This entry represents the SH3 domain of UBASH3B. UBASH3B (also known as STS-1 or TULA-2), belongs to the TULA family, is an active phosphatase that is expressed ubiquitously []. The phosphatase activity of UBASH3B is essential for its roles in the suppression of TCR signaling []and the regulation of EGFR []. It also interacts with Syk and functions as a negative regulator of platelet glycoprotein VI signaling in platelets []. The TULA family includes two members termed p70/STS-1/TULA-2 and UBASH3A/STS-2/TULA/Cbl-InteractingProtein 4 (CLIP4). TULA proteins contain an N-terminal UBA domain, a central SH3 domain, and a C-terminal histidine phosphatase domain. They bind c-Cbl (a multidomain adaptor and an E3 ubiquitinligase) through the SH3 domain []and to ubiquitin via UBA [].
