This entry includes a group of pre-mRNA 3' end processing proteins, including Pfs2 from yeasts, WDR33 form animals and FY from Arabidopsis.In Saccharomyces cerevisiae, Polyadenylation factor subunit 2 (Pfs2) is an integral and essential component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB []. In animals WDR33 is part of the pre-mRNA 3' processing complex that is essential for both cleavage and polyadenylation of pre-mRNA 3' ends [].In Arabidopsis, FY acts as an RNA 3' end-processing factor that interacts with FCA (an nuclear RNA binding protein) to control the Arabidopsis floral transition [].
