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Search results 101 to 170 out of 170 for Appl1

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Type Details Score
GXD Expression    
Probe: MGI:6369367
Assay Type: Western blot
Annotation Date: 2019-11-04
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1672826
Stage: TS26
Assay Id: MGI:6369448
Age: embryonic day 18.5
Image: 2
Specimen Label: -/-
Detected: false
Specimen Num: 14
Publication
First Author: Yeo JC
Year: 2015
Journal: Mol Biol Cell
Title: Rab31 and APPL2 enhance FcγR-mediated phagocytosis through PI3K/Akt signaling in macrophages.
Volume: 26
Issue: 5
Pages: 952-65
Publication
First Author: Tu Q
Year: 2011
Journal: J Biol Chem
Title: Adiponectin inhibits osteoclastogenesis and bone resorption via APPL1-mediated suppression of Akt1.
Volume: 286
Issue: 14
Pages: 12542-53
Publication
First Author: Fu X
Year: 2011
Journal: Mol Biol Cell
Title: Retrolinkin cooperates with endophilin A1 to mediate BDNF-TrkB early endocytic trafficking and signaling from early endosomes.
Volume: 22
Issue: 19
Pages: 3684-98
Publication
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
Publication
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
Publication      
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication
First Author: Cheng KK
Year: 2007
Journal: Diabetes
Title: Adiponectin-induced endothelial nitric oxide synthase activation and nitric oxide production are mediated by APPL1 in endothelial cells.
Volume: 56
Issue: 5
Pages: 1387-94
Publication
First Author: Zhu G
Year: 2007
Journal: EMBO J
Title: Structure of the APPL1 BAR-PH domain and characterization of its interaction with Rab5.
Volume: 26
Issue: 14
Pages: 3484-93
Interaction Experiment
Description: Serine 707 of APPL1 is Critical for the Synaptic NMDA Receptor-Mediated Akt Phosphorylation Signaling Pathway.
DO Term
Publication
First Author: Wang J
Year: 2016
Journal: Neurosci Bull
Title: Serine 707 of APPL1 is Critical for the Synaptic NMDA Receptor-Mediated Akt Phosphorylation Signaling Pathway.
Volume: 32
Issue: 4
Pages: 323-30
Publication
First Author: Bohdanowicz M
Year: 2012
Journal: Mol Biol Cell
Title: Recruitment of OCRL and Inpp5B to phagosomes by Rab5 and APPL1 depletes phosphoinositides and attenuates Akt signaling.
Volume: 23
Issue: 1
Pages: 176-87
Publication
First Author: Li J
Year: 2007
Journal: Structure
Title: Crystal structures of the BAR-PH and PTB domains of human APPL1.
Volume: 15
Issue: 5
Pages: 525-33
Publication
First Author: Deepa SS
Year: 2009
Journal: Am J Physiol Endocrinol Metab
Title: APPL1: role in adiponectin signaling and beyond.
Volume: 296
Issue: 1
Pages: E22-36
Protein Domain
Type: Domain
Description: Adaptor protein, Phosphotyrosine interaction, PH domain and Leucine zipper containing (APPL) proteins are effectors of the small GTPase Rab5 that function in endosome-mediated signaling []. They contain BAR, pleckstrin homology (PH) and phosphotyrosine binding (PTB) domains. They form homo- and hetero-oligomers that are mediated by their BAR domains []. Vertebrates contain two APPL proteins, APPL1 and APPL2. APPL1 interacts with diverse receptors (e.g. NGF receptor TrkA, FSHR, adiponectin receptors) and signaling proteins (e.g. Akt, PI3K), and may function as an adaptor linked to many distinct signaling pathways []. This entry represents the BAR domain of APPL1.
Protein Domain
Type: Domain
Description: OCRL1 hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events []. OCRL1 resides on vesicular structures throughout the endosomal system and the Golgi complex, and is also present at the plasma membrane in membrane ruffles and at late-stage endocytic clathrin-coated pits. It binds clathrin, clathrin adaptors, several GTPases, and the endocytic proteins APPL1 and Ses1/2 []. Mutations in the OCRL1 gene cause Lowe Syndrome, leading to cataracts, mental retardation and renal failure []. Mutations in OCRL can also give rise to a milder pathology, Dent disease 2, which is characterised by renal Fanconi syndrome in the absence of extrarenal pathologies [].OCRL1 shares ~45% sequence identity with INPP5B and has the same domain organization. However, a loop in the Rho GAP domain contains a second clathrin box which is absent in INPP5B. INPP5B shares most interacting partners with OCRL, except for clathrin and the endocytic clathrin adaptor AP-2 []. OCRL1 contains a PH domain, a 5-phosphatase domain, an ASH domain and a Rho-GAP domain. The RhoGAP domain lacks the catalytic arginine and is catalytically inactive. However, the RhoGAP domain of OCRL interacts with Rac and Cdc42, but only the Cdc42 interaction is GTP-dependent. The RhoGAP domain also interacts with three endocytic proteins containing the F&H motif: APPL1, Ses1 and Ses2. OCRL1 interacts with Rab GTPase (Rab8) through its ASH domain []. This entry represents the inositol polyphosphate 5-phosphatase (INPP5c) domain of OCRL1/INPP5B.
Publication
First Author: Swan LE
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Two closely related endocytic proteins that share a common OCRL-binding motif with APPL1.
Volume: 107
Issue: 8
Pages: 3511-6
Publication
First Author: Cheng KK
Year: 2014
Journal: Diabetes
Title: The adaptor protein APPL2 inhibits insulin-stimulated glucose uptake by interacting with TBC1D1 in skeletal muscle.
Volume: 63
Issue: 11
Pages: 3748-58
Publication
First Author: Perini ED
Year: 2014
Journal: Traffic
Title: Mammalian CORVET is required for fusion and conversion of distinct early endosome subpopulations.
Volume: 15
Issue: 12
Pages: 1366-89
Publication
First Author: Wang B
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: The adaptor protein APPL2 controls glucose-stimulated insulin secretion via F-actin remodeling in pancreatic β-cells.
Volume: 117
Issue: 45
Pages: 28307-28315
Publication
First Author: Wang Y
Year: 2012
Journal: Arterioscler Thromb Vasc Biol
Title: Essential role of caveolin-3 in adiponectin signalsome formation and adiponectin cardioprotection.
Volume: 32
Issue: 4
Pages: 934-42
Publication
First Author: Ding X
Year: 2017
Journal: Genetics
Title: Survival of BRCA2-Deficient Cells Is Promoted by GIPC3, a Novel Genetic Interactor of BRCA2.
Volume: 207
Issue: 4
Pages: 1335-1345
Publication      
First Author: McGowan SE
Year: 2020
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Neuropilin-1 directs PDGFRα-entry into lung fibroblasts and signaling from very early endosomes.
Publication
First Author: Pirruccello M
Year: 2012
Journal: Trends Biochem Sci
Title: Inositol 5-phosphatases: insights from the Lowe syndrome protein OCRL.
Volume: 37
Issue: 4
Pages: 134-43
Publication
First Author: Grieve AG
Year: 2011
Journal: PLoS One
Title: Lowe Syndrome protein OCRL1 supports maturation of polarized epithelial cells.
Volume: 6
Issue: 8
Pages: e24044
Publication
First Author: Vicinanza M
Year: 2011
Journal: EMBO J
Title: OCRL controls trafficking through early endosomes via PtdIns4,5P₂-dependent regulation of endosomal actin.
Volume: 30
Issue: 24
Pages: 4970-85
Publication
First Author: De Matteis MA
Year: 2017
Journal: Nat Rev Nephrol
Title: The 5-phosphatase OCRL in Lowe syndrome and Dent disease 2.
Volume: 13
Issue: 8
Pages: 455-470
Protein Domain
Type: Domain
Description: OCRL1 hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events []. OCRL1 resides on vesicular structures throughout the endosomal system and the Golgi complex, and is also present at the plasma membrane in membrane ruffles and at late-stage endocytic clathrin-coated pits. It binds clathrin, clathrin adaptors, several GTPases, and the endocytic proteins APPL1 and Ses1/2 []. Mutations in the OCRL1 gene cause Lowe Syndrome, leading to cataracts, mental retardation and renal failure []. Mutations in OCRL can also give rise to a milder pathology, Dent disease 2, which is characterised by renal Fanconi syndrome in the absence of extrarenal pathologies [].OCRL1 shares ~45% sequence identity with INPP5B (not included in this entry) and has the same domain organization. However, a loop in the Rho GAP domain contains a second clathrin box which is absent in INPP5B. INPP5B shares most interacting partners with OCRL, except for clathrin and the endocytic clathrin adaptor AP-2 []. OCRL1 contains a PH domain, a 5-phosphatase domain, an ASH domain and a Rho-GAP domain. The RhoGAP domain lacks the catalytic arginine and is catalytically inactive. However, the RhoGAP domain of OCRL interacts with Rac and Cdc42, but only the Cdc42 interaction is GTP-dependent. The RhoGAP domain also interacts with three endocytic proteins containing the F&H motif: APPL1, Ses1 and Ses2. OCRL1 interacts with Rab GTPase (Rab8) through its ASH domain []. This entry represents the PH domain of OCRL1 []. The PH domain connects to the 5-phosphatase domain, which has a Dnase I-like fold [].
Publication  
First Author: Katoh M
Year: 2013
Journal: Exp Mol Med
Title: Functional proteomics, human genetics and cancer biology of GIPC family members.
Volume: 45
Pages: e26
Publication
First Author: Fang X
Year: 2009
Journal: Diabetologia
Title: Leptin prevents the metabolic effects of adiponectin in L6 myotubes.
Volume: 52
Issue: 10
Pages: 2190-200
Publication  
First Author: Mukherjee S
Year: 2023
Journal: Mol Metab
Title: Ube4A maintains metabolic homeostasis and facilitates insulin signaling in vivo.
Volume: 75
Pages: 101767
Publication
First Author: Mao Y
Year: 2009
Journal: EMBO J
Title: A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism.
Volume: 28
Issue: 13
Pages: 1831-42
Protein
Organism: Mus musculus/domesticus
Length: 511  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 707  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 900  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 993  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 995  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 757  
Fragment?: true