Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:4422445 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1691123 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4825729 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008387_05 |
|
Specimen Label: |
euxassay_008387_05 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4422445 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1691123 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4825729 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008387_06 |
|
Specimen Label: |
euxassay_008387_06 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4422445 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1691123 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4825729 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008387_07 |
|
Specimen Label: |
euxassay_008387_07 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4422445 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1691123 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4825729 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008387_20 |
|
Specimen Label: |
euxassay_008387_20 |
Detected: |
true |
Specimen Num: |
20 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4422445 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1691123 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4825729 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008387_21 |
|
Specimen Label: |
euxassay_008387_21 |
Detected: |
true |
Specimen Num: |
21 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4422445 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1691123 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4825729 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008387_22 |
|
Specimen Label: |
euxassay_008387_22 |
Detected: |
true |
Specimen Num: |
22 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4422445 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1691123 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4825729 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008387_23 |
|
Specimen Label: |
euxassay_008387_23 |
Detected: |
true |
Specimen Num: |
23 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4422445 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1691123 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4825729 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008387_24 |
|
Specimen Label: |
euxassay_008387_24 |
Detected: |
true |
Specimen Num: |
24 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4422445 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1801023 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4825729 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008387_03 |
|
Specimen Label: |
euxassay_008387_03 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4422445 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1801023 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4825729 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008387_04 |
|
Specimen Label: |
euxassay_008387_04 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4422445 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1801023 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4825729 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008387_05 |
|
Specimen Label: |
euxassay_008387_05 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4422445 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1801023 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4825729 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008387_19 |
|
Specimen Label: |
euxassay_008387_19 |
Detected: |
true |
Specimen Num: |
19 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4422445 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1801023 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4825729 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008387_20 |
|
Specimen Label: |
euxassay_008387_20 |
Detected: |
true |
Specimen Num: |
20 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4422445 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1801023 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4825729 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008387_21 |
|
Specimen Label: |
euxassay_008387_21 |
Detected: |
true |
Specimen Num: |
21 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4422445 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1801023 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4825729 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008387_22 |
|
Specimen Label: |
euxassay_008387_22 |
Detected: |
true |
Specimen Num: |
22 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4422445 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1801023 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4825729 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008387_23 |
|
Specimen Label: |
euxassay_008387_23 |
Detected: |
true |
Specimen Num: |
23 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4422445 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1625523 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4825729 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008387_09 |
|
Specimen Label: |
euxassay_008387_09 |
Detected: |
true |
Specimen Num: |
9 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4422445 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1625523 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4825729 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008387_10 |
|
Specimen Label: |
euxassay_008387_10 |
Detected: |
true |
Specimen Num: |
10 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4422445 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1625523 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4825729 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008387_11 |
|
Specimen Label: |
euxassay_008387_11 |
Detected: |
true |
Specimen Num: |
11 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4422445 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1625523 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4825729 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008387_13 |
|
Specimen Label: |
euxassay_008387_13 |
Detected: |
true |
Specimen Num: |
13 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4422445 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1625523 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4825729 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008387_17 |
|
Specimen Label: |
euxassay_008387_17 |
Detected: |
true |
Specimen Num: |
17 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4422445 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1625523 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4825729 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008387_18 |
|
Specimen Label: |
euxassay_008387_18 |
Detected: |
true |
Specimen Num: |
18 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4422445 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1625523 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4825729 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008387_19 |
|
Specimen Label: |
euxassay_008387_19 |
Detected: |
true |
Specimen Num: |
19 |
|
•
•
•
•
•
|
Publication |
First Author: |
Isbrandt D |
Year: |
2002 |
Journal: |
GenBank Submission |
Title: |
Mus musculus potassium voltage-gated channel subfamily Q member 3 (Kcnq3) mRNA, complete cds |
|
|
Pages: |
AY118171 |
|
•
•
•
•
•
|
Publication |
First Author: |
Watanabe H |
Year: |
2000 |
Journal: |
J Neurochem |
Title: |
Disruption of the epilepsy KCNQ2 gene results in neural hyperexcitability. |
Volume: |
75 |
Issue: |
1 |
Pages: |
28-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Friedman AK |
Year: |
2016 |
Journal: |
Nat Commun |
Title: |
KCNQ channel openers reverse depressive symptoms via an active resilience mechanism. |
Volume: |
7 |
|
Pages: |
11671 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhou X |
Year: |
2011 |
Journal: |
Cell Death Differ |
Title: |
Novel role of KCNQ2/3 channels in regulating neuronal cell viability. |
Volume: |
18 |
Issue: |
3 |
Pages: |
493-505 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li S |
Year: |
2013 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Pathogenic plasticity of Kv7.2/3 channel activity is essential for the induction of tinnitus. |
Volume: |
110 |
Issue: |
24 |
Pages: |
9980-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li S |
Year: |
2015 |
Journal: |
Elife |
Title: |
Noise-induced plasticity of KCNQ2/3 and HCN channels underlies vulnerability and resilience to tinnitus. |
Volume: |
4 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marowsky A |
Year: |
2009 |
Journal: |
Neuroscience |
Title: |
Distribution of soluble and microsomal epoxide hydrolase in the mouse brain and its contribution to cerebral epoxyeicosatrienoic acid metabolism. |
Volume: |
163 |
Issue: |
2 |
Pages: |
646-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen X |
Year: |
2021 |
Journal: |
J Biol Chem |
Title: |
The SUMO-specific protease SENP2 plays an essential role in the regulation of Kv7.2 and Kv7.3 potassium channels. |
Volume: |
297 |
Issue: |
4 |
Pages: |
101183 |
|
•
•
•
•
•
|
Publication |
First Author: |
Soh H |
Year: |
2018 |
Journal: |
Elife |
Title: |
Deletion of KCNQ2/3 potassium channels from PV+ interneurons leads to homeostatic potentiation of excitatory transmission. |
Volume: |
7 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Markenscoff-Papadimitriou E |
Year: |
2020 |
Journal: |
Cell |
Title: |
A Chromatin Accessibility Atlas of the Developing Human Telencephalon. |
Volume: |
182 |
Issue: |
3 |
Pages: |
754-769.e18 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang J |
Year: |
2012 |
Journal: |
Neuron |
Title: |
Activity-dependent transcriptional regulation of M-Type (Kv7) K(+) channels by AKAP79/150-mediated NFAT actions. |
Volume: |
76 |
Issue: |
6 |
Pages: |
1133-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ballif BA |
Year: |
2004 |
Journal: |
Curr Biol |
Title: |
Activation of a Dab1/CrkL/C3G/Rap1 pathway in Reelin-stimulated neurons. |
Volume: |
14 |
Issue: |
7 |
Pages: |
606-10 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kurrasch DM |
Year: |
2007 |
Journal: |
J Neurosci |
Title: |
The neonatal ventromedial hypothalamus transcriptome reveals novel markers with spatially distinct patterning. |
Volume: |
27 |
Issue: |
50 |
Pages: |
13624-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hirst CS |
Year: |
2015 |
Journal: |
PLoS One |
Title: |
Ion channel expression in the developing enteric nervous system. |
Volume: |
10 |
Issue: |
3 |
Pages: |
e0123436 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sapir T |
Year: |
2022 |
Journal: |
Nat Commun |
Title: |
Heterogeneous nuclear ribonucleoprotein U (HNRNPU) safeguards the developing mouse cortex. |
Volume: |
13 |
Issue: |
1 |
Pages: |
4209 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bedogni F |
Year: |
2016 |
Journal: |
Cereb Cortex |
Title: |
Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms. |
Volume: |
26 |
Issue: |
6 |
Pages: |
2517-2529 |
|
•
•
•
•
•
|
Publication |
First Author: |
Elsen GE |
Year: |
2013 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
The protomap is propagated to cortical plate neurons through an Eomes-dependent intermediate map. |
Volume: |
110 |
Issue: |
10 |
Pages: |
4081-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Harrell MD |
Year: |
2007 |
Journal: |
Physiol Genomics |
Title: |
Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development. |
Volume: |
28 |
Issue: |
3 |
Pages: |
273-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
NIH Mouse Knockout Inventory |
Year: |
2004 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the NIH Mouse Knockout Inventory |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Blackshaw S |
Year: |
2004 |
Journal: |
PLoS Biol |
Title: |
Genomic analysis of mouse retinal development. |
Volume: |
2 |
Issue: |
9 |
Pages: |
E247 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGI and IMPC |
Year: |
2018 |
Journal: |
Database Release |
Title: |
MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bedogni F |
Year: |
2021 |
Journal: |
Front Mol Neurosci |
Title: |
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. |
Volume: |
14 |
|
Pages: |
686034 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2016 |
|
Title: |
Automatic assignment of GO terms using logical inference, based on on inter-ontology links |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Thompson CL |
Year: |
2014 |
Journal: |
Neuron |
Title: |
A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. |
Volume: |
83 |
Issue: |
2 |
Pages: |
309-323 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Magdaleno S |
Year: |
2006 |
Journal: |
PLoS Biol |
Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
Volume: |
4 |
Issue: |
4 |
Pages: |
e86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
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Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
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Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
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Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
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Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
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Title: |
Annotation inferences using phylogenetic trees |
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Publication |
First Author: |
Hou B |
Year: |
2021 |
Journal: |
eNeuro |
Title: |
Loss of KCNQ2 or KCNQ3 Leads to Multifocal Time-Varying Activity in the Neonatal Forebrain Ex Vivo. |
Volume: |
8 |
Issue: |
3 |
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Publication |
First Author: |
Chen KJ |
Year: |
2023 |
Journal: |
Front Mol Neurosci |
Title: |
Behavioral and neuro-functional consequences of eliminating the KCNQ3 GABA binding site in mice. |
Volume: |
16 |
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Pages: |
1192628 |
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Protein Domain |
Type: |
Family |
Description: |
Potassium channels are the most diverse group of the ion channel family [, ]. They are important in shaping the action potential, and in neuronal excitability and plasticity []. The potassium channel family is composed of several functionally distinct isoforms, which can be broadly separated into 2 groups []: the practically non-inactivating 'delayed' group and the rapidly inactivating 'transient' group.These are all highly similar proteins, with only small amino acid changes causing the diversity of the voltage-dependent gating mechanism, channel conductance and toxin binding properties. Each type of K+channel is activated by different signals and conditions depending on their type of regulation: some open in response to depolarisation of the plasma membrane; others in response to hyperpolarisation or an increase in intracellular calcium concentration; some can be regulated by binding of a transmitter, together with intracellular kinases; while others are regulated by GTP-binding proteins or other second messengers []. In eukaryotic cells, K+channels are involved in neural signalling and generation of the cardiac rhythm, act as effectors in signal transduction pathways involving G protein-coupled receptors (GPCRs) and may have a role in target cell lysis by cytotoxic T-lymphocytes []. In prokaryotic cells, they play a role in the maintenance of ionic homeostasis [].All K+channels discovered so far possess a core of alpha subunits, each comprising either one or two copies of a highly conserved pore loop domain (P-domain). The P-domain contains the sequence (T/SxxTxGxG), which has been termed the K+selectivity sequence. In families that contain one P-domain, four subunits assemble to form a selective pathway for K+across the membrane. However, it remains unclear how the 2 P-domain subunits assemble to form a selective pore. The functional diversity of these families can arise through homo- or hetero-associations of alpha subunits or association with auxiliary cytoplasmic beta subunits. K+channel subunits containing one pore domain can be assigned into one of two superfamilies: those that possess six transmembrane (TM) domains and those that possess only two TM domains. The six TM domain superfamily can be further subdivided into conserved gene families: the voltage-gated (Kv) channels; the KCNQ channels (originally known as KvLQT channels); the EAG-like K+channels; and three types of calcium (Ca)-activated K+channels (BK, IK and SK) []. The 2TM domain family comprises inward-rectifying K+channels. In addition, there are K+channel alpha-subunits that possess two P-domains. These are usually highly regulated K+selective leak channels.KCNQ channels (also known as KQT-like channels) differ from other voltage-gated 6 TM helix channels, chiefly in that they possess no tetramerisation domain. Consequently, they rely on interaction with accessory subunits, or form heterotetramers with other members of the family []. Currently, 5 members of the KCNQ family are known. These have been found to be widely distributed within the body, having been shown to be expressed in the heart, brain, pancreas, lung, placenta and ear. They were initially cloned as a result of a search for proteins involved in cardiac arhythmia. Subsequently, mutations in other KCNQ family members have been shown to be responsible for some forms of hereditary deafness []and benign familial neonatal epilepsy [].The KCNQ3 channel subunit is thought to form active channels by hetero- tetramerisation with KCNQ2, although some K+ channel activity does result from the expression of KCNQ3 alone []. Channel function is modulated by phosphorylation; experiments have demonstrated that an increase in intracellular cAMP concentration can enhance channel activity. Frameshift mutations in both KCNQ2 and KCNQ3 are associated with benign familial neonatal epilepsy [], a disorder in which infants suffer convulsions within the first 3 days of life. These symptoms usually disappear after about 3 months, but affected individuals have a higher than average chance of subsequently developing epilepsy (10-15%) in later life []. |
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Publication |
First Author: |
Schroeder BC |
Year: |
1998 |
Journal: |
Nature |
Title: |
Moderate loss of function of cyclic-AMP-modulated KCNQ2/KCNQ3 K+ channels causes epilepsy. |
Volume: |
396 |
Issue: |
6712 |
Pages: |
687-90 |
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Publication |
First Author: |
Chung HJ |
Year: |
2006 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Polarized axonal surface expression of neuronal KCNQ channels is mediated by multiple signals in the KCNQ2 and KCNQ3 C-terminal domains. |
Volume: |
103 |
Issue: |
23 |
Pages: |
8870-5 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
873
|
Fragment?: |
false |
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•
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Publication |
First Author: |
Sanguinetti MC |
Year: |
2000 |
Journal: |
Trends Pharmacol Sci |
Title: |
Maximal function of minimal K+ channel subunits. |
Volume: |
21 |
Issue: |
6 |
Pages: |
199-201 |
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•
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Publication |
First Author: |
Wang Q |
Year: |
1996 |
Journal: |
Nat Genet |
Title: |
Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias. |
Volume: |
12 |
Issue: |
1 |
Pages: |
17-23 |
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•
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•
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Publication |
First Author: |
Biervert C |
Year: |
1998 |
Journal: |
Science |
Title: |
A potassium channel mutation in neonatal human epilepsy. |
Volume: |
279 |
Issue: |
5349 |
Pages: |
403-6 |
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•
•
•
•
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Publication |
First Author: |
Lemaillet G |
Year: |
2003 |
Journal: |
J Biol Chem |
Title: |
Identification of a conserved ankyrin-binding motif in the family of sodium channel alpha subunits. |
Volume: |
278 |
Issue: |
30 |
Pages: |
27333-9 |
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•
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Publication |
First Author: |
Rasmussen HB |
Year: |
2007 |
Journal: |
J Cell Sci |
Title: |
Requirement of subunit co-assembly and ankyrin-G for M-channel localization at the axon initial segment. |
Volume: |
120 |
Issue: |
Pt 6 |
Pages: |
953-63 |
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Publication |
First Author: |
Hill AS |
Year: |
2008 |
Journal: |
PLoS Genet |
Title: |
Ion channel clustering at the axon initial segment and node of Ranvier evolved sequentially in early chordates. |
Volume: |
4 |
Issue: |
12 |
Pages: |
e1000317 |
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•
•
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Protein Domain |
Type: |
Binding_site |
Description: |
Interactions with ankyrin-G are crucial to the localisation of voltage-gated sodium channels (VGSCs) at the axon initial segment and for neurons to initiate action potentials. This conserved 9-amino acid motif ((V/A)P(I/L)AXXE(S/D)D) is required for ankyrin-G binding and functions to localise sodium channels to a variety of 'excitable' membrane domains both inside and outside of the nervous system []. This motif has also been identified in the potassium channel 6TM proteins KCNQ2 and KCNQ3 []that correspond to the M channels that exert a crucial influence over neuronal excitability. KCNQ2/KCNQ3 channels are preferentially localised to the surface of axons both at the axonal initial segment and more distally, and this axonal initial segment targeting of surface KCNQ channels is mediated by these ankyrin-G binding motifs of KCNQ2 and KCNQ3 []. KCNQ3 is a major determinant of M channel localisation to the AIS, rather than KCNQ2 []. Phylogenetic analysis reveals that anchor motifs evolved sequentially in chordates (NaV channel) and jawed vertebrates (KCNQ2/3) []. |
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Publication |
First Author: |
Fidzinski P |
Year: |
2015 |
Journal: |
Nat Commun |
Title: |
KCNQ5 K(+) channels control hippocampal synaptic inhibition and fast network oscillations. |
Volume: |
6 |
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Pages: |
6254 |
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•
•
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Publication |
First Author: |
Manville RW |
Year: |
2018 |
Journal: |
Nat Commun |
Title: |
Direct neurotransmitter activation of voltage-gated potassium channels. |
Volume: |
9 |
Issue: |
1 |
Pages: |
1847 |
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•
•
•
•
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Publication |
First Author: |
Tzingounis AV |
Year: |
2010 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
The KCNQ5 potassium channel mediates a component of the afterhyperpolarization current in mouse hippocampus. |
Volume: |
107 |
Issue: |
22 |
Pages: |
10232-7 |
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•
•
•
•
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Publication |
First Author: |
Jing J |
Year: |
2022 |
Journal: |
Exp Neurol |
Title: |
Removal of KCNQ2 from parvalbumin-expressing interneurons improves anti-seizure efficacy of retigabine. |
Volume: |
355 |
|
Pages: |
114141 |
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•
•
•
•
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Publication |
First Author: |
Neverisky DL |
Year: |
2017 |
Journal: |
FASEB J |
Title: |
KCNQ-SMIT complex formation facilitates ion channel-solute transporter cross talk. |
Volume: |
31 |
Issue: |
7 |
Pages: |
2828-2838 |
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•
•
•
•
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Publication |
First Author: |
Roepke TA |
Year: |
2011 |
Journal: |
J Neurosci |
Title: |
Fasting and 17β-estradiol differentially modulate the M-current in neuropeptide Y neurons. |
Volume: |
31 |
Issue: |
33 |
Pages: |
11825-35 |
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•
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•
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Publication |
First Author: |
Zhang J |
Year: |
2011 |
Journal: |
J Neurosci |
Title: |
AKAP79/150 signal complexes in G-protein modulation of neuronal ion channels. |
Volume: |
31 |
Issue: |
19 |
Pages: |
7199-211 |
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•
•
•
•
|
Publication |
First Author: |
Tempel BL |
Year: |
1988 |
Journal: |
Nature |
Title: |
Cloning of a probable potassium channel gene from mouse brain. |
Volume: |
332 |
Issue: |
6167 |
Pages: |
837-9 |
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•
•
•
•
•
|
Publication |
First Author: |
Perney TM |
Year: |
1991 |
Journal: |
Curr Opin Cell Biol |
Title: |
The molecular biology of K+ channels. |
Volume: |
3 |
Issue: |
4 |
Pages: |
663-70 |
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•
•
•
•
|
Publication |
First Author: |
Luneau C |
Year: |
1991 |
Journal: |
FEBS Lett |
Title: |
Shaw-like rat brain potassium channel cDNA's with divergent 3' ends. |
Volume: |
288 |
Issue: |
1-2 |
Pages: |
163-7 |
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•
•
•
•
|
Publication |
First Author: |
Attali B |
Year: |
1992 |
Journal: |
J Biol Chem |
Title: |
Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes. |
Volume: |
267 |
Issue: |
12 |
Pages: |
8650-7 |
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•
•
•
•
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Publication |
First Author: |
Schwarz TL |
Year: |
1988 |
Journal: |
Nature |
Title: |
Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Drosophila. |
Volume: |
331 |
Issue: |
6152 |
Pages: |
137-42 |
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•
•
•
•
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Publication |
First Author: |
Stühmer W |
Year: |
1989 |
Journal: |
EMBO J |
Title: |
Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain. |
Volume: |
8 |
Issue: |
11 |
Pages: |
3235-44 |
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•
•
•
•
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Publication |
First Author: |
Miller C |
Year: |
2000 |
Journal: |
Genome Biol |
Title: |
An overview of the potassium channel family. |
Volume: |
1 |
Issue: |
4 |
Pages: |
REVIEWS0004 |
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•
•
•
•
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Publication |
First Author: |
Vanhoof-Villalba SL |
Year: |
2018 |
Journal: |
Epilepsia |
Title: |
Pharmacogenetics of KCNQ channel activation in 2 potassium channelopathy mouse models of epilepsy. |
Volume: |
59 |
Issue: |
2 |
Pages: |
358-368 |
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•
•
•
•
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Publication |
First Author: |
Robbins J |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Effects of KCNQ2 gene truncation on M-type Kv7 potassium currents. |
Volume: |
8 |
Issue: |
8 |
Pages: |
e71809 |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
795
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
870
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
842
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
726
|
Fragment?: |
true |
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•
•
•
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