Gasdermin-E, also known as DFNA5, is involved in the p53-regulated cellular response to response to DNA damage probably by cooperating with p53 []. It can be cleaved by CASP3 into two parts: GSDME-N and GSDME-C. The GSDME-N fragment can perforate membranes and thereby induce pyroptosis []. Purified GSDME-N has been shown to efficiently lyse phosphoinositide/cardiolipin-containing liposomes and form pores on membranes made of artificial or natural phospholipid mixtures [].
