DIAPH2 belongs to the formin homology family, Diaphanous subfamily (also known as the Diaphanous-related formins, Drfs). In addition to the FH1 and FH2 domains, Drfs contain an N-terminal GTPase-binding domain (mDiaN) and a C-terminal Diaphanous-autoregulatory domain (DAD).DIAPH2 may be involved in oogenesis and in the regulation of endosome dynamics. In humans, DIAPH2 has three isoforms produced by alternative splicing. Its isoform3, DIA2C, together with CSK are sequentially activated by GTPase RhoD to regulate the motility of early endosomes through interactions with the actin cytoskeleton [].
