Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
Not Specified |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5446225 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-12-19 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3264520 |
Pattern: |
Regionally restricted |
Stage: |
TS20 |
Assay Id: |
MGI:5446474 |
Age: |
embryonic day 12.5 |
Image: |
2 Gdf5 12.5 wt |
Note: |
Expression in perichondrium of early digital anlage, with a striped pattern of expression in developing joints of digits. |
Specimen Label: |
2 Gdf5 12.5 wt |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5446225 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-12-19 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3264520 |
Pattern: |
Regionally restricted |
Stage: |
TS20 |
Assay Id: |
MGI:5446474 |
Age: |
embryonic day 12.5 |
Image: |
2 Gdf5 12.5 spdh/spdh |
Note: |
No expression in phalangeal anlagen. |
Specimen Label: |
2 Gdf5 12.5 spdh/spdh |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5446225 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-12-19 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3264522 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5446491 |
Age: |
embryonic day 14.5 |
Image: |
5 Gdf5 14.5 wt |
Note: |
Subject: sclera & lacrimal glan |
Specimen Label: |
5 Gdf5 14.5 wt |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5446225 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-12-19 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:3264522 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5446491 |
Age: |
embryonic day 14.5 |
Image: |
5 Gdf5 14.5 spdh/spdh |
Note: |
Reduced expression in perichondrium. No expression in interzone. |
Specimen Label: |
5 Gdf5 14.5 spdh/spdh |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5446225 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-12-19 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3264524 |
Pattern: |
Regionally restricted |
Stage: |
TS24 |
Assay Id: |
MGI:5446491 |
Age: |
embryonic day 16.5 |
Image: |
5 Gdf5 16.5 wt |
Note: |
Expression in perichondrium, joint interzone, and cartilage of joint. |
Specimen Label: |
5 Gdf5 16.5 wt |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5446225 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-12-19 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:3264524 |
Pattern: |
Regionally restricted |
Stage: |
TS24 |
Assay Id: |
MGI:5446491 |
Age: |
embryonic day 16.5 |
Image: |
5 Gdf5 16.5 spdh/spdh |
Note: |
Reduced expression in perichondrium. No expression in interzone, with the exception of digit 1 and distal interphalangeal joints. |
Specimen Label: |
5 Gdf5 16.5 spdh/spdh |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5446225 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-12-19 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1745721 |
Pattern: |
Regionally restricted |
Stage: |
TS21 |
Assay Id: |
MGI:5446474 |
Age: |
embryonic day 13.5 |
Image: |
2 Gdf5 13.5 wt |
Note: |
Expression in developing joints of entire autopod. |
Specimen Label: |
2 Gdf5 13.5 wt |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5446225 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-12-19 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1745721 |
Pattern: |
Regionally restricted |
Stage: |
TS21 |
Assay Id: |
MGI:5446474 |
Age: |
embryonic day 13.5 |
Image: |
2 Gdf5 13.5 spdh/spdh |
Note: |
Some expression in joints between distal and middle phalanges, and between carpal bones. No expression in the joint interzone of digits. |
Specimen Label: |
2 Gdf5 13.5 spdh/spdh |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6780194 |
Assay Type: |
RNA in situ |
Annotation Date: |
2021-10-19 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3633623 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:6780206 |
Age: |
embryonic day 15.5 |
Image: |
2C Gdf5 Slit1+/+ |
Note: |
Expression in proximal and distal interphalangeal joints |
Specimen Label: |
2C Gdf5 Slit1+/+ |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6780194 |
Assay Type: |
RNA in situ |
Annotation Date: |
2021-10-19 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3633623 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:6780206 |
Age: |
embryonic day 15.5 |
Image: |
2C Gdf5 Slit1-/- Slit2-/- |
Note: |
Expression in proximal and distal interphalangeal joints |
Specimen Label: |
2C Gdf5 Slit1-/- Slit2-/- |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5446225 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-12-19 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1743121 |
Pattern: |
Regionally restricted |
Stage: |
TS21 |
Assay Id: |
MGI:5446474 |
Age: |
embryonic day 13.5 |
Image: |
2 Gdf5 13.5 spdh/spdh |
Note: |
Some expression in metacarpophalangeal joint of digit 1, |
Specimen Label: |
2 Gdf5 13.5 spdh/spdh |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6780194 |
Assay Type: |
RNA in situ |
Annotation Date: |
2021-10-19 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1930223 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:6780206 |
Age: |
embryonic day 15.5 |
Image: |
2C Gdf5 Slit1+/+ |
|
Specimen Label: |
2C Gdf5 Slit1+/+ |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6780194 |
Assay Type: |
RNA in situ |
Annotation Date: |
2021-10-19 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1930223 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:6780206 |
Age: |
embryonic day 15.5 |
Image: |
2C Gdf5 Slit1-/- Slit2-/- |
|
Specimen Label: |
2C Gdf5 Slit1-/- Slit2-/- |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6780194 |
Assay Type: |
RNA in situ |
Annotation Date: |
2021-10-19 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3804123 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:6780206 |
Age: |
embryonic day 15.5 |
Image: |
2C Gdf5 Slit1+/+ |
|
Specimen Label: |
2C Gdf5 Slit1+/+ |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6780194 |
Assay Type: |
RNA in situ |
Annotation Date: |
2021-10-19 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3804123 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:6780206 |
Age: |
embryonic day 15.5 |
Image: |
2C Gdf5 Slit1-/- Slit2-/- |
|
Specimen Label: |
2C Gdf5 Slit1-/- Slit2-/- |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3654010 |
Assay Type: |
RT-PCR |
Annotation Date: |
2006-09-13 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1737319 |
|
Stage: |
TS19 |
Assay Id: |
MGI:3654512 |
Age: |
embryonic day 11.5 |
Image: |
2 |
|
Specimen Label: |
GDF5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3654010 |
Assay Type: |
RT-PCR |
Annotation Date: |
2006-09-13 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603925 |
|
Stage: |
TS25 |
Assay Id: |
MGI:3654459 |
Age: |
embryonic day 17.5 |
Image: |
2 |
|
Specimen Label: |
GDF5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kania K |
Year: |
2020 |
Journal: |
Sci Rep |
Title: |
Regulation of Gdf5 expression in joint remodelling, repair and osteoarthritis. |
Volume: |
10 |
Issue: |
1 |
Pages: |
157 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
275
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Kan A |
Year: |
2013 |
Journal: |
BMC Dev Biol |
Title: |
SOX11 contributes to the regulation of GDF5 in joint maintenance. |
Volume: |
13 |
|
Pages: |
4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hagiwara Y |
Year: |
2020 |
Journal: |
Ann N Y Acad Sci |
Title: |
Cells from a GDF5 origin produce zonal tendon-to-bone attachments following anterior cruciate ligament reconstruction. |
Volume: |
1460 |
Issue: |
1 |
Pages: |
57-67 |
|
•
•
•
•
•
|
Publication |
First Author: |
Storm EE |
Year: |
1999 |
Journal: |
Dev Biol |
Title: |
GDF5 coordinates bone and joint formation during digit development. |
Volume: |
209 |
Issue: |
1 |
Pages: |
11-27 |
|
•
•
•
•
•
|
Publication |
First Author: |
Degenkolbe E |
Year: |
2013 |
Journal: |
PLoS Genet |
Title: |
A GDF5 point mutation strikes twice--causing BDA1 and SYNS2. |
Volume: |
9 |
Issue: |
10 |
Pages: |
e1003846 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu J |
Year: |
2016 |
Journal: |
Sci Rep |
Title: |
Mutant GDF5 enhances ameloblast differentiation via accelerated BMP2-induced Smad1/5/8 phosphorylation. |
Volume: |
6 |
|
Pages: |
23670 |
|
•
•
•
•
•
|
Publication |
First Author: |
Karst SY |
Year: |
2013 |
Journal: |
MGI Direct Data Submission |
Title: |
Brachypodism 5 Jackson, a mouse model of GDF5 genetic diseases |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Kiapour AM |
Year: |
2018 |
Journal: |
PLoS One |
Title: |
The role of Gdf5 regulatory regions in development of hip morphology. |
Volume: |
13 |
Issue: |
11 |
Pages: |
e0202785 |
|
•
•
•
•
•
|
Publication |
First Author: |
Coleman CM |
Year: |
2003 |
Journal: |
Anat Rec A Discov Mol Cell Evol Biol |
Title: |
Correlation of GDF5 and connexin 43 mRNA expression during embryonic development. |
Volume: |
275 |
Issue: |
2 |
Pages: |
1117-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Daans M |
Year: |
2011 |
Journal: |
Ann Rheum Dis |
Title: |
GDF5 deficiency in mice is associated with instability-driven joint damage, gait and subchondral bone changes. |
Volume: |
70 |
Issue: |
1 |
Pages: |
208-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen H |
Year: |
2016 |
Journal: |
PLoS Genet |
Title: |
Heads, Shoulders, Elbows, Knees, and Toes: Modular Gdf5 Enhancers Control Different Joints in the Vertebrate Skeleton. |
Volume: |
12 |
Issue: |
11 |
Pages: |
e1006454 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3687180 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-11-09 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1763522 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:3687181 |
Age: |
embryonic day 14.5 |
|
Note: |
Expression was strong in the perichondrium. |
Specimen Label: |
6B Gdf5 left |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3687180 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-11-09 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1763522 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:3687181 |
Age: |
embryonic day 14.5 |
|
Note: |
Expression was weak in the perichondrium. |
Specimen Label: |
6B Gdf5 right |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Traoré M |
Year: |
2019 |
Journal: |
Sci Transl Med |
Title: |
An embryonic CaVβ1 isoform promotes muscle mass maintenance via GDF5 signaling in adult mouse. |
Volume: |
11 |
Issue: |
517 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Dyment NA |
Year: |
2015 |
Journal: |
Dev Biol |
Title: |
Gdf5 progenitors give rise to fibrocartilage cells that mineralize via hedgehog signaling to form the zonal enthesis. |
Volume: |
405 |
Issue: |
1 |
Pages: |
96-107 |
|
•
•
•
•
•
|
Publication |
First Author: |
Howard M |
Year: |
2016 |
Journal: |
In Vitro Cell Dev Biol Anim |
Title: |
The function and interrelationship between GDF5 and ERG-010 during chondrogenesis in vitro. |
Volume: |
52 |
Issue: |
2 |
Pages: |
182-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hatazawa Y |
Year: |
2018 |
Journal: |
FASEB J |
Title: |
Reduced Dnmt3a increases Gdf5 expression with suppressed satellite cell differentiation and impaired skeletal muscle regeneration. |
Volume: |
32 |
Issue: |
3 |
Pages: |
1452-1467 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pregizer SK |
Year: |
2018 |
Journal: |
Ann Rheum Dis |
Title: |
Impact of broad regulatory regions on Gdf5 expression and function in knee development and susceptibility to osteoarthritis. |
Volume: |
77 |
Issue: |
3 |
Pages: |
450 |
|
•
•
•
•
•
|
Publication |
First Author: |
Masuya H |
Year: |
2007 |
Journal: |
Hum Mol Genet |
Title: |
A novel dominant-negative mutation in Gdf5 generated by ENU mutagenesis impairs joint formation and causes osteoarthritis in mice. |
Volume: |
16 |
Issue: |
19 |
Pages: |
2366-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Itoh S |
Year: |
2008 |
Journal: |
Genes Cells |
Title: |
Trps1 plays a pivotal role downstream of Gdf5 signaling in promoting chondrogenesis and apoptosis of ATDC5 cells. |
Volume: |
13 |
Issue: |
4 |
Pages: |
355-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Seemann P |
Year: |
2005 |
Journal: |
J Clin Invest |
Title: |
Activating and deactivating mutations in the receptor interaction site of GDF5 cause symphalangism or brachydactyly type A2. |
Volume: |
115 |
Issue: |
9 |
Pages: |
2373-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Settle SH Jr |
Year: |
2003 |
Journal: |
Dev Biol |
Title: |
Multiple joint and skeletal patterning defects caused by single and double mutations in the mouse Gdf6 and Gdf5 genes. |
Volume: |
254 |
Issue: |
1 |
Pages: |
116-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schwaerzer GK |
Year: |
2012 |
Journal: |
J Bone Miner Res |
Title: |
New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance. |
Volume: |
27 |
Issue: |
2 |
Pages: |
429-42 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6173449 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689419 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:6190391 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Table S2 - E11.5 - Gdf5 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6173449 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689421 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:6190391 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
Table S2 - E13.5 - Gdf5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6173449 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689424 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:6190391 |
Age: |
embryonic day 15.5 |
|
|
Specimen Label: |
Table S2 - E15.5 - Gdf5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6173449 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689426 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:6190391 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
Table S2 - E18.5 - Gdf5 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6173449 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190391 |
Age: |
postnatal day 4 |
|
|
Specimen Label: |
Table S2 - P4 - Gdf5 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6173449 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190391 |
Age: |
postnatal day 14 |
|
|
Specimen Label: |
Table S2 - P14 - Gdf5 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6173449 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6190391 |
Age: |
postnatal day 28 |
|
|
Specimen Label: |
Table S2 - P28 - Gdf5 |
Detected: |
false |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5806588 |
Assay Type: |
RNA in situ |
Annotation Date: |
2016-11-10 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1640520 |
Pattern: |
Regionally restricted |
Stage: |
TS20 |
Assay Id: |
MGI:5806796 |
Age: |
embryonic day 12.5 |
Image: |
5a,c |
Note: |
Gdf5 and Bmpr1b are expressed in nonoverlapping, but adjacent regions of the limb. |
Specimen Label: |
5a,c |
Detected: |
true |
Specimen Num: |
10 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5806588 |
Assay Type: |
RNA in situ |
Annotation Date: |
2016-11-10 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1640521 |
Pattern: |
Regionally restricted |
Stage: |
TS21 |
Assay Id: |
MGI:5806796 |
Age: |
embryonic day 13.5 |
Image: |
5d,f |
Note: |
Gdf5 and Bmpr1b are expressed in nonoverlapping, but adjacent regions of the limb. |
Specimen Label: |
5d,f |
Detected: |
true |
Specimen Num: |
11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shwartz Y |
Year: |
2016 |
Journal: |
Cell Rep |
Title: |
Joint Development Involves a Continuous Influx of Gdf5-Positive Cells. |
Volume: |
15 |
Issue: |
12 |
Pages: |
2577-87 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rountree RB |
Year: |
2004 |
Journal: |
PLoS Biol |
Title: |
BMP receptor signaling is required for postnatal maintenance of articular cartilage. |
Volume: |
2 |
Issue: |
11 |
Pages: |
e355 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang Y |
Year: |
2020 |
Journal: |
Dev Dyn |
Title: |
Cruciate ligament, patellar tendon, and patella formation involves differential cellular sources and dynamics as joint cavitation proceeds. |
Volume: |
249 |
Issue: |
6 |
Pages: |
711-722 |
|
•
•
•
•
•
|
Publication |
First Author: |
Suto J |
Year: |
2006 |
Journal: |
J Vet Med Sci |
Title: |
Identification of mutation in the growth differentiation factor 5 (Gdf5) gene in NC-brp/brp mice. |
Volume: |
68 |
Issue: |
10 |
Pages: |
1121-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Harris BS |
Year: |
2015 |
Journal: |
MGI Direct Data Submission |
Title: |
brachypodism 6 Jackson |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Gamer LW |
Year: |
2018 |
Journal: |
J Bone Miner Res |
Title: |
The Role of Bmp2 in the Maturation and Maintenance of the Murine Knee Joint. |
Volume: |
33 |
Issue: |
9 |
Pages: |
1708-1717 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dy P |
Year: |
2010 |
Journal: |
Dev Biol |
Title: |
Synovial joint morphogenesis requires the chondrogenic action of Sox5 and Sox6 in growth plate and articular cartilage. |
Volume: |
341 |
Issue: |
2 |
Pages: |
346-59 |
|
•
•
•
•
•
|
Publication |
First Author: |
Takahara M |
Year: |
2004 |
Journal: |
Bone |
Title: |
Developmental failure of phalanges in the absence of growth/differentiation factor 5. |
Volume: |
35 |
Issue: |
5 |
Pages: |
1069-76 |
|
•
•
•
•
•
|
Publication |
First Author: |
O'Keeffe GW |
Year: |
2016 |
Journal: |
Neural Dev |
Title: |
Region-specific role of growth differentiation factor-5 in the establishment of sympathetic innervation. |
Volume: |
11 |
|
Pages: |
4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zaidi SH |
Year: |
2010 |
Journal: |
J Am Coll Cardiol |
Title: |
Growth differentiation factor 5 regulates cardiac repair after myocardial infarction. |
Volume: |
55 |
Issue: |
2 |
Pages: |
135-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Osório C |
Year: |
2013 |
Journal: |
Development |
Title: |
Growth differentiation factor 5 is a key physiological regulator of dendrite growth during development. |
Volume: |
140 |
Issue: |
23 |
Pages: |
4751-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hinoi E |
Year: |
2014 |
Journal: |
Diabetes |
Title: |
Growth differentiation factor-5 promotes brown adipogenesis in systemic energy expenditure. |
Volume: |
63 |
Issue: |
1 |
Pages: |
162-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Storm EE |
Year: |
1996 |
Journal: |
Development |
Title: |
Joint patterning defects caused by single and double mutations in members of the bone morphogenetic protein (BMP) family. |
Volume: |
122 |
Issue: |
12 |
Pages: |
3969-79 |
|
•
•
•
•
•
|
Publication |
First Author: |
Storm EE |
Year: |
1994 |
Journal: |
Nature |
Title: |
Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily. |
Volume: |
368 |
Issue: |
6472 |
Pages: |
639-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Perez WD |
Year: |
2010 |
Journal: |
Dev Dyn |
Title: |
Survival of Hoxa13 homozygous mutants reveals a novel role in digit patterning and appendicular skeletal development. |
Volume: |
239 |
Issue: |
2 |
Pages: |
446-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim M |
Year: |
2022 |
Journal: |
Biol Open |
Title: |
Synovial joint cavitation initiates with microcavities in interzone and is coupled to skeletal flexion and elongation in developing mouse embryo limbs. |
Volume: |
11 |
Issue: |
6 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Leung AOW |
Year: |
2024 |
Journal: |
Nat Commun |
Title: |
Suppression of apoptosis impairs phalangeal joint formation in the pathogenesis of brachydactyly type A1. |
Volume: |
15 |
Issue: |
1 |
Pages: |
2229 |
|
•
•
•
•
•
|
Publication |
First Author: |
Macpherson PC |
Year: |
2015 |
Journal: |
Development |
Title: |
Dach2-Hdac9 signaling regulates reinnervation of muscle endplates. |
Volume: |
142 |
Issue: |
23 |
Pages: |
4038-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hinoi E |
Year: |
2014 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Nuclear factor-κB is a common upstream signal for growth differentiation factor-5 expression in brown adipocytes exposed to pro-inflammatory cytokines and palmitate. |
Volume: |
452 |
Issue: |
4 |
Pages: |
974-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hinoi E |
Year: |
2014 |
Journal: |
Biochem Biophys Res Commun |
Title: |
PI3K/Akt is involved in brown adipogenesis mediated by growth differentiation factor-5 in association with activation of the Smad pathway. |
Volume: |
450 |
Issue: |
1 |
Pages: |
255-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Meech R |
Year: |
2005 |
Journal: |
Development |
Title: |
The homeobox transcription factor Barx2 regulates chondrogenesis during limb development. |
Volume: |
132 |
Issue: |
9 |
Pages: |
2135-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Choe Y |
Year: |
2012 |
Journal: |
Neuron |
Title: |
A cascade of morphogenic signaling initiated by the meninges controls corpus callosum formation. |
Volume: |
73 |
Issue: |
4 |
Pages: |
698-712 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yi SE |
Year: |
2000 |
Journal: |
Development |
Title: |
The type I BMP receptor BMPRIB is required for chondrogenesis in the mouse limb. |
Volume: |
127 |
Issue: |
3 |
Pages: |
621-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Raz R |
Year: |
2008 |
Journal: |
Development |
Title: |
The mutation ROR2W749X, linked to human BDB, is a recessive mutation in the mouse, causing brachydactyly, mediating patterning of joints and modeling recessive Robinow syndrome. |
Volume: |
135 |
Issue: |
9 |
Pages: |
1713-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tavella S |
Year: |
2006 |
Journal: |
Matrix Biol |
Title: |
Forced chondrocyte expression of sonic hedgehog impairs joint formation affecting proliferation and apoptosis. |
Volume: |
25 |
Issue: |
7 |
Pages: |
389-97 |
|
•
•
•
•
•
|
Publication |
First Author: |
Koyama E |
Year: |
2007 |
Journal: |
Ann N Y Acad Sci |
Title: |
Synovial joint formation during mouse limb skeletogenesis: roles of Indian hedgehog signaling. |
Volume: |
1116 |
|
Pages: |
100-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mead TJ |
Year: |
2022 |
Journal: |
Elife |
Title: |
Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development. |
Volume: |
11 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Tang L |
Year: |
2017 |
Journal: |
Hum Mol Genet |
Title: |
A point mutation in Fgf9 impedes joint interzone formation leading to multiple synostoses syndrome. |
Volume: |
26 |
Issue: |
7 |
Pages: |
1280-1293 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ohta Y |
Year: |
2015 |
Journal: |
Arthritis Rheumatol |
Title: |
Articular cartilage endurance and resistance to osteoarthritic changes require transcription factor Erg. |
Volume: |
67 |
Issue: |
10 |
Pages: |
2679-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Baur ST |
Year: |
2000 |
Journal: |
Development |
Title: |
Combinatorial signaling through BMP receptor IB and GDF5: shaping of the distal mouse limb and the genetics of distal limb diversity. |
Volume: |
127 |
Issue: |
3 |
Pages: |
605-19 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mundy C |
Year: |
2011 |
Journal: |
Dev Biol |
Title: |
Synovial joint formation requires local Ext1 expression and heparan sulfate production in developing mouse embryo limbs and spine. |
Volume: |
351 |
Issue: |
1 |
Pages: |
70-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tucker AS |
Year: |
2004 |
Journal: |
Development |
Title: |
Bapx1 regulates patterning in the middle ear: altered regulatory role in the transition from the proximal jaw during vertebrate evolution. |
Volume: |
131 |
Issue: |
6 |
Pages: |
1235-45 |
|
•
•
•
•
•
|
Publication |
First Author: |
Eyal S |
Year: |
2015 |
Journal: |
Development |
Title: |
On the development of the patella. |
Volume: |
142 |
Issue: |
10 |
Pages: |
1831-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kahn J |
Year: |
2009 |
Journal: |
Dev Cell |
Title: |
Muscle contraction is necessary to maintain joint progenitor cell fate. |
Volume: |
16 |
Issue: |
5 |
Pages: |
734-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chiang C |
Year: |
2001 |
Journal: |
Dev Biol |
Title: |
Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function. |
Volume: |
236 |
Issue: |
2 |
Pages: |
421-35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Decker RS |
Year: |
2017 |
Journal: |
Dev Biol |
Title: |
Cell origin, volume and arrangement are drivers of articular cartilage formation, morphogenesis and response to injury in mouse limbs. |
Volume: |
426 |
Issue: |
1 |
Pages: |
56-68 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|