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Search results 101 to 173 out of 173 for Gp6

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Type Details Score
Publication
First Author: Thomas DH
Year: 2010
Journal: Blood
Title: A novel histidine tyrosine phosphatase, TULA-2, associates with Syk and negatively regulates GPVI signaling in platelets.
Volume: 116
Issue: 14
Pages: 2570-8
Publication
First Author: Boilard E
Year: 2011
Journal: J Immunol
Title: Platelets participate in synovitis via Cox-1-dependent synthesis of prostacyclin independently of microparticle generation.
Volume: 186
Issue: 7
Pages: 4361-6
Publication
First Author: Schaff M
Year: 2013
Journal: Circulation
Title: Integrin α6β1 is the main receptor for vascular laminins and plays a role in platelet adhesion, activation, and arterial thrombosis.
Volume: 128
Issue: 5
Pages: 541-52
Publication
First Author: Mammadova-Bach E
Year: 2020
Journal: Blood
Title: Platelet glycoprotein VI promotes metastasis through interaction with cancer cell-derived galectin-3.
Volume: 135
Issue: 14
Pages: 1146-1160
Publication
First Author: Ragab A
Year: 2007
Journal: Blood
Title: Roles of the C-terminal tyrosine residues of LAT in GPVI-induced platelet activation: insights into the mechanism of PLC gamma 2 activation.
Volume: 110
Issue: 7
Pages: 2466-74
Publication
First Author: Ming Z
Year: 2011
Journal: Blood
Title: Lyn and PECAM-1 function as interdependent inhibitors of platelet aggregation.
Volume: 117
Issue: 14
Pages: 3903-6
Publication
First Author: Pearce AC
Year: 2004
Journal: J Biol Chem
Title: Vav1 and vav3 have critical but redundant roles in mediating platelet activation by collagen.
Volume: 279
Issue: 52
Pages: 53955-62
Publication
First Author: Mazharian A
Year: 2012
Journal: Sci Signal
Title: Mice lacking the ITIM-containing receptor G6b-B exhibit macrothrombocytopenia and aberrant platelet function.
Volume: 5
Issue: 248
Pages: ra78
Publication
First Author: Sarratt KL
Year: 2005
Journal: Blood
Title: GPVI and alpha2beta1 play independent critical roles during platelet adhesion and aggregate formation to collagen under flow.
Volume: 106
Issue: 4
Pages: 1268-77
Publication
First Author: Malehmir M
Year: 2019
Journal: Nat Med
Title: Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer.
Volume: 25
Issue: 4
Pages: 641-655
Publication
First Author: Hitchcock JR
Year: 2015
Journal: J Clin Invest
Title: Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets.
Volume: 125
Issue: 12
Pages: 4429-46
Publication
First Author: Haining EJ
Year: 2017
Journal: Platelets
Title: Tetraspanin Tspan9 regulates platelet collagen receptor GPVI lateral diffusion and activation.
Volume: 28
Issue: 7
Pages: 629-642
Publication
First Author: Gupta S
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Hemostasis vs. homeostasis: Platelets are essential for preserving vascular barrier function in the absence of injury or inflammation.
Volume: 117
Issue: 39
Pages: 24316-24325
Publication
First Author: Semeniak D
Year: 2016
Journal: J Cell Sci
Title: Proplatelet formation is selectively inhibited by collagen type I through Syk-independent GPVI signaling.
Volume: 129
Issue: 18
Pages: 3473-84
Publication
First Author: Zhou J
Year: 2017
Journal: Blood
Title: The disulfide isomerase ERp72 supports arterial thrombosis in mice.
Volume: 130
Issue: 6
Pages: 817-828
Publication
First Author: Reppschläger K
Year: 2016
Journal: J Biol Chem
Title: TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk.
Volume: 291
Issue: 43
Pages: 22427-22441
Publication
First Author: Gilio K
Year: 2010
Journal: J Biol Chem
Title: Roles of platelet STIM1 and Orai1 in glycoprotein VI- and thrombin-dependent procoagulant activity and thrombus formation.
Volume: 285
Issue: 31
Pages: 23629-38
Publication
First Author: Pachel C
Year: 2016
Journal: Arterioscler Thromb Vasc Biol
Title: Inhibition of Platelet GPVI Protects Against Myocardial Ischemia-Reperfusion Injury.
Volume: 36
Issue: 4
Pages: 629-35
Publication
First Author: Cunin P
Year: 2017
Journal: J Clin Invest
Title: Megakaryocytes compensate for Kit insufficiency in murine arthritis.
Volume: 127
Issue: 5
Pages: 1714-1724
Publication      
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
Publication      
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Publication      
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Protein Domain
Type: Family
Description: This family includes baseplate wedge protein gp6 (gp6) from bacteriophage T4 and its relatives. Contractile tail bacteriophages use a multiprotein tubular apparatus resembling a coiled spring wound round a rigid tube to attach to and penetrate host cell membranes. The structure known as the baseplate replays the contraction signal to the sheath [, ]. gp6 is located next to the tail tube and is an intermediate (or inner) baseplate protein involved in tail assembly [, ]. Two molecules of gp6 form a complex with gp25 and gp7 which is involved sheath contraction [].
Publication
First Author: Dearborn AD
Year: 2011
Journal: J Mol Biol
Title: The Staphylococcus aureus pathogenicity island 1 protein gp6 functions as an internal scaffold during capsid size determination.
Volume: 412
Issue: 4
Pages: 710-22
Protein Domain
Type: Homologous_superfamily
Description: Gp6, a Staphylococcus aureus pathogenicity island 1 protein, is a mobile genetic element that carries genes for several superantigen toxins. It is a dimeric protein produced from the pathogenicity island with a helix-loop-helix motif similar to that of bacteriophage scaffolding proteins. It is thought to determine the size of the capsids of distribution of the SAPI1 genome as it acts as an internal scaffolding protein during capsid size determination [].
Publication
First Author: Leiman PG
Year: 2004
Journal: Cell
Title: Three-dimensional rearrangement of proteins in the tail of bacteriophage T4 on infection of its host.
Volume: 118
Issue: 4
Pages: 419-29
Publication
First Author: Taylor NM
Year: 2016
Journal: Nature
Title: Structure of the T4 baseplate and its function in triggering sheath contraction.
Volume: 533
Issue: 7603
Pages: 346-52
Protein Domain
Type: Family
Description: This family consists of several Barley yellow dwarf virus proteins of unknown function.
Allele
Name: glycoprotein 6 platelet; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Publication  
First Author: Leiman PG
Year: 2010
Journal: Virol J
Title: Morphogenesis of the T4 tail and tail fibers.
Volume: 7
Pages: 355
Allele
Name: glycoprotein 6 platelet; targeted mutation 1.1, Mouse Clinical Institute
Allele Type: Targeted
Attribute String: Inserted expressed sequence
Publication
First Author: Krištić J
Year: 2018
Journal: Nat Chem Biol
Title: Profiling and genetic control of the murine immunoglobulin G glycome.
Volume: 14
Issue: 5
Pages: 516-524
DO Term
Genotype
Symbol: Gp6/Gp6
Background: involves: 129S2/SvPas
Zygosity: hm
Has Mutant Allele: true
Publication
First Author: Lebedev AA
Year: 2007
Journal: EMBO J
Title: Structural framework for DNA translocation via the viral portal protein.
Volume: 26
Issue: 7
Pages: 1984-94
Protein Domain
Type: Family
Description: The bacteriophage portal protein forms a gateway, or portal, enabling DNA passage during packaging and ejection of the phage genome. It also forms the junction between the phage head (capsid) and the tail proteins []. During SPP1 morphogenesis, Gp6 participates in the procapsid assembly reaction [, ].In the mature SPP1 virion, the portal protein, GP6, exists as a dodecamer, whereas recombinant SPP1 Gp6 has been shown to form 13-subunit assemblies [, ].This entry includes Bacillus phage SPP1-type portal proteins, Mycobacterium phage portal proteins and putative portal proteins of the Listeria phage A118-type.
Publication
First Author: Cardarelli L
Year: 2010
Journal: J Mol Biol
Title: The crystal structure of bacteriophage HK97 gp6: defining a large family of head-tail connector proteins.
Volume: 395
Issue: 4
Pages: 754-68
Protein Domain
Type: Family
Description: This family of proteins contain head-tail connector proteins related to gp6 from bacteriophage HK97 []. The gp15 protein of Bacillus phage SPP1, for which the tertiary structure is known, is included in this entry [].This family contain head-tail connector proteins related to gp6 from bacteriophage HK97 [], including the head completion protein from Enterobacteria phage T5 (also known as T5p144) that closes the capsid once the viral DNA has been packaged. These proteins show similarities to the gp6 protein of phage HK97, and, probably, it is part of the head-tail connector by binding to the portal protein and to the tail completion protein []. The bacteriophage HK97 gp6 protein is critical in the assembly of the connector, a specialized structure that serves as an interface for head and tail attachment, as well as a point at which DNA exits the head during infection by the bacteriophage []. The gp15 protein of Bacillus phage SPP1, for which the tertiary structure is known, is included in this entry [].
Publication
First Author: Lhuillier S
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Structure of bacteriophage SPP1 head-to-tail connection reveals mechanism for viral DNA gating.
Volume: 106
Issue: 21
Pages: 8507-12
Publication
First Author: Leiman PG
Year: 2003
Journal: J Mol Biol
Title: Structure and location of gene product 8 in the bacteriophage T4 baseplate.
Volume: 328
Issue: 4
Pages: 821-33
Protein Domain
Type: Homologous_superfamily
Description: Members of this superfamily of viral baseplate structural proteins adopt a structure consisting of a three-layer β-sandwich with two finger-like loops containing an α-helix at the opposite sides of the sandwich. The two peripheral, five-stranded, antiparallel β-sheets are stacked against the middle, four-stranded, antiparallel β-sheet. Attachment of this family of proteins to the baseplate during assembly creates a binding site for subsequent attachment of Gp6 [].
Protein Domain
Type: Domain
Description: Members of this family of viral baseplate structural proteins adopt a structure consisting of a three-layer β-sandwich with two finger-like loops containing an α-helix at the opposite sides of the sandwich. The two peripheral, five-stranded, antiparallel β-sheets are stacked against the middle, four-stranded, antiparallel β-sheet. Attachment of this family of proteins to the baseplate during assembly creates a binding site for subsequent attachment of Gp6 [].
Publication
First Author: Szewczyk B
Year: 1986
Journal: Mol Gen Genet
Title: Identification of T4 gene 25 product, a component of the tail baseplate, as a 15K lysozyme.
Volume: 202
Issue: 3
Pages: 363-7
Publication
First Author: Lossi NS
Year: 2011
Journal: Microbiology
Title: Structure-function analysis of HsiF, a gp25-like component of the type VI secretion system, in Pseudomonas aeruginosa.
Volume: 157
Issue: Pt 12
Pages: 3292-305
Publication
First Author: Chaban Y
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Structural rearrangements in the phage head-to-tail interface during assembly and infection.
Volume: 112
Issue: 22
Pages: 7009-14
Publication
First Author: Zivanovic Y
Year: 2014
Journal: J Virol
Title: Insights into bacteriophage T5 structure from analysis of its morphogenesis genes and protein components.
Volume: 88
Issue: 2
Pages: 1162-74
Protein Domain
Type: Domain
Description: This domain is found in baseplate protein Gp25 from phage T4 and related phages, and Gp25-like proteins from bacteria [, ]. Gp25 is a component of the conserved wedge in the inner part of the baseplate and serves as a nucleus for sheath polymerisation, playing a critical role in sheath assembly and contraction [, ]. The EPR motif (Glu-Pro-Arg, residues 85-87 of gp25) is conserved across all members of the family including orthologs from the RpoS-mediated general stress response system (called IraD) []. This motif interacts with the 'core bundle' composed of orthologs of T4 gp6 and gp7 proteins in contractile injection systems.
Protein Domain
Type: Family
Description: This family includes baseplate wedge protein gp7 (gp7) from bacteriophage T4 and its relatives. Contractile tail bacteriophages use a multiprotein tubular apparatus resembling a coiled spring wound round a rigid tube to attach to and penetrate host cell membranes. The structure known as the baseplate replays the contraction signal to the sheath [, ]. gp7 is an intermediate (or inner) baseplate protein involved in tail assembly []. It also forms a complex with gp25 and two molecules of gp6 which is involved in sheath contraction [].
Publication
First Author: Lurz R
Year: 2001
Journal: J Mol Biol
Title: Structural organisation of the head-to-tail interface of a bacterial virus.
Volume: 310
Issue: 5
Pages: 1027-37
Protein Domain
Type: Homologous_superfamily
Description: This entry describes the head-tail adaptor protein of bacteriophage SPP1and related proteins in other bacteriophage and prophage regions of bacterial genomes. Homologues are also found in Gene Transfer Agents (GTA) [], including ORFg7 (RCAP_rcc01689) of the GTA of Rhodobacter capsulatus (Rhodopseudomonas capsulata) [].In bacteriophage SPP1, the gp16 protein functions as a stopper, locking the viral DNA into the capsid. When the tail attachment binds to the entry receptor, gp16 opens by a diaphragm-like motion, allowing the genome to exit the capsid through the tail tube to the host cell. During virion assembly, gp16 functions as a docking platform to which the preassembled tail binds [].The SPP1 head-to-tail connector is composed of cyclical dodecamers of the portal protein gp6 and of the 2 head completion proteins gp15 and gp16 [].
Protein Domain
Type: Family
Description: This entry describes the head-tail adaptor protein of bacteriophage SPP1and related proteins in other bacteriophage and prophage regions of bacterial genomes. Homologues are also found in Gene Transfer Agents (GTA) [], including ORFg7 (RCAP_rcc01689) of the GTA of Rhodobacter capsulatus (Rhodopseudomonas capsulata) [].In bacteriophage SPP1, the gp16 protein functions as a stopper, locking the viral DNA into the capsid. When the tail attachment binds to the entry receptor, gp16 opens by a diaphragm-like motion, allowing the genome to exit the capsid through the tail tube to the host cell. During virion assembly, gp16 functions as a docking platform to which the preassembled tail binds [].The SPP1 head-to-tail connector is composed of cyclical dodecamers of the portal protein gp6 and of the 2 head completion proteins gp15 and gp16 [].
Publication  
First Author: Battesti A
Year: 2011
Journal: Annu Rev Microbiol
Title: The RpoS-mediated general stress response in Escherichia coli.
Volume: 65
Pages: 189-213
Publication
First Author: Lang AS
Year: 2001
Journal: Arch Microbiol
Title: The gene transfer agent of Rhodobacter capsulatus and "constitutive transduction" in prokaryotes.
Volume: 175
Issue: 4
Pages: 241-9
Publication
First Author: Lang AS
Year: 2002
Journal: J Mol Evol
Title: Evolutionary implications of phylogenetic analyses of the gene transfer agent (GTA) of Rhodobacter capsulatus.
Volume: 55
Issue: 5
Pages: 534-43
Publication
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7