This is a family of conserved poxvirus proteins related to Protein B14 and Protein B22/C16 from Vaccinia virus. B14 contributes to virulence by binding to the host IKBKB subunit of the IKK complex and preventing host NF-kappa-B activation in response to pro-inflammatory stimuli such as TNF-alpha or IL1B. Mechanistically, it sterically hinders the direct contact between the kinase domains of IKBKB in the IKK complex containing IKBKB, CHUK/IKKA and NEMO [, , ].
This is the C-terminal scaffold dimerization domain (SDD) found in inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB) []. IKBKB is one of the core component of IKB kinases (IKK), which is an enzyme that quickly becomes active in response to diverse stresses. The SDD consists primarily of two long α-helices []. This domain can also be found in inhibitor of nuclear factor kappa-B kinase subunit alpha (IKKA).
This superfamily represents the C-terminal scaffold dimerization domain (SDD) found in inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB) []. IKBKB is one of the core component of IKB kinases (IKK), which is an enzyme that quickly becomes active in response to diverse stresses. The SDD consists primarily of two long α-helices []. This domain can also be found in inhibitor of nuclear factor kappa-B kinase subunit alpha (IKKA).
