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Search results 501 to 600 out of 632 for Mcm2

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Type Details Score
Publication
First Author: Bashford AL
Year: 2022
Journal: Hum Mol Genet
Title: Hippocampals neurogenesis is impaired in mice with a deletion in the coiled coil domain of Talpid3-implications for Joubert syndrome.
Volume: 31
Issue: 19
Pages: 3245-3265
Publication
First Author: Li F
Year: 2015
Journal: Endocrinology
Title: Conditional deletion of Men1 in the pancreatic β-cell leads to glucagon-expressing tumor development.
Volume: 156
Issue: 1
Pages: 48-57
Publication
First Author: Polanetzki V
Year: 2022
Journal: Sci Rep
Title: Role of the Pbrm1 subunit and the PBAF complex in Schwann cell development.
Volume: 12
Issue: 1
Pages: 2651
Publication
First Author: Carracedo S
Year: 2014
Journal: PLoS One
Title: Redundant role of protein kinase C delta and epsilon during mouse embryonic development.
Volume: 9
Issue: 8
Pages: e103686
Publication
First Author: McDonel P
Year: 2012
Journal: Dev Biol
Title: Sin3a is essential for the genome integrity and viability of pluripotent cells.
Volume: 363
Issue: 1
Pages: 62-73
Publication
First Author: Kim TH
Year: 2007
Journal: Dev Cell
Title: Phactr4 regulates neural tube and optic fissure closure by controlling PP1-, Rb-, and E2F1-regulated cell-cycle progression.
Volume: 13
Issue: 1
Pages: 87-102
Publication
First Author: Kueh AJ
Year: 2011
Journal: Mol Cell Biol
Title: HBO1 is required for H3K14 acetylation and normal transcriptional activity during embryonic development.
Volume: 31
Issue: 4
Pages: 845-60
Publication
First Author: Breunig JJ
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling.
Volume: 105
Issue: 35
Pages: 13127-32
Publication
First Author: Parveen N
Year: 2023
Journal: Diabetes
Title: DNA Methylation-Dependent Restriction of Tyrosine Hydroxylase Contributes to Pancreatic β-Cell Heterogeneity.
Volume: 72
Issue: 5
Pages: 575-589
Publication
First Author: Ajioka I
Year: 2006
Journal: Eur J Neurosci
Title: Identification of ventricular-side-enriched molecules regulated in a stage-dependent manner during cerebral cortical development.
Volume: 23
Issue: 2
Pages: 296-308
Publication
First Author: Uchibe K
Year: 2012
Journal: Dev Dyn
Title: Identification of novel transcription-regulating genes expressed during murine molar development.
Volume: 241
Issue: 7
Pages: 1217-26
Publication  
First Author: Akagawa R
Year: 2021
Journal: Front Cell Dev Biol
Title: Alternative Functions of Cell Cycle-Related and DNA Repair Proteins in Post-mitotic Neurons.
Volume: 9
Pages: 753175
Publication
First Author: Machold R
Year: 2011
Journal: Gene Expr Patterns
Title: Genes expressed in Atoh1 neuronal lineages arising from the r1/isthmus rhombic lip.
Volume: 11
Issue: 5-6
Pages: 349-59
Publication
First Author: Campbell GR
Year: 2011
Journal: Mol Cell Neurosci
Title: Transcription factors expressed in olfactory bulb local progenitor cells revealed by genome-wide transcriptome profiling.
Volume: 46
Issue: 2
Pages: 548-61
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Koss M
Year: 2012
Journal: Dev Cell
Title: Congenital asplenia in mice and humans with mutations in a Pbx/Nkx2-5/p15 module.
Volume: 22
Issue: 5
Pages: 913-26
Publication
First Author: Shimizu H
Year: 2013
Journal: PLoS One
Title: The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo.
Volume: 8
Issue: 10
Pages: e75754
Publication
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
Title: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Volume: 17
Issue: 6
Pages: 836-48
Publication  
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
Publication      
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
UniProt Feature
Begin: 2
Description: DNA replication licensing factor MCM2
Type: chain
End: 904
Allele
Name: minichromosome maintenance complex component 2; gene trap AB0178, Wellcome Trust Sanger Institute
Allele Type: Gene trapped
Attribute String: Null/knockout, Reporter
Protein
Organism: Mus musculus/domesticus
Length: 34  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 90  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 418  
Fragment?: false
DO Term
Heritable Phenotypic Marker
Type: heritable_phenotypic_marker
Organism: mouse, laboratory
Publication
First Author: Clément C
Year: 2015
Journal: Nat Struct Mol Biol
Title: MCM2 binding to histones H3-H4 and ASF1 supports a tetramer-to-dimer model for histone inheritance at the replication fork.
Volume: 22
Issue: 8
Pages: 587-9
Publication
First Author: Richet N
Year: 2015
Journal: Nucleic Acids Res
Title: Structural insight into how the human helicase subunit MCM2 may act as a histone chaperone together with ASF1 at the replication fork.
Volume: 43
Issue: 3
Pages: 1905-17
Allele
Name: minichromosome maintenance complex component 2; targeted mutation 1, Steven C Pruitt
Allele Type: Targeted
Attribute String: Inducible, Recombinase
Strain
Attribute String: targeted mutation, mutant strain, coisogenic
Genotype
Symbol: Mcm2/Mcm2
Background: involves: 129S6/SvEvTac
Zygosity: hm
Has Mutant Allele: true
Protein Domain
Type: Domain
Description: This entry represents the AAA-lid domain found in MCM proteins.MCM proteins are DNA-dependent ATPases required for the initiation ofeukaryotic DNA replication [, , ]. In eukaryotes there is a family of six proteins, MCM2 to MCM7. They were first identified in yeast where most of them have adirect role in the initiation of chromosomal DNA replication by interacting directly with autonomously replicating sequences (ARS). They were thus called minichromosome maintenance proteins, MCM proteins [].
Publication
First Author: Fletcher RJ
Year: 2003
Journal: Nat Struct Biol
Title: The structure and function of MCM from archaeal M. Thermoautotrophicum.
Volume: 10
Issue: 3
Pages: 160-7
Protein Domain
Type: Domain
Description: This entry represents the N-terminal region of MCM proteins. This region is composed of three structural domains. Firstly a four helical bundle, secondly a zinc binding motif and thirdly an OB-like fold [].MCM proteins are DNA-dependent ATPases required for the initiation ofeukaryotic DNA replication [, , ]. In eukaryotes there is a family of six proteins, MCM2 to MCM7. They were first identified in yeast where most of them have adirect role in the initiation of chromosomal DNA replication by interacting directly with autonomously replicating sequences (ARS). They were thus called minichromosome maintenance proteins, MCM proteins [].
Publication
First Author: Zou Y
Year: 2013
Journal: J Cell Biol
Title: CUL4B promotes replication licensing by up-regulating the CDK2-CDC6 cascade.
Volume: 200
Issue: 6
Pages: 743-56
Genotype
Symbol: Mcm2/Mcm2<+> Tg(CAG-Bgeo/GFP)21Lbe/?
Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Forsburg SL
Year: 1997
Journal: Genetics
Title: Mutational analysis of Cdc19p, a Schizosaccharomyces pombe MCM protein.
Volume: 147
Issue: 3
Pages: 1025-41
Protein Domain
Type: Conserved_site
Description: MCM proteins are DNA-dependent ATPases required for the initiation ofeukaryotic DNA replication [, , ]. In eukaryotes there is a family of six proteins, MCM2 to MCM7. They were first identified in yeast where most of them have adirect role in the initiation of chromosomal DNA replication by interacting directly with autonomously replicating sequences (ARS). They were thus called minichromosome maintenance proteins, MCM proteins [].This family is also present in the archebacteria in 1 to 4 copies. Methanocaldococcus jannaschii (Methanococcus jannaschii) has four members, MJ0363, MJ0961, MJ1489 and MJECL13.The "MCM motif"contains Walker-A and Walker-B type nucleotide binding motifs. The diagnostic sequence defining the MCMs is IDEFDKM. Only Mcm2 (aka Cdc19 or Nda1) has been subjected to mutational analysis in this region, and most mutations abolish its activity []. The presence of a putative ATP-binding domain implies that these proteins may be involved in an ATP-consuming step in the initiation of DNA replication in eukaryotes.The MCM proteins bind together in a large complex [].Within this complex, individual subunits associate with different affinities, and there is a tightly associated core of Mcm4 (Cdc21), Mcm6 (Mis5) and Mcm7 []. This core complex in human MCMs has been associated with helicase activity in vitro[], leading to the suggestion that the MCM proteins are the eukaryotic replicative helicase.Schizosaccharomyces pombe (Fission yeast) MCMs, like those in metazoans, are found in the nucleus throughout the cell cycle. This is in contrast to the Saccharomyces cerevisiae (Baker's yeast) in which MCM proteins move in and out of the nucleus during each cell cycle. The assembly of the MCM complex in S. pombe is required for MCM localisation, ensuring that only intact MCM complexes remain in the nucleus [].The signature pattern used in this entry represents a perfectly conserved region that is a special version of the B motif found in ATP-binding proteins.
Publication  
First Author: Sun J
Year: 2015
Journal: Mol Brain
Title: A septo-temporal molecular gradient of sfrp3 in the dentate gyrus differentially regulates quiescent adult hippocampal neural stem cell activation.
Volume: 8
Pages: 52
Publication
First Author: Petropoulos M
Year: 2023
Journal: J Pathol
Title: Cdt1 overexpression drives colorectal carcinogenesis through origin overlicensing and DNA damage.
Volume: 259
Issue: 1
Pages: 10-20
Publication  
First Author: Chen GY
Year: 2020
Journal: Front Cell Dev Biol
Title: Mediator Med23 Regulates Adult Hippocampal Neurogenesis.
Volume: 8
Pages: 699
Publication
First Author: Chow CL
Year: 2016
Journal: Stem Cells Dev
Title: Evaluation of Nestin Expression in the Developing and Adult Mouse Inner Ear.
Volume: 25
Issue: 19
Pages: 1419-32
Publication
First Author: Lal A
Year: 2011
Journal: PLoS Genet
Title: Capture of microRNA-bound mRNAs identifies the tumor suppressor miR-34a as a regulator of growth factor signaling.
Volume: 7
Issue: 11
Pages: e1002363
Publication
First Author: Mlcochova P
Year: 2017
Journal: EMBO J
Title: A G1-like state allows HIV-1 to bypass SAMHD1 restriction in macrophages.
Volume: 36
Issue: 5
Pages: 604-616
Publication
First Author: You Z
Year: 2008
Journal: J Biol Chem
Title: Cdt1 forms a complex with the minichromosome maintenance protein (MCM) and activates its helicase activity.
Volume: 283
Issue: 36
Pages: 24469-77
Publication
First Author: Ray S
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: KLF15 negatively regulates estrogen-induced epithelial cell proliferation by inhibition of DNA replication licensing.
Volume: 109
Issue: 21
Pages: E1334-43
Publication
First Author: Ishimi Y
Year: 1997
Journal: J Biol Chem
Title: A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex.
Volume: 272
Issue: 39
Pages: 24508-13
Publication
First Author: Adachi Y
Year: 1997
Journal: Genes Cells
Title: A globular complex formation by Nda1 and the other five members of the MCM protein family in fission yeast.
Volume: 2
Issue: 7
Pages: 467-79
Publication
First Author: Sherman DA
Year: 1998
Journal: Mol Biol Cell
Title: Multiple domains of fission yeast Cdc19p (MCM2) are required for its association with the core MCM complex.
Volume: 9
Issue: 7
Pages: 1833-45
Publication
First Author: Pasion SG
Year: 1999
Journal: Mol Biol Cell
Title: Nuclear localization of Schizosaccharomyces pombe Mcm2/Cdc19p requires MCM complex assembly.
Volume: 10
Issue: 12
Pages: 4043-57
Publication  
First Author: Seigel GM
Year: 2005
Journal: Mol Vis
Title: Cancer stem cell characteristics in retinoblastoma.
Volume: 11
Pages: 729-37
Publication
First Author: Smith JC
Year: 2007
Journal: J Proteome Res
Title: A differential phosphoproteomic analysis of retinoic acid-treated P19 cells.
Volume: 6
Issue: 8
Pages: 3174-86
Publication
First Author: Coxon A
Year: 1992
Journal: Nucleic Acids Res
Title: Fission yeast cdc21+ belongs to a family of proteins involved in an early step of chromosome replication.
Volume: 20
Issue: 21
Pages: 5571-7
Publication
First Author: Koonin EV
Year: 1993
Journal: Nucleic Acids Res
Title: A common set of conserved motifs in a vast variety of putative nucleic acid-dependent ATPases including MCM proteins involved in the initiation of eukaryotic DNA replication.
Volume: 21
Issue: 11
Pages: 2541-7
Publication
First Author: Hu B
Year: 1993
Journal: Nucleic Acids Res
Title: The P1 family: a new class of nuclear mammalian proteins related to the yeast Mcm replication proteins.
Volume: 21
Issue: 23
Pages: 5289-93
Publication
First Author: Tye BK
Year: 1994
Journal: Trends Cell Biol
Title: The MCM2-3-5 proteins: are they replication licensing factors?
Volume: 4
Issue: 5
Pages: 160-6
Protein
Organism: Mus musculus/domesticus
Length: 681  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 692  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 393  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 489  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 358  
Fragment?: false
Protein Domain
Type: Family
Description: MCM proteins are DNA-dependent ATPases required for the initiation of eukaryotic DNA replication [, , ]. In eukaryotes there is a family of eight proteins, MCM2 to MCM9. They were first identified in yeast where most of them have adirect role in the initiation of chromosomal DNA replication by interacting directly with autonomously replicating sequences (ARS). They were thus called minichromosome maintenance proteins, MCM proteins []. These proteins are evolutionarily related and belong to the AAA+ superfamily. They contain the Mcm family domain, which includes motifs that are required for ATP hydrolysis (such as the Walker A and B, and R-finger motifs). Mcm2-7 forms a hexameric complex []in which individual subunits associate with different affinities, and there is a tightly associated core of Mcm4 (Cdc21), Mcm6 (Mis5) and Mcm7 []. Mcm2-7 complex is the replicative helicase involved in replication initiation and elongation [], whereas Mcm8 and Mcm9 from and separate one, conserved among many eukaryotes except yeast and C. elegans. Mcm8/9 complex play a role during replication elongation or recombination, being involved in the repair of double-stranded DNA breaks and DNA interstrand cross-links by homologous recombination. Drosophila is the only organism that has MCM8 without MCM9, involved in meiotic recombination [, ].This family is also present in the archebacteria in 1 to 4 copies. Methanocaldococcus jannaschii (Methanococcus jannaschii) has four members, MJ0363, MJ0961, MJ1489 and MJECL13.Schizosaccharomyces pombe (Fission yeast) MCMs, like those in metazoans, are found in the nucleus throughout the cell cycle. This is in contrast to the Saccharomyces cerevisiae (Baker's yeast) in which MCM proteins move in and out of the nucleus during each cell cycle. The assembly of the MCM complex in S. pombe is required for MCM localisation, ensuring that only intact MCM complexes remain in the nucleus [].
Protein
Organism: Mus musculus/domesticus
Length: 821  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 719  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 734  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 812  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 821  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 719  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 720  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 821  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 734  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 812  
Fragment?: false