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Search results 101 to 200 out of 265 for Cdh16

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Category: Publication
Type Details Score
Publication
First Author: Ueda K
Year: 2017
Journal: Hypertension
Title: Renal Dysfunction Induced by Kidney-Specific Gene Deletion of Hsd11b2 as a Primary Cause of Salt-Dependent Hypertension.
Volume: 70
Issue: 1
Pages: 111-118
Publication
First Author: Jun JH
Year: 2022
Journal: Exp Mol Med
Title: Reduced expression of TAZ inhibits primary cilium formation in renal glomeruli.
Volume: 54
Issue: 2
Pages: 169-179
Publication
First Author: Yang B
Year: 2008
Journal: J Am Soc Nephrol
Title: Small-molecule CFTR inhibitors slow cyst growth in polycystic kidney disease.
Volume: 19
Issue: 7
Pages: 1300-10
Publication
First Author: Battini L
Year: 2008
Journal: Hum Mol Genet
Title: Loss of polycystin-1 causes centrosome amplification and genomic instability.
Volume: 17
Issue: 18
Pages: 2819-33
Publication
First Author: Takiar V
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis.
Volume: 108
Issue: 6
Pages: 2462-7
Publication      
First Author: Ishimoto Y
Year: 2017
Journal: Mol Cell Biol
Title: Mitochondrial Abnormality Facilitates Cyst Formation in Autosomal Dominant Polycystic Kidney Disease.
Publication
First Author: Cassina L
Year: 2020
Journal: FASEB J
Title: Increased mitochondrial fragmentation in polycystic kidney disease acts as a modifier of disease progression.
Volume: 34
Issue: 5
Pages: 6493-6507
Publication  
First Author: Podrini C
Year: 2018
Journal: Commun Biol
Title: Dissection of metabolic reprogramming in polycystic kidney disease reveals coordinated rewiring of bioenergetic pathways.
Volume: 1
Pages: 194
Publication
First Author: Wu M
Year: 2015
Journal: Oncotarget
Title: Flcn-deficient renal cells are tumorigenic and sensitive to mTOR suppression.
Volume: 6
Issue: 32
Pages: 32761-73
Publication
First Author: Hasumi H
Year: 2017
Journal: Hum Mol Genet
Title: H255Y and K508R missense mutations in tumour suppressor folliculin (FLCN) promote kidney cell proliferation.
Volume: 26
Issue: 2
Pages: 354-366
Publication
First Author: Goodwin JE
Year: 2010
Journal: Biochem Biophys Res Commun
Title: The glucocorticoid receptor in the distal nephron is not necessary for the development or maintenance of dexamethasone-induced hypertension.
Volume: 394
Issue: 2
Pages: 266-71
Publication
First Author: Chen J
Year: 2008
Journal: PLoS One
Title: Deficiency of FLCN in mouse kidney led to development of polycystic kidneys and renal neoplasia.
Volume: 3
Issue: 10
Pages: e3581
Publication
First Author: Hong SB
Year: 2010
Journal: PLoS One
Title: Inactivation of the FLCN tumor suppressor gene induces TFE3 transcriptional activity by increasing its nuclear localization.
Volume: 5
Issue: 12
Pages: e15793
Publication
First Author: Formica C
Year: 2019
Journal: J Pathol
Title: Four-jointed knock-out delays renal failure in an ADPKD model with kidney injury.
Volume: 249
Issue: 1
Pages: 114-125
Publication
First Author: Zhou D
Year: 2012
Journal: Kidney Int
Title: Tubule-specific ablation of endogenous β-catenin aggravates acute kidney injury in mice.
Volume: 82
Issue: 5
Pages: 537-47
Publication  
First Author: Zhou D
Year: 2013
Journal: Sci Rep
Title: Kidney tubular β-catenin signaling controls interstitial fibroblast fate via epithelial-mesenchymal communication.
Volume: 3
Pages: 1878
Publication  
First Author: Bartram MP
Year: 2015
Journal: BMC Nephrol
Title: Loss of Dgcr8-mediated microRNA expression in the kidney results in hydronephrosis and renal malformation.
Volume: 16
Pages: 55
Publication
First Author: Couillard M
Year: 2009
Journal: Dev Dyn
Title: C-myc as a modulator of renal stem/progenitor cell population.
Volume: 238
Issue: 2
Pages: 405-14
Publication
First Author: Manning JA
Year: 2020
Journal: Cell Death Differ
Title: Dietary sodium modulates nephropathy in Nedd4-2-deficient mice.
Volume: 27
Issue: 6
Pages: 1832-1843
Publication
First Author: Henshall TL
Year: 2017
Journal: Cell Death Differ
Title: Deletion of Nedd4-2 results in progressive kidney disease in mice.
Volume: 24
Issue: 12
Pages: 2150-2160
Publication
First Author: Chan SC
Year: 2020
Journal: J Biol Chem
Title: Hepatocyte nuclear factor 1β suppresses canonical Wnt signaling through transcriptional repression of lymphoid enhancer-binding factor 1.
Volume: 295
Issue: 51
Pages: 17560-17572
Publication
First Author: Kompatscher A
Year: 2018
Journal: Am J Physiol Renal Physiol
Title: Transcription factor HNF1β regulates expression of the calcium-sensing receptor in the thick ascending limb of the kidney.
Volume: 315
Issue: 1
Pages: F27-F35
Publication
First Author: Ma Z
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Mutations of HNF-1beta inhibit epithelial morphogenesis through dysregulation of SOCS-3.
Volume: 104
Issue: 51
Pages: 20386-91
Publication
First Author: Chan SC
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Hepatocyte nuclear factor-1β regulates Wnt signaling through genome-wide competition with β-catenin/lymphoid enhancer binding factor.
Volume: 116
Issue: 48
Pages: 24133-24142
Publication
First Author: Hajarnis SS
Year: 2015
Journal: J Biol Chem
Title: Transcription Factor Hepatocyte Nuclear Factor-1β (HNF-1β) Regulates MicroRNA-200 Expression through a Long Noncoding RNA.
Volume: 290
Issue: 41
Pages: 24793-805
Publication
First Author: Kompatscher A
Year: 2017
Journal: Kidney Int
Title: Loss of transcriptional activation of the potassium channel Kir5.1 by HNF1β drives autosomal dominant tubulointerstitial kidney disease.
Volume: 92
Issue: 5
Pages: 1145-1156
Publication
First Author: Horiguchi H
Year: 2019
Journal: Genes Dev
Title: Dual functions of angiopoietin-like protein 2 signaling in tumor progression and anti-tumor immunity.
Volume: 33
Issue: 23-24
Pages: 1641-1656
Publication
First Author: Lee HW
Year: 2014
Journal: Am J Physiol Renal Physiol
Title: Effect of collecting duct-specific deletion of both Rh B Glycoprotein (Rhbg) and Rh C Glycoprotein (Rhcg) on renal response to metabolic acidosis.
Volume: 306
Issue: 4
Pages: F389-400
Publication  
First Author: Rossaint J
Year: 2022
Journal: JCI Insight
Title: Remote ischemic preconditioning causes transient cell cycle arrest and renal protection by a NF-κB-dependent Sema5B pathway.
Volume: 7
Issue: 14
Publication
First Author: Patel V
Year: 2012
Journal: J Am Soc Nephrol
Title: MicroRNAs regulate renal tubule maturation through modulation of Pkd1.
Volume: 23
Issue: 12
Pages: 1941-8
Publication
First Author: Rao H
Year: 2021
Journal: Cancer Res
Title: Multilevel Regulation of β-Catenin Activity by SETD2 Suppresses the Transition from Polycystic Kidney Disease to Clear Cell Renal Cell Carcinoma.
Volume: 81
Issue: 13
Pages: 3554-3567
Publication
First Author: Li R
Year: 2013
Journal: Kidney Int
Title: The microRNA miR-433 promotes renal fibrosis by amplifying the TGF-β/Smad3-Azin1 pathway.
Volume: 84
Issue: 6
Pages: 1129-44
Publication
First Author: Fragiadaki M
Year: 2017
Journal: Kidney Int
Title: STAT5 drives abnormal proliferation in autosomal dominant polycystic kidney disease.
Volume: 91
Issue: 3
Pages: 575-586
Publication
First Author: Qiu C
Year: 2018
Journal: Nat Med
Title: Renal compartment-specific genetic variation analyses identify new pathways in chronic kidney disease.
Volume: 24
Issue: 11
Pages: 1721-1731
Publication
First Author: Zhou H
Year: 2012
Journal: Am J Physiol Renal Physiol
Title: Ginkgolide B inhibits renal cyst development in in vitro and in vivo cyst models.
Volume: 302
Issue: 10
Pages: F1234-42
Publication
First Author: Yang B
Year: 2019
Journal: Am J Physiol Renal Physiol
Title: Interleukin-1 receptor activation aggravates autosomal dominant polycystic kidney disease by modulating regulated necrosis.
Volume: 317
Issue: 2
Pages: F221-F228
Publication  
First Author: van Megen WH
Year: 2022
Journal: EBioMedicine
Title: Differential parathyroid and kidney Ca(2+)-sensing receptor activation in autosomal dominant hypocalcemia 1.
Volume: 78
Pages: 103947
Publication
First Author: Hell MP
Year: 2014
Journal: Cancer Res
Title: miR-28-5p promotes chromosomal instability in VHL-associated cancers by inhibiting Mad2 translation.
Volume: 74
Issue: 9
Pages: 2432-43
Publication
First Author: Hell MP
Year: 2014
Journal: Cancer Res
Title: Tumor suppressor VHL functions in the control of mitotic fidelity.
Volume: 74
Issue: 9
Pages: 2422-31
Publication
First Author: Douma LG
Year: 2018
Journal: Am J Physiol Renal Physiol
Title: Renal Na-handling defect associated with PER1-dependent nondipping hypertension in male mice.
Volume: 314
Issue: 6
Pages: F1138-F1144
Publication
First Author: Tiwari S
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Impaired sodium excretion and increased blood pressure in mice with targeted deletion of renal epithelial insulin receptor.
Volume: 105
Issue: 17
Pages: 6469-74
Publication
First Author: Crislip GR
Year: 2020
Journal: Am J Physiol Renal Physiol
Title: Differences in renal BMAL1 contribution to Na+ homeostasis and blood pressure control in male and female mice.
Volume: 318
Issue: 6
Pages: F1463-F1477
Publication
First Author: Zhang D
Year: 2014
Journal: J Am Soc Nephrol
Title: Tubular p53 regulates multiple genes to mediate AKI.
Volume: 25
Issue: 10
Pages: 2278-89
Publication
First Author: Qian CN
Year: 2005
Journal: J Biol Chem
Title: Cystic renal neoplasia following conditional inactivation of apc in mouse renal tubular epithelium.
Volume: 280
Issue: 5
Pages: 3938-45
Publication
First Author: Adam J
Year: 2013
Journal: Cell Rep
Title: A role for cytosolic fumarate hydratase in urea cycle metabolism and renal neoplasia.
Volume: 3
Issue: 5
Pages: 1440-8
Publication
First Author: Breiderhoff T
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Deletion of claudin-10 (Cldn10) in the thick ascending limb impairs paracellular sodium permeability and leads to hypermagnesemia and nephrocalcinosis.
Volume: 109
Issue: 35
Pages: 14241-6
Publication
First Author: Gao M
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Disruption of prostaglandin E2 receptor EP4 impairs urinary concentration via decreasing aquaporin 2 in renal collecting ducts.
Volume: 112
Issue: 27
Pages: 8397-402
Publication
First Author: Malik S
Year: 2018
Journal: Am J Physiol Renal Physiol
Title: Potassium conservation is impaired in mice with reduced renal expression of Kir4.1.
Volume: 315
Issue: 5
Pages: F1271-F1282
Publication
First Author: Grahammer F
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress.
Volume: 111
Issue: 27
Pages: E2817-26
Publication  
First Author: Tan RJ
Year: 2019
Journal: JCI Insight
Title: Tubular injury triggers podocyte dysfunction by β-catenin-driven release of MMP-7.
Volume: 4
Issue: 24
Publication
First Author: Lazo-Fernández Y
Year: 2017
Journal: Am J Physiol Renal Physiol
Title: Kidney-specific genetic deletion of both AMPK α-subunits causes salt and water wasting.
Volume: 312
Issue: 2
Pages: F352-F365
Publication
First Author: Conduit SE
Year: 2019
Journal: Hum Mol Genet
Title: β-catenin ablation exacerbates polycystic kidney disease progression.
Volume: 28
Issue: 2
Pages: 230-244
Publication
First Author: Church RH
Year: 2017
Journal: Am J Physiol Renal Physiol
Title: Gremlin1 plays a key role in kidney development and renal fibrosis.
Volume: 312
Issue: 6
Pages: F1141-F1157
Publication
First Author: Han X
Year: 2016
Journal: PLoS One
Title: Conditional Deletion of Fgfr1 in the Proximal and Distal Tubule Identifies Distinct Roles in Phosphate and Calcium Transport.
Volume: 11
Issue: 2
Pages: e0147845
Publication
First Author: Chan SC
Year: 2018
Journal: J Am Soc Nephrol
Title: Mechanism of Fibrosis in HNF1B-Related Autosomal Dominant Tubulointerstitial Kidney Disease.
Volume: 29
Issue: 10
Pages: 2493-2509
Publication
First Author: Saifudeen Z
Year: 2009
Journal: J Am Soc Nephrol
Title: p53 regulates metanephric development.
Volume: 20
Issue: 11
Pages: 2328-37
Publication
First Author: Lin SH
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Impaired phosphorylation of Na(+)-K(+)-2Cl(-) cotransporter by oxidative stress-responsive kinase-1 deficiency manifests hypotension and Bartter-like syndrome.
Volume: 108
Issue: 42
Pages: 17538-43
Publication
First Author: Iaconis D
Year: 2017
Journal: Sci Rep
Title: The centrosomal OFD1 protein interacts with the translation machinery and regulates the synthesis of specific targets.
Volume: 7
Issue: 1
Pages: 1224
Publication
First Author: Hakim S
Year: 2016
Journal: Hum Mol Genet
Title: Inpp5e suppresses polycystic kidney disease via inhibition of PI3K/Akt-dependent mTORC1 signaling.
Volume: 25
Issue: 11
Pages: 2295-2313
Publication
First Author: Lantinga-van Leeuwen IS
Year: 2006
Journal: Genesis
Title: Transgenic mice expressing tamoxifen-inducible Cre for somatic gene modification in renal epithelial cells.
Volume: 44
Issue: 5
Pages: 225-32
Publication
First Author: Aboudehen K
Year: 2018
Journal: J Biol Chem
Title: Long noncoding RNA Hoxb3os is dysregulated in autosomal dominant polycystic kidney disease and regulates mTOR signaling.
Volume: 293
Issue: 24
Pages: 9388-9398
Publication
First Author: Milatz S
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Mosaic expression of claudins in thick ascending limbs of Henle results in spatial separation of paracellular Na+ and Mg2+ transport.
Volume: 114
Issue: 2
Pages: E219-E227
Publication      
First Author: Meng C
Year: 2020
Journal: Cell Death Differ
Title: Hippo kinases MST1 and MST2 control the differentiation of the epididymal initial segment via the MEK-ERK pathway.
Publication
First Author: Nam SA
Year: 2019
Journal: Cell Death Dis
Title: Autophagy attenuates tubulointerstital fibrosis through regulating transforming growth factor-β and NLRP3 inflammasome signaling pathway.
Volume: 10
Issue: 2
Pages: 78
Publication
First Author: Kaminski MM
Year: 2016
Journal: Nat Cell Biol
Title: Direct reprogramming of fibroblasts into renal tubular epithelial cells by defined transcription factors.
Volume: 18
Issue: 12
Pages: 1269-1280
Publication
First Author: Wang W
Year: 2015
Journal: FASEB J
Title: Aquaporin-1 retards renal cyst development in polycystic kidney disease by inhibition of Wnt signaling.
Volume: 29
Issue: 4
Pages: 1551-63
Publication  
First Author: Pema M
Year: 2016
Journal: Nat Commun
Title: mTORC1-mediated inhibition of polycystin-1 expression drives renal cyst formation in tuberous sclerosis complex.
Volume: 7
Pages: 10786
Publication
First Author: Lantinga-van Leeuwen IS
Year: 2007
Journal: Hum Mol Genet
Title: Kidney-specific inactivation of the Pkd1 gene induces rapid cyst formation in developing kidneys and a slow onset of disease in adult mice.
Volume: 16
Issue: 24
Pages: 3188-96
Publication
First Author: Hassane S
Year: 2010
Journal: J Pathol
Title: Elevated TGFbeta-Smad signalling in experimental Pkd1 models and human patients with polycystic kidney disease.
Volume: 222
Issue: 1
Pages: 21-31
Publication
First Author: Gamba G
Year: 2014
Journal: Am J Physiol Renal Physiol
Title: Regulation of NKCC2 activity by SPAK truncated isoforms.
Volume: 306
Issue: 1
Pages: F49-50
Publication
First Author: Yheskel M
Year: 2019
Journal: Sci Rep
Title: Anti-microRNA screen uncovers miR-17 family within miR-17~92 cluster as the primary driver of kidney cyst growth.
Volume: 9
Issue: 1
Pages: 1920
Publication
First Author: Wang W
Year: 2019
Journal: FASEB J
Title: Aquaporin-3 deficiency slows cyst enlargement in experimental mouse models of autosomal dominant polycystic kidney disease.
Volume: 33
Issue: 5
Pages: 6185-6196
Publication
First Author: Albers J
Year: 2013
Journal: EMBO Mol Med
Title: Combined mutation of Vhl and Trp53 causes renal cysts and tumours in mice.
Volume: 5
Issue: 6
Pages: 949-64
Publication
First Author: Nargund AM
Year: 2017
Journal: Cell Rep
Title: The SWI/SNF Protein PBRM1 Restrains VHL-Loss-Driven Clear Cell Renal Cell Carcinoma.
Volume: 18
Issue: 12
Pages: 2893-2906
Publication
First Author: Han X
Year: 2018
Journal: J Am Soc Nephrol
Title: Cardiovascular Effects of Renal Distal Tubule Deletion of the FGF Receptor 1 Gene.
Volume: 29
Issue: 1
Pages: 69-80
Publication
First Author: Pollard PJ
Year: 2007
Journal: Cancer Cell
Title: Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway.
Volume: 11
Issue: 4
Pages: 311-9
Publication
First Author: Adam J
Year: 2011
Journal: Cancer Cell
Title: Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling.
Volume: 20
Issue: 4
Pages: 524-37
Publication
First Author: Hoefflin R
Year: 2020
Journal: Nat Commun
Title: HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice.
Volume: 11
Issue: 1
Pages: 4111
Publication
First Author: Olauson H
Year: 2012
Journal: J Am Soc Nephrol
Title: Targeted deletion of Klotho in kidney distal tubule disrupts mineral metabolism.
Volume: 23
Issue: 10
Pages: 1641-51
Publication
First Author: Schell C
Year: 2016
Journal: Am J Pathol
Title: The Rapamycin-Sensitive Complex of Mammalian Target of Rapamycin Is Essential to Maintain Male Fertility.
Volume: 186
Issue: 2
Pages: 324-36
Publication
First Author: Wang X
Year: 2018
Journal: Am J Physiol Renal Physiol
Title: Physiological functions of ferroportin in the regulation of renal iron recycling and ischemic acute kidney injury.
Volume: 315
Issue: 4
Pages: F1042-F1057
Publication
First Author: Palicharla VR
Year: 2023
Journal: Mol Biol Cell
Title: Interactions between TULP3 tubby domain and ARL13B amphipathic helix promote lipidated protein transport to cilia.
Volume: 34
Issue: 3
Pages: ar18
Publication  
First Author: Wang R
Year: 2021
Journal: JCI Insight
Title: Pdcd10-Stk24/25 complex controls kidney water reabsorption by regulating Aqp2 membrane targeting.
Volume: 6
Issue: 12
Publication
First Author: Jin H
Year: 2020
Journal: Am J Pathol
Title: Innate Immune Signaling Contributes to Tubular Cell Senescence in the Glis2 Knockout Mouse Model of Nephronophthisis.
Volume: 190
Issue: 1
Pages: 176-189
Publication  
First Author: Ramani K
Year: 2018
Journal: JCI Insight
Title: Unexpected kidney-restricted role for IL-17 receptor signaling in defense against systemic Candida albicans infection.
Volume: 3
Issue: 9
Publication
First Author: Gresh L
Year: 2004
Journal: EMBO J
Title: A transcriptional network in polycystic kidney disease.
Volume: 23
Issue: 7
Pages: 1657-68
Publication
First Author: Lee HW
Year: 2015
Journal: Am J Physiol Renal Physiol
Title: Effect of dietary protein restriction on renal ammonia metabolism.
Volume: 308
Issue: 12
Pages: F1463-73
Publication
First Author: Zhou HL
Year: 2019
Journal: Nature
Title: Metabolic reprogramming by the S-nitroso-CoA reductase system protects against kidney injury.
Volume: 565
Issue: 7737
Pages: 96-100
Publication
First Author: Faria D
Year: 2014
Journal: Kidney Int
Title: The calcium-activated chloride channel Anoctamin 1 contributes to the regulation of renal function.
Volume: 85
Issue: 6
Pages: 1369-81
Publication
First Author: Bonucci M
Year: 2020
Journal: Nat Commun
Title: mTOR and S6K1 drive polycystic kidney by the control of Afadin-dependent oriented cell division.
Volume: 11
Issue: 1
Pages: 3200
Publication
First Author: Joshi A
Year: 2015
Journal: Am J Pathol
Title: Activated mutant p110α causes endometrial carcinoma in the setting of biallelic Pten deletion.
Volume: 185
Issue: 4
Pages: 1104-13
Publication
First Author: Frew IJ
Year: 2008
Journal: EMBO J
Title: pVHL and PTEN tumour suppressor proteins cooperatively suppress kidney cyst formation.
Volume: 27
Issue: 12
Pages: 1747-57
Publication
First Author: Chu PY
Year: 2013
Journal: PLoS One
Title: SPAK deficiency corrects pseudohypoaldosteronism II caused by WNK4 mutation.
Volume: 8
Issue: 9
Pages: e72969
Publication
First Author: Hasumi H
Year: 2012
Journal: J Natl Cancer Inst
Title: Regulation of mitochondrial oxidative metabolism by tumor suppressor FLCN.
Volume: 104
Issue: 22
Pages: 1750-64
Publication
First Author: Grahammer F
Year: 2016
Journal: J Clin Invest
Title: mTORC2 critically regulates renal potassium handling.
Volume: 126
Issue: 5
Pages: 1773-82
Publication
First Author: Schönenberger D
Year: 2016
Journal: Cancer Res
Title: Formation of Renal Cysts and Tumors in Vhl/Trp53-Deficient Mice Requires HIF1α and HIF2α.
Volume: 76
Issue: 7
Pages: 2025-36
Publication
First Author: Adam J
Year: 2017
Journal: Cell Rep
Title: Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes.
Volume: 20
Issue: 13
Pages: 3135-3148
Publication
First Author: Lehmann H
Year: 2015
Journal: J Am Soc Nephrol
Title: Combined Deletion of Vhl and Kif3a Accelerates Renal Cyst Formation.
Volume: 26
Issue: 11
Pages: 2778-88
Publication
First Author: Fu H
Year: 2021
Journal: iScience
Title: The hepatocyte growth factor/c-met pathway is a key determinant of the fibrotic kidney local microenvironment.
Volume: 24
Issue: 10
Pages: 103112
Publication  
First Author: Lakhia R
Year: 2020
Journal: JCI Insight
Title: Interstitial microRNA miR-214 attenuates inflammation and polycystic kidney disease progression.
Volume: 5
Issue: 7