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Search results 601 to 700 out of 755 for Abl1

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Type Details Score
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
14729625 | J:87478
First Author: Zukerberg LR
Year: 2004
Journal: Cancer Res
Title: Loss of cables, a cyclin-dependent kinase regulatory protein, is associated with the development of endometrial hyperplasia and endometrial cancer.
Volume: 64
Issue: 1
Pages: 202-8
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Publication
14637168 | -
First Author: Matsuoka M
Year: 2003
Journal: Biochem Biophys Res Commun
Title: ik3-2, a relative to ik3-1/Cables, is involved in both p53-mediated and p53-independent apoptotic pathways.
Volume: 312
Issue: 2
Pages: 520-9
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Publication
18059193 | -
First Author: Sakamoto H
Year: 2008
Journal: Cancer Biol Ther
Title: Mechanisms of Cables 1 gene inactivation in human ovarian cancer development.
Volume: 7
Issue: 2
Pages: 180-88
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Protein Domain
IPR012388 | CABLES1/2
Type: Family
Description: This group represents protein CABLES (CDK5 and ABL1 enzyme substrate), including CABLES1 and CABLES2 [, ]. CABLES1 is a cyclin-dependent kinase binding protein, primarily involved in cell cycle regulation []. CABLES1 binds to different functional domains of p53 and p73 and modifies their cell death-inducing activities []. It may be a tumour suppressor in human ovarian cancer []. CABLES2 is involved in both p53-mediated and p53-independent apoptotic pathways [].
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UniProt Feature
UniProt Feature
Begin: 1
Description: Tyrosine-protein kinase ABL1
Type: chain
End: 1123
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UniProt Feature
UniProt Feature
Begin: 698
Description: Phosphotyrosine; by ABL1
Type: modified residue
End: 698
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UniProt Feature
UniProt Feature
Begin: 547
Description: Phosphotyrosine; by ABL1
Type: modified residue
End: 547
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UniProt Feature
UniProt Feature
Begin: 52
Description: Phosphotyrosine; by ABL1
Type: modified residue
End: 52
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UniProt Feature
UniProt Feature
Begin: 54
Description: Phosphotyrosine; by ABL1
Type: modified residue
End: 54
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UniProt Feature
UniProt Feature
Begin: 105
Description: Phosphotyrosine; by ABL1
Type: modified residue
End: 105
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UniProt Feature
UniProt Feature
Begin: 439
Description: Phosphotyrosine; by ABL1
Type: modified residue
End: 439
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UniProt Feature
UniProt Feature
Begin: 718
Description: Phosphotyrosine; by ABL1
Type: modified residue
End: 718
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UniProt Feature
UniProt Feature
Begin: 221
Description: Phosphotyrosine; by ABL1
Type: modified residue
End: 221
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UniProt Feature
UniProt Feature
Begin: 91
Description: Phosphotyrosine; by ABL1
Type: modified residue
End: 91
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UniProt Feature
UniProt Feature
Begin: 694
Description: Phosphotyrosine; by ABL1
Type: modified residue
End: 694
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UniProt Feature
UniProt Feature
Begin: 570
Description: Phosphotyrosine; by ABL1
Type: modified residue
End: 570
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UniProt Feature
UniProt Feature
Begin: 594
Description: Phosphotyrosine; by ABL1
Type: modified residue
End: 594
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UniProt Feature
UniProt Feature
Begin: 553
Description: Phosphotyrosine; by ABL1
Type: modified residue
End: 553
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UniProt Feature
UniProt Feature
Begin: 513
Description: Phosphotyrosine; by ABL1
Type: modified residue
End: 513
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UniProt Feature
UniProt Feature
Begin: 191
Description: Phosphotyrosine; by ABL1
Type: modified residue
End: 191
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UniProt Feature
UniProt Feature
Begin: 325
Description: Phosphotyrosine; by ABL1
Type: modified residue
End: 325
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UniProt Feature
UniProt Feature
Begin: 421
Description: Phosphotyrosine; by ABL1
Type: modified residue
End: 421
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UniProt Feature
UniProt Feature
Begin: 1238
Description: Phosphotyrosine; by ABL1
Type: modified residue
End: 1238
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UniProt Feature
UniProt Feature
Begin: 344
Description: Phosphotyrosine; by ABL1
Type: modified residue
End: 344
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UniProt Feature
UniProt Feature
Begin: 757
Description: Phosphotyrosine; by ABL1
Type: modified residue
End: 757
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UniProt Feature
UniProt Feature
Begin: 392
Description: Phosphotyrosine; by ABL1
Type: modified residue
End: 392
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UniProt Feature
UniProt Feature
Begin: 226
Description: Phosphotyrosine; by ABL1
Type: modified residue
End: 226
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UniProt Feature
UniProt Feature
Begin: 1597
Description: Phosphotyrosine; by ABL1
Type: modified residue
End: 1597
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UniProt Feature
UniProt Feature
Begin: 1657
Description: Phosphotyrosine; by ABL1
Type: modified residue
End: 1657
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UniProt Feature
UniProt Feature
Begin: 1471
Description: Phosphotyrosine; by ABL1
Type: modified residue
End: 1471
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UniProt Feature
UniProt Feature
Begin: 780
Description: Phosphotyrosine; by ABL1
Type: modified residue
End: 780
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UniProt Feature
UniProt Feature
Begin: 156
Description: Phosphotyrosine; by ABL1
Type: modified residue
End: 156
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UniProt Feature
UniProt Feature
Begin: 248
Description: Phosphotyrosine; by ABL1
Type: modified residue
End: 248
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UniProt Feature
UniProt Feature
Begin: 337
Description: Phosphotyrosine; by ABL1
Type: modified residue
End: 337
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UniProt Feature
UniProt Feature
Begin: 151
Description: Phosphotyrosine; by ABL1
Type: modified residue
End: 151
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UniProt Feature
UniProt Feature
Begin: 485
Description: Phosphotyrosine; by ABL1
Type: modified residue
End: 485
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UniProt Feature
UniProt Feature
Begin: 654
Description: Phosphotyrosine; by ABL1
Type: modified residue
End: 654
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UniProt Feature
UniProt Feature
Begin: 304
Description: Phosphotyrosine; by ABL1
Type: modified residue
End: 304
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UniProt Feature
UniProt Feature
Begin: 265
Description: Phosphotyrosine; by ABL1
Type: modified residue
End: 265
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UniProt Feature
UniProt Feature
Begin: 219
Description: Phosphotyrosine; by ABL1
Type: modified residue
End: 219
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Protein
P00520-2
Organism: Mus musculus/domesticus
Length: 1117  
Fragment?: false
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Protein
P00520-3
Organism: Mus musculus/domesticus
Length: 1118  
Fragment?: false
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Protein
P00520-4
Organism: Mus musculus/domesticus
Length: 1142  
Fragment?: false
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Protein
A0A0A6YVY6
Organism: Mus musculus/domesticus
Length: 71  
Fragment?: false
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Protein
A0A0A6YXS9
Organism: Mus musculus/domesticus
Length: 78  
Fragment?: false
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Protein
A0A0A6YY65
Organism: Mus musculus/domesticus
Length: 64  
Fragment?: true
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Protein
A2AV23
Organism: Mus musculus/domesticus
Length: 114  
Fragment?: true
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UniProt Feature
UniProt Feature
Begin: 685
Description: Phosphotyrosine; by ABL1 and ABL2
Type: modified residue
End: 685
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UniProt Feature
UniProt Feature
Begin: 933
Description: Phosphotyrosine; by ABL1 and ABL2
Type: modified residue
End: 933
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UniProt Feature
UniProt Feature
Begin: 969
Description: Phosphotyrosine; by ABL1 and ABL2
Type: modified residue
End: 969
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UniProt Feature
UniProt Feature
Begin: 261
Description: Phosphotyrosine; by ABL1 and autocatalysis
Type: modified residue
End: 261
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UniProt Feature
UniProt Feature
Begin: 14
Description: Phosphotyrosine; by ABL1 and INSR
Type: modified residue
End: 14
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UniProt Feature
UniProt Feature
Begin: 153
Description: Phosphotyrosine; by ABL1 and ABL2
Type: modified residue
End: 153
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UniProt Feature
UniProt Feature
Begin: 452
Description: Phosphotyrosine; by ABL1 and SRC
Type: modified residue
End: 452
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UniProt Feature
UniProt Feature
Begin: 35
Description: Phosphotyrosine; by ABL1 and ABL2
Type: modified residue
End: 35
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GXD Expression
GXD Expression
 
Probe: MGI:7282081
Assay Type: Immunohistochemistry
Annotation Date: 2022-06-03
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3291617
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:7282100
Age: embryonic day 10.25
Note: Strong expression in marginal zone early neurons. Significant colocalization with Abl1 at apical surface of neuroepithelium.
Specimen Label: 7C Arg
Detected: true
Specimen Num: 1
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UniProt Feature
UniProt Feature
Begin: 1
Description: CDK5 and ABL1 enzyme substrate 2
Type: chain
End: 476
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UniProt Feature
UniProt Feature
Begin: 1
Description: CDK5 and ABL1 enzyme substrate 1
Type: chain
End: 568
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Publication
10873625 | J:63221
First Author: Matsuoka M
Year: 2000
Journal: Biochem Biophys Res Commun
Title: Molecular cloning of a cyclin-like protein associated with cyclin-dependent kinase 3 (cdk 3) in vivo.
Volume: 273
Issue: 2
Pages: 442-7
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Protein
Q3TYS6
Organism: Mus musculus/domesticus
Length: 594  
Fragment?: false
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Protein
B2RWU9
Organism: Mus musculus/domesticus
Length: 568  
Fragment?: false
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Protein
Q8R3U5
Organism: Mus musculus/domesticus
Length: 149  
Fragment?: true
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Protein
Q7TSU3
Organism: Mus musculus/domesticus
Length: 213  
Fragment?: false
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Allele
Gt(ROSA)26Sor<tm1(Nup214/Abl1)Cool> | MGI:6197969
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Jan Cools
Allele Type: Targeted
Attribute String: Conditional ready, Inserted expressed sequence, Reporter
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Publication
11585773 | J:168213
First Author: Wu CL
Year: 2001
Journal: Cancer Res
Title: Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers.
Volume: 61
Issue: 19
Pages: 7325-32
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Publication
7665185 | -
First Author: Chissoe SL
Year: 1995
Journal: Genomics
Title: Sequence and analysis of the human ABL gene, the BCR gene, and regions involved in the Philadelphia chromosomal translocation.
Volume: 27
Issue: 1
Pages: 67-82
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Publication
2183353 | -
First Author: Kipreos ET
Year: 1990
Journal: Science
Title: Differential phosphorylation of c-Abl in cell cycle determined by cdc2 kinase and phosphatase activity.
Volume: 248
Issue: 4952
Pages: 217-20
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Publication
1566087 | -
First Author: Kipreos ET
Year: 1992
Journal: Science
Title: Cell cycle-regulated binding of c-Abl tyrosine kinase to DNA.
Volume: 256
Issue: 5055
Pages: 382-5
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Publication
7780740 | -
First Author: Mayer BJ
Year: 1995
Journal: Curr Biol
Title: Evidence that SH2 domains promote processive phosphorylation by protein-tyrosine kinases.
Volume: 5
Issue: 3
Pages: 296-305
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Publication
11114745 | -
First Author: Wang JY
Year: 2000
Journal: Oncogene
Title: Regulation of cell death by the Abl tyrosine kinase.
Volume: 19
Issue: 49
Pages: 5643-50
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Publication
11350980 | -
First Author: Kumar S
Year: 2001
Journal: J Biol Chem
Title: Targeting of the c-Abl tyrosine kinase to mitochondria in the necrotic cell death response to oxidative stress.
Volume: 276
Issue: 20
Pages: 17281-5
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Publication
12021275 | -
First Author: Li B
Year: 2002
Journal: J Biol Chem
Title: Aph2, a protein with a zf-DHHC motif, interacts with c-Abl and has pro-apoptotic activity.
Volume: 277
Issue: 32
Pages: 28870-6
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Publication
12775773 | -
First Author: Woodring PJ
Year: 2003
Journal: J Cell Sci
Title: Regulation of F-actin-dependent processes by the Abl family of tyrosine kinases.
Volume: 116
Issue: Pt 13
Pages: 2613-26
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Publication
15686624 | -
First Author: Shaul Y
Year: 2005
Journal: Cell Res
Title: Role of c-Abl in the DNA damage stress response.
Volume: 15
Issue: 1
Pages: 33-5
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Publication
7664083 | -
First Author: Musacchio A
Year: 1994
Journal: Nat Struct Biol
Title: High-resolution crystal structures of tyrosine kinase SH3 domains complexed with proline-rich peptides.
Volume: 1
Issue: 8
Pages: 546-51
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Publication
10988075 | -
First Author: Schindler T
Year: 2000
Journal: Science
Title: Structural mechanism for STI-571 inhibition of abelson tyrosine kinase.
Volume: 289
Issue: 5486
Pages: 1938-42
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Publication
12654251 | -
First Author: Nagar B
Year: 2003
Journal: Cell
Title: Structural basis for the autoinhibition of c-Abl tyrosine kinase.
Volume: 112
Issue: 6
Pages: 859-71
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Publication
17718712 | -
First Author: Zhou T
Year: 2007
Journal: Chem Biol Drug Des
Title: Crystal structure of the T315I mutant of AbI kinase.
Volume: 70
Issue: 3
Pages: 171-81
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Publication
19878872 | -
First Author: O'Hare T
Year: 2009
Journal: Cancer Cell
Title: AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance.
Volume: 16
Issue: 5
Pages: 401-12
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Publication
19895503 | -
First Author: Zhou T
Year: 2010
Journal: Chem Biol Drug Des
Title: Structural analysis of DFG-in and DFG-out dual Src-Abl inhibitors sharing a common vinyl purine template.
Volume: 75
Issue: 1
Pages: 18-28
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Publication
20072125 | -
First Author: Zhang J
Year: 2010
Journal: Nature
Title: Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors.
Volume: 463
Issue: 7280
Pages: 501-6
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Publication
11527406 | -
First Author: Yamochi T
Year: 2001
Journal: Biochem Biophys Res Commun
Title: ik3-1/Cables is associated with Trap and Pctaire2.
Volume: 286
Issue: 5
Pages: 1045-50
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DO Term
DOID:0080643 | B-lymphoblastic leukemia/lymphoma with BCR-ABL1
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Allele
Tg(Tec-BCR/ABL1)#Hhi | MGI:3527269
Name: transgene insertion, Hisamaru Hirai
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Tec-BCR/ABL1)5Hhi | MGI:3039034
Name: transgene insertion 5, Hisamaru Hirai
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(ACTB-Abl1*I)1Spg | MGI:4361569
Name: transgene insertion 1, Stephen P Goff
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(ACTB-Abl1*IV)1Spg | MGI:4361572
Name: transgene insertion 1, Stephen P Goff
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Tec-BCR/ABL1)1Hhi | MGI:7507535
Name: transgene insertion 1, Hisamaru Hirai
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Tec-BCR/ABL1)3Hhi | MGI:3039032
Name: transgene insertion 3, Hisamaru Hirai
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Publication
8194526 | -
First Author: Feller SM
Year: 1994
Journal: EMBO J
Title: c-Abl kinase regulates the protein binding activity of c-Crk.
Volume: 13
Issue: 10
Pages: 2341-51
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Publication
12107171 | -
First Author: Cong F
Year: 2002
Journal: J Biol Chem
Title: Interaction between UV-damaged DNA binding activity proteins and the c-Abl tyrosine kinase.
Volume: 277
Issue: 38
Pages: 34870-8
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Publication
11733001 | -
First Author: Yamochi T
Year: 2001
Journal: Eur J Biochem
Title: ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3).
Volume: 268
Issue: 23
Pages: 6076-82
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Publication
24833663 | J:258718
First Author: Sánchez-Sánchez B
Year: 2014
Journal: Clin Cancer Res
Title: NADPH oxidases as therapeutic targets in chronic myelogenous leukemia.
Volume: 20
Issue: 15
Pages: 4014-25
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Publication
18193087 | J:135601
First Author: Mizuno T
Year: 2008
Journal: Oncogene
Title: Overexpression/enhanced kinase activity of BCR/ABL and altered expression of Notch1 induced acute leukemia in p210BCR/ABL transgenic mice.
Volume: 27
Issue: 24
Pages: 3465-74
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Publication
30167087 | J:346826
First Author: Takita M
Year: 2018
Journal: Oncotarget
Title: Paradoxical counteraction by imatinib against cell death in myeloid progenitor 32D cells expressing p210BCR-ABL.
Volume: 9
Issue: 60
Pages: 31682-31696
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Publication
19234145 | J:148525
First Author: Miyazaki K
Year: 2009
Journal: Blood
Title: Enhanced expression of p210BCR/ABL and aberrant expression of Zfp423/ZNF423 induce blast crisis of chronic myelogenous leukemia.
Volume: 113
Issue: 19
Pages: 4702-10
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Strain
MGI:4361736 | B6.Cg-Tg(ACTB-Abl1*I)1Spg/J
Attribute String: transgenic, mutant strain, congenic
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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