MyoXV is a MyTH-FERM myosin, which are actin-based motor proteins essential for a variety of biological processes in actin cytoskeleton function. Specifically MyoXV functions in the actin organization in hair cells of the organ of Corti. Mutations in human MyoXVa causes non-syndromic deafness, DFNB3 [], and the mouse shaker-2 mutation []. MyoXV consists of a N-terminal motor/head region, a neck made of 1-3 IQ motifs, and a tail that consists of either a myosin tail homology 4 (MyTH4) domain followed by an SH3 domain and a MyTH-FERM domain, as in rat Myo15, or two MyTH-FERM domains separated by a SH3 domain as in human Myo15A. The MyTH-FERM domains are thought to mediate dimerization and binding to other proteins or cargo [].The FERM domain has a cloverleaf tripart structure composed of: (1) FERM_N (A-lobe or F1); (2) FERM_M (B-lobe, or F2); and (3) FERM_C (C-lobe or F3) []. This entry represents the C-lobe of the Myo15 FERM domain.
