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Search results 201 to 265 out of 265 for Frs2

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Type Details Score
Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:155856
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Pathway
R-MMU-9028731 | Activated NTRK2 signals through FRS2 and FRS3
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Interaction Experiment
Wu Y (2003)
Description: EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2.
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Interaction Experiment
Lim YP (1999)
Description: Association of atypical protein kinase C isotypes with the docker protein FRS2 in fibroblast growth factor signaling.
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Publication
9632781 | -
First Author: Hadari YR
Year: 1998
Journal: Mol Cell Biol
Title: Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation.
Volume: 18
Issue: 7
Pages: 3966-73
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Publication
11997436 | -
First Author: Wong A
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl.
Volume: 99
Issue: 10
Pages: 6684-9
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Publication
18452557 | -
First Author: Gotoh N
Year: 2008
Journal: Cancer Sci
Title: Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins.
Volume: 99
Issue: 7
Pages: 1319-25
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Publication
17274988 | -
First Author: Degoutin J
Year: 2007
Journal: FEBS Lett
Title: ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation.
Volume: 581
Issue: 4
Pages: 727-34
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Publication
12974390 | -
First Author: Wu Y
Year: 2003
Journal: Biol Chem
Title: EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2.
Volume: 384
Issue: 8
Pages: 1215-26
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Interaction Experiment
Zhang Y (2008)
Description: Fibroblast growth factor receptor 1 (FGFR1) tyrosine phosphorylation regulates binding of FGFR substrate 2alpha (FRS2alpha) but not FRS2 to the receptor.
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Interaction Experiment
Burgar HR (2002)
Description: Association of the signaling adaptor FRS2 with fibroblast growth factor receptor 1 (Fgfr1) is mediated by alternative splicing of the juxtamembrane domain.
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Publication
10629055 | -
First Author: Ong SH
Year: 2000
Journal: Mol Cell Biol
Title: FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors.
Volume: 20
Issue: 3
Pages: 979-89
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Publication
11390647 | -
First Author: Melillo RM
Year: 2001
Journal: Mol Cell Biol
Title: Docking protein FRS2 links the protein tyrosine kinase RET and its oncogenic forms with the mitogen-activated protein kinase signaling cascade.
Volume: 21
Issue: 13
Pages: 4177-87
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Publication
10383403 | -
First Author: Lim YP
Year: 1999
Journal: J Biol Chem
Title: Association of atypical protein kinase C isotypes with the docker protein FRS2 in fibroblast growth factor signaling.
Volume: 274
Issue: 27
Pages: 19025-34
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Protein Coding Gene
MGI:97381 | Ntf5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q80VU4
Organism: Mus musculus/domesticus
Length: 209  
Fragment?: false
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Publication
12181353 | -
First Author: Cross MJ
Year: 2002
Journal: Mol Biol Cell
Title: The Shb adaptor protein binds to tyrosine 766 in the FGFR-1 and regulates the Ras/MEK/MAPK pathway via FRS2 phosphorylation in endothelial cells.
Volume: 13
Issue: 8
Pages: 2881-93
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Publication
11729184 | -
First Author: Burgar HR
Year: 2002
Journal: J Biol Chem
Title: Association of the signaling adaptor FRS2 with fibroblast growth factor receptor 1 (Fgfr1) is mediated by alternative splicing of the juxtamembrane domain.
Volume: 277
Issue: 6
Pages: 4018-23
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Protein Coding Gene
MGI:97384 | Ntrk2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:88145 | Bdnf
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P21237
Organism: Mus musculus/domesticus
Length: 249  
Fragment?: false
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Protein
P15209
Organism: Mus musculus/domesticus
Length: 821  
Fragment?: false
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Protein
Q8C180
Organism: Mus musculus/domesticus
Length: 508  
Fragment?: false
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Publication
11090629 | -
First Author: Dhalluin C
Year: 2000
Journal: Mol Cell
Title: Structural basis of SNT PTB domain interactions with distinct neurotrophic receptors.
Volume: 6
Issue: 4
Pages: 921-9
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Publication
20454865 | -
First Author: Koshiba S
Year: 2010
Journal: J Struct Funct Genomics
Title: Structural basis for the recognition of nucleophosmin-anaplastic lymphoma kinase oncoprotein by the phosphotyrosine binding domain of Suc1-associated neurotrophic factor-induced tyrosine-phosphorylated target-2.
Volume: 11
Issue: 2
Pages: 125-41
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Publication
27526776 | -
 
First Author: Sain N
Year: 2016
Journal: Sci Rep
Title: Understanding the molecular basis of substrate binding specificity of PTB domains.
Volume: 6
Pages: 31418
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Protein Domain
IPR038742 | FRS2_PTB
Type: Domain
Description: FRS2 (also called Suc1-associated neurotrophic factor (SNT)-induced tyrosine-phosphorylated target) proteins are membrane-anchored adaptor proteins. They are composed of an N-terminal myristoylation site followed by a phosphotyrosine binding (PTB) domain, which has a PH-like fold, and a C-terminal effector domain containing multiple tyrosine and serine/threonine phosphorylation site. The FRS2/SNT proteins show increased tyrosine phosphorylation by activated receptors, such as fibroblast growth factor receptor (FGFR) and TrkA, recruit SH2 domain containing proteins such as Grb2, and mediate signals from activated receptors to a variety of downstream pathways. The PTB domains of the SNT proteins directly interact with the canonical NPXpY motif of TrkA in a phosphorylation dependent manner, they directly bind to the juxtamembrane region of FGFR in a phosphorylation-independent manner [, ]. This domain can also be found in FRS3 []. PTB domains have a common PH-like fold and are found in various eukaryotic signaling molecules. This domain was initially shown to binds peptides with a NPXY motif with differing requirements for phosphorylation of the tyrosine, although more recent studies have found that some types of PTB domains can bind to peptides lacking tyrosine residues altogether. In contrast to SH2 domains, which recognize phosphotyrosine and adjacent carboxy-terminal residues, PTB-domain binding specificity is conferred by residues amino-terminal to the phosphotyrosine. PTB domains are classified into three groups: phosphotyrosine-dependent Shc-like, phosphotyrosine-dependent IRS-like, and phosphotyrosine-independent Dab-like PTB domains. This domain is part of the IRS-like subgroup [, ].
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Publication
25926357 | J:239277
First Author: Dabrowski A
Year: 2015
Journal: Development
Title: Distinct sets of FGF receptors sculpt excitatory and inhibitory synaptogenesis.
Volume: 142
Issue: 10
Pages: 1818-30
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Publication
26341559 | J:226497
First Author: Brewer JR
Year: 2015
Journal: Genes Dev
Title: Fgfr1 regulates development through the combinatorial use of signaling proteins.
Volume: 29
Issue: 17
Pages: 1863-74
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Publication
27338794 | J:235729
First Author: Manchado E
Year: 2016
Journal: Nature
Title: A combinatorial strategy for treating KRAS-mutant lung cancer.
Volume: 534
Issue: 7609
Pages: 647-51
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Publication
19943849 | J:157011
First Author: Hryciw T
Year: 2010
Journal: J Neurochem
Title: The fibroblast growth factor receptor substrate 3 adapter is a developmentally regulated microtubule-associated protein expressed in migrating and differentiated neurons.
Volume: 112
Issue: 4
Pages: 924-39
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Protein Coding Gene
MGI:98354 | Sos1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q62245
Organism: Mus musculus/domesticus
Length: 1319  
Fragment?: false
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Protein
Q60631-1
 
Organism: Mus musculus/domesticus
Length:  
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Protein
Q91WJ0
Organism: Mus musculus/domesticus
Length: 492  
Fragment?: false
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Publication
15567406 | -
First Author: Uhlik MT
Year: 2005
Journal: J Mol Biol
Title: Structural and evolutionary division of phosphotyrosine binding (PTB) domains.
Volume: 345
Issue: 1
Pages: 1-20
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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