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Search results 401 to 497 out of 497 for Eps8

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Type Details Score
Publication
- | J:58777
     
First Author: Elliott R
Year: 2000
Journal: Personal Communication
Title: Chromosome Locations Based on RH mapping
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Publication
24154525 | J:205051
First Author: Miller JA
Year: 2013
Journal: Development
Title: Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates.
Volume: 140
Issue: 22
Pages: 4633-44
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Publication
10512203 | J:93290
First Author: Araki K
Year: 1999
Journal: Cell Mol Biol (Noisy-le-grand)
Title: Exchangeable gene trap using the Cre/mutated lox system.
Volume: 45
Issue: 5
Pages: 737-50
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Publication
15840001 | J:110088
First Author: Taniwaki T
Year: 2005
Journal: Dev Growth Differ
Title: Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.
Volume: 47
Issue: 3
Pages: 163-72
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Publication
- | J:345476
       
First Author: Haiming Tang, Dustin Ebert, Matthias Blum, Robert Finn, Paul Thomas
Year: 2023
Title: TreeGrafter-generated GO annotations
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Gene
100381072 | eps8l1.L
Type: gene
Organism: frog, African clawed
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Gene
108697742 | eps8l1.S
Type: gene
Organism: frog, African clawed
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Publication
16868024 | J:111709
First Author: Goicoechea S
Year: 2006
Journal: J Cell Sci
Title: Palladin binds to Eps8 and enhances the formation of dorsal ruffles and podosomes in vascular smooth muscle cells.
Volume: 119
Issue: Pt 16
Pages: 3316-24
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HT Experiment
E-GEOD-14454 | Loss of the actin remodeler Eps8 causes calorie restriction and improved metabolic status in mice
Series Id: GSE14454
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
26163656 | J:225986
 
First Author: Logue JS
Year: 2015
Journal: Elife
Title: Erk regulation of actin capping and bundling by Eps8 promotes cortex tension and leader bleb-based migration.
Volume: 4
Pages: e08314
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Publication
27278019 | J:246512
First Author: Sudhaharan T
Year: 2016
Journal: J Cell Sci
Title: The Rho GTPase Rif signals through IRTKS, Eps8 and WAVE2 to generate dorsal membrane ruffles and filopodia.
Volume: 129
Issue: 14
Pages: 2829-40
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Publication
12127568 | -
First Author: Di Fiore PP
Year: 2002
Journal: Int J Biochem Cell Biol
Title: Eps8 in the midst of GTPases.
Volume: 34
Issue: 10
Pages: 1178-83
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Interaction Experiment
Offenhaeuser N (2006)
Description: Increased ethanol resistance and consumption in Eps8 knockout mice correlates with altered actin dynamics.
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DO Term
DOID:0110463 | autosomal recessive nonsyndromic deafness 102
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Publication
9303002 | -
First Author: Kishan KV
Year: 1997
Journal: Nat Struct Biol
Title: The SH3 domain of Eps8 exists as a novel intertwined dimer.
Volume: 4
Issue: 9
Pages: 739-43
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Publication
11099046 | -
First Author: Lanzetti L
Year: 2000
Journal: Nature
Title: The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5.
Volume: 408
Issue: 6810
Pages: 374-7
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Protein
Q8CBW3
Organism: Mus musculus/domesticus
Length: 481  
Fragment?: false
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Protein
Q8CBW3-5
Organism: Mus musculus/domesticus
Length: 388  
Fragment?: false
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Protein
Q8CBW3-3
Organism: Mus musculus/domesticus
Length: 476  
Fragment?: false
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Protein
Q8CBW3-2
Organism: Mus musculus/domesticus
Length: 446  
Fragment?: false
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Protein
Q8CBW3-4
Organism: Mus musculus/domesticus
Length: 475  
Fragment?: false
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Publication
22710157 | -
First Author: Saksela K
Year: 2012
Journal: FEBS Lett
Title: SH3 domain ligand binding: What's the consensus and where's the specificity?
Volume: 586
Issue: 17
Pages: 2609-14
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Protein Domain
IPR035462 | Eps8_SH3
Type: Domain
Description: This entry represents the SH3 domain found in Eps8 and Eps8-like proteins including Eps8-like 1-3. These proteins contain N-terminal phosphotyrosine-binding (PTB), central SH3, and C-terminal effector domains. The SH3 domains of Eps8 and similar proteins recognize peptides containing a PxxDY motif, instead of the classical PxxP motif []. Epidermal growth factor receptor kinase substrate 8 (EPS8) is a signalling adapter that possesses actin binding, bundling, and barbed-end capping activities []. It forms a complex with Sos-1, Abi1 and the lipid kinase phosphoinositide 3-kinase (PI3-K) to regulate Rac activation that leads to actin cytoskeletal remodeling []. It is critical for dendritic cell migration []. It is involved in the initial growth of stereocilia in both inner hair cells and outer hair cells []. It also regulates axonal filopodia in hippocampal neurons in response to brain-derived neurotrophic factor (BDNF) []. It has been linked to proliferation, metastasis and prognosis of many malignant tumours [].
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Publication
14983521 | -
First Author: Boukhelifa M
Year: 2004
Journal: Cell Motil Cytoskeleton
Title: Palladin is a novel binding partner for Ena/VASP family members.
Volume: 58
Issue: 1
Pages: 17-29
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Publication
15950489 | J:100650
First Author: Luo H
Year: 2005
Journal: Mol Cell Neurosci
Title: Disruption of palladin results in neural tube closure defects in mice.
Volume: 29
Issue: 4
Pages: 507-15
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Publication
16492705 | J:107003
First Author: Rachlin AS
Year: 2006
Journal: J Cell Sci
Title: Identification of palladin isoforms and characterization of an isoform-specific interaction between Lasp-1 and palladin.
Volume: 119
Issue: Pt 6
Pages: 995-1004
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Publication
18180288 | -
First Author: Dixon RD
Year: 2008
Journal: J Biol Chem
Title: Palladin is an actin cross-linking protein that uses immunoglobulin-like domains to bind filamentous actin.
Volume: 283
Issue: 10
Pages: 6222-31
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Publication
23806659 | -
First Author: Beck MR
Year: 2013
Journal: J Mol Biol
Title: Structure and function of palladin's actin binding domain.
Volume: 425
Issue: 18
Pages: 3325-37
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Publication
17537434 | -
First Author: Rönty M
Year: 2007
Journal: Exp Cell Res
Title: Palladin interacts with SH3 domains of SPIN90 and Src and is required for Src-induced cytoskeletal remodeling.
Volume: 313
Issue: 12
Pages: 2575-85
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Publication
20471940 | -
First Author: Chin YR
Year: 2010
Journal: Mol Cell
Title: The actin-bundling protein palladin is an Akt1-specific substrate that regulates breast cancer cell migration.
Volume: 38
Issue: 3
Pages: 333-44
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Publication
11598191 | J:114007
First Author: Mykkänen OM
Year: 2001
Journal: Mol Biol Cell
Title: Characterization of human palladin, a microfilament-associated protein.
Volume: 12
Issue: 10
Pages: 3060-73
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Publication
16367745 | -
First Author: Boukhelifa M
Year: 2006
Journal: FEBS J
Title: The proline-rich protein palladin is a binding partner for profilin.
Volume: 273
Issue: 1
Pages: 26-33
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Publication
25875253 | -
First Author: Nguyen NU
Year: 2015
Journal: PLoS One
Title: Dual roles of palladin protein in in vitro myogenesis: inhibition of early induction but promotion of myotube maturation.
Volume: 10
Issue: 4
Pages: e0124762
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Publication
25194811 | J:220095
First Author: Nguyen NU
Year: 2014
Journal: Biochem Biophys Res Commun
Title: Actin-associated protein palladin is required for migration behavior and differentiation potential of C2C12 myoblast cells.
Volume: 452
Issue: 3
Pages: 728-33
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Publication
20877641 | J:165108
First Author: Jin L
Year: 2010
Journal: PLoS One
Title: The actin associated protein palladin is important for the early smooth muscle cell differentiation.
Volume: 5
Issue: 9
Pages: e12823
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Publication
19015263 | J:146948
First Author: Jin L
Year: 2009
Journal: J Biol Chem
Title: The actin-associated protein Palladin is required for development of normal contractile properties of smooth muscle cells derived from embryoid bodies.
Volume: 284
Issue: 4
Pages: 2121-30
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Protein Domain
IPR039801 | EPS8-like
Type: Family
Description: This entry includes EPS8 and EPS8L1-3 from animals.Epidermal growth factor receptor kinase substrate 8 (EPS8) is a signalling adapter that possesses actin binding, bundling, and barbed-end capping activities []. It forms a complex with Sos-1, Abi1 and the lipid kinase phosphoinositide 3-kinase (PI3-K) to regulate Rac activation that leads to actin cytoskeletal remodeling []. It is critical for dendritic cell migration []. It is involved in the initial growth of stereocilia in both inner hair cells and outer hair cells []. It also regulates axonal filopodia in hippocampal neurons in response to brain-derived neurotrophic factor (BDNF) []. It has been linked to proliferation, metastasis and prognosis of many malignant tumours [].Similarly to EPS8, EPSLs interact with Abi1 and Sos-1. However, only EPS8L1 and EPS8L2 activate the Rac-GEF activity of Sos-1, and bind to actin in vivo []. Eps8L2 null-mutant mice has been shown to exhibit a late-onset, progressive hearing loss that is directly linked to a gradual deterioration in hair bundle morphology [].
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Protein Domain
IPR033017 | Palladin_C
Type: Domain
Description: Palladin is a cytoskeletal actin scaffold protein that regulates actin dynamics. The immunoglobulin-like domain of palladin is directly responsible for both actin binding and bundling [, ]. Palladin also interacts with different actin binding proteins and signalling intermediaries required for regulation of cytoskeleton organisation, including profilin [], VASP [], Eps8 [], ezrin [], Lasp-1 [], and Src []. Palladin plays an important role in smooth and skeletal muscle differentiation [, , ], contraction []and cell migration [, , ].Palladin is expressed as several alternatively spliced isoforms, having various combinations of Ig-like domains, in a cell-type-specific manner. It has been suggested that palladin's different Ig-like domains may be specialized for distinct functions []. This entry represents the C-terminal immunoglobulin-like domain (Ig5).
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Publication
11696321 | J:196124
First Author: Krugmann S
Year: 2001
Journal: Curr Biol
Title: Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex.
Volume: 11
Issue: 21
Pages: 1645-55
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Publication
19913105 | -
First Author: Ahmed S
Year: 2010
Journal: Semin Cell Dev Biol
Title: I-BAR domains, IRSp53 and filopodium formation.
Volume: 21
Issue: 4
Pages: 350-6
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Publication
23740402 | -
First Author: Ferrari I
Year: 2012
Journal: Commun Integr Biol
Title: LIN7-IRSp53: A novel pathway for filopodia and neurite formation?
Volume: 5
Issue: 6
Pages: 631-3
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Publication
31902726 | J:292584
First Author: Krey JF
Year: 2020
Journal: Curr Biol
Title: Mechanotransduction-Dependent Control of Stereocilia Dimensions and Row Identity in Inner Hair Cells.
Volume: 30
Issue: 3
Pages: 442-454.e7
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Publication
35235570 | J:322529
First Author: Lorente-Cánovas B
Year: 2022
Journal: PLoS One
Title: Grxcr1 regulates hair bundle morphogenesis and is required for normal mechanoelectrical transduction in mouse cochlear hair cells.
Volume: 17
Issue: 3
Pages: e0261530
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Publication
19286134 | -
First Author: Weiss SM
Year: 2009
Journal: Cell Host Microbe
Title: IRSp53 links the enterohemorrhagic E. coli effectors Tir and EspFU for actin pedestal formation.
Volume: 5
Issue: 3
Pages: 244-58
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Protein Domain
IPR030128 | IRSp53
Type: Family
Description: IRSp53, also known as IRS-58 or BAIAP2 (brain-specific angiogenesis inhibitor 1-associated protein 2), is an I-BAR (Bin/amphipysin/Rvs) domain containing protein. BAR domain forms an anti-parallel all-helical dimer, with a curved (banana-like) shape, that promotes membrane tubulation. BAR domain proteins can be classified into three types: BAR, F-BAR and I-BAR. BAR and F-BAR proteins generate positive membrane curvature, while I-BAR proteins induce negative curvature [].IRSp53 is an adaptor protein that acts at the membrane-actin interface, coupling membrane deformation with F-actin polymerisation []. It is involved in the formation of filopodia and lamellipodia in cultured mesenchymal cells and contributes to assembly/maintenance of tight junctions in cultured epithelial cells []. IRSp53 contains an N-terminal I-BAR domain, followed by a partial CRIB domain and a SH3 domain. It binds to small GTPase Cdc42, Rac1 and WAVE1 []. IRSp53 binds Rac through its I-BAR domain and to WAVE through its SH3 domain, and thus contributes to membrane ruffling []. Its SH3 domain also interacts with other regulators of actin dynamics, such as WAVE2, Mena, mDia1, Dynamin1, Eps8 and N-WASP [].
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Protein Domain
IPR035594 | Irsp53_SH3
Type: Domain
Description: This entry represents the SH3 domain of IRSp53. The SH3 domain of IRSp53 has been shown to bind the proline-rich C terminus of EspFu (E. coli secreted protein F-like from prophage U) [].IRSp53, also known as IRS-58 or BAIAP2 (brain-specific angiogenesis inhibitor 1-associated protein 2), is an I-BAR (Bin/amphipysin/Rvs) domain containing protein. BAR domain forms an anti-parallel all-helical dimer, with a curved (banana-like) shape, that promotes membrane tubulation. BAR domain proteins can be classified into three types: BAR, F-BAR and I-BAR. BAR and F-BAR proteins generate positive membrane curvature, while I-BAR proteins induce negative curvature [].IRSp53 is an adaptor protein that acts at the membrane-actin interface, coupling membrane deformation with F-actin polymerisation []. It is involved in the formation of filopodia and lamellipodia in cultured mesenchymal cells and contributes to assembly/maintenance of tight junctions in cultured epithelial cells []. IRSp53 contains an N-terminal I-BAR domain, followed by a partial CRIB domain and a SH3 domain. It binds to small GTPase Cdc42, Rac1 and WAVE1 []. IRSp53 binds Rac through its I-BAR domain and to WAVE through its SH3 domain, and thus contributes to membrane ruffling []. Its SH3 domain also interacts with other regulators of actin dynamics, such as WAVE2, Mena, mDia1, Dynamin1, Eps8 and N-WASP [].
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Protein
E9PZ95
Organism: Mus musculus/domesticus
Length: 52  
Fragment?: true
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Protein
D3YWI5
Organism: Mus musculus/domesticus
Length: 80  
Fragment?: true
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Publication
33151556 | J:305454
First Author: Carlton AJ
Year: 2021
Journal: J Physiol
Title: Loss of Baiap2l2 destabilizes the transducing stereocilia of cochlear hair cells and leads to deafness.
Volume: 599
Issue: 4
Pages: 1173-1198
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Publication
37011103 | J:346281
First Author: Krey JF
Year: 2023
Journal: PLoS Biol
Title: Control of stereocilia length during development of hair bundles.
Volume: 21
Issue: 4
Pages: e3001964
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Publication
31830989 | J:292496
First Author: Zhang Y
Year: 2019
Journal: BMC Biol
Title: SATB1 establishes ameloblast cell polarity and regulates directional amelogenin secretion for enamel formation.
Volume: 17
Issue: 1
Pages: 104
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Publication
21093245 | -
First Author: Zhao H
Year: 2011
Journal: Curr Opin Cell Biol
Title: I-BAR domain proteins: linking actin and plasma membrane dynamics.
Volume: 23
Issue: 1
Pages: 14-21
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Protein
Q91WL0
Organism: Mus musculus/domesticus
Length: 600  
Fragment?: false
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Protein
E9PWX4
Organism: Mus musculus/domesticus
Length: 152  
Fragment?: true
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Protein
E9PVI7
Organism: Mus musculus/domesticus
Length: 93  
Fragment?: true
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Protein
E9Q2P3
Organism: Mus musculus/domesticus
Length: 109  
Fragment?: false
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Protein
A0A0G2JGZ0
Organism: Mus musculus/domesticus
Length: 89  
Fragment?: true
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Protein
Q99K30
Organism: Mus musculus/domesticus
Length: 729  
Fragment?: false
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Protein
Q8R5F8
Organism: Mus musculus/domesticus
Length: 716  
Fragment?: false
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Protein
E9Q4X5
Organism: Mus musculus/domesticus
Length: 777  
Fragment?: false
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Publication
21743456 | J:175296
First Author: Pykäläinen A
Year: 2011
Journal: Nat Struct Mol Biol
Title: Pinkbar is an epithelial-specific BAR domain protein that generates planar membrane structures.
Volume: 18
Issue: 8
Pages: 902-7
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Protein
Q8BKX1
Organism: Mus musculus/domesticus
Length: 535  
Fragment?: false
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Protein
B1AZ46
Organism: Mus musculus/domesticus
Length: 521  
Fragment?: false
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Protein
Q3UKP6
Organism: Mus musculus/domesticus
Length: 522  
Fragment?: false
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Protein
Q3TV50
Organism: Mus musculus/domesticus
Length: 282  
Fragment?: false
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Protein
Q9ET54
Organism: Mus musculus/domesticus
Length: 1408  
Fragment?: false
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Protein
K0BWC3
Organism: Mus musculus/domesticus
Length: 1002  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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