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Search results 201 to 290 out of 290 for Ezh1

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Type Details Score
Publication
22312437 | J:185237
First Author: Chen L
Year: 2012
Journal: PLoS One
Title: Conditional ablation of Ezh2 in murine hearts reveals its essential roles in endocardial cushion formation, cardiomyocyte proliferation and survival.
Volume: 7
Issue: 2
Pages: e31005
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Publication
26994968 | J:235040
First Author: Dauber KL
Year: 2016
Journal: J Invest Dermatol
Title: Dissecting the Roles of Polycomb Repressive Complex 2 Subunits in the Control of Skin Development.
Volume: 136
Issue: 8
Pages: 1647-55
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Publication
22267199 | J:181488
First Author: Delgado-Olguín P
Year: 2012
Journal: Nat Genet
Title: Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis.
Volume: 44
Issue: 3
Pages: 343-7
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Publication
26621269 | J:243678
 
First Author: Zemke M
Year: 2015
Journal: BMC Biol
Title: Loss of Ezh2 promotes a midbrain-to-forebrain identity switch by direct gene derepression and Wnt-dependent regulation.
Volume: 13
Pages: 103
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Publication
28049658 | J:239161
First Author: Guo C
Year: 2017
Journal: Development
Title: Stage- and subunit-specific functions of polycomb repressive complex 2 in bladder urothelial formation and regeneration.
Volume: 144
Issue: 3
Pages: 400-408
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Publication
19303854 | J:148710
First Author: Ezhkova E
Year: 2009
Journal: Cell
Title: Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells.
Volume: 136
Issue: 6
Pages: 1122-35
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Publication
34994686 | J:317827
   
First Author: Sawai A
Year: 2022
Journal: Elife
Title: PRC1 sustains the integrity of neural fate in the absence of PRC2 function.
Volume: 11
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Publication
27414999 | J:234178
First Author: Perdigoto CN
Year: 2016
Journal: PLoS Genet
Title: Polycomb-Mediated Repression and Sonic Hedgehog Signaling Interact to Regulate Merkel Cell Specification during Skin Development.
Volume: 12
Issue: 7
Pages: e1006151
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Publication
34368113 | J:313616
 
First Author: Zhang F
Year: 2021
Journal: Front Cell Dev Biol
Title: Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice.
Volume: 9
Pages: 642931
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Publication
21122108 | J:166749
 
First Author: Hammock EA
Year: 2010
Journal: Neural Dev
Title: Homologs of genes expressed in Caenorhabditis elegans GABAergic neurons are also found in the developing mouse forebrain.
Volume: 5
Pages: 32
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Publication
12465718 | J:86755
First Author: Okazaki N
Year: 2002
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 9
Issue: 5
Pages: 179-88
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Publication
35084365 | J:326026
First Author: Prokopuk L
Year: 2022
Journal: Reproduction
Title: An essential role for Polycomb Repressive Complex 2 in the mouse ovary.
Volume: 163
Issue: 3
Pages: 167-182
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:72245
       
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
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Publication
15226823 | J:93300
First Author: Blackshaw S
Year: 2004
Journal: PLoS Biol
Title: Genomic analysis of mouse retinal development.
Volume: 2
Issue: 9
Pages: E247
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Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
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Publication
20059953 | J:156017
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
Title: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Volume: 17
Issue: 6
Pages: 836-48
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Publication
27626380 | J:236599
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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UniProt Feature
UniProt Feature
Begin: 1
Description: Histone-lysine N-methyltransferase EZH1
Type: chain
End: 747
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Protein
P70351-2
Organism: Mus musculus/domesticus
Length: 579  
Fragment?: false
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Publication
32554463 | J:298947
First Author: Liu H
Year: 2020
Journal: J Biol Chem
Title: The polycomb proteins EZH1 and EZH2 co-regulate chromatin accessibility and nephron progenitor cell lifespan in mice.
Volume: 295
Issue: 33
Pages: 11542-11558
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Publication
25395428 | J:220776
First Author: Xu B
Year: 2015
Journal: Blood
Title: Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia.
Volume: 125
Issue: 2
Pages: 346-57
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HT Experiment
E-GEOD-53627 | Disruption of H3K27me3 through loss of EZH1 and EZH2 accelerates progression of hepatosteatosis to fatal liver fibrosis
Series Id: GSE53627
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Allele
Ezh1<em1Smoc> | MGI:7289565
Name: enhancer of zeste 1 polycomb repressive complex 2 subunit; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Strain
MGI:6475234 | C57BL/6J-Ezh1<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Protein Domain
IPR044438 | EZH1_SET
Type: Domain
Description: This entry represents the SET domain found in EZH1.The Polycomb Repressive Complex 2 (PRC2) is a chromatin modifying complex that consists of three core components: EED, SUZ12 and one of the two histone H3K27 methyltransferases, EZH1 or EZH2 []. The PRC2 complex catalyses di- and trimethylation of histone H3 lysine 27 (H3K37me2/3), which has a repressive role. Even though EZH1 and EZH2 form similar PRC2 complexes, they exhibit contrasting repressive roles. In terms of their expression in mice, EZH1 is more abundant in nonproliferative adult organs, while EZH2 expression is tightly associated with proliferation [].
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Protein Domain
IPR044439 | EZH2_SET
Type: Domain
Description: This entry represents the SET domain found in EZH2.The Polycomb Repressive Complex 2 (PRC2) is a chromatin modifying complex that consists of three core components: EED, SUZ12 and one of the two histone H3K27 methyltransferases, EZH1 or EZH2 []. The PRC2 complex catalyses di- and trimethylation of histone H3 lysine 27 (H3K37me2/3), which has a repressive role. Even though EZH1 and EZH2 form similar PRC2 complexes, they exhibit contrasting repressive roles. In terms of their expression in mice, EZH1 is more abundant in nonproliferative adult organs, while EZH2 expression is tightly associated with proliferation [].
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Protein Domain
IPR021654 | EZH1/EZH2
Type: Family
Description: The Polycomb Repressive Complex 2 (PRC2) is a chromatin modifying complex that consists of three core components: EED, SUZ12 and one of the two histone H3K27 methyltransferases, EZH1 or EZH2 []. The PRC2 complex catalyses di- and trimethylation of histone H3 lysine 27 (H3K37me2/3), which has a repressive role. Even though EZH1 and EZH2 form similar PRC2 complexes, they exhibit contrasting repressive roles. In terms of their expression in mice, EZH1 is more abundant in nonproliferative adult organs, while EZH2 expression is tightly associated with proliferation [].
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HT Experiment
E-GEOD-70440 | Loss of EZH2 results in precocious mammary gland development and the activation of STAT5-dependent genes
Series Id: GSE70440
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Protein
E9PWK3
Organism: Mus musculus/domesticus
Length: 233  
Fragment?: true
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Protein
Q3U575
Organism: Mus musculus/domesticus
Length: 391  
Fragment?: true
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Protein
Q8C2I5
Organism: Mus musculus/domesticus
Length: 231  
Fragment?: true
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Protein Domain
IPR041343 | PRC2_HTH_1
Type: Domain
Description: This domain can be found in the polycomb repressive complex 2 (PRC2) subunits EZH1 and EZH2. Three core subunits make up the catalytic core of PRC2: EZH1 or EZH2, the zinc-finger containing SUZ12 and EED. Polycomb complexes maintain repressive chromatin states by silencing gene expression. PRC2 does this by methylating lysine 27 of histone H3 []. This domain makes up part of the N-lobe which consists of EED and the N-terminal region of EZH2, and is involved in regulation [].
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Protein
A0A0N4SUQ7
Organism: Mus musculus/domesticus
Length: 93  
Fragment?: false
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Protein
F7AQX0
Organism: Mus musculus/domesticus
Length: 156  
Fragment?: true
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Protein
F6T3Z0
Organism: Mus musculus/domesticus
Length: 123  
Fragment?: true
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Protein
F7CW38
Organism: Mus musculus/domesticus
Length: 52  
Fragment?: true
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Protein Domain
IPR045318 | EZH1/2-like
Type: Family
Description: This entry represents a group of histone-lysine N-methyltransferases that belong to the Polycomb group (Pc-G), including:Drosophila melanogaster Enhancer of zeste E(z).Mammalian EZH-1 and EZH-2.Arabidopsis thaliana CURLY LEAF (CLF), a transcriptional repressor of floral homeotic gene AGAMOUS.Arabidopsis thaliana CLF-like.Arabidopsis thaliana MEDEA (MEA), a suppressor of endosperm development.Arabidopsis thaliana EZA1.The Polycomb Repressive Complex 2 (PRC2) is a chromatin modifying complex that consists of three core components: EED, SUZ12 and one of the two histone H3K27 methyltransferases, EZH1 or EZH2 []. The PRC2 complex catalyses di- and trimethylation of histone H3 lysine 27 (H3K37me2/3), which has a repressive role. Even though EZH1 and EZH2 form similar PRC2 complexes, they exhibit contrasting repressive roles. In terms of their expression in mice, EZH1 is more abundant in nonproliferative adult organs, while EZH2 expression is tightly associated with proliferation [].
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HT Experiment
GSE110925 | Whole kidneys at embryonic day 17.5: wildtype (WT) vs. various combinations of the conditional homozygous Ezh2-knockout (Ezh2-KO) from Six2-positive nephron progenitor cells (NPC) and/or germline Ezh1-knockout (Ezh1-KO)
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
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Publication
21248841 | -
First Author: Margueron R
Year: 2011
Journal: Nature
Title: The Polycomb complex PRC2 and its mark in life.
Volume: 469
Issue: 7330
Pages: 343-9
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Publication
27121947 | -
 
First Author: Justin N
Year: 2016
Journal: Nat Commun
Title: Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2.
Volume: 7
Pages: 11316
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HT Experiment
E-GEOD-52016 | EZH2 controls mammary differentiation independently of its methyltransferase activity through controlling genomic STAT5 access
Series Id: GSE52016
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Protein
Q61188
Organism: Mus musculus/domesticus
Length: 746  
Fragment?: false
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Protein
Q3TZH6
Organism: Mus musculus/domesticus
Length: 746  
Fragment?: false
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Protein
Q571L5
Organism: Mus musculus/domesticus
Length: 779  
Fragment?: true
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Protein
D3Z774
Organism: Mus musculus/domesticus
Length: 707  
Fragment?: false
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Protein
Q6AXH7
Organism: Mus musculus/domesticus
Length: 742  
Fragment?: false
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Publication
17937919 | J:247419
First Author: Han Z
Year: 2007
Journal: Structure
Title: Structural basis of EZH2 recognition by EED.
Volume: 15
Issue: 10
Pages: 1306-15
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Publication
33311485 | J:301418
First Author: Meng TG
Year: 2020
Journal: Nat Commun
Title: PRC2 and EHMT1 regulate H3K27me2 and H3K27me3 establishment across the zygote genome.
Volume: 11
Issue: 1
Pages: 6354
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Publication
29681498 | J:262396
First Author: Lee CH
Year: 2018
Journal: Mol Cell
Title: Distinct Stimulatory Mechanisms Regulate the Catalytic Activity of Polycomb Repressive Complex 2.
Volume: 70
Issue: 3
Pages: 435-448.e5
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Publication
37491148 | J:340470
First Author: Mätlik K
Year: 2023
Journal: Genes Dev
Title: Histone bivalency regulates the timing of cerebellar granule cell development.
Volume: 37
Issue: 13-14
Pages: 570-589
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Publication
27694924 | J:241036
First Author: Hasegawa N
Year: 2017
Journal: Leukemia
Title: Impact of combinatorial dysfunctions of Tet2 and Ezh2 on the epigenome in the pathogenesis of myelodysplastic syndrome.
Volume: 31
Issue: 4
Pages: 861-871
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Publication
27630126 | J:236852
First Author: Xie H
Year: 2016
Journal: Cancer Discov
Title: Chronic Myelogenous Leukemia- Initiating Cells Require Polycomb Group Protein EZH2.
Volume: 6
Issue: 11
Pages: 1237-1247
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Publication
26118502 | J:230773
First Author: Danis E
Year: 2015
Journal: Exp Hematol
Title: Inactivation of Eed impedes MLL-AF9-mediated leukemogenesis through Cdkn2a-dependent and Cdkn2a-independent mechanisms in a murine model.
Volume: 43
Issue: 11
Pages: 930-935.e6
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Publication
29967375 | J:271284
First Author: Hervás-Corpión I
Year: 2018
Journal: Sci Rep
Title: Early alteration of epigenetic-related transcription in Huntington's disease mouse models.
Volume: 8
Issue: 1
Pages: 9925
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Publication
9566901 | J:47030
First Author: Jones CA
Year: 1998
Journal: Mol Cell Biol
Title: The Drosophila esc and E(z) proteins are direct partners in polycomb group-mediated repression.
Volume: 18
Issue: 5
Pages: 2825-34
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Protein
A0A0N4SUQ8
Organism: Mus musculus/domesticus
Length: 127  
Fragment?: true
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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