In budding yeasts, Mak16 forms part of the 66S pre-ribosomal particles and functions as a transacting actor involved in rRNA processing [, ]. The Schistosoma mansoni (Blood fluke) Mak16 has been shown to target protein transport to the nucleolus [].
Ribosomal protein L28e forms part of the 60S ribosomal subunit []. This family is found in eukaryotes. In rat there are 9 or 10 copies of the L28 gene. The L28 protein contains a possible internal duplication of 9 residues [].In budding yeast, Mak16 forms part of the 66S pre-ribosomal particles and functions as a transacting actor involved in rRNA processing [, ].This entry represents a ribosomal L28e domain that also matches the N-terminal region of Mak16.