This entry represents the RNA recognition motif 2 (RRM2) of SRSF9 (also known as SRp30c), an essential splicing regulatory serine/arginine (SR) protein that has been implicated in the activity of many elements that control splice site selection [, ]. SRSF9 can also interact with other proteins implicated in alternative splicing, such as YB-1 []. It represses the splicing of Tau exon 10 [, ]. SRSF9 contains two N-terminal RNA recognition motifs (RRMs), followed by an unusually short C-terminal RS domains rich in serine-arginine dipeptides.
This entry represents the RNA recognition motif 1 (RRM1) of SRSF9 (also known as SRp30C). SRSF9 is a member of the SR (serine/arginine) protein family of splicing regulators. It interacts with Y-box protein 1 (YB-1) and is involved in the alternative splice site selection. Besides stimulating the mRNA splicing [], it also functions as a repressor of 3' splice site utilization []and has been shown to promote skipping of exon 7B in the hnRNP A1 pre-mRNA [].
