This entry represents a domain found in a group of proteins, including Csm3 from budding yeasts, Swi3 from fission yeasts and TIPIN from animals. They are involved in DNA replication and the maintenance of replication fork stability [, , ].
Proteins in this family contain a domain found in yeast chromosome segregation in meiosis protein 3. Proteins include:Chromosome segregation in meiosis protein 3, which is required for required for chromosome segregation during meiosis and DNA damage repair, forming a fork protection complex with TOF1 [, ].TIMELESS-interacting protein (also known as TIPIN), which is a nuclear protein that associates with the replicative helicase, and is required for efficient cell cycle arrest in response to DNA damage. It forms a checkpoint complex with TIMELESS []. Protein TIPIN homolog, which is the orthologue of TIPIN from Caenorhabditis elegans and Drosophila melanogaster.Swi1-interacting protein swi3, from Schizosaccharomyces pombe, which forms a fork protection complex with swi1 [].
