Type |
Details |
Score |
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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•
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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Allele |
Name: |
hyaluronan synthase 3; targeted mutation 1.1, Genoway |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Humanized sequence, Inserted expressed sequence, Null/knockout |
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Allele |
Name: |
hyaluronan synthase 3; targeted mutation 1.2, Genoway |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
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Protein Domain |
Type: |
Family |
Description: |
This entry represents the hyaluronan synthase 2 (HAS2), which plays a role in hyaluronan/hyaluronic acid (HA) synthesis []. There are three different, but related hyaluronan synthases - HAS1, HAS2 and HAS3. They are multipass transmembrane enzymes, the active sites of which protrude from the inner face of the plasma membrane. HA is an unbranched disaccharide glucuronic acid/N-acetylglucosamine polymer and is one of the main components of the extracellular matrix []. High level of HA in humans is associated with cancer progression [, ]. In vertebrates, different HA polymer length can trigger different biological responses. High-molecular-mass HA represses mitogenic signalling and has anti-inflammatory properties, while low-molecular-mass HA promotes proliferation and inflammation [, ]. A study of the naked mole rat showed that HAS2 is overexpressed in naked mole rat fibroblasts, while the expression levels of HAS1 and HAS3 are similar between mouse, human and naked mole-rat cells []. HAS2 is responsible for the synthesis of the high-molecular-mass HA (HMM-HA), which triggers ECI (early contact inhibition) via the CD44 receptor and plays a key role in mediating the cancer resistance of the naked mole rat []. |
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Publication |
First Author: |
Collum SD |
Year: |
2019 |
Journal: |
Dis Model Mech |
Title: |
Adenosine and hyaluronan promote lung fibrosis and pulmonary hypertension in combined pulmonary fibrosis and emphysema. |
Volume: |
12 |
Issue: |
5 |
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Publication |
First Author: |
Sukowati CHC |
Year: |
2019 |
Journal: |
Sci Rep |
Title: |
Hyaluronic acid inhibition by 4-methylumbelliferone reduces the expression of cancer stem cells markers during hepatocarcinogenesis. |
Volume: |
9 |
Issue: |
1 |
Pages: |
4026 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
552
|
Fragment?: |
false |
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•
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Publication |
First Author: |
Tian X |
Year: |
2013 |
Journal: |
Nature |
Title: |
High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat. |
Volume: |
499 |
Issue: |
7458 |
Pages: |
346-9 |
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Publication |
First Author: |
Toole BP |
Year: |
2004 |
Journal: |
Nat Rev Cancer |
Title: |
Hyaluronan: from extracellular glue to pericellular cue. |
Volume: |
4 |
Issue: |
7 |
Pages: |
528-39 |
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•
•
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•
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Publication |
First Author: |
Lipponen P |
Year: |
2001 |
Journal: |
Eur J Cancer |
Title: |
High stromal hyaluronan level is associated with poor differentiation and metastasis in prostate cancer. |
Volume: |
37 |
Issue: |
7 |
Pages: |
849-56 |
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•
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Publication |
First Author: |
Kothapalli D |
Year: |
2007 |
Journal: |
J Cell Biol |
Title: |
Hyaluronan and CD44 antagonize mitogen-dependent cyclin D1 expression in mesenchymal cells. |
Volume: |
176 |
Issue: |
4 |
Pages: |
535-44 |
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