ameliorates murine lupus by inhibiting inflammatory cytokine production.
Volume: 74
Pages: 105680
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Publication
32657463 | J:293897
First Author: Scott-Hewitt N
Year: 2020
Journal: EMBO J
Title: Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia.
Volume: 39
Issue: 16
Pages: e105380
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Publication
32079227 | J:304892
 
First Author: Hong J
Year: 2020
Journal: Int J Mol Sci
Title: The Rho/Rac Guanine Nucleotide Exchange Factor Vav1 Regulates Hif-1α and Glut-1 Expression and Glucose Uptake in the Brain.
Volume: 21
Issue: 4
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Publication
32737331 | J:299914
First Author: Asega AF
Year: 2020
Journal: Sci Rep
Title: Cleavage of proteoglycans, plasma proteins and the platelet-derived growth factor receptor in the hemorrhagic process induced by snake venom metalloproteinases.
Volume: 10
Issue: 1
Pages: 12912
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Publication
32769120 | J:301513
First Author: Zarantonello A
Year: 2020
Journal: J Immunol
Title: An Ultrahigh-Affinity Complement C4b-Specific Nanobody Inhibits In Vivo Assembly of the Classical Pathway Proconvertase.
Volume: 205
Issue: 6
Pages: 1678-1694
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Publication
33187113 | J:303513
 
First Author: Jabri Y
Year: 2020
Journal: Int J Mol Sci
Title: Cell-Type-Specific Complement Profiling in the ABCA4-/- Mouse Model of Stargardt Disease.
Volume: 21
Issue: 22
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Publication
33603169 | J:303966
First Author: Turgu B
Year: 2021
Journal: Oncogene
Title: HACE1 blocks HIF1α accumulation under hypoxia in a RAC1 dependent manner.
Volume: 40
Issue: 11
Pages: 1988-2001
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Publication
33753502 | J:304473
 
First Author: Malik TH
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Gain-of-function factor H-related 5 protein impairs glomerular complement regulation resulting in kidney damage.
Volume: 118
Issue: 13
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Publication
32754267 | J:306845
First Author: Ding P
Year: 2020
Journal: Theranostics
Title: C5aR1 is a master regulator in Colorectal Tumorigenesis via Immune modulation.
Volume: 10
Issue: 19
Pages: 8619-8632
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Publication
11247969 | J:308410
First Author: Tankersley CG
Year: 2001
Journal: J Appl Physiol (1985)
Title: Selected contribution: variation in acute hypoxic ventilatory response is linked to mouse chromosome 9.
Volume: 90
Issue: 4
Pages: 1615-22; discussion 1606
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Publication
33838249 | J:308770
 
First Author: Chen MM
Year: 2021
Journal: Brain Behav Immun
Title: Astrocytic Kir6.1 deletion aggravates neurodegeneration in the lipopolysaccharide-induced mouse model of Parkinson's disease via astrocyte-neuron cross talk through complement C3-C3R signaling.
Volume: 95
Pages: 310-320
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Publication
28670268 | J:310898
 
First Author: Gorelik A
Year: 2017
Journal: Front Cell Neurosci
Title: Serping1/C1 Inhibitor Affects Cortical Development in a Cell Autonomous and Non-cell Autonomous Manner.
Volume: 11
Pages: 169
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Publication
35003083 | J:317696
 
First Author: Yi YS
Year: 2021
Journal: Front Immunol
Title: Syk-MyD88 Axis Is a Critical Determinant of Inflammatory-Response in Activated Macrophages.
Volume: 12
Pages: 767366
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Publication
26719095 | J:318310
First Author: Yamanaka T
Year: 2016
Journal: Immunobiology
Title: Release from Th1-type immune tolerance in spleen and enhanced production of IL-5 in Peyer's patch by cholera toxin B induce the glomerular deposition of IgA.
Volume: 221
Issue: 4
Pages: 577-85
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Publication
35105928 | J:319757
First Author: Choi YJ
Year: 2022
Journal: Sci Rep
Title: Promotion of the inflammatory response in mid colon of complement component 3 knockout mice.
Volume: 12
Issue: 1
Pages: 1700
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Publication
19302245 | J:320300
First Author: Gullstrand B
Year: 2009
Journal: Clin Exp Immunol
Title: Complement classical pathway components are all important in clearance of apoptotic and secondary necrotic cells.
Volume: 156
Issue: 2
Pages: 303-11
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Publication
26468229 | J:345387
First Author: Block H
Year: 2016
Journal: Blood
Title: Gnb isoforms control a signaling pathway comprising Rac1, Plcβ2, and Plcβ3 leading to LFA-1 activation and neutrophil arrest in vivo.
Volume: 127
Issue: 3
Pages: 314-24
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Publication
36185485 | J:330873
 
First Author: Peng W
Year: 2022
Journal: Front Aging Neurosci
Title: Spatiotemporal patterns of gliosis and neuroinflammation in presenilin 1/2 conditional double knockout mice.
Volume: 14
Pages: 966153
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Publication
36211424 | J:330052
 
First Author: Shende R
Year: 2022
Journal: Front Immunol
Title: Protective role of host complement system in Aspergillus fumigatus infection.
Volume: 13
Pages: 978152
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Publication
36250347 | J:330264
First Author: Chau DD
Year: 2022
Journal: FASEB J
Title: Insulin stimulates atypical protein kinase C-mediated phosphorylation of the neuronal adaptor FE65 to potentiate neurite outgrowth by activating ARF6-Rac1 signaling.
Volume: 36
Issue: 11
Pages: e22594
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Publication
34479967 | J:344793
First Author: Li H
Year: 2021
Journal: J Am Soc Nephrol
Title: MicroRNA-23b-3p Deletion Induces an IgA Nephropathy-like Disease Associated with Dysregulated Mucosal IgA Synthesis.
Volume: 32
Issue: 10
Pages: 2561-2578
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Publication
37846480 | J:343275
First Author: Turgu B
Year: 2023
Journal: EMBO Rep
Title: The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes.
Volume: 24
Issue: 12
Pages: e56815
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Publication
38117903 | J:344390
First Author: Wang J
Year: 2023
Journal: Sci Transl Med
Title: Liver macrophages and sinusoidal endothelial cells execute vaccine-elicited capture of invasive bacteria.
Volume: 15
Issue: 727
Pages: eade0054
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Publication
- | J:4766
 
First Author: Amorim A
Year: 1984
Journal: Cytogenet Cell Genet
Title: Linkage studies on the ALADH polymorphism (Abstracts of meeting presentations: Human gene mapping 7, Los Angeles Conference (1983) Seventh International Workshop on Human Gene Mapping)
Volume: 37 (1-4)
Pages: 400 (Abstr.) (399-616)
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Protein
F6WZA2
Organism: Mus musculus/domesticus
Length: 81  
Fragment?: true
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Publication
9683576 | -
First Author: Thole V
Year: 1998
Journal: Virology
Title: Rice tungro spherical virus polyprotein processing: identification of a virus-encoded protease and mutational analysis of putative cleavage sites.
Volume: 247
Issue: 1
Pages: 106-14
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Publication
15503215 | -
First Author: Sekiguchi H
Year: 2005
Journal: Arch Virol
Title: 3C-like protease encoded by Rice tungro spherical virus is autocatalytically processed.
Volume: 150
Issue: 3
Pages: 595-601
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Protein Domain
IPR024387 | Pept_C3G_Picornavir
Type: Domain
Description: Viruses in the order Picornavirales infect different vertebrate, invertebrate, and plant hosts and are responsible for a variety of human, animal, and plant diseases. These viruses have a single-stranded, positive sense RNA genome that generally translates a large precursor polyprotein which is proteolytically cleaved after translation to generate mature functional viral proteins. This process is usually mediated by (more than one) proteases, and a 3C (for the family Picornaviridae) or 3C-like (3CL) protease (for other families) plays a central role in the cleavage of the viral precursor polyprotein. In addition to this key role, 3C/3C-like protease is able to cleave a number of host proteins to remodel the cellular environment for virus reproduction [, , , , , ]. The Picornavirales 3C/3C-like protease domain forms the MEROPS peptidase family C3 (picornain family) of clan PA.The 3C/3CL protease domain adopts a chymotrypsin-like fold with a cysteine nucleophile in place of a commonly found serine which suggests that the cysteine and serine perform an analogous catalytic function. The catalytic triad is made of a histidine, an aspartate/glutamate and the conserved cysteine in this sequential order. The 3C/3CL protease domain folds into two antiparallel beta barrels that are linked by a loop with a short α-helix in its middle, and flanked by two other α-helices at the N- and C-terminal. The two barrels are topologically equivalent and are formed by six antiparallel beta strands with the first four organised into a Greek key motif. The active-site residues are located in the cleft between the two barrels with the nucleophilic Cys from the C-terminal barrel and the general acid base His-Glu/Asp from the N-terminal barrel [, , ].This entry represents a rice tungro spherical waikavirus-type peptidase that belongs to MEROPS peptidase family C3G. It is a picornain 3C-type protease, and is responsible for the self-cleavage of the positive single-stranded polyproteins of a number of plant viral genomes. The location of the protease activity of the polyprotein is at the C-terminal end, adjacent and N-terminal to the putative RNA polymerase [, ].
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Protein Domain
IPR002801 | Asp_carbamoylTrfase_reg
Type: Family
Description: Aspartate carbamoyltransferase (aspartate transcarbamylase, ATCase) is an allosteric enzyme that plays a central role in the regulation of the pyrimidine pathway in bacteria. The holoenzyme is a dodecamer composed of six catalytic chains, each with an active site, and six regulatory chains lacking catalytic activity []. The catalytic subunits exist as a dimer of catalytic trimers, (c3)2, while the regulatory subunits exist as a trimer of regulatory dimers, (r2)3, therefore the complete holoenzyme can be represented as (c3)2(r2)3. The association of the catalytic subunits c3 with the regulatory subunits r2 is responsible for the establishment of positive co-operativity between catalytic sites for the binding of aspartate and it dictates the pattern of allosteric response toward nucleotide effectors. ATCase from Escherichia coli is the most extensively studied allosteric enzyme []. The crystal structure of the T-state, the T-state with CTP bound, the R-state with N-phosphonacetyl-L-aspartate (PALA) bound, and the R-state with phosphonoacetamide plus malonate bound have been used in interpreting kinetic and mutational studies.A high-resolution structure of E. coli ATCase in the presence of PALA (a bisubstrate analog) allows a detailed description of the binding at the active site of the enzyme and allows a detailed model of the tetrahedral intermediate to be constructed. The entire regulatory chain has been traced showing that the N-terminal regions of the regulatory chains R1 and R6 are located in close proximity to each other and to the regulatory site. This portion of the molecule may be involved in the observed asymmetry between the regulatory binding sites as well as in the heterotropic response of the enzyme []. The C-terminal domain of the regulatory chains have a rubredoxin-like zinc-bound fold. ATCase from Enterobacter agglomerans (Erwinia herbicola) (Pantoea agglomerans) differs from the other investigated enterobacterial ATCases by its absence of homotropic co-operativity toward the substrate aspartate and its lack of response to ATP which is an allosteric effector (activator) of this family of enzymes. Nevertheless, the E. herbicola ATCase has the same quaternary structure, two trimers of catalytic chains with three dimers of regulatory chains, (c3)2(r2)3, as other enterobacterial ATCases and shows extensive primary structure conservation [].
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Protein Domain
IPR036793 | Asp_carbatrfase_reg_N_sf
Type: Homologous_superfamily
Description: Aspartate carbamoyltransferase (aspartate transcarbamylase, ATCase) is an allosteric enzyme that plays a central role in the regulation of the pyrimidine pathway in bacteria. The holoenzyme is a dodecamer composed of six catalytic chains, each with an active site, and six regulatory chains lacking catalytic activity []. The catalytic subunits exist as a dimer of catalytic trimers, (c3)2, while the regulatory subunits exist as a trimer of regulatory dimers, (r2)3, therefore the complete holoenzyme can be represented as (c3)2(r2)3. The association of the catalytic subunits c3 with the regulatory subunits r2 is responsible for the establishment of positive co-operativity between catalytic sites for the binding of aspartate and it dictates the pattern of allosteric response toward nucleotide effectors. ATCase from Escherichia coli is the most extensively studied allosteric enzyme []. The crystal structure of the T-state, the T-state with CTP bound, the R-state with N-phosphonacetyl-L-aspartate (PALA) bound, and the R-state with phosphonoacetamide plus malonate bound have been used in interpreting kinetic and mutational studies.A high-resolution structure of E. coli ATCase in the presence of PALA (a bisubstrate analog) allows a detailed description of the binding at the active site of the enzyme and allows a detailed model of the tetrahedral intermediate to be constructed. The entire regulatory chain has been traced showing that the N-terminal regions of the regulatory chains R1 and R6 are located in close proximity to each other and to the regulatory site. This portion of the molecule may be involved in the observed asymmetry between the regulatory binding sites as well as in the heterotropic response of the enzyme []. The C-terminal domain of the regulatory chains have a rubredoxin-like zinc-bound fold. ATCase from Enterobacter agglomerans (Erwinia herbicola) (Pantoea agglomerans) differs from the other investigated enterobacterial ATCases by its absence of homotropic co-operativity toward the substrate aspartate and its lack of response to ATP which is an allosteric effector (activator) of this family of enzymes. Nevertheless, the E. herbicola ATCase has the same quaternary structure, two trimers of catalytic chains with three dimers of regulatory chains, (c3)2(r2)3, as other enterobacterial ATCases and shows extensive primary structure conservation []. This entry represents the N-terminal domain superfamily. Structurally, this domain has a ferredoxin-like fold, which consists of an alpha+beta sandwich with antiparallel β-sheet.
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Protein Domain
IPR036792 | Asp_carbatrfase_reg_C_sf
Type: Homologous_superfamily
Description: Aspartate carbamoyltransferase (aspartate transcarbamylase, ATCase) is an allosteric enzyme that plays a central role in the regulation of the pyrimidine pathway in bacteria. The holoenzyme is a dodecamer composed of six catalytic chains, each with an active site, and six regulatory chains lacking catalytic activity []. The catalytic subunits exist as a dimer of catalytic trimers, (c3)2, while the regulatory subunits exist as a trimer of regulatory dimers, (r2)3, therefore the complete holoenzyme can be represented as (c3)2(r2)3. The association of the catalytic subunits c3 with the regulatory subunits r2 is responsible for the establishment of positive co-operativity between catalytic sites for the binding of aspartate and it dictates the pattern of allosteric response toward nucleotide effectors. ATCase from Escherichia coli is the most extensively studied allosteric enzyme []. The crystal structure of the T-state, the T-state with CTP bound, the R-state with N-phosphonacetyl-L-aspartate (PALA) bound, and the R-state with phosphonoacetamide plus malonate bound have been used in interpreting kinetic and mutational studies.A high-resolution structure of E. coli ATCase in the presence of PALA (a bisubstrate analog) allows a detailed description of the binding at the active site of the enzyme and allows a detailed model of the tetrahedral intermediate to be constructed. The entire regulatory chain has been traced showing that the N-terminal regions of the regulatory chains R1 and R6 are located in close proximity to each other and to the regulatory site. This portion of the molecule may be involved in the observed asymmetry between the regulatory binding sites as well as in the heterotropic response of the enzyme []. The C-terminal domain of the regulatory chains have a rubredoxin-like zinc-bound fold. ATCase from Enterobacter agglomerans (Erwinia herbicola) (Pantoea agglomerans) differs from the other investigated enterobacterial ATCases by its absence of homotropic co-operativity toward the substrate aspartate and its lack of response to ATP which is an allosteric effector (activator) of this family of enzymes. Nevertheless, the E. herbicola ATCase has the same quaternary structure, two trimers of catalytic chains with three dimers of regulatory chains, (c3)2(r2)3, as other enterobacterial ATCases and shows extensive primary structure conservation []. This entry represents the C-terminal domain superfamily.
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Protein Domain
IPR020542 | Asp_carbamoyltrfase_reg_C
Type: Domain
Description: Aspartate carbamoyltransferase (aspartate transcarbamylase, ATCase) is an allosteric enzyme that plays a central role in the regulation of the pyrimidine pathway in bacteria. The holoenzyme is a dodecamer composed of six catalytic chains, each with an active site, and six regulatory chains lacking catalytic activity []. The catalytic subunits exist as a dimer of catalytic trimers, (c3)2, while the regulatory subunits exist as a trimer of regulatory dimers, (r2)3, therefore the complete holoenzyme can be represented as (c3)2(r2)3. The association of the catalytic subunits c3 with the regulatory subunits r2 is responsible for the establishment of positive co-operativity between catalytic sites for the binding of aspartate and it dictates the pattern of allosteric response toward nucleotide effectors. ATCase from Escherichia coli is the most extensively studied allosteric enzyme []. The crystal structure of the T-state, the T-state with CTP bound, the R-state with N-phosphonacetyl-L-aspartate (PALA) bound, and the R-state with phosphonoacetamide plus malonate bound have been used in interpreting kinetic and mutational studies.A high-resolution structure of E. coli ATCase in the presence of PALA (a bisubstrate analog) allows a detailed description of the binding at the active site of the enzyme and allows a detailed model of the tetrahedral intermediate to be constructed. The entire regulatory chain has been traced showing that the N-terminal regions of the regulatory chains R1 and R6 are located in close proximity to each other and to the regulatory site. This portion of the molecule may be involved in the observed asymmetry between the regulatory binding sites as well as in the heterotropic response of the enzyme []. The C-terminal domain of the regulatory chains have a rubredoxin-like zinc-bound fold. ATCase from Enterobacter agglomerans (Erwinia herbicola) (Pantoea agglomerans) differs from the other investigated enterobacterial ATCases by its absence of homotropic co-operativity toward the substrate aspartate and its lack of response to ATP which is an allosteric effector (activator) of this family of enzymes. Nevertheless, the E. herbicola ATCase has the same quaternary structure, two trimers of catalytic chains with three dimers of regulatory chains, (c3)2(r2)3, as other enterobacterial ATCases and shows extensive primary structure conservation []. This entry represents the C-terminal domain.
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Protein Domain
IPR020545 | Asp_carbamoyltransf_reg_N
Type: Domain
Description: Aspartate carbamoyltransferase (aspartate transcarbamylase, ATCase) is an allosteric enzyme that plays a central role in the regulation of the pyrimidine pathway in bacteria. The holoenzyme is a dodecamer composed of six catalytic chains, each with an active site, and six regulatory chains lacking catalytic activity []. The catalytic subunits exist as a dimer of catalytic trimers, (c3)2, while the regulatory subunits exist as a trimer of regulatory dimers, (r2)3, therefore the complete holoenzyme can be represented as (c3)2(r2)3. The association of the catalytic subunits c3 with the regulatory subunits r2 is responsible for the establishment of positive co-operativity between catalytic sites for the binding of aspartate and it dictates the pattern of allosteric response toward nucleotide effectors. ATCase from Escherichia coli is the most extensively studied allosteric enzyme []. The crystal structure of the T-state, the T-state with CTP bound, the R-state with N-phosphonacetyl-L-aspartate (PALA) bound, and the R-state with phosphonoacetamide plus malonate bound have been used in interpreting kinetic and mutational studies.A high-resolution structure of E. coli ATCase in the presence of PALA (a bisubstrate analog) allows a detailed description of the binding at the active site of the enzyme and allows a detailed model of the tetrahedral intermediate to be constructed. The entire regulatory chain has been traced showing that the N-terminal regions of the regulatory chains R1 and R6 are located in close proximity to each other and to the regulatory site. This portion of the molecule may be involved in the observed asymmetry between the regulatory binding sites as well as in the heterotropic response of the enzyme []. The C-terminal domain of the regulatory chains have a rubredoxin-like zinc-bound fold. ATCase from Enterobacter agglomerans (Erwinia herbicola) (Pantoea agglomerans) differs from the other investigated enterobacterial ATCases by its absence of homotropic co-operativity toward the substrate aspartate and its lack of response to ATP which is an allosteric effector (activator) of this family of enzymes. Nevertheless, the E. herbicola ATCase has the same quaternary structure, two trimers of catalytic chains with three dimers of regulatory chains, (c3)2(r2)3, as other enterobacterial ATCases and shows extensive primary structure conservation [].
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Protein Domain
IPR001821 | NiFe_hydrogenase_ssu
Type: Family
Description: Hydrogenases catalyse the reversible oxidation of molecular hydrogen and play a vital role in anaerobic metabolism. Metal-containing hydrogenases are subdivided into three classes: Fe ('iron only') hydrogenases; Ni-Fe hydrogenases; and Ni-Fe-Se hydrogenases []. Hydrogen oxidation is coupled to the reduction of electron acceptors (such as oxygen, nitrate, sulphate, carbon dioxide and fumarate), whereas proton reduction (hydrogen evolution) is essential in pyruvate fermentation or in the disposal of excess electrons.The Ni-Fe hydrogenases,when isolated, are found to catalyse both hydrogen evolution and uptake, with low-potential multihaem cytochromes, such as cytochrome c3, acting as either electron donors or acceptors, depending on their oxidation state. Both periplasmic (soluble) and membrane-bound hydrogenases are known.The Ni-Fe hydrogenases are heterodimeric proteins consisting of small (S) and large (L) subunits. The small subunit contains three iron-sulphur clusters (two [4Fe-4S]and one [3Fe-4S]); the large subunit contains a nickel ion []. Small subunits of membrane-bound Ni-Fe hydrogenases contain a C-terminal domain of about 40 residues that is absent in periplasmic forms.The 3D structure of the Ni-Fe hydrogenase from Desulfovibrio gigas has been determined at 2.85A resolution []. The small subunit consists of two domains, I(S) and II(S). The alpha/beta twisted open sheet structure of the N-terminal I(S) domain is similar to that of flavodoxin; the C-terminal II(S) domain contains two α-helices and has no β-structure. The Fe-S clusters are distributed almost along a straight line, with the [3Fe-4S]cluster located half-way between the two [4Fe-4S]clusters. The two [4Fe-4S]clusters have been termed proximal (prox) and distal (dist), based on their distance to the Ni atom. Domain I(S) binds the [4Fe-4S]prox cluster, while domain II(S) binds the [4Fe-4S]dist and [3Fe-4S]clusters. The [4Fe-4S]prox cluster is coordinated by Cys-17, Cys-20, Cys-112 and Cys-148; [4Fe-4S]dist is coordinated by His-185, Cys-188, Cys-213 and Cys-219; and [3Fe-4S]is coordinated by Cys-228, Cys-246 and Cys-249 [4Fe-4S]dist is the first known example of a [4Fe-4S]cluster in protein structure ligated by a His side chain. A crown of acidic residues surrounds the partially-exposed His-185 and this might provide a recognition site for the redox partner (cytochrome c3) []. A mechanism of electron transfer from the Ni active site through the Fe-S clusters to the cytochrome c3 has been suggested []. The role of the [3Fe-4S]cluster is not clear: its high redox potential and its absence from some homologous hydrogenases put its involvement in electron transfer in doubt [].
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Publication
28489004 | J:259186
   
First Author: Heng X
Year: 2017
Journal: Elife
Title: Analogous mechanism regulating formation of neocortical basal radial glia and cerebellar Bergmann glia.
Volume: 6
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Publication
21846369 | J:216041
First Author: Zhu M
Year: 2011
Journal: Genome Biol
Title: Integrated miRNA and mRNA expression profiling of mouse mammary tumor models identifies miRNA signatures associated with mammary tumor lineage.
Volume: 12
Issue: 8
Pages: R77
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Publication
31704972 | J:336875
First Author: Nie L
Year: 2019
Journal: Nat Commun
Title: CDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer.
Volume: 10
Issue: 1
Pages: 5114
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Publication
25908435 | J:222799
 
First Author: Pathania R
Year: 2015
Journal: Nat Commun
Title: DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis.
Volume: 6
Pages: 6910
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Publication
16216087 | J:103689
First Author: Shimshek DR
Year: 2005
Journal: PLoS Biol
Title: Enhanced odor discrimination and impaired olfactory memory by spatially controlled switch of AMPA receptors.
Volume: 3
Issue: 11
Pages: e354
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Publication
30655318 | J:272408
First Author: Vaidya M
Year: 2019
Journal: J Lipid Res
Title: Regulation of ABCA1-mediated cholesterol efflux by sphingosine-1-phosphate signaling in macrophages.
Volume: 60
Issue: 3
Pages: 506-515
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Publication
18305483 | J:133917
First Author: Niessen F
Year: 2008
Journal: Nature
Title: Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation.
Volume: 452
Issue: 7187
Pages: 654-8
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Publication
11431570 | J:76021
First Author: Mack V
Year: 2001
Journal: Science
Title: Conditional restoration of hippocampal synaptic potentiation in Glur-A-deficient mice.
Volume: 292
Issue: 5526
Pages: 2501-4
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Publication
31485072 | J:283275
First Author: Padmanaban V
Year: 2019
Journal: Nature
Title: E-cadherin is required for metastasis in multiple models of breast cancer.
Volume: 573
Issue: 7774
Pages: 439-444
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Publication
18242514 | J:131913
First Author: Kouros-Mehr H
Year: 2008
Journal: Cancer Cell
Title: GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model.
Volume: 13
Issue: 2
Pages: 141-52
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Publication
24332913 | J:205494
First Author: Cheung KJ
Year: 2013
Journal: Cell
Title: Collective invasion in breast cancer requires a conserved basal epithelial program.
Volume: 155
Issue: 7
Pages: 1639-51
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Publication
9175875 | J:87415
First Author: Okabe M
Year: 1997
Journal: FEBS Lett
Title: 'Green mice' as a source of ubiquitous green cells.
Volume: 407
Issue: 3
Pages: 313-9
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Publication
31073169 | J:279844
First Author: Takagaki S
Year: 2019
Journal: Sci Rep
Title: Galactosyl carbohydrate residues on hematopoietic stem/progenitor cells are essential for homing and engraftment to the bone marrow.
Volume: 9
Issue: 1
Pages: 7133
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Publication
25263123 | J:259350
First Author: Levine AG
Year: 2014
Journal: Nat Immunol
Title: Continuous requirement for the TCR in regulatory T cell function.
Volume: 15
Issue: 11
Pages: 1070-8
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Publication
36604170 | J:338247
First Author: Steffen DM
Year: 2023
Journal: J Neurosci
Title: A Unique Role for Protocadherin γC3 in Promoting Dendrite Arborization through an Axin1-Dependent Mechanism.
Volume: 43
Issue: 6
Pages: 918-935
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Publication
29316433 | J:253731
First Author: de Mingo Pulido Á
Year: 2018
Journal: Cancer Cell
Title: TIM-3 Regulates CD103+ Dendritic Cell Function and Response to Chemotherapy in Breast Cancer.
Volume: 33
Issue: 1
Pages: 60-74.e6
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Publication
30855280 | J:294427
First Author: McCann JV
Year: 2019
Journal: J Clin Invest
Title: Endothelial miR-30c suppresses tumor growth via inhibition of TGF-β-induced Serpine1.
Volume: 129
Issue: 4
Pages: 1654-1670
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Publication
2472396 | -
First Author: Enghild JJ
Year: 1989
Journal: J Biol Chem
Title: Proteinase binding and inhibition by the monomeric alpha-macroglobulin rat alpha 1-inhibitor-3.
Volume: 264
Issue: 19
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Publication
2469470 | -
First Author: Enghild JJ
Year: 1989
Journal: Biochemistry
Title: A conserved region in alpha-macroglobulins participates in binding to the mammalian alpha-macroglobulin receptor.
Volume: 28
Issue: 3
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Publication
2430968 | -
First Author: Van Leuven F
Year: 1986
Journal: J Biol Chem
Title: Human pregnancy zone protein and alpha 2-macroglobulin. High-affinity binding of complexes to the same receptor on fibroblasts and characterization by monoclonal antibodies.
Volume: 261
Issue: 35
Pages: 16622-5
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Publication
9914899 | -
 
First Author: Dodds AW
Year: 1998
Journal: Immunol Rev
Title: The phylogeny and evolution of the thioester bond-containing proteins C3, C4 and alpha 2-macroglobulin.
Volume: 166
Pages: 15-26
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Publication
10426429 | -
First Author: Armstrong PB
Year: 1999
Journal: Dev Comp Immunol
Title: Alpha2-macroglobulin: an evolutionarily conserved arm of the innate immune system.
Volume: 23
Issue: 4-5
Pages: 375-90
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Strain
MGI:2159755 | C58/J
Attribute String: inbred strain
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Publication
25660970 | J:223833
First Author: Li X
Year: 2015
Journal: Mol Immunol
Title: Extracellular, but not intracellular HMGB1, facilitates self-DNA induced macrophage activation via promoting DNA accumulation in endosomes and contributes to the pathogenesis of lupus nephritis.
Volume: 65
Issue: 1
Pages: 177-88
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Publication
21900451 | J:180032
First Author: Kim JH
Year: 2012
Journal: Am J Physiol Renal Physiol
Title: WT1-interacting protein (Wtip) regulates podocyte phenotype by cell-cell and cell-matrix contact reorganization.
Volume: 302
Issue: 1
Pages: F103-15
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Publication
12855677 | J:85943
First Author: Song MS
Year: 2003
Journal: J Biol Chem
Title: Identification of a mouse short-chain dehydrogenase/reductase gene, retinol dehydrogenase-similar. Function of non-catalytic amino acid residues in enzyme activity.
Volume: 278
Issue: 41
Pages: 40079-87
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Publication
20062804 | J:157242
First Author: Yu S
Year: 2010
Journal: PLoS One
Title: Nrf2 expression is regulated by epigenetic mechanisms in prostate cancer of TRAMP mice.
Volume: 5
Issue: 1
Pages: e8579
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Publication
36691905 | J:334050
First Author: Salarian M
Year: 2023
Journal: Circ Res
Title: Homeostatic, Non-Canonical Role of Macrophage Elastase in Vascular Integrity.
Volume: 132
Issue: 4
Pages: 432-448
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Publication
25816012 | J:246681
First Author: Hewitson JP
Year: 2015
Journal: PLoS Pathog
Title: Concerted activity of IgG1 antibodies and IL-4/IL-25-dependent effector cells trap helminth larvae in the tissues following vaccination with defined secreted antigens, providing sterile immunity to challenge infection.
Volume: 11
Issue: 3
Pages: e1004676
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