|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 501 to 586 out of 586 for Dyrk1a

<< First    < Previous  |  Next >    Last >>
0.052s

Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Publication
First Author: Park J
Year: 2012
Journal: J Cell Sci
Title: Dyrk1A negatively regulates the actin cytoskeleton through threonine phosphorylation of N-WASP.
Volume: 125
Issue: Pt 1
Pages: 67-80
Publication  
First Author: Hijazi M
Year: 2013
Journal: Exp Neurol
Title: Overexpression of DYRK1A inhibits choline acetyltransferase induction by oleic acid in cellular models of Down syndrome.
Volume: 239
Pages: 229-34
Transgene
Type: transgene
Organism: mouse, laboratory
GXD Expression  
Probe: MGI:6506451
Assay Type: RNA in situ
Annotation Date: 2021-02-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608916
Pattern: Regionally restricted
Stage: TS16
Assay Id: MGI:6506463
Age: embryonic day 10.0
Note: Expression pattern similar to that of Dyrk1a in proliferative regious surrounding ventricles
Specimen Label: 1A Dscr1 E10
Detected: true
Specimen Num: 1
Publication
First Author: Kim D
Year: 2004
Journal: Biochem Biophys Res Commun
Title: Regulation of Dyrk1A kinase activity by 14-3-3.
Volume: 323
Issue: 2
Pages: 499-504
Interaction Experiment
Description: Dyrk1A potentiates steroid hormone-induced transcription via the chromatin remodeling factor Arip4.
Interaction Experiment
Description: DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1.
Interaction Experiment
Description: DYRK1a mediates BAFF-induced noncanonical NF-?B activation to promote autoimmunity and B-cell leukemogenesis.
Protein
Organism: Mus musculus/domesticus
Length: 41  
Fragment?: true
Protein Domain
Type: Family
Description: This entry includes PHYHIP and PHYHIPL from humans. PHYHIP interacts with DYRK1A and may contribute to new cellular functions of DYRK1A [].
Publication
First Author: Park J
Year: 2013
Journal: Exp Neurobiol
Title: New Perspectives of Dyrk1A Role in Neurogenesis and Neuropathologic Features of Down Syndrome.
Volume: 22
Issue: 4
Pages: 244-8
Allele
Name: dual-specificity tyrosine phosphorylation regulated kinase 1a; targeted mutation 1, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
Allele
Name: dual-specificity tyrosine phosphorylation regulated kinase 1a; endonuclease-mediated mutation 1, Kazuhiro Yamakawa
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Publication  
First Author: Song WJ
Year: 2013
Journal: Neurosci Lett
Title: Dyrk1A-mediated phosphorylation of RCAN1 promotes the formation of insoluble RCAN1 aggregates.
Volume: 554
Pages: 135-40
Genotype
Symbol: Dyrk1a/Dyrk1a<+>
Background: C57BL/6J-Dyrk1a
Zygosity: ht
Has Mutant Allele: true
Publication
First Author: Bescond M
Year: 2005
Journal: Int J Biochem Cell Biol
Title: Dual-specificity tyrosine-phosphorylated and regulated kinase 1A (DYRK1A) interacts with the phytanoyl-CoA alpha-hydroxylase associated protein 1 (PAHX-AP1), a brain specific protein.
Volume: 37
Issue: 4
Pages: 775-83
Publication
First Author: Souchet B
Year: 2019
Journal: Sci Rep
Title: Prenatal treatment with EGCG enriched green tea extract rescues GAD67 related developmental and cognitive defects in Down syndrome mouse models.
Volume: 9
Issue: 1
Pages: 3914
HT Experiment
Series Id: E-GEOD-67052
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Allele
Name: transgene insertion JF4, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
Protein Domain
Type: Domain
Description: Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) () phosphorylates serine, threonine and tyrosine residues in proteins such as CRY2, FOXO1 and SIRT1 [, , , ]. It can be activated by tyrosine autophosphorylation [, ]. DYRK1A play a role in a signaling pathway regulating nuclear functions of cell proliferation. DYRK1A is a neurogenesis regulator and plays an important role in altered brain development in Down syndrome [, ]. Dual specificity tyrosine-phosphorylation-regulated kinase 1B (DYRK1B also known as Mirk) also phosphorylates serine, threonine and tyrosine residues, and has been shown to enhance the transcriptional activity of HNF1A and FOXO1 []. Mirk is reported to be an inhibitor of epithelial cell migration [], and appears to mediate carcinoma cell survival in specific environments [].This entry also includes mnb from Drosophila melanogaster. It plays a role in the specific control of proper proliferation of optic lobe neuronal progeny [].This entry represents the catalytic domain found in DYRK1A and DYRK1B.
Publication
First Author: Shindoh N
Year: 1996
Journal: Biochem Biophys Res Commun
Title: Cloning of a human homolog of the Drosophila minibrain/rat Dyrk gene from "the Down syndrome critical region" of chromosome 21.
Volume: 225
Issue: 1
Pages: 92-9
Publication
First Author: Tejedor FJ
Year: 2011
Journal: FEBS J
Title: MNB/DYRK1A as a multiple regulator of neuronal development.
Volume: 278
Issue: 2
Pages: 223-35
Publication
First Author: Park J
Year: 2009
Journal: Cell Mol Life Sci
Title: Function and regulation of Dyrk1A: towards understanding Down syndrome.
Volume: 66
Issue: 20
Pages: 3235-40
Publication
First Author: Walte A
Year: 2013
Journal: FEBS J
Title: Mechanism of dual specificity kinase activity of DYRK1A.
Volume: 280
Issue: 18
Pages: 4495-511
Publication
First Author: Kentrup H
Year: 1996
Journal: J Biol Chem
Title: Dyrk, a dual specificity protein kinase with unique structural features whose activity is dependent on tyrosine residues between subdomains VII and VIII.
Volume: 271
Issue: 7
Pages: 3488-95
Publication
First Author: Hong SH
Year: 2012
Journal: PLoS Genet
Title: Minibrain/Dyrk1a regulates food intake through the Sir2-FOXO-sNPF/NPY pathway in Drosophila and mammals.
Volume: 8
Issue: 8
Pages: e1002857
Publication
First Author: Lim S
Year: 2002
Journal: J Biol Chem
Title: Mirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alpha.
Volume: 277
Issue: 28
Pages: 25040-6
Publication
First Author: Zou Y
Year: 2003
Journal: J Biol Chem
Title: Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M.
Volume: 278
Issue: 49
Pages: 49573-81
Publication
First Author: Lee K
Year: 2000
Journal: Cancer Res
Title: Mirk protein kinase is a mitogen-activated protein kinase substrate that mediates survival of colon cancer cells.
Volume: 60
Issue: 13
Pages: 3631-7
Strain
Attribute String: mutant stock, transgenic
Allele
Name: transgene insertion 189N3, Yann Herault
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Publication  
First Author: Nguyen TL
Year: 2018
Journal: Dis Model Mech
Title: Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A.
Volume: 11
Issue: 9
Protein
Organism: Mus musculus/domesticus
Length: 110  
Fragment?: true
Protein Domain
Type: Family
Description: Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) () phosphorylates serine, threonine and tyrosine residues in proteins such as CRY2, FOXO1 and SIRT1 [, , , ]. It can be activated by tyrosine autophosphorylation [, ]. DYRK1A play a role in a signaling pathway regulating nuclear functions of cell proliferation. DYRK1A is a neurogenesis regulator and plays an important role in altered brain development in Down syndrome [, ]. Dual specificity tyrosine-phosphorylation-regulated kinase 1B (DYRK1B also known as Mirk) also phosphorylates serine, threonine and tyrosine residues, and has been shown to enhance the transcriptional activity of HNF1A and FOXO1 []. Mirk is reported to be an inhibitor of epithelial cell migration [], and appears to mediate carcinoma cell survival in specific environments [].This entry also includes mnb from Drosophila melanogaster. It plays a role in the specific control of proper proliferation of optic lobe neuronal progeny [].
Strain
Attribute String: coisogenic, mutant strain, transgenic
Allele
Name: transgene insertion 12, Edward M Rubin
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Strain
Attribute String: transgenic, mutant strain, congenic
Strain
Attribute String: transgenic, congenic, mutant strain
Genotype
Symbol: Tg(DYRK1A)36Wjs/?
Background: involves: C57BL/6NCrjBgi
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(Dyrk1a)189N3Yah/?
Background: B6.129P2-Tg(Dyrk1a)189N3Yah/Yah
Zygosity: ot
Has Mutant Allele: true
Allele
Name: deletion, Chr 16, Y Eugene Yu 14
Allele Type: Targeted
Attribute String: Null/knockout
Strain
Attribute String: coisogenic, mutant strain, transgenic
Strain
Attribute String: transgenic, mutant strain, congenic
Strain
Attribute String: coisogenic, mutant strain, transgenic
Genotype
Symbol: Tg(CEPHY152F7)12Hgc/?
Background: (C57BL/6 x FVB/N)F1
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(CEPHY152F7)12Hgc/?
Background: FVB-Tg(CEPHY152F7)12Hgc
Zygosity: ot
Has Mutant Allele: true
Protein
Organism: Mus musculus/domesticus
Length: 181  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 329  
Fragment?: true
Strain
Attribute String: mutant strain, congenic, chromosome aberration
Genotype
Symbol: Del(16Dyrk1a-Kcnj6)14Yey/+
Background: B6.129S7-Del(16Dyrk1a-Kcnj6)14Yey
Zygosity: ht
Has Mutant Allele: true
Publication
First Author: Leder S
Year: 1999
Journal: Biochem Biophys Res Commun
Title: Cloning and characterization of DYRK1B, a novel member of the DYRK family of protein kinases.
Volume: 254
Issue: 2
Pages: 474-9
Publication  
First Author: Schneider P
Year: 2015
Journal: Nat Commun
Title: Identification of a novel actin-dependent signal transducing module allows for the targeted degradation of GLI1.
Volume: 6
Pages: 8023
Publication
First Author: Sheppard O
Year: 2012
Journal: Neurobiol Aging
Title: Altered regulation of tau phosphorylation in a mouse model of down syndrome aging.
Volume: 33
Issue: 4
Pages: 828.e31-44
Publication
First Author: Lee P
Year: 2016
Journal: Leukemia
Title: The biology, pathogenesis and clinical aspects of acute lymphoblastic leukemia in children with Down syndrome.
Volume: 30
Issue: 9
Pages: 1816-23
Protein
Organism: Mus musculus/domesticus
Length: 629  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 763  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 725  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 593  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 763  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 523  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 754  
Fragment?: false
Strain
Attribute String: congenic, duplication, mutant strain, chromosome aberration, deletion
Strain
Attribute String: congenic, mutant strain, targeted mutation, deletion
Genotype
Symbol: Del(16Dyrk1a-Kcnj6)14Yey/? Dp(16Lipi-Zbtb21)1Yey/?
Background: B6.129S7-Del(16Dyrk1a-Kcnj6)14Yey/Dp(16Lipi-Zbtb21)1Yey
Zygosity: cx
Has Mutant Allele: true
Publication
First Author: Forristal C
Year: 2014
Journal: Mol Cell Biol
Title: Loss of the mammalian DREAM complex deregulates chondrocyte proliferation.
Volume: 34
Issue: 12
Pages: 2221-34
Publication
First Author: Sengül GF
Year: 2024
Journal: Biochim Biophys Acta Mol Cell Res
Title: Hsc70 phosphorylation patterns and calmodulin regulate AP2 Clathrin-Coated-Vesicle life span for cell adhesion protein transport.
Volume: 1871
Issue: 1
Pages: 119611
Publication
First Author: Siddiqui A
Year: 2008
Journal: Genes Brain Behav
Title: Molecular responses of the Ts65Dn and Ts1Cje mouse models of Down syndrome to MK-801.
Volume: 7
Issue: 7
Pages: 810-20
Publication  
First Author: Trovò L
Year: 2020
Journal: Neurobiol Dis
Title: The green tea polyphenol epigallocatechin-3-gallate (EGCG) restores CDKL5-dependent synaptic defects in vitro and in vivo.
Volume: 138
Pages: 104791
Publication
First Author: Deitz SL
Year: 2011
Journal: Genetics
Title: Trisomic and allelic differences influence phenotypic variability during development of Down syndrome mice.
Volume: 189
Issue: 4
Pages: 1487-95
Publication  
First Author: Navarro-Romero A
Year: 2019
Journal: Neurobiol Dis
Title: Cannabinoid type-1 receptor blockade restores neurological phenotypes in two models for Down syndrome.
Volume: 125
Pages: 92-106
Publication
First Author: Jamal R
Year: 2022
Journal: PLoS One
Title: Increased dosage and treatment time of Epigallocatechin-3-gallate (EGCG) negatively affects skeletal parameters in normal mice and Down syndrome mouse models.
Volume: 17
Issue: 2
Pages: e0264254
Publication  
First Author: Thomazeau A
Year: 2023
Journal: Front Neurosci
Title: Glutamatergic synaptic deficits in the prefrontal cortex of the Ts65Dn mouse model for Down syndrome.
Volume: 17
Pages: 1171797
Publication
First Author: Rachidi M
Year: 2007
Journal: Biochem Biophys Res Commun
Title: New cerebellar phenotypes in YAC transgenic mouse in vivo library of human Down syndrome critical region-1.
Volume: 364
Issue: 3
Pages: 488-94
Publication
First Author: Kim J
Year: 2016
Journal: Cancer Res
Title: Ablation of miR-10b Suppresses Oncogene-Induced Mammary Tumorigenesis and Metastasis and Reactivates Tumor-Suppressive Pathways.
Volume: 76
Issue: 21
Pages: 6424-6435
Publication
First Author: Egusa H
Year: 2011
Journal: Bone
Title: The small molecule harmine regulates NFATc1 and Id2 expression in osteoclast progenitor cells.
Volume: 49
Issue: 2
Pages: 264-74
Publication
First Author: Weiss CS
Year: 2013
Journal: PLoS One
Title: DYRK2 negatively regulates cardiomyocyte growth by mediating repressor function of GSK-3β on eIF2Bε.
Volume: 8
Issue: 9
Pages: e70848
Protein
Organism: Mus musculus/domesticus
Length: 330  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 375  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 88  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 330  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 330  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 212  
Fragment?: true
Publication
First Author: Gupta M
Year: 2016
Journal: Mamm Genome
Title: Mouse models of Down syndrome: gene content and consequences.
Volume: 27
Issue: 11-12
Pages: 538-555
Publication
First Author: Smith DJ
Year: 1995
Journal: Genomics
Title: Construction of a panel of transgenic mice containing a contiguous 2-Mb set of YAC/P1 clones from human chromosome 21q22.2.
Volume: 27
Issue: 3
Pages: 425-34
Publication
First Author: Smith DJ
Year: 1997
Journal: Nat Genet
Title: Functional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndrome.
Volume: 16
Issue: 1
Pages: 28-36
Publication      
First Author: The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year: 2005
Journal: Database Download
Title: MGI download of GENSAT transgene data