This entry represents the RNA recognition motif 2 (RRM2) of insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3).IGF2BP3 plays an important role in the differentiation process during early embryogenesis. It is known to bind to and repress the translation of IGF2 leader 3 mRNA []. IGF2BP3 also acts as a Glioblastoma-specific proproliferative and proinvasive marker acting through IGF2 resulting in the activation of oncogenic phosphatidylinositol 3-kinase/mitogen-activated protein kinase (PI3K/MAPK) pathways []. IGF2BP3 contains four hnRNP K-homology (KH) domains, two RNA recognition motifs (RRMs) and a RGG RNA-binding domain.IGF2BP3 belongs to the IGF2BP family (includes IGF2BP1, IGF2BP2, IGF2BP3). They have different functions, such as cell polarisation, migration, morphology, metabolism, proliferation and differentiation [].
