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Search results 1 to 100 out of 415 for Trem2

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0.021s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: chimpanzee
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Guerreiro R
Year: 2013
Journal: N Engl J Med
Title: TREM2 variants in Alzheimer's disease.
Volume: 368
Issue: 2
Pages: 117-27
Publication
First Author: Wu R
Year: 2017
Journal: Mol Brain
Title: TREM2 protects against cerebral ischemia/reperfusion injury.
Volume: 10
Issue: 1
Pages: 20
Publication
First Author: Qiao W
Year: 2023
Journal: Mol Neurodegener
Title: Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology.
Volume: 18
Issue: 1
Pages: 8
Publication
First Author: Leyns CEG
Year: 2019
Journal: Nat Neurosci
Title: TREM2 function impedes tau seeding in neuritic plaques.
Volume: 22
Issue: 8
Pages: 1217-1222
Publication
First Author: Ulland TK
Year: 2017
Journal: Cell
Title: TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease.
Volume: 170
Issue: 4
Pages: 649-663.e13
Publication
First Author: Nugent AA
Year: 2020
Journal: Neuron
Title: TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge.
Volume: 105
Issue: 5
Pages: 837-854.e9
Publication
First Author: Linnartz-Gerlach B
Year: 2019
Journal: Glia
Title: TREM2 triggers microglial density and age-related neuronal loss.
Volume: 67
Issue: 3
Pages: 539-550
Publication
First Author: Zheng H
Year: 2017
Journal: J Neurosci
Title: TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway.
Volume: 37
Issue: 7
Pages: 1772-1784
Publication
First Author: Molgora M
Year: 2020
Journal: Cell
Title: TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy.
Volume: 182
Issue: 4
Pages: 886-900.e17
Publication
First Author: Zhao Y
Year: 2018
Journal: Neuron
Title: TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function.
Volume: 97
Issue: 5
Pages: 1023-1031.e7
Publication
First Author: Liu Z
Year: 2020
Journal: Cell Death Dis
Title: TMEM59 interacts with TREM2 and modulates TREM2-dependent microglial activities.
Volume: 11
Issue: 8
Pages: 678
Publication
First Author: Cheng-Hathaway PJ
Year: 2018
Journal: Mol Neurodegener
Title: The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease.
Volume: 13
Issue: 1
Pages: 29
Publication
First Author: Poliani PL
Year: 2015
Journal: J Clin Invest
Title: TREM2 sustains microglial expansion during aging and response to demyelination.
Volume: 125
Issue: 5
Pages: 2161-70
Publication
First Author: Chen X
Year: 2023
Journal: Glia
Title: TREM2 promotes glioma progression and angiogenesis mediated by microglia/brain macrophages.
Volume: 71
Issue: 11
Pages: 2679-2695
Publication  
First Author: Meng J
Year: 2024
Journal: Int Immunopharmacol
Title: TREM2 regulates microglial phagocytosis of synapses in innate immune tolerance.
Volume: 127
Pages: 111445
Publication
First Author: Zhong L
Year: 2017
Journal: J Exp Med
Title: Soluble TREM2 induces inflammatory responses and enhances microglial survival.
Volume: 214
Issue: 3
Pages: 597-607
Publication
First Author: Dhandapani R
Year: 2022
Journal: Cell Rep
Title: Sustained Trem2 stabilization accelerates microglia heterogeneity and Aβ pathology in a mouse model of Alzheimer's disease.
Volume: 39
Issue: 9
Pages: 110883
Publication  
First Author: Patterson MT
Year: 2023
Journal: Nat Cardiovasc Res
Title: Trem2 promotes foamy macrophage lipid uptake and survival in atherosclerosis.
Volume: 2
Pages: 1015-1031
Publication
First Author: Mazaheri F
Year: 2017
Journal: EMBO Rep
Title: TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury.
Volume: 18
Issue: 7
Pages: 1186-1198
Publication
First Author: Zhu B
Year: 2022
Journal: Mol Neurodegener
Title: Trem2 deletion enhances tau dispersion and pathology through microglia exosomes.
Volume: 17
Issue: 1
Pages: 58
Publication
First Author: Lee CYD
Year: 2018
Journal: Neuron
Title: Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models.
Volume: 97
Issue: 5
Pages: 1032-1048.e5
Publication
First Author: Jadhav VS
Year: 2020
Journal: Mol Neurodegener
Title: Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice.
Volume: 15
Issue: 1
Pages: 62
Publication
First Author: Beckmann N
Year: 2023
Journal: J Neuroinflammation
Title: Genetic models of cleavage-reduced and soluble TREM2 reveal distinct effects on myelination and microglia function in the cuprizone model.
Volume: 20
Issue: 1
Pages: 29
Publication
First Author: Seno H
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Efficient colonic mucosal wound repair requires Trem2 signaling.
Volume: 106
Issue: 1
Pages: 256-61
Publication
First Author: Kleinberger G
Year: 2014
Journal: Sci Transl Med
Title: TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis.
Volume: 6
Issue: 243
Pages: 243ra86
Publication
First Author: Tagliatti E
Year: 2024
Journal: Immunity
Title: Trem2 expression in microglia is required to maintain normal neuronal bioenergetics during development.
Volume: 57
Issue: 1
Pages: 86-105.e9
Publication
First Author: Kosack L
Year: 2017
Journal: Sci Rep
Title: The lipid-sensor TREM2 aggravates disease in a model of LCMV-induced hepatitis.
Volume: 7
Issue: 1
Pages: 11289
Publication
First Author: Parhizkar S
Year: 2019
Journal: Nat Neurosci
Title: Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE.
Volume: 22
Issue: 2
Pages: 191-204
Publication
First Author: Song WM
Year: 2018
Journal: J Exp Med
Title: Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism.
Volume: 215
Issue: 3
Pages: 745-760
Publication
First Author: Sun R
Year: 2023
Journal: Sci Adv
Title: TREM2 inhibition triggers antitumor cell activity of myeloid cells in glioblastoma.
Volume: 9
Issue: 19
Pages: eade3559
Publication
First Author: Lee SH
Year: 2021
Journal: Neuron
Title: Trem2 restrains the enhancement of tau accumulation and neurodegeneration by β-amyloid pathology.
Volume: 109
Issue: 8
Pages: 1283-1301.e6
Publication
First Author: Jay TR
Year: 2019
Journal: Glia
Title: TREM2 is required for microglial instruction of astrocytic synaptic engulfment in neurodevelopment.
Volume: 67
Issue: 10
Pages: 1873-1892
Publication
First Author: Xiang X
Year: 2018
Journal: Mol Neurodegener
Title: The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans.
Volume: 13
Issue: 1
Pages: 49
Publication
First Author: Wang Y
Year: 2015
Journal: Cell
Title: TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model.
Volume: 160
Issue: 6
Pages: 1061-71
Publication
First Author: Griciuc A
Year: 2019
Journal: Neuron
Title: TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer's Disease.
Volume: 103
Issue: 5
Pages: 820-835.e7
Publication
First Author: Park MD
Year: 2023
Journal: Nat Immunol
Title: TREM2 macrophages drive NK cell paucity and dysfunction in lung cancer.
Volume: 24
Issue: 5
Pages: 792-801
Publication
First Author: Kim SM
Year: 2017
Journal: Sci Rep
Title: TREM2 promotes Aβ phagocytosis by upregulating C/EBPα-dependent CD36 expression in microglia.
Volume: 7
Issue: 1
Pages: 11118
Publication
First Author: Guo Y
Year: 2019
Journal: FASEB J
Title: TREM2 deficiency aggravates α-synuclein-induced neurodegeneration and neuroinflammation in Parkinson's disease models.
Volume: 33
Issue: 11
Pages: 12164-12174
Publication
First Author: Long H
Year: 2019
Journal: Neurochem Res
Title: TREM2 Attenuates Aβ1-42-Mediated Neuroinflammation in BV-2 Cells by Downregulating TLR Signaling.
Volume: 44
Issue: 8
Pages: 1830-1839
Publication
First Author: Yoo Y
Year: 2023
Journal: Cell Stem Cell
Title: A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer's disease.
Volume: 30
Issue: 8
Pages: 1043-1053.e6
Publication
First Author: Otero K
Year: 2012
Journal: J Immunol
Title: TREM2 and β-catenin regulate bone homeostasis by controlling the rate of osteoclastogenesis.
Volume: 188
Issue: 6
Pages: 2612-21
Publication
First Author: Xie M
Year: 2022
Journal: Nat Neurosci
Title: TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration.
Volume: 25
Issue: 1
Pages: 26-38
Publication  
First Author: Weng Y
Year: 2021
Journal: Redox Biol
Title: Trem2 mediated Syk-dependent ROS amplification is essential for osteoclastogenesis in periodontitis microenvironment.
Volume: 40
Pages: 101849
Publication
First Author: Berner DK
Year: 2020
Journal: FASEB J
Title: Meprin β cleaves TREM2 and controls its phagocytic activity on macrophages.
Volume: 34
Issue: 5
Pages: 6675-6687
Publication  
First Author: Jiang T
Year: 2016
Journal: Neuropharmacology
Title: TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice.
Volume: 105
Pages: 196-206
Publication
First Author: Filipello F
Year: 2018
Journal: Immunity
Title: The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity.
Volume: 48
Issue: 5
Pages: 979-991.e8
Publication
First Author: Zhong L
Year: 2023
Journal: Immunity
Title: TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration.
Volume: 56
Issue: 8
Pages: 1794-1808.e8
Publication
First Author: Jay TR
Year: 2015
Journal: J Exp Med
Title: TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models.
Volume: 212
Issue: 3
Pages: 287-95
Publication
First Author: Zhong L
Year: 2019
Journal: Nat Commun
Title: Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model.
Volume: 10
Issue: 1
Pages: 1365
Publication
First Author: Katzenelenbogen Y
Year: 2020
Journal: Cell
Title: Coupled scRNA-Seq and Intracellular Protein Activity Reveal an Immunosuppressive Role of TREM2 in Cancer.
Volume: 182
Issue: 4
Pages: 872-885.e19
Publication  
First Author: Ren M
Year: 2018
Journal: Exp Neurol
Title: TREM2 overexpression attenuates neuroinflammation and protects dopaminergic neurons in experimental models of Parkinson's disease.
Volume: 302
Pages: 205-213
Publication
First Author: Iizasa E
Year: 2021
Journal: Nat Commun
Title: TREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits anti-mycobacterial macrophage activation.
Volume: 12
Issue: 1
Pages: 2299
Publication
First Author: Cantoni C
Year: 2015
Journal: Acta Neuropathol
Title: TREM2 regulates microglial cell activation in response to demyelination in vivo.
Volume: 129
Issue: 3
Pages: 429-47
Publication
First Author: Bemiller SM
Year: 2017
Journal: Mol Neurodegener
Title: TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy.
Volume: 12
Issue: 1
Pages: 74
Publication
First Author: Wood JI
Year: 2022
Journal: Cell Rep
Title: Plaque contact and unimpaired Trem2 is required for the microglial response to amyloid pathology.
Volume: 41
Issue: 8
Pages: 111686
Publication  
First Author: Das M
Year: 2023
Journal: Neurobiol Dis
Title: Alzheimer risk-increasing TREM2 variant causes aberrant cortical synapse density and promotes network hyperexcitability in mouse models.
Volume: 186
Pages: 106263
Publication
First Author: Kleinberger G
Year: 2017
Journal: EMBO J
Title: The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism.
Volume: 36
Issue: 13
Pages: 1837-1853
Publication
First Author: Thornton P
Year: 2017
Journal: EMBO Mol Med
Title: TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant.
Volume: 9
Issue: 10
Pages: 1366-1378
Publication
First Author: Li C
Year: 2019
Journal: Cell Biol Int
Title: TREM2 inhibits inflammatory responses in mouse microglia by suppressing the PI3K/NF-κB signaling.
Volume: 43
Issue: 4
Pages: 360-372
Publication
First Author: Leyns CEG
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy.
Volume: 114
Issue: 43
Pages: 11524-11529
Publication
First Author: Liu W
Year: 2020
Journal: Hum Mol Genet
Title: Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions.
Volume: 29
Issue: 19
Pages: 3224-3248
Publication
First Author: Cignarella F
Year: 2020
Journal: Acta Neuropathol
Title: TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis.
Volume: 140
Issue: 4
Pages: 513-534
Publication  
First Author: Carbajosa G
Year: 2018
Journal: Neurobiol Aging
Title: Loss of Trem2 in microglia leads to widespread disruption of cell coexpression networks in mouse brain.
Volume: 69
Pages: 151-166
Publication
First Author: Sayed FA
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy.
Volume: 115
Issue: 40
Pages: 10172-10177
Publication
First Author: Price BR
Year: 2020
Journal: J Neuroinflammation
Title: Therapeutic Trem2 activation ameliorates amyloid-beta deposition and improves cognition in the 5XFAD model of amyloid deposition.
Volume: 17
Issue: 1
Pages: 238
Publication
First Author: Stoiljkovic M
Year: 2022
Journal: J Alzheimers Dis
Title: TREM2 Deficiency Disrupts Network Oscillations Leading to Epileptic Activity and Aggravates Amyloid-β-Related Hippocampal Pathophysiology in Mice.
Volume: 88
Issue: 3
Pages: 837-847
Publication
First Author: Qu W
Year: 2020
Journal: J Neurosci
Title: Loss of TREM2 Confers Resilience to Synaptic and Cognitive Impairment in Aged Mice.
Volume: 40
Issue: 50
Pages: 9552-9563
Publication
First Author: Liu C
Year: 2019
Journal: J Transl Med
Title: TREM2 regulates obesity-induced insulin resistance via adipose tissue remodeling in mice of high-fat feeding.
Volume: 17
Issue: 1
Pages: 300
Publication
First Author: Hwang M
Year: 2022
Journal: J Neuroinflammation
Title: Trem2 deficiency impairs recovery and phagocytosis and dysregulates myeloid gene expression during virus-induced demyelination.
Volume: 19
Issue: 1
Pages: 267
Publication
First Author: Bhattacharjee S
Year: 2016
Journal: PLoS One
Title: microRNA-34a-Mediated Down-Regulation of the Microglial-Enriched Triggering Receptor and Phagocytosis-Sensor TREM2 in Age-Related Macular Degeneration.
Volume: 11
Issue: 3
Pages: e0150211
Publication
First Author: Gonçalves LA
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: TREM2 governs Kupffer cell activation and explains belr1 genetic resistance to malaria liver stage infection.
Volume: 110
Issue: 48
Pages: 19531-6
Publication  
First Author: Götzl JK
Year: 2019
Journal: EMBO Mol Med
Title: Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism.
Volume: 11
Issue: 6
Publication  
First Author: Liebold I
Year: 2023
Journal: Cells
Title: TREM2 Regulates the Removal of Apoptotic Cells and Inflammatory Processes during the Progression of NAFLD.
Volume: 12
Issue: 3
Publication
First Author: Fassler M
Year: 2021
Journal: J Neuroinflammation
Title: Engagement of TREM2 by a novel monoclonal antibody induces activation of microglia and improves cognitive function in Alzheimer's disease models.
Volume: 18
Issue: 1
Pages: 19
Publication
First Author: Xie X
Year: 2023
Journal: Blood
Title: TREM2 acts as a receptor for IL-34 to suppress acute myeloid leukemia in mice.
Volume: 141
Issue: 26
Pages: 3184-3198
Publication
First Author: Thrash JC
Year: 2009
Journal: Neurochem Res
Title: Developmental regulation of TREM2 and DAP12 expression in the murine CNS: implications for Nasu-Hakola disease.
Volume: 34
Issue: 1
Pages: 38-45
Publication
First Author: Yuan P
Year: 2016
Journal: Neuron
Title: TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy.
Volume: 90
Issue: 4
Pages: 724-39
Publication
First Author: Gao H
Year: 2023
Journal: Cell Rep
Title: Distinct myeloid population phenotypes dependent on TREM2 expression levels shape the pathology of traumatic versus demyelinating CNS disorders.
Volume: 42
Issue: 6
Pages: 112629
Publication
First Author: Fitz NF
Year: 2020
Journal: Mol Neurodegener
Title: Trem2 deficiency differentially affects phenotype and transcriptome of human APOE3 and APOE4 mice.
Volume: 15
Issue: 1
Pages: 41
Publication
First Author: Jiang T
Year: 2015
Journal: Neurobiol Aging
Title: Silencing of TREM2 exacerbates tau pathology, neurodegenerative changes, and spatial learning deficits in P301S tau transgenic mice.
Volume: 36
Issue: 12
Pages: 3176-3186
Publication  
First Author: Vautheny A
Year: 2021
Journal: Neurobiol Dis
Title: THY-Tau22 mouse model accumulates more tauopathy at late stage of the disease in response to microglia deactivation through TREM2 deficiency.
Volume: 155
Pages: 105398
Publication  
First Author: Ruganzu JB
Year: 2021
Journal: Exp Neurol
Title: TREM2 overexpression rescues cognitive deficits in APP/PS1 transgenic mice by reducing neuroinflammation via the JAK/STAT/SOCS signaling pathway.
Volume: 336
Pages: 113506
Publication
First Author: Varnum MM
Year: 2017
Journal: J Biol Chem
Title: A split-luciferase complementation, real-time reporting assay enables monitoring of the disease-associated transmembrane protein TREM2 in live cells.
Volume: 292
Issue: 25
Pages: 10651-10663
Publication  
First Author: Ruganzu JB
Year: 2022
Journal: Mol Immunol
Title: Downregulation of TREM2 expression exacerbates neuroinflammatory responses through TLR4-mediated MAPK signaling pathway in a transgenic mouse model of Alzheimer's disease.
Volume: 142
Pages: 22-36
Publication
First Author: Jay TR
Year: 2017
Journal: J Neurosci
Title: Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease.
Volume: 37
Issue: 3
Pages: 637-647
Publication
First Author: Jiang Y
Year: 2018
Journal: Cell Physiol Biochem
Title: Upregulation of TREM2 Ameliorates Neuroinflammatory Responses and Improves Cognitive Deficits Triggered by Surgical Trauma in Appswe/PS1dE9 Mice.
Volume: 46
Issue: 4
Pages: 1398-1411
Publication
First Author: Delizannis AT
Year: 2021
Journal: Acta Neuropathol Commun
Title: Effects of microglial depletion and TREM2 deficiency on Aβ plaque burden and neuritic plaque tau pathology in 5XFAD mice.
Volume: 9
Issue: 1
Pages: 150
Publication
First Author: Liu AH
Year: 2019
Journal: Neurosci Bull
Title: Up-Regulation of Trem2 Inhibits Hippocampal Neuronal Apoptosis and Alleviates Oxidative Stress in Epilepsy via the PI3K/Akt Pathway in Mice.
Volume: 35
Issue: 3
Pages: 471-485
Publication  
First Author: Lefterov I
Year: 2015
Journal: Neurobiol Dis
Title: RNA-sequencing reveals transcriptional up-regulation of Trem2 in response to bexarotene treatment.
Volume: 82
Pages: 132-140
Publication
First Author: Yan J
Year: 2022
Journal: J Neuroinflammation
Title: TREM2 activation alleviates neural damage via Akt/CREB/BDNF signalling after traumatic brain injury in mice.
Volume: 19
Issue: 1
Pages: 289