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Search results 701 to 800 out of 909 for Cdk4

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Type Details Score
Publication
37712417 | J:340622
 
First Author: Stamateris RE
Year: 2023
Journal: J Clin Invest
Title: Noncanonical CDK4 signaling rescues diabetes in a mouse model by promoting β cell differentiation.
Volume: 133
Issue: 18
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Publication
10475236 | J:56941
First Author: Lukas C
Year: 1999
Journal: Hybridoma
Title: Immunohistochemical analysis of the D-type cyclin-dependent kinases Cdk4 and Cdk6, using a series of monoclonal antibodies.
Volume: 18
Issue: 3
Pages: 225-34
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Interaction Experiment
Wang H (2002)
Description: C/EBPalpha triggers proteasome-dependent degradation of cdk4 during growth arrest.
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Publication
32294430 | J:306324
First Author: Romero-Pozuelo J
Year: 2020
Journal: Cell Rep
Title: Cdk4 and Cdk6 Couple the Cell-Cycle Machinery to Cell Growth via mTORC1.
Volume: 31
Issue: 2
Pages: 107504
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Publication
10526130 | J:58023
First Author: Watanabe Y
Year: 1999
Journal: Brain Res
Title: pRb phosphorylation is regulated differentially by cyclin-dependent kinase (Cdk) 2 and Cdk4 in retinoic acid-induced neuronal differentiation of P19 cells.
Volume: 842
Issue: 2
Pages: 342-50
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Publication
12614625 | J:82414
First Author: Cammett TJ
Year: 2003
Journal: J Mol Biol
Title: Design and characterization of a hyperstable p16INK4a that restores Cdk4 binding activity when combined with oncogenic mutations.
Volume: 327
Issue: 1
Pages: 285-97
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Publication
25234309 | J:216356
First Author: Tan M
Year: 2014
Journal: Am J Physiol Renal Physiol
Title: Novel inhibitors of nuclear transport cause cell cycle arrest and decrease cyst growth in ADPKD associated with decreased CDK4 levels.
Volume: 307
Issue: 11
Pages: F1179-86
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Publication
9851971 | J:51558
First Author: Holland EC
Year: 1998
Journal: Genes Dev
Title: Modeling mutations in the G1 arrest pathway in human gliomas: overexpression of CDK4 but not loss of INK4a-ARF induces hyperploidy in cultured mouse astrocytes.
Volume: 12
Issue: 23
Pages: 3644-9
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Publication
28446612 | J:245891
First Author: Chen H
Year: 2017
Journal: J Biol Chem
Title: CDK4 protein is degraded by anaphase-promoting complex/cyclosome in mitosis and reaccumulates in early G1 phase to initiate a new cell cycle in HeLa cells.
Volume: 292
Issue: 24
Pages: 10131-10141
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Interaction Experiment
Chan FK (1995)
Description: Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4.
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Publication
20466002 | J:161318
First Author: Arakawa-Takeuchi S
Year: 2010
Journal: FEBS Lett
Title: Mammalian target of rapamycin complex 1 signaling opposes the effects of anchorage loss, leading to activation of Cdk4 and Cdc6 stabilization.
Volume: 584
Issue: 13
Pages: 2779-85
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Publication
10580009 | -
First Author: Sugimoto M
Year: 1999
Journal: Genes Dev
Title: Regulation of CDK4 activity by a novel CDK4-binding protein, p34(SEI-1).
Volume: 13
Issue: 22
Pages: 3027-33
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Publication
19237565 | -
First Author: Day PJ
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Crystal structure of human CDK4 in complex with a D-type cyclin.
Volume: 106
Issue: 11
Pages: 4166-70
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Publication
14726699 | -
First Author: Samady L
Year: 2004
Journal: Cancer Biol Ther
Title: Activation of CDK4 gene expression in human breast cancer cells by the Brn-3b POU family transcription factor.
Volume: 3
Issue: 3
Pages: 317-23
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Publication
11779854 | -
First Author: Dawson S
Year: 2002
Journal: J Biol Chem
Title: Gankyrin is an ankyrin-repeat oncoprotein that interacts with CDK4 kinase and the S6 ATPase of the 26 S proteasome.
Volume: 277
Issue: 13
Pages: 10893-902
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Publication
11438484 | J:108690
First Author: Miliani de Marval PL
Year: 2001
Journal: Am J Pathol
Title: Transgenic expression of cyclin-dependent kinase 4 results in epidermal hyperplasia, hypertrophy, and severe dermal fibrosis.
Volume: 159
Issue: 1
Pages: 369-79
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Allele
Tg(KRT5-CDK4)2303Mlrp | MGI:3624634
Name: transgene insertion 2303, Marcelo L Rodriguez-Puebla
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Cdk4-EGFP)ET103Gsat | MGI:4846930
Name: transgene insertion ET103, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
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Strain
MGI:5003565 | STOCK Tg(Cdk4-EGFP)ET103Gsat/Mmucd
Attribute String: mutant stock, transgenic
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Allele
Tg(GFAP-CDK4)2Gtm | MGI:3620555
Name: transgene insertion 2, David H Gutmann
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Genotype
Genotype
Symbol: Tg(KRT5-CDK4)2303Mlrp/?
Background: involves: FVB * SSIN
Zygosity: ot
Has Mutant Allele: true
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Publication
17942901 | J:125987
First Author: Macias E
Year: 2007
Journal: Cancer Res
Title: Cdk2 deficiency decreases ras/CDK4-dependent malignant progression, but not myc-induced tumorigenesis.
Volume: 67
Issue: 20
Pages: 9713-20
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Strain
MGI:5654352 | STOCK Tg(GFAP-CDK4)2Gtm/Nci
Attribute String: transgenic, mutant stock
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Genotype
Genotype
Symbol: Cdkn1b/Cdkn1b Tg(KRT5-CDK4)2303Mlrp/?
Background: involves: 129S4/SvJae * C57BL/6 * FVB * SENCAR * SSIN
Zygosity: cx
Has Mutant Allele: true
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Publication
16537495 | J:107588
First Author: Chien WM
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Genetic mosaics reveal both cell-autonomous and cell-nonautonomous function of murine p27Kip1.
Volume: 103
Issue: 11
Pages: 4122-7
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Publication
21734724 | J:174617
First Author: Musgrove EA
Year: 2011
Journal: Nat Rev Cancer
Title: Cyclin D as a therapeutic target in cancer.
Volume: 11
Issue: 8
Pages: 558-72
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Publication
8078588 | J:20317
First Author: Hannon GJ
Year: 1994
Journal: Nature
Title: p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest.
Volume: 371
Issue: 6494
Pages: 257-61
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Publication
8521522 | J:41563
First Author: Quelle DE
Year: 1995
Journal: Cell
Title: Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest.
Volume: 83
Issue: 6
Pages: 993-1000
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Publication
31110312 | J:282492
First Author: Ji Y
Year: 2019
Journal: Nat Immunol
Title: Toll-like receptors TLR2 and TLR4 block the replication of pancreatic β cells in diet-induced obesity.
Volume: 20
Issue: 6
Pages: 677-686
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Publication
28278054 | J:274980
First Author: Scott A
Year: 2017
Journal: Cell Cycle
Title: p16 loss rescues functional decline of Brca1-deficient mammary stem cells.
Volume: 16
Issue: 8
Pages: 759-764
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Publication
32109375 | J:285842
First Author: Salvador-Barbero B
Year: 2020
Journal: Cancer Cell
Title: CDK4/6 Inhibitors Impair Recovery from Cytotoxic Chemotherapy in Pancreatic Adenocarcinoma.
Volume: 37
Issue: 3
Pages: 340-353.e6
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Publication
28092373 | J:260616
First Author: Linke M
Year: 2017
Journal: Nat Immunol
Title: Chronic signaling via the metabolic checkpoint kinase mTORC1 induces macrophage granuloma formation and marks sarcoidosis progression.
Volume: 18
Issue: 3
Pages: 293-302
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Publication
12965216 | J:85412
First Author: Mori S
Year: 2003
Journal: FEBS Lett
Title: Forced expression of cyclin D1 does not compensate for Id2 deficiency in the mammary gland.
Volume: 551
Issue: 1-3
Pages: 123-7
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Publication
9169494 | J:40920
First Author: Soonpaa MH
Year: 1997
Journal: J Clin Invest
Title: Cyclin D1 overexpression promotes cardiomyocyte DNA synthesis and multinucleation in transgenic mice.
Volume: 99
Issue: 11
Pages: 2644-54
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Publication
28368413 | J:248100
First Author: Qi Q
Year: 2017
Journal: Oncogene
Title: Co-amplification of phosphoinositide 3-kinase enhancer A and cyclin-dependent kinase 4 triggers glioblastoma progression.
Volume: 36
Issue: 32
Pages: 4562-4572
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Publication
28460268 | J:320763
 
First Author: Escudero B
Year: 2017
Journal: DNA Repair (Amst)
Title: Polμ deficiency induces moderate shortening of P53-/- mouse lifespan and modifies tumor spectrum.
Volume: 54
Pages: 40-45
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Publication
25959802 | J:303198
First Author: Tanaka T
Year: 2015
Journal: J Reprod Dev
Title: The CDKN1B-RB1-E2F1 pathway protects mouse spermatogonial stem cells from genomic damage.
Volume: 61
Issue: 4
Pages: 305-16
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Publication
16650383 | J:108995
First Author: Kim SS
Year: 2006
Journal: Biochem Biophys Res Commun
Title: TGF-beta signaling pathway inactivation and cell cycle deregulation in the development of gastric cancer: role of the beta-spectrin, ELF.
Volume: 344
Issue: 4
Pages: 1216-23
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Publication
9548727 | J:47169
First Author: Brugarolas J
Year: 1998
Journal: J Cell Biol
Title: p21 is a critical CDK2 regulator essential for proliferation control in Rb-deficient cells.
Volume: 141
Issue: 2
Pages: 503-14
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Publication
10437914 | J:122911
First Author: Rodriguez-Puebla ML
Year: 1999
Journal: Cell Growth Differ
Title: Cyclin D1 overexpression in mouse epidermis increases cyclin-dependent kinase activity and cell proliferation in vivo but does not affect skin tumor development.
Volume: 10
Issue: 7
Pages: 467-72
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Publication
20386739 | J:159211
First Author: Luo Y
Year: 2010
Journal: PLoS Genet
Title: Fragile x mental retardation protein regulates proliferation and differentiation of adult neural stem/progenitor cells.
Volume: 6
Issue: 4
Pages: e1000898
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Publication
16721052 | J:196054
First Author: Sim KG
Year: 2006
Journal: Cell Cycle
Title: The TRIP-Br family of transcriptional regulators is essential for the execution of cyclin E-mediated cell cycle progression.
Volume: 5
Issue: 10
Pages: 1111-5
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Publication
27806297 | J:242337
First Author: Yan X
Year: 2016
Journal: Cell Rep
Title: Deletion of the Imprinted Gene Grb10 Promotes Hematopoietic Stem Cell Self-Renewal and Regeneration.
Volume: 17
Issue: 6
Pages: 1584-1594
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Publication
23160194 | J:193973
First Author: Jones K
Year: 2012
Journal: J Clin Invest
Title: GSK3β mediates muscle pathology in myotonic dystrophy.
Volume: 122
Issue: 12
Pages: 4461-72
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Publication
30089269 | J:271103
First Author: Nguyen P
Year: 2018
Journal: Cell Rep
Title: Elimination of Age-Associated Hepatic Steatosis and Correction of Aging Phenotype by Inhibition of cdk4-C/EBPα-p300 Axis.
Volume: 24
Issue: 6
Pages: 1597-1609
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Publication
12556487 | J:81540
First Author: Bai F
Year: 2003
Journal: Mol Cell Biol
Title: Haploinsufficiency of p18(INK4c) sensitizes mice to carcinogen-induced tumorigenesis.
Volume: 23
Issue: 4
Pages: 1269-77
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Publication
8275715 | J:16272
First Author: Demetrick DJ
Year: 1994
Journal: Cytogenet Cell Genet
Title: Chromosomal mapping of human CDK2, CDK4, and CDK5 cell cycle kinase genes.
Volume: 66
Issue: 1
Pages: 72-4
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Publication
10075928 | J:54048
First Author: Cheng M
Year: 1999
Journal: EMBO J
Title: The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts.
Volume: 18
Issue: 6
Pages: 1571-83
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Publication
12711305 | J:83337
First Author: Li J
Year: 2003
Journal: Biochem Biophys Res Commun
Title: Expression and characterization of Syrian golden hamster p16, a homologue of human tumor suppressor p16 INK4A.
Volume: 304
Issue: 2
Pages: 241-7
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Publication
15545627 | J:93880
First Author: Sherr CJ
Year: 2004
Journal: Genes Dev
Title: Living with or without cyclins and cyclin-dependent kinases.
Volume: 18
Issue: 22
Pages: 2699-711
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Publication
16236519 | J:106087
First Author: Malumbres M
Year: 2005
Journal: Trends Biochem Sci
Title: Mammalian cyclin-dependent kinases.
Volume: 30
Issue: 11
Pages: 630-41
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Publication
9751051 | J:116365
First Author: Brotherton DH
Year: 1998
Journal: Nature
Title: Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d.
Volume: 395
Issue: 6699
Pages: 244-50
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Publication
24604117 | J:210828
First Author: Liu G
Year: 2014
Journal: J Pathol
Title: MiR-506 suppresses proliferation and induces senescence by directly targeting the CDK4/6-FOXM1 axis in ovarian cancer.
Volume: 233
Issue: 3
Pages: 308-18
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Publication
27541004 | J:246014
First Author: Badia R
Year: 2016
Journal: PLoS Pathog
Title: The G1/S Specific Cyclin D2 Is a Regulator of HIV-1 Restriction in Non-proliferating Cells.
Volume: 12
Issue: 8
Pages: e1005829
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Publication
16732323 | J:183970
First Author: Pasder O
Year: 2006
Journal: Oncogene
Title: Downregulation of Fer induces PP1 activation and cell-cycle arrest in malignant cells.
Volume: 25
Issue: 30
Pages: 4194-206
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Publication
8887674 | J:51744
First Author: Hirai H
Year: 1996
Journal: Mol Cell Biol
Title: Interaction of D-type cyclins with a novel myb-like transcription factor, DMP1.
Volume: 16
Issue: 11
Pages: 6457-67
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Publication
33854235 | J:305916
First Author: Simoneschi D
Year: 2021
Journal: Nature
Title: CRL4AMBRA1 is a master regulator of D-type cyclins.
Volume: 592
Issue: 7856
Pages: 789-793
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Publication
16024603 | J:100086
First Author: Jansen AP
Year: 2005
Journal: Cancer Res
Title: Epidermal expression of the translation inhibitor programmed cell death 4 suppresses tumorigenesis.
Volume: 65
Issue: 14
Pages: 6034-41
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Publication
11896600 | J:133728
First Author: Vasseur S
Year: 2002
Journal: Oncogene
Title: p8-deficient fibroblasts grow more rapidly and are more resistant to adriamycin-induced apoptosis.
Volume: 21
Issue: 11
Pages: 1685-94
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Publication
8666233 | J:39400
First Author: Stepanova L
Year: 1996
Journal: Genes Dev
Title: Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4.
Volume: 10
Issue: 12
Pages: 1491-502
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Publication
15110991 | J:89375
First Author: Bryja V
Year: 2004
Journal: Biochim Biophys Acta
Title: The role of p27(Kip1) in maintaining the levels of D-type cyclins in vivo.
Volume: 1691
Issue: 2-3
Pages: 105-16
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Publication
9121767 | J:48597
First Author: Nakagawa H
Year: 1997
Journal: Oncogene
Title: The targeting of the cyclin D1 oncogene by an Epstein-Barr virus promoter in transgenic mice causes dysplasia in the tongue, esophagus and forestomach.
Volume: 14
Issue: 10
Pages: 1185-90
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Publication
26795955 | J:250192
 
First Author: Qin Z
Year: 2016
Journal: Sci Rep
Title: Tsc1 deficiency impairs mammary development in mice by suppression of AKT, nuclear ERα, and cell-cycle-driving proteins.
Volume: 6
Pages: 19587
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Publication
11884607 | J:75235
First Author: Muraoka RS
Year: 2002
Journal: Mol Cell Biol
Title: ErbB2/Neu-induced, cyclin D1-dependent transformation is accelerated in p27-haploinsufficient mammary epithelial cells but impaired in p27-null cells.
Volume: 22
Issue: 7
Pages: 2204-19
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Publication
11158317 | J:67129
First Author: Tong W
Year: 2001
Journal: Mol Cell Biol
Title: Genetic evidence for the interactions of cyclin D1 and p27(Kip1) in mice.
Volume: 21
Issue: 4
Pages: 1319-28
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Publication
11381079 | J:69805
First Author: Muraoka RS
Year: 2001
Journal: J Cell Biol
Title: Cyclin-dependent kinase inhibitor p27(Kip1) is required for mouse mammary gland morphogenesis and function.
Volume: 153
Issue: 5
Pages: 917-32
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Publication
17631145 | J:128291
First Author: Smartt HJ
Year: 2007
Journal: Gastroenterology
Title: p27kip1 Regulates cdk2 activity in the proliferating zone of the mouse intestinal epithelium: potential role in neoplasia.
Volume: 133
Issue: 1
Pages: 232-43
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Publication
15591344 | J:95280
First Author: Huang X
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Homeostatic cell-cycle control by BLyS: Induction of cell-cycle entry but not G1/S transition in opposition to p18INK4c and p27Kip1.
Volume: 101
Issue: 51
Pages: 17789-94
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Publication
17308082 | J:118667
First Author: Bailly-Maitre B
Year: 2007
Journal: Cancer Res
Title: Mice lacking bi-1 gene show accelerated liver regeneration.
Volume: 67
Issue: 4
Pages: 1442-50
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Publication
22983396 | J:238049
First Author: Kwong LN
Year: 2012
Journal: Nat Med
Title: Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma.
Volume: 18
Issue: 10
Pages: 1503-10
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Publication
9851974 | J:52161
First Author: Holland EC
Year: 1998
Journal: Genes Dev
Title: A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice.
Volume: 12
Issue: 23
Pages: 3675-85
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Publication
17510401 | J:121732
First Author: Ramsey MR
Year: 2007
Journal: Cancer Res
Title: Expression of p16Ink4a compensates for p18Ink4c loss in cyclin-dependent kinase 4/6-dependent tumors and tissues.
Volume: 67
Issue: 10
Pages: 4732-41
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Publication
27811360 | J:297700
First Author: Scott A
Year: 2016
Journal: Oncotarget
Title: p16INK4a suppresses BRCA1-deficient mammary tumorigenesis.
Volume: 7
Issue: 51
Pages: 84496-84507
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Publication
21984813 | J:194442
First Author: Shu B
Year: 2011
Journal: J Cell Sci
Title: BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development.
Volume: 124
Issue: Pt 20
Pages: 3428-40
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Publication
22367880 | J:183774
First Author: Adhikari D
Year: 2012
Journal: Hum Mol Genet
Title: Cdk1, but not Cdk2, is the sole Cdk that is essential and sufficient to drive resumption of meiosis in mouse oocytes.
Volume: 21
Issue: 11
Pages: 2476-84
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Publication
33245729 | J:310581
First Author: Melo-Hanchuk TD
Year: 2020
Journal: Oncotarget
Title: Intracellular hyaluronic acid-binding protein 4 (HABP4): a candidate tumor suppressor in colorectal cancer.
Volume: 11
Issue: 46
Pages: 4325-4337
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Publication
10594039 | J:58959
First Author: Zindy F
Year: 2000
Journal: Mol Cell Biol
Title: INK4d-deficient mice are fertile despite testicular atrophy.
Volume: 20
Issue: 1
Pages: 372-8
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Publication
17393423 | J:124134
First Author: Buchold GM
Year: 2007
Journal: Mol Reprod Dev
Title: Mice lacking cyclin-dependent kinase inhibitor p19Ink4d show strain-specific effects on male reproduction.
Volume: 74
Issue: 8
Pages: 1008-20
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Publication
28174173 | J:240401
First Author: Wan L
Year: 2017
Journal: Cancer Discov
Title: The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function.
Volume: 7
Issue: 4
Pages: 424-441
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Publication
30143714 | J:279146
First Author: Giannattasio S
Year: 2018
Journal: Sci Rep
Title: Lack of cyclin D3 induces skeletal muscle fiber-type shifting, increased endurance performance and hypermetabolism.
Volume: 8
Issue: 1
Pages: 12792
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Publication
10880462 | J:63299
First Author: Latres E
Year: 2000
Journal: EMBO J
Title: Limited overlapping roles of P15(INK4b) and P18(INK4c) cell cycle inhibitors in proliferation and tumorigenesis.
Volume: 19
Issue: 13
Pages: 3496-506
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Publication
17662109 | J:129886
First Author: Nakakuki M
Year: 2007
Journal: FEBS J
Title: A transcription factor of lipid synthesis, sterol regulatory element-binding protein (SREBP)-1a causes G(1) cell-cycle arrest after accumulation of cyclin-dependent kinase (cdk) inhibitors.
Volume: 274
Issue: 17
Pages: 4440-52
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Publication
16738322 | J:109606
First Author: Bai F
Year: 2006
Journal: Mol Cell Biol
Title: p18 Ink4c and Pten constrain a positive regulatory loop between cell growth and cell cycle control.
Volume: 26
Issue: 12
Pages: 4564-76
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Publication
16980623 | J:112972
First Author: Kohno M
Year: 2006
Journal: Mol Cell Biol
Title: Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation.
Volume: 26
Issue: 19
Pages: 7211-23
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Publication
20581865 | J:169196
First Author: Zeng X
Year: 2010
Journal: Oncogene
Title: The Ras oncogene signals centrosome amplification in mammary epithelial cells through cyclin D1/Cdk4 and Nek2.
Volume: 29
Issue: 36
Pages: 5103-12
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Publication
23010077 | J:192878
First Author: Qian X
Year: 2012
Journal: Cancer Res
Title: Inactivation of the Dlc1 gene cooperates with downregulation of p15INK4b and p16Ink4a, leading to neoplastic transformation and poor prognosis in human cancer.
Volume: 72
Issue: 22
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