This entry includes calcium-dependent secretion activators (CAPS) from animals, including CAPS1/2 from humans and unc-31 from worms. Mammalian CAPS1 and CAPS2 regulate the exocytosis of catecholamine-containing or neuropeptide-containing dense-core vesicles (DCVs) at secretion sites such as nerve terminals []. Like its mammalian homologues, unc-31/CAPS from C. elegans and CAPS from Drosophila are indispensable for exocytosis of dense core vesicle (DCV) and synaptic vesicle (SV) [, ]. In C. elegans unc-31 functions with G-alpha proteins from the same motor neurons to regulate locomotion []. It is involved in regulating entry into quiescence triggered by satiety []and plays a role in octopamine signaling and specifically, the octopamine inhibition of aversion responses in olfactory sensory neurons [].
