Receptor-type tyrosine-protein phosphatase C, also known as CD45, is a tyrosine-protein phosphatase required for T-cell activation through the antigen receptor []. It acts as a positive regulator of T-cell co-activation upon binding to DPP4 (CD26) [].
This group represents protein tyrosine phosphatase receptor type C (PTPRC)-associated protein, also known as CD45-associated protein [, ]. It is a positive regulator of PTPRC (CD45), which activates Src family kinases implicated in tumorigenesis [].
