AP-1 complex-associated regulatory protein (AP1AR), also known as gadkin or gamma-BAR, is a negative regulator of the actin-related protein (ARP)2/3 complex, a major regulator of actin dynamics. Through inhibition of ARP2/3, gadkin negatively regulates cell spreading and motility []. Gadkin is also a modulator of adaptor protein (AP)-1-mediated endosomal membrane trafficking [, , ].
