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Search results 801 to 900 out of 1062 for Smo

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Type Details Score
Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
26130651 | J:225591
First Author: Zhao X
Year: 2015
Journal: Cancer Res
Title: RAS/MAPK Activation Drives Resistance to Smo Inhibition, Metastasis, and Tumor Evolution in Shh Pathway-Dependent Tumors.
Volume: 75
Issue: 17
Pages: 3623-35
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HT Sample
GSM279679 1
       
Organism Name: mouse, laboratory
Notes: Smo gain-of-function mutant limb bud
Curation Status: Not curated (Transgenic sample)
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HT Sample
GSM279680 1
       
Organism Name: mouse, laboratory
Notes: Smo gain-of-function mutant limb bud
Curation Status: Not curated (Transgenic sample)
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HT Sample
GSM279681 1
       
Organism Name: mouse, laboratory
Notes: Smo gain-of-function mutant limb bud
Curation Status: Not curated (Transgenic sample)
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Publication
29463581 | J:262302
First Author: Rahman MM
Year: 2018
Journal: Cancer Res
Title: A Novel Mechanism for Activation of GLI1 by Nuclear SMO That Escapes Anti-SMO Inhibitors.
Volume: 78
Issue: 10
Pages: 2577-2588
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GO Term
GO:0005119 | smoothened binding
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Pathway
R-MMU-5635838 | Activation of SMO
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Publication
23026747 | J:188176
First Author: Caparrós-Martín JA
Year: 2013
Journal: Hum Mol Genet
Title: The ciliary Evc/Evc2 complex interacts with Smo and controls Hedgehog pathway activity in chondrocytes by regulating Sufu/Gli3 dissociation and Gli3 trafficking in primary cilia.
Volume: 22
Issue: 1
Pages: 124-39
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Publication
25908617 | J:223812
First Author: Caparrós-Martín JA
Year: 2015
Journal: Hum Mol Genet
Title: Specific variants in WDR35 cause a distinctive form of Ellis-van Creveld syndrome by disrupting the recruitment of the EvC complex and SMO into the cilium.
Volume: 24
Issue: 14
Pages: 4126-37
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GXD Expression
GXD Expression
Probe: MGI:6385332
Assay Type: RNA in situ
Annotation Date: 2020-01-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2856120
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:6385389
Age: embryonic day 12.5
Image: 1C Tbx18;Smo
Note: Loss of Smo had no effect on Tbx2 expression in the ureteric mesenchyme at E12.5.
Specimen Label: 1C Tbx18;Smo
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
Probe: MGI:6385333
Assay Type: RNA in situ
Annotation Date: 2020-01-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2856120
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:6385390
Age: embryonic day 12.5
Image: 1C Tbx18;Smo
Note: Loss of Smo had no effect on Tbx3 expression in the ureteric mesenchyme at E12.5.
Specimen Label: 1C Tbx18;Smo
Detected: true
Specimen Num: 8
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Protein Coding Gene
MGI:2445356 | Smox
Type: protein_coding_gene
Organism: mouse, laboratory
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Transgene
MGI:3693107 | Tg(KRT5-SMO)#Fjs
Type: transgene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:95655 | Gas1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:105373 | Ptch1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2151153 | Boc
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1202386 | Gas8
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1926387 | Cdon
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q60779
Organism: Mus musculus/domesticus
Length: 478  
Fragment?: false
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Protein
Q01721
Organism: Mus musculus/domesticus
Length: 343  
Fragment?: false
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Protein
Q32MD9
Organism: Mus musculus/domesticus
Length: 1250  
Fragment?: false
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Protein
Q6AZB0
Organism: Mus musculus/domesticus
Length: 1110  
Fragment?: false
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Protein
Q61115
Organism: Mus musculus/domesticus
Length: 1434  
Fragment?: false
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Publication
29290584 | J:253667
First Author: Pusapati GV
Year: 2018
Journal: Dev Cell
Title: CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog.
Volume: 44
Issue: 1
Pages: 113-129.e8
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Protein
Q99K82
Organism: Mus musculus/domesticus
Length: 555  
Fragment?: false
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Protein
Q99K82-2
Organism: Mus musculus/domesticus
Length: 585  
Fragment?: false
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Protein
Q99K82-9
Organism: Mus musculus/domesticus
Length: 543  
Fragment?: false
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Protein
Q99K82-8
Organism: Mus musculus/domesticus
Length: 419  
Fragment?: false
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Protein
Q99K82-10
Organism: Mus musculus/domesticus
Length: 190  
Fragment?: false
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Protein
Q99K82-3
Organism: Mus musculus/domesticus
Length: 238  
Fragment?: false
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Protein
Q99K82-7
Organism: Mus musculus/domesticus
Length: 512  
Fragment?: false
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Protein
Q99K82-4
Organism: Mus musculus/domesticus
Length: 209  
Fragment?: false
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Protein
Q99K82-6
Organism: Mus musculus/domesticus
Length: 536  
Fragment?: false
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Protein
Q99K82-5
Organism: Mus musculus/domesticus
Length: 248  
Fragment?: false
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Allele
Smo<em1Smoc> | MGI:7292485
Name: smoothened, frizzled class receptor; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Protein Coding Gene
MGI:96533 | Ihh
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:94891 | Dhh
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98297 | Shh
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P97812
Organism: Mus musculus/domesticus
Length: 411  
Fragment?: false
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Protein
Q61488
Organism: Mus musculus/domesticus
Length: 396  
Fragment?: false
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Protein
Q62226
Organism: Mus musculus/domesticus
Length: 437  
Fragment?: false
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Publication
8706127 | -
First Author: Alcedo J
Year: 1996
Journal: Cell
Title: The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal.
Volume: 86
Issue: 2
Pages: 221-32
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Protein Domain
IPR041771 | SMO_CRD
Type: Domain
Description: The cysteine-rich domain (CRD) is part of the smoothened receptor (Smo), an integral membrane protein and one of the key players in the Hedgehog (Hh) signaling pathway, critical for development, cell growth and migration, as well as stem cell maintenance. The CRD of Smo is conserved in vertebrates and can also be identified in invertebrates. The precise function of the CRD in Smo is unknown []. Mutations in the Drosophila CRD disrupt Smo activity in vivo, while deletion of the CRD in mammalian cells does not seem to affect the activity of overexpressed Smo [].
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HT Experiment
GSE221389 | BMP7 expression in mammalian cortical radial glial cells increases the length of the neurogenic period
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Protein
Q8C784
Organism: Mus musculus/domesticus
Length: 167  
Fragment?: false
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Protein
A0A140LII5
Organism: Mus musculus/domesticus
Length: 89  
Fragment?: true
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Protein
A0A140LH99
Organism: Mus musculus/domesticus
Length: 108  
Fragment?: false
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Protein Domain
IPR037663 | Mosmo
Type: Family
Description: MOSMO, also known as Atthog (attenuator of hedgehog) in mouse, acts as a negative regulator of hedgehog (Hh) signaling, probably by promoting internalization and subsequent degradation of Smoothened (SMO). SMO is an oncoprotein that transduces the Hh signal across the membrane. In the absence of Atthog, SMO was stabilized at the cell surface and concentrated in the ciliary membrane [].
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GO Term
GO:1990788 | GLI-SUFU complex
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Publication
14977528 | -
 
First Author: Malbon CC
Year: 2004
Journal: Front Biosci
Title: Frizzleds: new members of the superfamily of G-protein-coupled receptors.
Volume: 9
Pages: 1048-58
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Publication
24148123 | -
First Author: Ruat M
Year: 2013
Journal: Med Sci (Paris)
Title: [Structure of the Smoothened receptor].
Volume: 29
Issue: 10
Pages: 855-60
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Protein Domain
IPR035683 | SMO_7TM
Type: Domain
Description: Smoothened (SMO) is a transmembrane G protein-coupled receptor that acts as the transducer of the hedgehog (HH) signaling pathway []. SMO is activated by the hedgehog (HH) family of proteins acting on the 12-transmembrane domain receptor patched (PTCH), which constitutively inhibits SMO. Thus, in the absence of HH proteins, PTCH inhibits SMO signaling. On the other hand, binding of HH to the PTCH receptor activates its internalization and degradation, thereby releasing the PTCH inhibition of SMO. This allows SMO to trigger intracellular signaling and the subsequent activation of the Gli family of zinc finger transcriptional factors and induction of HH target gene expression (PTCH, Gli1, cyclin, Bcl-2, etc) []. SMO is closely related to the frizzled (FZD) family of seven transmembrane-spanning proteins, which constitute a novel and separate family of G-protein coupled receptors [, ].
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Publication
36438482 | J:331709
First Author: Zhang S
Year: 2022
Journal: Theranostics
Title: The PROTAC selectively degrading Bcl-x(L) represents a novel Hedgehog pathway inhibitor with capacity of combating resistance to Smoothened inhibitors while sparing bone growth.
Volume: 12
Issue: 17
Pages: 7476-7490
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Allele
Tg(KRT5-SMO*W535L)#Fjs | MGI:3525058
Name: transgene insertion #, Frederic J de Sauvage
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(Neurod2-Smo*A1)199Jols | MGI:3830738
Name: transgene insertion 199, James M Olson
Allele Type: Transgenic
Attribute String: Constitutively active, Inserted expressed sequence
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Strain
MGI:6476345 | C57BL/6-Smo<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
30487124 | J:320766
First Author: Rodriguez-Blanco J
Year: 2019
Journal: Clin Cancer Res
Title: A CK1α Activator Penetrates the Brain and Shows Efficacy Against Drug-resistant Metastatic Medulloblastoma.
Volume: 25
Issue: 4
Pages: 1379-1388
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Protein Coding Gene
MGI:107689 | Kif3a
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1934950 | Csnk1a1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q8BK63
Organism: Mus musculus/domesticus
Length: 337  
Fragment?: false
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Protein
P28741
Organism: Mus musculus/domesticus
Length: 701  
Fragment?: false
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Publication
9811578 | -
First Author: Chen Y
Year: 1998
Journal: Development
Title: In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components of a Hedgehog receptor complex.
Volume: 125
Issue: 24
Pages: 4943-8
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Publication
35857834 | J:327233
First Author: Swiderska-Syn M
Year: 2022
Journal: Sci Adv
Title: Noncanonical activation of GLI signaling in SOX2+ cells drives medulloblastoma relapse.
Volume: 8
Issue: 29
Pages: eabj9138
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Allele
Tg(UAS-Smo*W539L)1Amc | MGI:3584023
Name: transgene insertion 1, Andrew P McMahon
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Neurod2-Smo*A2)#Jols | MGI:5447065
Name: transgene insertion, James M Olson
Allele Type: Transgenic
Attribute String: Constitutively active, Inserted expressed sequence
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Strain
MGI:3831147 | C57BL/6-Tg(Neurod2-Smo*A1)199Jols/J
Attribute String: coisogenic, targeted mutation
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Strain
MGI:3831128 | C57BL/6-Tg(Neurod2-Smo*A1)199Jols
Attribute String: transgenic, coisogenic
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Publication
19638572 | J:150937
First Author: Veiseh O
Year: 2009
Journal: Cancer Res
Title: Specific targeting of brain tumors with an optical/magnetic resonance imaging nanoprobe across the blood-brain barrier.
Volume: 69
Issue: 15
Pages: 6200-7
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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