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Search results 1301 to 1400 out of 1601 for Smad2

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Type Details Score
Publication
26120963 | J:225716
First Author: Schachtrup C
Year: 2015
Journal: Nat Neurosci
Title: Nuclear pore complex remodeling by p75(NTR) cleavage controls TGF-β signaling and astrocyte functions.
Volume: 18
Issue: 8
Pages: 1077-80
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Protein
A0S860
Organism: Mus musculus/domesticus
Length: 706  
Fragment?: false
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Publication
32531799 | J:306879
First Author: Chen L
Year: 2020
Journal: FEBS Lett
Title: Islet-cell autoantigen 69 accelerates liver regeneration by downregulating Tgfbr1 and attenuating Tgfβ signaling in mice.
Volume: 594
Issue: 17
Pages: 2881-2893
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Publication
22796494 | J:188522
First Author: Yan G
Year: 2012
Journal: FEBS Lett
Title: MicroRNA-145 suppresses mouse granulosa cell proliferation by targeting activin receptor IB.
Volume: 586
Issue: 19
Pages: 3263-70
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Protein Domain
IPR003619 | MAD_homology1_Dwarfin-type
Type: Domain
Description: Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth []. The dwarfin family also includes the Drosophila protein MAD that is required for the function of decapentaplegic (DPP) and may play a role in DPP signalling. Drosophila Mad binds to DNA and directly mediates activation of vestigial by Dpp []. This domain is also found in nuclear factor I (NF-I) or CCAAT box-binding transcription factor (CTF).This entry represents the MH1 (MAD homology 1) domain is found at the amino terminus of MAD related proteins such as Smads. This domain is separated from the MH2 domain by a non-conserved linker region. The crystal structure of the MH1 domain shows that a highly conserved 11 residue beta hairpin is used to bind the DNA consensus sequence GNCN in the major groove, shown to be vital for the transcriptional activation of target genes. Not all examples of MH1 can bind to DNA however. Smad2 cannot bind DNA and has a large insertion within the hairpin that presumably abolishes DNA binding. A basic helix (H2) in MH1 with the nuclear localisation signal KKLKK has been shown to be essential for Smad3 nuclear import. Smads also use the MH1 domain to interact with transcription factors such as Jun, TFE3, Sp1, and Runx [, , ].
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Publication
20129061 | J:212798
First Author: Watanabe Y
Year: 2010
Journal: Mol Cell
Title: TMEPAI, a transmembrane TGF-beta-inducible protein, sequesters Smad proteins from active participation in TGF-beta signaling.
Volume: 37
Issue: 1
Pages: 123-34
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Publication
9335507 | J:43278
First Author: Nakao A
Year: 1997
Journal: Nature
Title: Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling.
Volume: 389
Issue: 6651
Pages: 631-5
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Publication
16424156 | J:126434
First Author: Wohlfert EA
Year: 2006
Journal: J Immunol
Title: Cutting edge: deficiency in the E3 ubiquitin ligase Cbl-b results in a multifunctional defect in T cell TGF-beta sensitivity in vitro and in vivo.
Volume: 176
Issue: 3
Pages: 1316-20
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Publication
21949412 | J:177724
First Author: Danussi C
Year: 2011
Journal: J Cell Biol
Title: EMILIN1-α4/α9 integrin interaction inhibits dermal fibroblast and keratinocyte proliferation.
Volume: 195
Issue: 1
Pages: 131-45
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Publication
24703841 | J:211820
First Author: Bereshchenko O
Year: 2014
Journal: Cell Rep
Title: GILZ promotes production of peripherally induced Treg cells and mediates the crosstalk between glucocorticoids and TGF-β signaling.
Volume: 7
Issue: 2
Pages: 464-75
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Publication
31289197 | J:279777
 
First Author: Arnò B
Year: 2019
Journal: J Cell Sci
Title: TNAP limits TGF-β-dependent cardiac and skeletal muscle fibrosis by inactivating the SMAD2/3 transcription factors.
Volume: 132
Issue: 15
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Publication
28400474 | J:242008
First Author: Fu G
Year: 2017
Journal: J Exp Med
Title: Suppression of Th17 cell differentiation by misshapen/NIK-related kinase MINK1.
Volume: 214
Issue: 5
Pages: 1453-1469
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Publication
21493862 | J:171338
First Author: Holm TM
Year: 2011
Journal: Science
Title: Noncanonical TGFβ signaling contributes to aortic aneurysm progression in Marfan syndrome mice.
Volume: 332
Issue: 6027
Pages: 358-61
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Publication
19147584 | J:143706
First Author: Zeng Q
Year: 2009
Journal: Cancer Res
Title: Tgfbr1 haploinsufficiency is a potent modifier of colorectal cancer development.
Volume: 69
Issue: 2
Pages: 678-86
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Publication
21333552 | J:168978
First Author: Chang X
Year: 2011
Journal: Immunity
Title: The kinases MEKK2 and MEKK3 regulate transforming growth factor-β-mediated helper T cell differentiation.
Volume: 34
Issue: 2
Pages: 201-12
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Publication
32843541 | J:328080
 
First Author: Gannam ZTK
Year: 2020
Journal: Sci Signal
Title: An allosteric site on MKP5 reveals a strategy for small-molecule inhibition.
Volume: 13
Issue: 646
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Publication
31676717 | J:282137
 
First Author: Göngrich C
Year: 2020
Journal: J Cell Biol
Title: ALK4 coordinates extracellular and intrinsic signals to regulate development of cortical somatostatin interneurons.
Volume: 219
Issue: 1
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Publication
20304828 | J:159864
First Author: Lu L
Year: 2010
Journal: J Immunol
Title: Role of SMAD and non-SMAD signals in the development of Th17 and regulatory T cells.
Volume: 184
Issue: 8
Pages: 4295-306
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Publication
25266657 | J:224324
First Author: Curado F
Year: 2014
Journal: Mol Cell Biol
Title: ALK5 and ALK1 play antagonistic roles in transforming growth factor β-induced podosome formation in aortic endothelial cells.
Volume: 34
Issue: 24
Pages: 4389-403
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Publication
21894148 | J:180037
First Author: Siebert N
Year: 2011
Journal: Lab Invest
Title: Erythropoietin improves skin wound healing and activates the TGF-β signaling pathway.
Volume: 91
Issue: 12
Pages: 1753-65
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Publication
10708960 | J:61301
First Author: Ashcroft GS
Year: 2000
Journal: Cytokine Growth Factor Rev
Title: Loss of Smad3 modulates wound healing.
Volume: 11
Issue: 1-2
Pages: 125-31
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Publication
24929238 | J:214985
First Author: Sun LT
Year: 2014
Journal: Dev Biol
Title: Nanog co-regulated by Nodal/Smad2 and Oct4 is required for pluripotency in developing mouse epiblast.
Volume: 392
Issue: 2
Pages: 182-92
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Publication
28356385 | J:247877
First Author: Rus V
Year: 2017
Journal: J Immunol
Title: RGC-32 Promotes Th17 Cell Differentiation and Enhances Experimental Autoimmune Encephalomyelitis.
Volume: 198
Issue: 10
Pages: 3869-3877
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Publication
24928396 | J:219439
First Author: Nomura M
Year: 2014
Journal: Biochem Biophys Res Commun
Title: Activation of activin type IB receptor signals in pancreatic β cells leads to defective insulin secretion through the attenuation of ATP-sensitive K+ channel activity.
Volume: 450
Issue: 1
Pages: 440-6
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Publication
15654327 | J:96049
First Author: Reynolds LE
Year: 2005
Journal: Nat Med
Title: Accelerated re-epithelialization in beta3-integrin-deficient- mice is associated with enhanced TGF-beta1 signaling.
Volume: 11
Issue: 2
Pages: 167-74
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Publication
21182936 | J:170588
First Author: Stoppani E
Year: 2011
Journal: Biochim Biophys Acta
Title: Point mutated caveolin-3 form (P104L) impairs myoblast differentiation via Akt and p38 signalling reduction, leading to an immature cell signature.
Volume: 1812
Issue: 4
Pages: 468-79
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Publication
22036565 | J:182366
First Author: Mullen AC
Year: 2011
Journal: Cell
Title: Master transcription factors determine cell-type-specific responses to TGF-β signaling.
Volume: 147
Issue: 3
Pages: 565-76
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Publication
11389842 | J:190004
First Author: Yeo C
Year: 2001
Journal: Mol Cell
Title: Nodal signals to Smads through Cripto-dependent and Cripto-independent mechanisms.
Volume: 7
Issue: 5
Pages: 949-57
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Publication
15604265 | J:94958
First Author: Muraoka-Cook RS
Year: 2004
Journal: Cancer Res
Title: Conditional overexpression of active transforming growth factor beta1 in vivo accelerates metastases of transgenic mammary tumors.
Volume: 64
Issue: 24
Pages: 9002-11
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Publication
16916642 | J:112622
First Author: Seo SR
Year: 2006
Journal: Mol Cell
Title: Nuclear retention of the tumor suppressor cPML by the homeodomain protein TGIF restricts TGF-beta signaling.
Volume: 23
Issue: 4
Pages: 547-59
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Publication
11170302 | J:67506
First Author: Rossmanith W
Year: 2001
Journal: Microsc Res Tech
Title: Biology of transforming growth factor beta in hepatocarcinogenesis.
Volume: 52
Issue: 4
Pages: 430-6
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Publication
10393693 | J:56152
First Author: Nakao A
Year: 1999
Journal: J Clin Invest
Title: Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice.
Volume: 104
Issue: 1
Pages: 5-11
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Publication
12839923 | J:84342
First Author: Vijayachandra K
Year: 2003
Journal: Cancer Res
Title: Smad3 regulates senescence and malignant conversion in a mouse multistage skin carcinogenesis model.
Volume: 63
Issue: 13
Pages: 3447-52
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Publication
12902406 | J:85642
First Author: Owens DM
Year: 2003
Journal: J Cell Sci
Title: Suprabasal alpha6beta4 integrin expression in epidermis results in enhanced tumourigenesis and disruption of TGFbeta signalling.
Volume: 116
Issue: Pt 18
Pages: 3783-91
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Publication
14581455 | J:86330
First Author: Parisi S
Year: 2003
Journal: J Cell Biol
Title: Nodal-dependent Cripto signaling promotes cardiomyogenesis and redirects the neural fate of embryonic stem cells.
Volume: 163
Issue: 2
Pages: 303-14
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Publication
17768379 | J:124970
 
First Author: Okada Y
Year: 2007
Journal: Mol Vis
Title: TNFalpha suppression of corneal epithelium migration.
Volume: 13
Pages: 1428-35
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Publication
16394011 | J:126440
First Author: Xiao YQ
Year: 2006
Journal: J Immunol
Title: Oxidants selectively reverse TGF-beta suppression of proinflammatory mediator production.
Volume: 176
Issue: 2
Pages: 1209-17
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Publication
18783722 | J:141269
First Author: Wang B
Year: 2008
Journal: Biochem Biophys Res Commun
Title: Roles of mono-ubiquitinated Smad4 in the formation of Smad transcriptional complexes.
Volume: 376
Issue: 2
Pages: 288-92
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Publication
21496456 | J:172061
First Author: Wanninger J
Year: 2011
Journal: FEBS Lett
Title: Adiponectin induces the transforming growth factor decoy receptor BAMBI in human hepatocytes.
Volume: 585
Issue: 9
Pages: 1338-44
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Publication
25683711 | J:222039
     
First Author: Prunier C
Year: 2015
Journal: Cell Rep
Title: Disruption of the PHRF1 Tumor Suppressor Network by PML-RARα Drives Acute Promyelocytic Leukemia Pathogenesis.
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Publication
26351675 | J:226902
First Author: Hachisuga M
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Hyperglycemia impairs left-right axis formation and thereby disturbs heart morphogenesis in mouse embryos.
Volume: 112
Issue: 38
Pages: E5300-7
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Publication
29490279 | J:271128
First Author: Zhao Y
Year: 2018
Journal: Cell Rep
Title: USP2a Supports Metastasis by Tuning TGF-β Signaling.
Volume: 22
Issue: 9
Pages: 2442-2454
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Publication
37059312 | J:340602
First Author: Zhao Y
Year: 2023
Journal: Biochim Biophys Acta Mol Basis Dis
Title: USP25 inhibits renal fibrosis by regulating TGFβ-SMAD signaling pathway in Ang II-induced hypertensive mice.
Volume: 1869
Issue: 6
Pages: 166713
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Publication
11546807 | -
First Author: Seet LF
Year: 2001
Journal: J Biol Chem
Title: Endofin, an endosomal FYVE domain protein.
Volume: 276
Issue: 45
Pages: 42445-54
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Protein
A2A8R0
Organism: Mus musculus/domesticus
Length: 1397  
Fragment?: false
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Publication
12208849 | J:78819
First Author: Sterner-Kock A
Year: 2002
Journal: Genes Dev
Title: Disruption of the gene encoding the latent transforming growth factor-beta binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancer.
Volume: 16
Issue: 17
Pages: 2264-73
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Publication
24627487 | J:213178
First Author: Nakano N
Year: 2014
Journal: J Biol Chem
Title: C18 ORF1, a novel negative regulator of transforming growth factor-β signaling.
Volume: 289
Issue: 18
Pages: 12680-92
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Publication
20881059 | J:182937
First Author: Penheiter SG
Year: 2010
Journal: Mol Biol Cell
Title: Type II transforming growth factor-beta receptor recycling is dependent upon the clathrin adaptor protein Dab2.
Volume: 21
Issue: 22
Pages: 4009-19
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Publication
15356634 | J:92664
First Author: Lin HK
Year: 2004
Journal: Nature
Title: Cytoplasmic PML function in TGF-beta signalling.
Volume: 431
Issue: 7005
Pages: 205-11
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Publication
10331191 | J:57220
First Author: Kano K
Year: 1999
Journal: J Vet Med Sci
Title: Cloning and studies of the mouse cDNA encoding Smad3.
Volume: 61
Issue: 3
Pages: 213-9
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Publication
9335505 | J:43279
First Author: Imamura T
Year: 1997
Journal: Nature
Title: Smad6 inhibits signalling by the TGF-beta superfamily.
Volume: 389
Issue: 6651
Pages: 622-6
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Publication
19218245 | J:149064
First Author: Wang G
Year: 2009
Journal: J Biol Chem
Title: Transforming growth factor-{beta}-inducible phosphorylation of Smad3.
Volume: 284
Issue: 15
Pages: 9663-73
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Publication
10458166 | J:114795
First Author: Zhu H
Year: 1999
Journal: Nature
Title: A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation.
Volume: 400
Issue: 6745
Pages: 687-93
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Publication
25750188 | J:251060
First Author: Awwad K
Year: 2015
Journal: Cardiovasc Res
Title: Role of secreted modular calcium-binding protein 1 (SMOC1) in transforming growth factor β signalling and angiogenesis.
Volume: 106
Issue: 2
Pages: 284-94
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Publication
21037076 | J:167636
First Author: Sullivan BP
Year: 2010
Journal: Am J Pathol
Title: The coagulation system contributes to alphaVbeta6 integrin expression and liver fibrosis induced by cholestasis.
Volume: 177
Issue: 6
Pages: 2837-49
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Publication
25056700 | J:215596
First Author: Munjal C
Year: 2014
Journal: Dis Model Mech
Title: TGF-β mediates early angiogenesis and latent fibrosis in an Emilin1-deficient mouse model of aortic valve disease.
Volume: 7
Issue: 8
Pages: 987-96
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Publication
16120603 | J:102696
First Author: Grimm SL
Year: 2005
Journal: J Biol Chem
Title: Cell cycle defects contribute to a block in hormone-induced mammary gland proliferation in CCAAT/enhancer-binding protein (C/EBPbeta)-null mice.
Volume: 280
Issue: 43
Pages: 36301-9
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Publication
26987815 | J:245447
First Author: Nahomi RB
Year: 2016
Journal: Biochem J
Title: αB-crystallin is essential for the TGF-β2-mediated epithelial to mesenchymal transition of lens epithelial cells.
Volume: 473
Issue: 10
Pages: 1455-69
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Publication
21828051 | J:176724
First Author: Hattori N
Year: 2011
Journal: J Biol Chem
Title: Pericellular versican regulates the fibroblast-myofibroblast transition: a role for ADAMTS5 protease-mediated proteolysis.
Volume: 286
Issue: 39
Pages: 34298-310
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Publication
18474728 | J:140155
First Author: Zhou L
Year: 2008
Journal: Blood
Title: Inhibition of the TGF-beta receptor I kinase promotes hematopoiesis in MDS.
Volume: 112
Issue: 8
Pages: 3434-43
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Publication
24793237 | J:213230
First Author: Grafe I
Year: 2014
Journal: Nat Med
Title: Excessive transforming growth factor-β signaling is a common mechanism in osteogenesis imperfecta.
Volume: 20
Issue: 6
Pages: 670-5
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Publication
25694587 | J:250641
First Author: Skrbic B
Year: 2015
Journal: Cardiovasc Res
Title: Lack of collagen VIII reduces fibrosis and promotes early mortality and cardiac dilatation in pressure overload in mice.
Volume: 106
Issue: 1
Pages: 32-42
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Publication
21245136 | J:170624
First Author: Shimano M
Year: 2011
Journal: J Biol Chem
Title: Cardiac myocyte-specific ablation of follistatin-like 3 attenuates stress-induced myocardial hypertrophy.
Volume: 286
Issue: 11
Pages: 9840-8
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Publication
15548578 | J:98373
First Author: Carvalho RL
Year: 2004
Journal: Development
Title: Defective paracrine signalling by TGFbeta in yolk sac vasculature of endoglin mutant mice: a paradigm for hereditary haemorrhagic telangiectasia.
Volume: 131
Issue: 24
Pages: 6237-47
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Publication
29891777 | J:277992
 
First Author: Lu J
Year: 2018
Journal: Int J Mol Sci
Title: Caveolin-1 Scaffolding Domain Peptides Alleviate Liver Fibrosis by Inhibiting TGF-β1/Smad Signaling in Mice.
Volume: 19
Issue: 6
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Publication
15923183 | J:100819
First Author: Pece-Barbara N
Year: 2005
Journal: J Biol Chem
Title: Endoglin null endothelial cells proliferate faster and are more responsive to transforming growth factor beta1 with higher affinity receptors and an activated Alk1 pathway.
Volume: 280
Issue: 30
Pages: 27800-8
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Publication
23370707 | J:310516
First Author: Lee JM
Year: 2013
Journal: Histochem Cell Biol
Title: Abnormal liver differentiation and excessive angiogenesis in mice lacking Runx3.
Volume: 139
Issue: 5
Pages: 751-8
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Publication
20142803 | J:158613
First Author: Hall BE
Year: 2010
Journal: Lab Invest
Title: Conditional overexpression of TGF-beta1 disrupts mouse salivary gland development and function.
Volume: 90
Issue: 4
Pages: 543-55
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Publication
25826092 | J:263152
First Author: Takemoto N
Year: 2015
Journal: Oncotarget
Title: Leucine-rich α-2-glycoprotein promotes TGFβ1-mediated growth suppression in the Lewis lung carcinoma cell lines.
Volume: 6
Issue: 13
Pages: 11009-22
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Publication
28370678 | J:275040
First Author: Chen L
Year: 2017
Journal: Wound Repair Regen
Title: Wound healing in Mac-1 deficient mice.
Volume: 25
Issue: 3
Pages: 366-376
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Publication
16622029 | J:125074
First Author: Ishida Y
Year: 2006
Journal: J Immunol
Title: Absence of IL-1 receptor antagonist impaired wound healing along with aberrant NF-kappaB activation and a reciprocal suppression of TGF-beta signal pathway.
Volume: 176
Issue: 9
Pages: 5598-606
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Publication
12748296 | J:83561
First Author: Beuschlein F
Year: 2003
Journal: Mol Cell Biol
Title: Activin induces x-zone apoptosis that inhibits luteinizing hormone-dependent adrenocortical tumor formation in inhibin-deficient mice.
Volume: 23
Issue: 11
Pages: 3951-64
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Publication
17967875 | J:128934
First Author: Pangas SA
Year: 2008
Journal: Mol Cell Biol
Title: Conditional deletion of Smad1 and Smad5 in somatic cells of male and female gonads leads to metastatic tumor development in mice.
Volume: 28
Issue: 1
Pages: 248-57
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Publication
31694392 | J:289954
First Author: Nishida N
Year: 2020
Journal: Arterioscler Thromb Vasc Biol
Title: High Salt Intake Worsens Aortic Dissection in Mice: Involvement of IL (Interleukin)-17A-Dependent ECM (Extracellular Matrix) Metabolism.
Volume: 40
Issue: 1
Pages: 189-205
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Publication
21383698 | J:174636
First Author: Knauf JA
Year: 2011
Journal: Oncogene
Title: Progression of BRAF-induced thyroid cancer is associated with epithelial-mesenchymal transition requiring concomitant MAP kinase and TGFβ signaling.
Volume: 30
Issue: 28
Pages: 3153-62
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Publication
12397035 | J:103379
First Author: Schiffer M
Year: 2002
Journal: J Am Soc Nephrol
Title: Inhibitory smads and tgf-Beta signaling in glomerular cells.
Volume: 13
Issue: 11
Pages: 2657-66
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Publication
15374947 | J:93668
First Author: Swallow CJ
Year: 2004
Journal: Cancer Res
Title: alpha2HS-glycoprotein, an antagonist of transforming growth factor beta in vivo, inhibits intestinal tumor progression.
Volume: 64
Issue: 18
Pages: 6402-9
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Publication
16554301 | J:113474
First Author: Stempien-Otero A
Year: 2006
Journal: J Biol Chem
Title: Mechanisms of cardiac fibrosis induced by urokinase plasminogen activator.
Volume: 281
Issue: 22
Pages: 15345-51
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Publication
18692037 | J:142136
First Author: Owens P
Year: 2008
Journal: Dev Biol
Title: Smad4-dependent desmoglein-4 expression contributes to hair follicle integrity.
Volume: 322
Issue: 1
Pages: 156-66
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Publication
22846721 | J:188696
First Author: Mii S
Year: 2012
Journal: Am J Pathol
Title: Epidermal hyperplasia and appendage abnormalities in mice lacking CD109.
Volume: 181
Issue: 4
Pages: 1180-9
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Publication
27756876 | J:310026
First Author: Sunagawa M
Year: 2016
Journal: Oncotarget
Title: Suppression of skin tumorigenesis in CD109-deficient mice.
Volume: 7
Issue: 50
Pages: 82836-82850
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Publication
24355923 | J:204960
First Author: Gallo EM
Year: 2014
Journal: J Clin Invest
Title: Angiotensin II-dependent TGF-β signaling contributes to Loeys-Dietz syndrome vascular pathogenesis.
Volume: 124
Issue: 1
Pages: 448-60
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Publication
17039257 | J:115012
First Author: Ohsawa Y
Year: 2006
Journal: J Clin Invest
Title: Muscular atrophy of caveolin-3-deficient mice is rescued by myostatin inhibition.
Volume: 116
Issue: 11
Pages: 2924-34
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Publication
25769722 | J:221120
First Author: Borcherding N
Year: 2015
Journal: Cancer Res
Title: Paracrine WNT5A Signaling Inhibits Expansion of Tumor-Initiating Cells.
Volume: 75
Issue: 10
Pages: 1972-82
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