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Search results 2401 to 2500 out of 2539 for Fgfr1

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Type Details Score
Publication
1383894 | -
First Author: Seulberger H
Year: 1992
Journal: Neurosci Lett
Title: HT7, Neurothelin, Basigin, gp42 and OX-47--many names for one developmentally regulated immuno-globulin-like surface glycoprotein on blood-brain barrier endothelium, epithelial tissue barriers and neurons.
Volume: 140
Issue: 1
Pages: 93-7
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Publication
9559645 | J:46952
First Author: Kuno N
Year: 1998
Journal: FEBS Lett
Title: Female sterility in mice lacking the basigin gene, which encodes a transmembrane glycoprotein belonging to the immunoglobulin superfamily.
Volume: 425
Issue: 2
Pages: 191-4
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Protein Domain
IPR028303 | FGF15/FGF19
Type: Family
Description: Fibroblast growth factors (FGFs) [, ]are a family of multifunctional proteins, often referred to as 'promiscuous growth factors' due to their diverse actions on multiple cell types [, ]. FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The function of FGFs in developmental processes include mesoderm induction, anterior-posterior patterning, limb development, and neural induction and development. In mature tissues, they are involved in diverse processes including keratinocyte organisation and wound healing [, , , , , ]. FGF involvement is critical during normal development of both vertebrates and invertebrates, and irregularities in their function leads to a range of developmental defects [, , , ]. Fibroblast growth factors are heparin-binding proteins and interactions with cell-surface-associated heparan sulfate proteoglycans have been shown to be essential for FGF signal transduction. FGFs have internal pseudo-threefold symmetry (β-trefoil topology) []. There are currently over 20 different FGF family members that have been identified in mammals, all of which are structurally related signaling molecules [, ]. They exert their effects through four distinct membrane fibroblast growth factor receptors (FGFRs), FGFR1 to FGFR4 [], which belong to the tyrosine kinase superfamily. Upon binding to FGF, the receptors dimerize and their intracellular tyrosine kinase domains become active [].Fibroblast growth factor 15 (FGF15) plays a key role in enterohepatic signaling, regulation of liver bile acid biosynthesis, gallbladder motility and metabolic homeostasis [, , ]. Mouse FGF15 has been shown to be stimulated when bile acids bind to farnesoid X receptor (FXR) [], and is therefore thought to a factor in chronic bile acid diarrhoea and in certain metabolic disorders [].FGF15 has been experimentally characterised in mouse, but has not been found in other species. However, there is an orthologous human protein, FGF19, and together they share about 50% amino acid identity and display similar endocrine functions, so are often referred to as FGF15/19 [, ]. FGF15 and FGF19 differ from other FGFs due to subtle changes in their tertiary structure, they have low heparin binding affinity enabling them to diffuse away from their site of secretion and signal to distantcells. FGF signaling through the FGF receptors is also different, as they require klotho protein cofactors rather than heparin sulfate proteoglycan [].Fibroblast growth factor 19 (FGF19) plays a key role in enterohepatic signaling, regulation of liver bile acid biosynthesis, gallbladder motility and metabolic homeostasis [, , ]. Human FGF19 expression has been shown to be stimulated approximately 300-fold by physiological concentrations of bile acids including chenodeoxycholic acid, glycochenodeoxycholic acid and obeticholic acid in explants of ileal mucosa []. The protein is thought to be a factor in chronic bile acid diarrhoea and in certain metabolic disorders [, ]. FGF19 has been experimentally characterised in humans and other species, but has not been found in mouse. However there is an orthologous mouse protein, FGF15, and together they share about 50% amino acid identity and display similar endocrine functions, so are often referred to as FGF15/19 [, ]. FGF15 and FGF19 differ from other FGFs due to subtle changes in their tertiary structure. They have low heparin binding affinity, enabling them to diffuse away from their site of secretion and signal to distant cells. FGF signaling through the FGF receptors is also different, as they require klotho protein cofactors rather than heparin sulfate proteoglycan []. Unlike other members of the family that can bind several FGF receptors, FGF19 is specific for FGFR4 [].
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Protein
Q9JJN1
Organism: Mus musculus/domesticus
Length: 210  
Fragment?: false
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Protein
A0A0A0MQN8
Organism: Mus musculus/domesticus
Length: 122  
Fragment?: false
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Protein
A0A7U3L6A3
Organism: Mus musculus/domesticus
Length: 210  
Fragment?: false
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Protein
O35622
Organism: Mus musculus/domesticus
Length: 218  
Fragment?: false
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Protein
P97300
Organism: Mus musculus/domesticus
Length: 397  
Fragment?: false
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Protein
Z4YLB7
Organism: Mus musculus/domesticus
Length: 277  
Fragment?: false
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Protein
H3BKA7
Organism: Mus musculus/domesticus
Length: 193  
Fragment?: false
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Protein
Q3TJ05
Organism: Mus musculus/domesticus
Length: 386  
Fragment?: false
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Protein
H3BIX4
Organism: Mus musculus/domesticus
Length: 221  
Fragment?: true
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Protein
Q790L8
Organism: Mus musculus/domesticus
Length: 218  
Fragment?: false
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Publication
10858549 | J:63008
First Author: Nishimura T
Year: 2000
Journal: Biochim Biophys Acta
Title: Identification of a novel FGF, FGF-21, preferentially expressed in the liver.
Volume: 1492
Issue: 1
Pages: 203-6
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Publication
15902306 | J:99202
First Author: Kharitonenkov A
Year: 2005
Journal: J Clin Invest
Title: FGF-21 as a novel metabolic regulator.
Volume: 115
Issue: 6
Pages: 1627-35
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Protein
A0A1W2P7R6
Organism: Mus musculus/domesticus
Length: 81  
Fragment?: true
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Publication
18687777 | -
First Author: Coskun T
Year: 2008
Journal: Endocrinology
Title: Fibroblast growth factor 21 corrects obesity in mice.
Volume: 149
Issue: 12
Pages: 6018-27
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Publication
25300137 | -
 
First Author: Mohebiany AN
Year: 2014
Journal: Adv Neurobiol
Title: New insights into the roles of the contactin cell adhesion molecules in neural development.
Volume: 8
Pages: 165-94
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Protein Coding Gene
MGI:1925544 | Rps27a
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98887 | Uba52
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98888 | Ubb
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98889 | Ubc
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P62984
Organism: Mus musculus/domesticus
Length: 128  
Fragment?: false
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Protein
P0CG50
Organism: Mus musculus/domesticus
Length: 734  
Fragment?: false
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Protein
P62983
Organism: Mus musculus/domesticus
Length: 156  
Fragment?: false
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Protein
P0CG49
Organism: Mus musculus/domesticus
Length: 305  
Fragment?: false
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Publication
16213224 | J:129677
First Author: Inagaki T
Year: 2005
Journal: Cell Metab
Title: Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis.
Volume: 2
Issue: 4
Pages: 217-25
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Protein
A2AST1
Organism: Mus musculus/domesticus
Length: 1451  
Fragment?: false
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Protein
Q6P6Q1
Organism: Mus musculus/domesticus
Length: 400  
Fragment?: false
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Protein
Q6P9Y5
Organism: Mus musculus/domesticus
Length: 219  
Fragment?: true
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Protein
A0A1W2P7X4
Organism: Mus musculus/domesticus
Length: 220  
Fragment?: true
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Protein
Q8R4B2
Organism: Mus musculus/domesticus
Length: 285  
Fragment?: true
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Protein
A0A0N4SUM4
Organism: Mus musculus/domesticus
Length: 428  
Fragment?: false
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Protein
A0A1L1SQZ7
Organism: Mus musculus/domesticus
Length: 286  
Fragment?: true
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Protein
Q3UY89
Organism: Mus musculus/domesticus
Length: 297  
Fragment?: true
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Protein
J3QP71
Organism: Mus musculus/domesticus
Length: 197  
Fragment?: true
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Protein
A0A1W2P6P3
Organism: Mus musculus/domesticus
Length: 175  
Fragment?: true
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Publication
22302876 | -
First Author: Potthoff MJ
Year: 2012
Journal: Genes Dev
Title: Endocrine fibroblast growth factors 15/19 and 21: from feast to famine.
Volume: 26
Issue: 4
Pages: 312-24
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Publication
23518683 | -
First Author: Zhang JH
Year: 2013
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Potent stimulation of fibroblast growth factor 19 expression in the human ileum by bile acids.
Volume: 304
Issue: 10
Pages: G940-8
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Publication
22396169 | -
 
First Author: Jones SA
Year: 2012
Journal: Adv Exp Med Biol
Title: Physiology of FGF15/19.
Volume: 728
Pages: 171-82
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Publication
10525310 | -
First Author: Xie MH
Year: 1999
Journal: Cytokine
Title: FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4.
Volume: 11
Issue: 10
Pages: 729-35
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Publication
21436455 | J:169835
First Author: Kir S
Year: 2011
Journal: Science
Title: FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis.
Volume: 331
Issue: 6024
Pages: 1621-4
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Publication
17823457 | J:129925
First Author: Jung D
Year: 2007
Journal: J Lipid Res
Title: FXR agonists and FGF15 reduce fecal bile acid excretion in a mouse model of bile acid malabsorption.
Volume: 48
Issue: 12
Pages: 2693-700
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Protein
J3QN85
Organism: Mus musculus/domesticus
Length: 833  
Fragment?: false
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Protein
Q60818
Organism: Mus musculus/domesticus
Length: 822  
Fragment?: false
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Protein
Q8CIM9
Organism: Mus musculus/domesticus
Length: 820  
Fragment?: false
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Protein
P18572
Organism: Mus musculus/domesticus
Length: 389  
Fragment?: false
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Protein
P21995
Organism: Mus musculus/domesticus
Length: 330  
Fragment?: false
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Protein
Q7TPW1
Organism: Mus musculus/domesticus
Length: 607  
Fragment?: false
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Protein
Q3TSZ8
Organism: Mus musculus/domesticus
Length: 330  
Fragment?: false
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Protein
Q3TQK2
Organism: Mus musculus/domesticus
Length: 410  
Fragment?: false
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Protein
A0A0G2JG59
Organism: Mus musculus/domesticus
Length: 473  
Fragment?: true
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Protein
O55107
Organism: Mus musculus/domesticus
Length: 275  
Fragment?: true
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Protein
G4W8R3
Organism: Mus musculus/domesticus
Length: 594  
Fragment?: false
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Protein
A0A0G2JFD8
Organism: Mus musculus/domesticus
Length: 536  
Fragment?: false
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Protein
O55108
Organism: Mus musculus/domesticus
Length: 257  
Fragment?: true
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Protein
A0A0G2JEX1
Organism: Mus musculus/domesticus
Length: 671  
Fragment?: false
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Protein
G4W8R2
Organism: Mus musculus/domesticus
Length: 671  
Fragment?: false
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Protein
A0A0G2JGI1
Organism: Mus musculus/domesticus
Length: 593  
Fragment?: false
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Protein
A0A1W2P814
Organism: Mus musculus/domesticus
Length: 232  
Fragment?: true
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Protein
G4W8R4
Organism: Mus musculus/domesticus
Length: 537  
Fragment?: false
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Protein
E9Q8Q6
Organism: Mus musculus/domesticus
Length: 1531  
Fragment?: false
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Protein
Q3UFK0
Organism: Mus musculus/domesticus
Length: 330  
Fragment?: false
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Protein
K3W4Q8
Organism: Mus musculus/domesticus
Length: 218  
Fragment?: false
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Protein
Q3TI59
Organism: Mus musculus/domesticus
Length: 330  
Fragment?: false
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Protein
Q8CIH5
Organism: Mus musculus/domesticus
Length: 1265  
Fragment?: false
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Publication
19926274 | -
First Author: Filippakopoulos P
Year: 2009
Journal: Curr Opin Struct Biol
Title: SH2 domains: modulators of nonreceptor tyrosine kinase activity.
Volume: 19
Issue: 6
Pages: 643-9
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Protein
Q69Z26
Organism: Mus musculus/domesticus
Length: 1026  
Fragment?: false
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Protein
P70232
Organism: Mus musculus/domesticus
Length: 1209  
Fragment?: false
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Protein
Q9ERC8
Organism: Mus musculus/domesticus
Length: 2013  
Fragment?: false
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Protein
Q2EY15
Organism: Mus musculus/domesticus
Length: 1191  
Fragment?: false
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Protein
Q810U3
Organism: Mus musculus/domesticus
Length: 1240  
Fragment?: false
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Protein
A0A087WPX3
Organism: Mus musculus/domesticus
Length: 1347  
Fragment?: false
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Protein
E9PW06
Organism: Mus musculus/domesticus
Length: 1174  
Fragment?: false
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Protein
Q8R4B1
Organism: Mus musculus/domesticus
Length: 381  
Fragment?: true
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Protein
A0A087WNW2
Organism: Mus musculus/domesticus
Length: 899  
Fragment?: false
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Protein
Q6ZQ54
Organism: Mus musculus/domesticus
Length: 1251  
Fragment?: true
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Protein
F8WH58
Organism: Mus musculus/domesticus
Length: 714  
Fragment?: false
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Protein
E9Q171
Organism: Mus musculus/domesticus
Length: 1157  
Fragment?: false
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Protein
A0A087WQQ9
Organism: Mus musculus/domesticus
Length: 544  
Fragment?: true
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Protein
A0A087WR56
Organism: Mus musculus/domesticus
Length: 1159  
Fragment?: true
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Protein
Q3UGZ2
Organism: Mus musculus/domesticus
Length: 887  
Fragment?: false
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Protein
Q2M4I9
Organism: Mus musculus/domesticus
Length: 1178  
Fragment?: false
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Protein
Q3UZ68
Organism: Mus musculus/domesticus
Length: 1178  
Fragment?: false
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Protein
A2A4A6
Organism: Mus musculus/domesticus
Length: 1290  
Fragment?: false
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Protein
Q810U4
Organism: Mus musculus/domesticus
Length: 1256  
Fragment?: false
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Protein
Q61851
Organism: Mus musculus/domesticus
Length: 801  
Fragment?: false
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Protein
P21803
Organism: Mus musculus/domesticus
Length: 821  
Fragment?: false
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Protein
Q03142
Organism: Mus musculus/domesticus
Length: 799  
Fragment?: false
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Protein
A1YYP0
Organism: Mus musculus/domesticus
Length: 704  
Fragment?: false
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Protein
A1YYN9
Organism: Mus musculus/domesticus
Length: 821  
Fragment?: false
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Protein
Q61563
Organism: Mus musculus/domesticus
Length: 782  
Fragment?: false
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Protein
E9QNJ9
Organism: Mus musculus/domesticus
Length: 802  
Fragment?: false
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Protein
Q7TSI8
Organism: Mus musculus/domesticus
Length: 800  
Fragment?: false
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Protein
A1YYM5
Organism: Mus musculus/domesticus
Length: 707  
Fragment?: false
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Protein
E9Q7T0
Organism: Mus musculus/domesticus
Length: 819  
Fragment?: true
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Protein
E9Q7E8
Organism: Mus musculus/domesticus
Length: 822  
Fragment?: true
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Protein
A1YYM9
Organism: Mus musculus/domesticus
Length: 820  
Fragment?: false
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Protein
A1YYN5
Organism: Mus musculus/domesticus
Length: 695  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom