This entry represents the SET domain of SET and MYND domain-containing protein 5 (SMYD5, also termed protein NN8-4AG, or retinoic acid-induced protein 15)). SMYD5 functions as a histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions []. It plays an important role in chromosome integrity by regulating heterochromatin and repressing endogenous repetitive DNA elements during differentiation []. In zebrafish embryogenesis, it plays pivotal roles in both primitive and definitive hematopoiesis [].The SMYD family consists of five members including SMYD1/2/3/4/5. They contain two highly conserved structural and functional domains, the SET and MYND domains. The SET domain is involved in lysine methylation, while the MYND domain is involved in protein-protein interaction. They are essential in several mammalian developmental pathways [, , , ].
